Osong Public Health and Research Perspectives

Economic effectiveness of training personnel for infectious disease response and improving information systems in Republic of Korea: a cost-benefit analysis: Sunung Moon, Sangwon Lee, Yunhyung Kwon, Chaeeun Lee, Nahyun Kwon; Received January 27, 2026 Accepted June 18, 2026 Published online August 14, 2026; DOI: https://doi.org/10.24171/j.phrp.2026.0019 [Epub ahead of print]

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Factor structure and measurement invariance of the EuroQol 5-dimensional questionnaire: a secondary analysis of the Korea Health Panel survey: Byungsun Park, Hanna Choi; Osong Public Health Res Perspect 2026;17(3):272-281.
Published online April 13, 2026; DOI: https://doi.org/10.24171/j.phrp.2025.0440

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Time-series decomposition and modeling of dengue cases in Malaysia, 2022–2024: a nationwide observational study: Mohamad Afiq Amsyar Hamedin, Kamarul Imran Musa, Mohd Rahim Sulong; Osong Public Health Res Perspect 2026;17(1):50-60.
Published online January 27, 2026; DOI: https://doi.org/10.24171/j.phrp.2025.0397

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Scrub typhus in the era of climate change: exploring lagged and cumulative effects of meteorological factors in the Republic of Korea, 2001–2024, a nationwide time-series study: Hye Young Lee, Jeong Ran Kwon, Yuna Kim; Osong Public Health Res Perspect 2025;16(5):437-452.
Published online October 15, 2025; DOI: https://doi.org/10.24171/j.phrp.2025.0177

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A confirmatory analysis of the knowledge, attitudes, and perceptions questionnaire for community-based surveillance of infectious diseases: a cross-sectional study in Malaysia: Ahmed Azeez Hasan, Anis Kausar Ghazali, Najib Majdi Yacoob, Norsa’adah Bachok, Suhaily Mohd Hairon, Nur Amira M. Nadir, Fatimah Muhd Shukri; Osong Public Health Res Perspect 2025;16(5):508-518.
Published online August 12, 2025; DOI: https://doi.org/10.24171/j.phrp.2025.0106

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Effectiveness of non-pharmacological school-based therapies for cigarette smoking cessation among adolescents in South and Southeast Asian countries: a systematic review and meta-analysis: Fahad Ali Mangrio, Penpaktr Uthis, Suwimon Rojnawee, Alicia K Matthews; Osong Public Health Res Perspect 2025;16(3):195-210.
Published online April 30, 2025; DOI: https://doi.org/10.24171/j.phrp.2024.0320

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Multilevel analysis of individual, household, and community factors influencing COVID-19 vaccination intention: evidence from the 2021 Korea Community Health Survey: Ji-seon Seong, Jong-Yeon Kim; Osong Public Health Res Perspect 2025;16(2):169-180.
Published online February 21, 2025; DOI: https://doi.org/10.24171/j.phrp.2024.0254

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The prevalence of tobacco, alcohol, stimulant, khat, and cannabis use among school-going students in African and Arab countries: a systematic review and meta-analysis: Chaimaa El Moubchiri, Mohamed Chahboune, Morad Guennouni, Abderraouf Hilali; Osong Public Health Res Perspect 2025;16(1):28-41.
Published online December 13, 2024; DOI: https://doi.org/10.24171/j.phrp.2024.0204

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Individual and contextual factors associated with measles infection in Malaysia: a multilevel analysis: Mohd Rujhan Hadfi Mat Daud, Nor Azwany Yaacob, Wan Nor Arifin, Jamiatul Aida Md Sani, Wan Abdul Hannan Wan Ibadullah; Osong Public Health Res Perspect 2024;15(5):429-439.
Published online August 21, 2024; DOI: https://doi.org/10.24171/j.phrp.2024.0156

Objectives
Despite effective vaccination strategies, measles remains a global public health challenge. The study explored individual and contextual factors associated with measles infection in Malaysia from 2018 to 2022, informing the development of targeted public health interventions. Methods: This cross-sectional study utilised data from the Ministry of Health, the Department of Statistics, and the Department of Environment Malaysia. Multilevel logistic regression analysis was employed to examine individual-level factors, including age, sex, ethnicity, nationality, contact history, travel history, and vaccination status. Concurrently, contextual factors were assessed, encompassing district-level determinants such as population density, median household income, urbanisation, the number of health and rural clinics, vaccination rates, fine particulate matter less than 2.5 μm (PM2.5) levels, relative humidity, and temperature, to determine their impact on measles infection risk. Results: Measles infection was significantly associated with various individual factors. These included age (adjusted odds ratio [aOR], 1.02; 95% confidence interval [CI], 1.02–1.03), ethnicity, non-Malaysian nationality (aOR, 34.53; 95% CI, 8.42– 141.51), prior contact with a measles case (aOR, 2.36; 95% CI, 2.07–2.69), travel history (aOR, 2.30; 95% CI, 1.13–4.70), and vaccination status (aOR, 0.76; 95% CI, 0.72–0.79). Among contextual factors, urbanisation (aOR, 1.56; 95% CI, 1.16– 2.10) and the number of clinics (aOR, 0.98; 95% CI, 0.97–0.99) were significant determinants. Conclusion: This multilevel logistic regression analysis illuminates the complexities of measles transmission, advocating public health interventions tailored to individual and contextual vulnerabilities. The findings highlight the need for a synergistic approach that combines vaccination campaigns, healthcare accessibility improvements, and socioeconomic interventions to effectively combat measles.

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Infectious disease research in the Association of Southeast Asian Nations region: a scientometric analysis: Joseph Christian Obnial, Catherine Joy Escuadra, Adriana Viola Miranda, Don Eliseo Lucero-Prisno, III; Osong Public Health Res Perspect 2024;15(4):329-339.
Published online August 2, 2024; DOI: https://doi.org/10.24171/j.phrp.2024.0058

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Predictors of outcomes 3 to 12 months after traumatic brain injury: a systematic review and meta-analysis: Younes Iderdar, Maryem Arraji, Nadia Al Wachami, Morad Guennouni, Karima Boumendil, Yassmine Mourajid, Noureddine Elkhoudri, Elmadani Saad, Mohamed Chahboune; Osong Public Health Res Perspect 2024;15(1):3-17.
Published online February 5, 2024; DOI: https://doi.org/10.24171/j.phrp.2023.0288

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Estimation of the onset time of diabetic complications in type 2 diabetes patients in Thailand: a survival analysis: Natthanicha Sauenram, Jutatip Sillabutra, Chukiat Viwatwongkasem, Pratana Satitvipawee; Osong Public Health Res Perspect 2023;14(6):508-519.
Published online November 23, 2023; DOI: https://doi.org/10.24171/j.phrp.2023.0084

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Risk factors for transmission in a COVID-19 cluster infection in a high school in the Republic of Korea: Jin-Hwan Jeon, Su Jin Kang, Se-Jin Jeong, Hyeon-Cheol Jang, Young-Joon Park, Sang-Eun Lee; Osong Public Health Res Perspect 2023;14(4):252-262.
Published online July 27, 2023; DOI: https://doi.org/10.24171/j.phrp.2023.0125

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Time-series comparison of COVID-19 case fatality rates across 21 countries with adjustment for multiple covariates: Yongmoon Kim, Bryan Inho Kim, Sangwoo Tak; Osong Public Health Res Perspect 2022;13(6):424-434.
Published online November 28, 2022; DOI: https://doi.org/10.24171/j.phrp.2022.0212

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Effects of medication adherence interventions for older adults with chronic illnesses: a systematic review and meta-analysis: Hae Ok Jeon, Myung-Ock Chae, Ahrin Kim; Osong Public Health Res Perspect 2022;13(5):328-340.
Published online October 12, 2022; DOI: https://doi.org/10.24171/j.phrp.2022.0168

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Phylogenetic and genome-wide mutational analysis of SARS-CoV-2 strains circulating in Nigeria: no implications for attenuated COVID-19 outcomes: Daniel B. Kolawole, Malachy I. Okeke; Osong Public Health Res Perspect 2022;13(2):101-113.
Published online April 22, 2022; DOI: https://doi.org/10.24171/j.phrp.2021.0329

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Spatiotemporal analysis of environmental and physiographic factors related to malaria in Bareilly district, India: Shikhar Chaudhary, Biju Soman; Osong Public Health Res Perspect 2022;13(2):123-132.
Published online March 31, 2022; DOI: https://doi.org/10.24171/j.phrp.2021.0304

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Worldwide prevalence of fungal coinfections among COVID-19 patients: a comprehensive systematic review and meta-analysis: Saber Soltani, Milad Zandi, Samireh Faramarzi, Ramin Shahbahrami, Mohebat Vali, Sara Akhavan Rezayat, Reza Pakzad, Pooneh Malekifar, Iraj Pakzad, Neda Jahandoost, Jalal Moludi; Osong Public Health Res Perspect 2022;13(1):15-23.
Published online February 8, 2022; DOI: https://doi.org/10.24171/j.phrp.2021.0293

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A spatial analysis of the association between social vulnerability and the cumulative number of confirmed deaths from COVID-19 in United States counties through November 14, 2020: Baksun Sung; Osong Public Health Res Perspect 2021;12(3):149-157.
Published online June 2, 2021; DOI: https://doi.org/10.24171/j.phrp.2020.0372

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The 100 top-cited articles on scrub typhus: a bibliometric analysis: Taha Hussein Musa, Wei Li, Joseph Kawuki, Pingmin Wei; Osong Public Health Res Perspect 2021;12(2):126-135.
Published online April 29, 2021; DOI: https://doi.org/10.24171/j.phrp.2021.12.2.10

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COVID-19 Patients: A Systematic Review and Meta-Analysis of Laboratory Findings, Comorbidities, and Clinical Outcomes Comparing Medical Staff versus the General Population: Mina Ebrahimi, Amal Saki Malehi, Fakher Rahim; Osong Public Health Res Perspect 2020;11(5):269-279.
Published online October 22, 2020; DOI: https://doi.org/10.24171/j.phrp.2020.11.5.02

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In Vitro Antibacterial Activity, Gas Chromatography–Mass Spectrometry Analysis of Woodfordia fruticosa Kurz. Leaf Extract and Host Toxicity Testing With In Vitro Cultured Lymphocytes From Human Umbilical Cord Blood: Debasmita Dubey, Rajashree Patnaik, Goutam Ghosh, Rabindra N. Padhy; Osong Public Health Res Perspect 2014;5(5):298-312.
Published online October 31, 2014; DOI: https://doi.org/10.1016/j.phrp.2014.08.001

Objectives
To locate a plant with suitable phytochemicals for use as antimicrobial agents to control multidrug-resistant (MDR) bacteria as a complementary medicine, without host toxicity as monitored through cultured lymphocytes from human umbilical cord blood.
Methods
The methanol crude leaf extract of the plant Woodfordia fruticosa was subjected to antimicrobial assay in vitro with nine pathogenic MDR bacteria from clinical samples. This was followed by bioassay-guided fractionation with seven non-polar to polar solvents, gas chromatography–mass spectrometry analysis of the n-butanol fraction, and monitoring of the host toxicity of the leaf extract with in vitro grown lymphocytes from human umbilical cord blood.
Results
The leaf extract of W. fruticosa had a controlling capacity for MDR bacteria. The minimum inhibitory concentration and minimum bactericidal concentration of the n-butanol fraction were < 1.89 mg/mL extract and 9.63 mg/mL extract, respectively. The gas chromatography–mass spectrometry spectrum of the n-butanol fraction confirmed the presence of 13 peaks of different compounds with retention times of 9.11 minutes, 9.72 minutes, 10.13 minutes, 10.78 minutes, 12.37 minutes, 12.93 minutes, 18.16 minutes, 21.74 minutes, 21.84 minutes, 5.96 minutes, 12.93 minutes, 24.70 minutes, and 25.76 minutes. The six leading compounds were: diethyl phthalate: <bold>IUPAC name:</bold> diethyl benzene-1,2-dicarboxylate; 5-methyl-2-(1-methylethyl) phenol: <bold>IUPAC name:</bold> 5-methyl-2-propan-2-ylphenol; (E )-3,7-dimethylocta-2,6-diene-1-thiol: <bold>IUPAC name:</bold> (2Z)-3,7-dimethylocta-2,6-diene-1-thiol; 2,6,10-dodecatrien-1-ol, 3,7,11-trimethyl-, (E,E ): <bold>IUPAC name:</bold> 2,6,10-dodecatrien-1-ol; 3,7,11-trimethyl-, (E,E); 2-methoxy-4-(2-propenyl) phenol: <bold>IUPAC name:</bold> 2-methoxy-4-[(1E)-prop-1-en-1-yl]phenol; hexadecanoic acid: <bold>IUPAC name:</bold> hexadecanoic acid.
Conclusion
The presence of antimicrobial compounds that are therapeutically potent against MDR bacteria was confirmed in W. fruticosa. The crude leaf extract showed no host toxicity with human lymphocytes; the n-butanol fraction of the extract was the most suitable bioactive fraction. The terpenes isolated were: 5-methyl-2-(1-methylethyl) phenol, 2-methoxy-4-(2-propenyl) phenol, 2,6-octadien-1-ol, 3,7-dimethyl-(E)-2,6-octadienal, 3,7-dimethylcyclohexanol, and cyclohexanol, 2-methylene-5-(1-methylethenyl) which were reported to have specifically antimicrobial activity.

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