Osong Public Health and Research Perspectives

Most-download articles are from the articles published in 2023 during the last three month.

Editorial

Which infectious diseases are currently posing problems in the Republic of Korea? One out of every two tuberculosis patients is over 65 years old: Jong-Koo Lee; Osong Public Health Res Perspect. 2024;15(5):383-384. Published online October 31, 2024; DOI: https://doi.org/10.24171/j.phrp.2024.0301

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Original Article

Individual and contextual factors associated with measles infection in Malaysia: a multilevel analysis: Mohd Rujhan Hadfi Mat Daud, Nor Azwany Yaacob, Wan Nor Arifin, Jamiatul Aida Md Sani, Wan Abdul Hannan Wan Ibadullah; Osong Public Health Res Perspect. 2024;15(5):429-439. Published online August 21, 2024; DOI: https://doi.org/10.24171/j.phrp.2024.0156

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Graphical Abstract Abstract PDF: Objectives
Despite effective vaccination strategies, measles remains a global public health challenge. The study explored individual and contextual factors associated with measles infection in Malaysia from 2018 to 2022, informing the development of targeted public health interventions. Methods: This cross-sectional study utilised data from the Ministry of Health, the Department of Statistics, and the Department of Environment Malaysia. Multilevel logistic regression analysis was employed to examine individual-level factors, including age, sex, ethnicity, nationality, contact history, travel history, and vaccination status. Concurrently, contextual factors were assessed, encompassing district-level determinants such as population density, median household income, urbanisation, the number of health and rural clinics, vaccination rates, fine particulate matter less than 2.5 μm (PM2.5) levels, relative humidity, and temperature, to determine their impact on measles infection risk. Results: Measles infection was significantly associated with various individual factors. These included age (adjusted odds ratio [aOR], 1.02; 95% confidence interval [CI], 1.02–1.03), ethnicity, non-Malaysian nationality (aOR, 34.53; 95% CI, 8.42– 141.51), prior contact with a measles case (aOR, 2.36; 95% CI, 2.07–2.69), travel history (aOR, 2.30; 95% CI, 1.13–4.70), and vaccination status (aOR, 0.76; 95% CI, 0.72–0.79). Among contextual factors, urbanisation (aOR, 1.56; 95% CI, 1.16– 2.10) and the number of clinics (aOR, 0.98; 95% CI, 0.97–0.99) were significant determinants. Conclusion: This multilevel logistic regression analysis illuminates the complexities of measles transmission, advocating public health interventions tailored to individual and contextual vulnerabilities. The findings highlight the need for a synergistic approach that combines vaccination campaigns, healthcare accessibility improvements, and socioeconomic interventions to effectively combat measles.

Editorial

The urgency of improving research infrastructure and institutional frameworks for the next pandemic: Jong-Koo Lee; Osong Public Health Res Perspect. 2024;15(6):477-478. Published online December 30, 2024; DOI: https://doi.org/10.24171/j.phrp.2024.0361

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Original Articles

Chronic kidney disease in Indonesia: evidence from a national health survey: Puti Sari Hidayangsih, Dwi Hapsari Tjandrarini, Noor Edi Widya Sukoco, Nikson Sitorus, Ika Dharmayanti, Feri Ahmadi; Osong Public Health Res Perspect. 2023;14(1):23-30. Published online February 14, 2023; DOI: https://doi.org/10.24171/j.phrp.2022.0290

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Graphical Abstract Abstract PDF: Objectives
Several previous studies have stated that consuming certain foods and beverages might increase the risk of chronic kidney disease (CKD). This study aimed to examine the relationships of food and beverage consumption with other risk factors for CKD. Methods: Data sources included the 2018 Basic Health Research (Riskesdas) and the National Socio-Economic Survey (Susenas), which were analyzed using a cross-sectional design. The study samples were households from 34 provinces in Indonesia, and the analysis was performed with provincial aggregates. Data were analyzed using risk factor analysis followed by linear regression to identify relationships with CKD. Results: The prevalence of CKD in Indonesia was 0.38%. The province with the highest prevalence was North Kalimantan (0.64%), while the lowest was found in West Sulawesi (0.18%). Five major groups were formed from 15 identified risk factors using factor analysis. A linear regression model presented 1 significant selected factor (p=0.006, R2 =31%). The final model of risk factors included water quality, consumption of fatty foods, and a history of diabetes. Conclusion: Drinking water quality, fatty food consumption, and diabetes are associated with CKD. There is a need to monitor drinking water, as well as to promote health education and provide comprehensive services for people with diabetes, to prevent CKD.

Rural-urban differences in common mental disorders among Indonesian youth: a cross-sectional national survey: Marizka Khairunnisa, Diah Yunitawati, Leny Latifah, Diyan Ermawan Effendi, Yunita Fitrianti, Sri Handayani, Hastin Dyah Kusumawardani; Osong Public Health Res Perspect. 2024;15(5):440-450. Published online August 21, 2024; DOI: https://doi.org/10.24171/j.phrp.2023.0385

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Graphical Abstract Abstract PDF: Objectives
The onset of common mental disorders (CMDs) is most prevalent among youth; thus, mental health management is crucial. We examined differences in risk and risk factor determinants regarding CMDs prevalence among youth in rural and urban Indonesia. Methods: This cross-sectional study utilized data from the 2018 Indonesia National Health Survey. The population comprised 122,114 respondents, aged 15 to 24 years, who had completed the 20-item Self-Report Questionnaire along with providing demographic and health behavior data. Chi-square testing and logistic regression were employed for analysis. Results: The CMDs risk was higher among urban than rural youth. Risk factors impacting both populations included being female, having a lower education level, consuming fewer than 7 portions of vegetables weekly, smoking, and drinking alcohol (p<0.05). Consuming under 7 portions of fruit weekly and being in the highest or lowest wealth quintile were significant risk factors only in urban youth, while unemployment and divorce were significant only among rural respondents (p<0.05). Marriage was protective against CMDs among rural participants. Conclusion: Being male, possessing a college degree, consuming at least 7 portions of vegetables weekly, not smoking, and not consuming alcohol were associated with reduced CMDs risk in urban and rural youth. Among rural youth, marriage and employment were linked to decreased risk, whereas divorce displayed the opposite relationship. In urban populations, consuming at least 7 portions of fruit weekly and belonging to neither the highest nor the lowest economic quintile were protective factors. Management strategies for CMDs in young people must address these considerations.

Factors associated with malaria infection in under-5 children in Papua Province, Indonesia: an observational study: Betty Roosihermiatie, Gurendro Putro, Arga Setyo Adji, Windy Tri Yuana, Selma Arsit Selto Siahaan, Rukmini Rukmini, Rustika Rustika; Osong Public Health Res Perspect. 2024;15(6):508-520. Published online November 28, 2024; DOI: https://doi.org/10.24171/j.phrp.2024.0152

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Graphical Abstract Abstract PDF: Objectives
Malaria remains a serious public health challenge in tropical and subtropical regions, including Indonesia. Children under 5 years old face particular risk of contracting malaria due to low immunity. We examined potential factors associated with malaria infection among under-5 children in Papua Province, Indonesia.
Methods
The study utilized secondary data from Indonesia Basic Health Research 2018. Multistage random sampling was employed, from the province level to census blocks (CBs). In Papua Province, interviews were conducted in 928 CBs. All 2,745 under-5 children were selected. The dependent variable was laboratory-confirmed malaria positivity; independent factors included residential area, socioeconomic characteristics, and behaviors such as sleeping under an insecticide net impregnated ≤3 years ago and the use of ventilation barriers. We also examined the conditions of the bedroom, kitchen, and living room according to the frequency of window-opening, proportion of ventilation area to the floor, and radiance.
Results
Not sleeping under an insecticide net impregnated within the last 3 years (adjusted odds ratio [aOR], 0.518; 95% confidence interval [CI], 0.391–0.685; p<0.001); having a kitchen without windows (aOR, 0.491; 95% CI, 0.285–0.844; p=0.01); rarely opening the living room window (aOR, 2.804; 95% CI, 1.232–6.383; p=0.01), and having a windowless living room (aOR, 3.027; 95% CI, 1.369–6.696; p=0.01) displayed significant relationships with malaria infection among under-5 children.
Conclusion
Not using an insecticide-treated net impregnated ≤3 years ago, along with opening the living room window daily and having a kitchen without windows, appear preventive of malaria infection among under-5 children.

Assessment of brucellosis-causing pathogens with an emphasis on the prevalence of Brucella melitensis in the Republic of Korea: insights from a decade of pathogen surveillance (2014–2023), a retrospective study: In-Sook Shin, Su-Gwon Roh, Byoung-Chul Gill, Young-Suk Kim, Kyung-Won Hwang; Osong Public Health Res Perspect. 2024;15(6):489-496. Published online November 19, 2024; DOI: https://doi.org/10.24171/j.phrp.2024.0134

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Graphical Abstract Abstract PDF: Objectives
The main Brucella species causing human infections in the Republic of Korea is Brucella abortus, which uses cattle as its host. However, since 2014, Brucella melitensis, which uses sheep and goats as hosts, has also been identified. This study investigated whether a shift has occurred in the predominant species of Brucella pathogens.
Methods
Brucellosis is a class 3 infectious disease requiring mandatory reporting and registration in the Korea Disease Control and Prevention Agency’s infectious disease surveillance system (http://is.kdca.go.kr). Cases from 2014 to 2023 were studied, and whole-genome sequencing analysis was conducted using BruMLSA21.
Results
Out of 51 patients, males (45 patients, 88.2%) were predominantly affected. Twenty-five patients (49%) came from the livestock industry, and within the livestock sector group, the route of infection occurred exclusively through contact (25/25, 100%), whereas in other occupations, it was split between contact (9/26 patients, 34.6%) and ingestion (8/26 patients, 30.8%). Among the 31 patients who underwent Brucella culture tests, B. melitensis was found to be more prevalent than B. abortus (14 patients, 45.2% vs. 11 patients, 35.5%). In all cases where B. melitensis was isolated, the infections were of foreign origin, consistent with the results of BruMLSA21.
Conclusion
Regular monitoring of the causative agent of brucellosis is necessary due to its varying host preferences and antibiotic resistance. Furthermore, given the increasing prevalence of B. melitensis worldwide, changes in dietary habits (e.g., increased lamb consumption), and the increase in foreign workers and Chinese immigrants, a multi-ministerial One Health response will be required.

Brief Report

Safety of the bivalent COVID-19 mRNA booster vaccination among persons aged over 18 years in the Republic of Korea: Seok-Kyoung Choi, Seontae Kim, Mijeong Ko, Yeseul Heo, Tae Eun Kim, Yeonkyeong Lee, Juyeon Jang, Eunok Bahng; Osong Public Health Res Perspect. 2024;15(6):542-549. Published online October 29, 2024; DOI: https://doi.org/10.24171/j.phrp.2024.0194

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Graphical Abstract Abstract PDF: Objectives
The aim of this study was to disseminate information about the safety of bivalent coronavirus disease 2019 (COVID-19) mRNA booster vaccines administered to adults in the Republic of Korea.
Methods
Two databases were used to assess the safety of COVID-19 booster doses of Pfizer BA.1, Pfizer BA.4/5, Moderna BA.1, and Moderna BA.4/5 vaccines for adults aged 18 years and older. Adverse events (AEs) were analyzed using data reported to the web-based COVID-19 vaccination management system (CVMS) and a self-reported text-message survey.
Results
Between October 11, 2022 and March 30, 2023, the CVMS received reports of 2,369 (93.7%) non-serious AEs from vaccinated adults, along with 158 (6.3%) serious AEs, which included 5 cases of anaphylaxis and 33 deaths. From October 11, 2022 to January 27, 2023, 40,022 people aged 18 and older responded to a survey conducted via text message. The booster doses were associated with fewer local and systemic AEs compared to the original vaccines. After receiving the bivalent vaccine, the most commonly reported AEs were pain at the injection site, headache, fatigue, and myalgia.
Conclusion
Overall, bivalent vaccines exhibited fewer AEs compared to the original vaccines. The majority of AEs were non-serious, and serious AEs were rare among adults aged 18 years and older following vaccination with the Pfizer and Moderna bivalent vaccines.

Original Articles

Effectiveness of a cognitive behavioral therapy program in stroke patients in the Republic of Korea: a mixed-methods study: So-Eun Choi, Deok-Ju Kim; Osong Public Health Res Perspect. 2024;15(5):461-475. Published online September 30, 2024; DOI: https://doi.org/10.24171/j.phrp.2024.0116

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Graphical Abstract Abstract PDF: Objectives
This study aimed to explore the effects of a cognitive behavioral therapy (CBT) program on stroke patients, as well as their experiences participating in the program. Methods: This study employed a mixed-methods design, integrating qualitative case studies with quantitative analysis. We included 20 stroke patients, randomly divided into 2 groups of 10 each: an experimental group and a control group. The experimental group underwent a CBT program comprising 20 sessions, in addition to receiving general occupational therapy. Conversely, the control group participated in meditation relaxation sessions alongside their general occupational therapy. Both interventions were administered daily for 60 minutes, 5 days a week, over a 4-week period. Results: After the intervention, the experimental group exhibited significant improvements in depression, anxiety, self-efficacy, and rehabilitation motivation (p<0.01, p<0.05). In contrast, the control group only demonstrated a significant reduction in anxiety (p<0.05). A comparison of the changes between the 2 groups showed significant differences in depression and anxiety (p<0.01), but no significant differences in self-efficacy and rehabilitation motivation (p>0.05). In-depth interviews with 10 participants from the experimental group were conducted and analyzed, revealing 4 core themes: “psychological stability,” “physical symptom relief,” “altered daily routines,” and “challenges and hopes for change.” Conclusion: The findings of this study suggest that CBT programs may serve as a valuable intervention, offering psychological support and rehabilitation for stroke patients.

Molecular characteristics of drug-susceptible Mycobacterium tuberculosis clinical isolates based on treatment duration: Eon-Min Ko, Jinsoo Min, Hyungjun Kim, Ji-A Jeong, Sungkyoung Lee, Seonghan Kim; Osong Public Health Res Perspect. 2024;15(5):385-394. Published online September 30, 2024; DOI: https://doi.org/10.24171/j.phrp.2024.0101

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Graphical Abstract Abstract PDF: Objectives
In this study, we performed comparative genomic and transcriptomic analysis of clinical isolates of Mycobacterium tuberculosis collected from patients with drug-susceptible tuberculosis (DS-TB). The clinical isolates were categorized based on treatment duration: standard 6 months or >6 months.
Methods
Study participants were recruited from a 2016 to 2018 tuberculosis cohort, and clinical M. tuberculosis isolates were collected from the sputum of patients with tuberculosis. We analyzed the genome and transcriptome of the isolated M. tuberculosis.
Results
Genomic analysis revealed a specific non-synonymous single-nucleotide polymorphism in pe_pgrs9 and ppe34, exclusive to the group treated for >6 months. Transcriptomic analysis revealed increased expression of various virulence-associated protein family genes and decreased expression of ribosomal protein genes and ppe38 genes in the group treated for >6 months.
Conclusion
The identified genetic variation and gene expression patterns may influence treatment outcomes by modulating host immune responses, increasing virulence, and potentially contributing to persister cell formation in M. tuberculosis. This study provides insights into the genetic and transcriptomic factors associated with prolonged DS-TB treatment. However, our study identified molecular characteristics using a small sample size, and further detailed studies are warranted.

Review Articles

Comparison and consideration of vaccine injury compensation programs in the Republic of Korea, Japan, and Taiwan: Cho Ryok Kang, Young June Choe, Jihyun Moon, Dooyoung Kim, Taemi Kim, Jong-Koo Lee; Osong Public Health Res Perspect. 2024;15(6):479-488. Published online November 12, 2024; DOI: https://doi.org/10.24171/j.phrp.2024.0129

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Graphical Abstract Abstract PDF: This study aimed to establish a foundation for future collaborations aimed at preparing for and responding to infectious diseases by examining the vaccine injury compensation programs (VICPs) of East Asian countries. We reviewed the current status of VICPs in the Republic of Korea, Japan, and Taiwan by searching national government websites and reviewing relevant literature. Additionally, we conducted email inquiries targeting experts from Japan and Taiwan. Through the comprehensive analysis of VICPs in these 3 countries covered various aspects, we identified several similarities and differences in the VICPs across these countries. While the governments of the Republic of Korea, Japan, and Taiwan play a central role in supporting investigations into vaccine injuries and managing compensation procedures based on legal statutes, they differ in terms of financial resources for compensation, the range of vaccines covered, and the criteria for assessing causality. In the Republic of Korea, Japan, and Taiwan, compensation is typically paid in a lump sum, although the specific benefits available vary by country. This study on VICPs in the Republic of Korea, Japan, and Taiwan provides valuable insights for the further development and management of domestic systems.

Effectiveness of virtual reality-supported exercise therapy in improving upper extremity function and activities of daily living among patients after stroke: a systematic review of randomized control trials: Priyanshi Dixit, Uma Phalswal, Nipin Kalal, Saumya P. Srivastava; Osong Public Health Res Perspect. 2024;15(3):189-200. Published online May 24, 2024; DOI: https://doi.org/10.24171/j.phrp.2023.0148

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Graphical Abstract Abstract PDF

Objectives
This systematic review describes the effectiveness of virtual reality (VR)-supported exercise therapy on upper limb motor function and activities of daily living after stroke. Methods: Studies published through January 24, 2022, were identified using CINAHL, Cochrane Library, Embase, Medline, and Web of Science. Randomized control trials comparing VR treatment with conventional therapy (CT) for upper extremity rehabilitation after stroke were included. Methodological quality was assessed using the Cochrane risk-of-bias tool. Results: Of 9 included studies, 5 concluded that the VR group outperformed control participants, 1 indicated the superiority of VR-supported exercises alone over CT, and 3 found VR comparable to CT in promoting upper limb motor function. Five studies analyzed independence in daily living, with 4 reporting no significant difference between VR and CT groups. No strong evidence indicated long-term benefits of VR-assisted exercise. All included studies demonstrated low risk of bias concerning random sequence generation, allocation concealment, outcome assessment blinding, incomplete outcome data, and selective reporting bias. However, a high risk of bias was observed regarding participant blinding due to the nature of the intervention. Conclusion: Most studies suggested that VR, used alongside CT, can improve motor function following stroke. However, the evidence was insufficient to conclude that VR outperforms conventional approaches.

Citations

Citations to this article as recorded by

Efficacy of a Virtual Reality Rehabilitation Protocol Based on Art Therapy in Patients with Stroke: A Single-Blind Randomized Controlled Trial
Gaetano Tieri, Marco Iosa, Antonio Fortini, Federica Aghilarre, Federico Gentili, Cristiano Rubeca, Tommaso Mastropietro, Gabriella Antonucci, Roberto De Giorgi
Brain Sciences.2024; 14(9): 863. CrossRef
Elevating patient experience: Transformative strategies in hand therapy
Jean Paul Brutus, Bianieff Tchiloemba, Anna Galstyan, Tom Lattré, Aviva Wolff, Alison Taylor
Hand Surgery and Rehabilitation.2024; 43(5): 101764. CrossRef

Original Article

Methodology of comparative studies on the relative effectiveness of COVID-19 vaccines: a systematic review: Erdenetuya Bolormaa, Jiae Shim, Young-Sook Choi, Donghyok Kwon, Young June Choe, Seung-Ah Choe; Osong Public Health Res Perspect. 2024;15(5):395-408. Published online October 15, 2024; DOI: https://doi.org/10.24171/j.phrp.2024.0063

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Graphical Abstract Abstract PDF: Objectives
This study aimed to comprehensively outline the methodological approaches used in published research comparing the vaccine effectiveness (VE) of coronavirus disease 2019 (COVID-19) vaccines.
Methods
A systematic search was conducted on June 13, 2024, to identify comparative studies evaluating the effectiveness of mRNA versus non-mRNA and monovalent versus bivalent COVID-19 vaccines. We screened titles, abstracts, and full texts, collecting data on publication year, country, sample size, study population composition, study design, VE estimates, outcomes, and covariates. Studies that reported relative VE (rVE) were analyzed separately from those that did not.
Results
We identified 25 articles comparing rVE between mRNA and non-mRNA COVID-19 vaccines, as well as between monovalent and bivalent formulations. Among the studies assessing VE by vaccine type, 126 did not provide rVE estimates. Comparative VE studies frequently employed retrospective cohort designs. Among the definitions of rVE used, the most common were hazard ratio and absolute VE, calculated as (1−odds ratio)×100. Studies were most frequently conducted in the United Kingdom and the United States, and the most common outcome was infection. Most targeted the general population and assessed the VE of mRNA vaccines using the AstraZeneca vaccine as a reference. A small proportion, 7.3% (n=11), did not adjust for any variables. Only 3 studies (2.0%) adjusted for all core confounding variables recommended by the World Health Organization.
Conclusion
Few comparative studies of COVID-19 vaccines have incorporated rVE methodologies. Reporting rVE and employing a consistent set of covariates can broaden our understanding of COVID-19 vaccines.

Review Article

Strategies to combat Gram-negative bacterial resistance to conventional antibacterial drugs: a review: Priyanka Bhowmik, Barkha Modi, Parijat Roy, Antarika Chowdhury; Osong Public Health Res Perspect. 2023;14(5):333-346. Published online October 18, 2023; DOI: https://doi.org/10.24171/j.phrp.2022.0323

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Graphical Abstract Abstract PDF

The emergence of antimicrobial resistance raises the fear of untreatable diseases. Antimicrobial resistance is a multifaceted and dynamic phenomenon that is the cumulative result of different factors. While Gram-positive pathogens, such as methicillin-resistant Staphylococcus aureus and Clostridium difficile, were previously the most concerning issues in the field of public health, Gram-negative pathogens are now of prime importance. The World Health Organization’s priority list of pathogens mostly includes multidrug-resistant Gram-negative organisms particularly carbapenem-resistant Enterobacterales, carbapenem-resistant Pseudomonas aeruginosa, and extensively drug-resistant Acinetobacter baumannii. The spread of Gram-negative bacterial resistance is a global issue, involving a variety of mechanisms. Several strategies have been proposed to control resistant Gram-negative bacteria, such as the development of antimicrobial auxiliary agents and research into chemical compounds with new modes of action. Another emerging trend is the development of naturally derived antibacterial compounds that aim for targets novel areas, including engineered bacteriophages, probiotics, metal-based antibacterial agents, odilorhabdins, quorum sensing inhibitors, and microbiome-modifying agents. This review focuses on the current status of alternative treatment regimens against multidrug-resistant Gram-negative bacteria, aiming to provide a snapshot of the situation and some information on the broader context.

Citations

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Efficacy of new generation biosorbents for the sustainable treatment of antibiotic residues and antibiotic resistance genes from polluted waste effluent
Barkha Madhogaria, Sangeeta Banerjee, Atreyee Kundu, Prasanta Dhak
Infectious Medicine.2024; 3(1): 100092. CrossRef
Evaluation of Plant-Based Silver Nanoparticles for Antioxidant Activity and Promising Wound-Healing Applications
Maria Qubtia, Shazia Akram Ghumman, Sobia Noreen, Huma Hameed, Shazia Noureen, Rizwana Kausar, Ali Irfan, Pervaiz Akhtar Shah, Hafsa Afzal, Misbah Hameed, Mohammad Raish, Maria Rana, Ajaz Ahmad, Katarzyna Kotwica-Mojzych, Yousef A. Bin Jardan
ACS Omega.2024; 9(10): 12146. CrossRef
Progress and potentialities in wood extractives-based materials for active food packaging applications
Eliana I. Fernández Sosa, Nanci Ehman, Fernando E. Felissia, M. Guadalupe Chaves, M. Cristina Area
Food Bioscience.2024; 60: 104489. CrossRef
Isolation, derivatization, and anti-microbial evaluation of secondary metabolites from Garcinia dryobalanoides
Nur Fazlin Zafirah Zaine, Nor Hisam Zamakshshari, Ainaa Nadiah Abd Halim, Vivien Jong Yi Mian, Ngieng Ngui Sing
Natural Product Research.2024; : 1. CrossRef
A comprehensive investigation of the anion inhibition profile of a β-carbonic anhydrase from Acinetobacter baumannii for crafting innovative antimicrobial treatments
Viviana De Luca, Simone Giovannuzzi, Claudiu T. Supuran, Clemente Capasso
Journal of Enzyme Inhibition and Medicinal Chemist.2024;[Epub] CrossRef

Original Article

The relationship between obstructive sleep apnea, dyspnea, and health-related quality of life in lung cancer survivors: a cross-sectional study in the Republic of Korea: Hyeong-pyo Kim, Duck-won Oh, Dong-kyu Kim; Osong Public Health Res Perspect. 2024;15(6):533-541. Published online November 7, 2024; DOI: https://doi.org/10.24171/j.phrp.2024.0146

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Graphical Abstract Abstract PDF

Objectives
The purpose of this study was to explore the relationships among obstructive sleep apnea (OSA), dyspnea, and health-related quality of life (HRQOL), as well as the factors influencing HRQOL.
Methods
A total of 129 lung cancer survivors (mean age, 53.4 years; 77 men and 52 women; mean time since diagnosis, 1.6 years; and cancer stage [1/2/3/4/relapse], 43/31/19/34/2, respectively) completed a questionnaire that included demographic and clinical information, as well as questions about the severity of sleep apnea, dyspnea, and HRQOL. The severity of OSA, dyspnea, and HRQOL were assessed using the Berlin questionnaire, the Dyspnea-10 item (FACIT-Dyspnea), and the European Organization for Research and Treatment of Cancer QLQ-C30, respectively.
Results
The severity of OSA and dyspnea exhibited negative correlations with HRQOL (p<0.05). Multiple regression analysis revealed that several factors significantly impacted the HRQOL of lung cancer survivors. These included the extent of dyspnea (β=–0.369, p<0.01), weight loss (β=0.192, p<0.01), OSA score (β=−0.215, p<0.01), stage 2 cancer (β=−0.181, p<0.01), and poor perceived health status (β=−0.179, p<0.05).
Conclusion
These findings suggest that breathing difficulties, including OSA and dyspnea, contribute to decreased HRQOL. This study offers valuable insights for researchers and clinicians, aiding in the development of effective strategies to manage these issues in daily life.

Citations

Citations to this article as recorded by

Factors Affecting Quality of Life Among Patients with Primary Lung Cancer
Mideum Kang, Myung Sun Hyun, Sun Hyoung Bae, Sunjoo Boo
Asian Oncology Nursing.2024; 24(3): 144. CrossRef

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