Osong Public Health and Research Perspectives

From articles published in Osong Public Health and Research Perspectives during the past two years (2023 ~ ).

Review Article

Pandemics: past, present, and future: multitasking challenges in need of cross-disciplinary, transdisciplinary, and multidisciplinary collaborative solutions: Amir Khorram-Manesh, Frederick Martin Burkle Jr, Krzysztof Goniewicz; Osong Public Health Res Perspect. 2024;15(4):267-285. Published online July 23, 2024; DOI: https://doi.org/10.24171/j.phrp.2023.0372

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The extensive history of pandemics has spanned many centuries, profoundly impacting societies, economies, and public health, and thereby shaping the course of history in various ways. Advances in medicine, science, and public health practices have played a pivotal role in mitigating the effects of pandemics over time. This review explores the scientific landscape of contemporary pandemics, examining their diverse and complex nature. It goes beyond the biological aspects of pandemics to consider socioeconomic, environmental, and technological factors. Through a scientific lens, this study aims to understand the complexities of pandemics and contribute to the expanding knowledge base that helps humanity strengthen its defenses against global health threats. By elucidating the enigmas of pandemics, the study hopes to foster a more resilient and prepared global health environment. Highlighting the importance of a multidisciplinary, cross-disciplinary, and transdisciplinary approach, this exploration emphasizes the critical need to integrate biological, socioeconomic, environmental, and technological domains to develop more robust defenses against these global health challenges.

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Transforming global public health: Climate collaboration, political challenges, and systemic change
Krzysztof Goniewicz, Frederick M. Burkle, Amir Khorram-Manesh
Journal of Infection and Public Health.2025; 18(1): 102615. CrossRef
The role of artificial intelligence and machine learning in predicting and combating antimicrobial resistance
Hazrat Bilal, Muhammad Nadeem Khan, Sabir Khan, Muhammad Shafiq, Wenjie Fang, Rahat Ullah Khan, Mujeeb Ur Rahman, Xiaohui Li, Qiao-Li Lv, Bin Xu
Computational and Structural Biotechnology Journal.2025; 27: 423. CrossRef
Innovative Diagnostic Approaches and Challenges in the Management of HIV: Bridging Basic Science and Clinical Practice
Mohd Afzal, Shagun Agarwal, Rabab H. Elshaikh, Asaad M. A. Babker, Einas Awad Ibrahim Osman, Ranjay Kumar Choudhary, Suresh Jaiswal, Farhana Zahir, Pranav Kumar Prabhakar, Anass M. Abbas, Manar G. Shalabi, Ashok Kumar Sah
Life.2025; 15(2): 209. CrossRef
BIOSURFACTANT PROPERTIES AND ITS APPLICATION IN CHROMIUM REMOVAL: A REVIEW
Usman Ali Bukar, Abdullahi Hassan Kawo, Sani Yahaya, Sani Yahaya, Abdullahi Balarabe Inuwa, Aminu Yusuf Fardami
FUDMA JOURNAL OF SCIENCES.2025; 9(1): 273. CrossRef
Tracking the Threat, 50 Years of Laboratory-Acquired Infections: A Systematic Review
Esteban Zavaleta-Monestel, Carolina Rojas-Chinchilla, Adriana Anchía-Alfaro, Diego Quesada-Loría, Jonathan García-Montero, Sebastián Arguedas-Chacón, Georgia Hanley-Vargas
Acta Microbiologica Hellenica.2025; 70(2): 11. CrossRef
Artificial Intelligence in Cardiology: Insights From a Multidisciplinary Perspective
Kalynn Niroda, Cristian Drudi, Joseph Byers, Jasmine Johnson, Gabrielle Cozzi, Leo Anthony Celi, Haitham Khraishah
Journal of the Society for Cardiovascular Angiogra.2025; 4(3): 102612. CrossRef
Shaping Safety: Unveiling the Dynamics of Incident Reporting and Safety Culture in Saudi Arabian Healthcare
Hind Alsahli, Ahmed Al-Wathinani, Tariq Althobaiti, Mohammed Abahussain, Krzysztof Goniewicz
Journal of Multidisciplinary Healthcare.2024; Volume 17: 3775. CrossRef
The Impacts of Narcissistic Leadership on Achieving the United Nations’ Sustainable Development Goals—A Scoping Review
Amir Khorram-Manesh, Krzysztof Goniewicz, Frederick M. Burkle
Challenges.2024; 15(3): 37. CrossRef
Global Health Emergencies of Extreme Drought Events: Historical Impacts and Future Preparedness
Zakaria A. Mani, Amir Khorram-Manesh, Krzysztof Goniewicz
Atmosphere.2024; 15(9): 1137. CrossRef
The Effectiveness and Benefits of Disaster Simulation Training for Undergraduate Medical Students in Saudi Arabia [Letter]
Ahmed Al-Wathinani, Krzysztof Goniewicz
Advances in Medical Education and Practice.2024; Volume 15: 1173. CrossRef
Evaluating the efficacy of full-scale and tabletop exercises in enhancing paramedic preparedness for external disasters: A quasi-experimental study
Ghadeer A. Alakrawi, Ahmed M. Al-Wathinani, Juan Gómez-Salgado, Abdullah M. Alobaid, Mohammed Abahussian, Riyadh Alhazmi, Abdulmajeed Mobrad, Albaraa Jebreel, Saqar Althunayyan, Krzysztof Goniewicz
Medicine.2024; 103(49): e40777. CrossRef

Special Article

A framework for nationwide COVID-19 vaccine safety research in the Republic of Korea: the COVID-19 Vaccine Safety Research Committee: Na-Young Jeong, Hyesook Park, Sanghoon Oh, Seung Eun Jung, Dong-Hyun Kim, Hyoung-Shik Shin, Hee Chul Han, Jong-Koo Lee, Jun Hee Woo, Byung-Joo Park, Nam-Kyong Choi; Osong Public Health Res Perspect. 2023;14(1):5-14. Published online February 28, 2023; DOI: https://doi.org/10.24171/j.phrp.2023.0026

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Graphical Abstract Abstract PDF

With the introduction of coronavirus disease 2019 (COVID-19) vaccines, the Korea Disease Control and Prevention Agency (KDCA) commissioned the National Academy of Medicine of Korea to gather experts to independently assess post-vaccination adverse events. Accordingly, the COVID-19 Vaccine Safety Research Committee (CoVaSC) was launched in November 2021 to perform safety studies and establish evidence for policy guidance. The CoVaSC established 3 committees for epidemiology, clinical research, and communication. The CoVaSC mainly utilizes pseudonymized data linking KDCA’s COVID-19 vaccination data and the National Health Insurance Service’s claims data. The CoVaSC’s 5-step research process involves defining the target diseases and organizing ad-hoc committees, developing research protocols, performing analyses, assessing causal relationships, and announcing research findings and utilizing them to guide compensation policies. As of 2022, the CoVaSC completed this research process for 15 adverse events. The CoVaSC launched the COVID-19 Vaccine Safety Research Center in September 2022 and has been reorganized into 4 divisions to promote research including international collaborative studies, long-/short-term follow-up studies, and education programs. Through these enhancements, the CoVaSC will continue to swiftly provide scientific evidence for COVID-19 vaccine research and compensation and may serve as a model for preparing for future epidemics of new diseases.

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Risk of Kawasaki Disease/Multisystem Inflammatory Syndrome Following COVID-19 Vaccination in Korean Children: A Self-Controlled Case Series Study
Suyeon Kim, Hwa Yeon Ko, Jeongin Oh, Dongwon Yoon, Ju Hwan Kim, Young June Choe, Ju-Young Shin
Journal of Korean Medical Science.2025;[Epub] CrossRef
The association between acute transverse myelitis and COVID‐19 vaccination in Korea: Self‐controlled case series study
Eunsun Lim, Yoo Hwan Kim, Na‐Young Jeong, Su‐Hyun Kim, Heehyun Won, Jong‐Seok Bae, Nam‐Kyong Choi
European Journal of Neurology.2025;[Epub] CrossRef
Coronavirus disease vaccine linked menstrual changes: mobile application study
Sung Eun Kim, Joseph J. Noh, Yoo-Young Lee
Obstetrics & Gynecology Science.2025; 68(2): 155. CrossRef
Multilevel analysis of individual, household, and community factors influencing COVID-19 vaccination intention: evidence from the 2021 Korea Community Health Survey
Ji-seon Seong, Jong-Yeon Kim
Osong Public Health and Research Perspectives.2025;[Epub] CrossRef
Risk of encephalitis and meningitis after COVID-19 vaccination in South Korea: a self-controlled case series analysis
Ju Hwan Kim, Dongwon Yoon, Hwa Yeon Ko, Kyungyeon Jung, Jun-Sang Sunwoo, Won Chul Shin, Jung-Ick Byun, Ju-Young Shin
BMC Medicine.2024;[Epub] CrossRef
The COVID-19 Vaccine Safety Research Center: a cornerstone for strengthening safety evidence for COVID-19 vaccination in the Republic of Korea
Na-Young Jeong, Hyesook Park, Sanghoon Oh, Seung Eun Jung, Dong-Hyun Kim, Hyoung-Shik Shin, Hee Chul Han, Jong-Koo Lee, Jun Hee Woo, Jaehun Jung, Joongyub Lee, Ju-Young Shin, Sun-Young Jung, Byung-Joo Park, Nam-Kyong Choi
Osong Public Health and Research Perspectives.2024; 15(2): 97. CrossRef
A Causality Assessment Framework for COVID-19 Vaccines and Adverse Events at the COVID-19 Vaccine Safety Research Center
Seyoung Kim, Jeong Ah Kim, Hyesook Park, Sohee Park, Sanghoon Oh, Seung Eun Jung, Hyoung-Shik Shin, Jong Koo Lee, Hee Chul Han, Jun Hee Woo, Byung-Joo Park, Nam-Kyong Choi, Dong-Hyun Kim
Journal of Korean Medical Science.2024;[Epub] CrossRef
To become a more stronger and safer country
Jong-Koo Lee
Osong Public Health and Research Perspectives.2023; 14(2): 67. CrossRef
Risk of lymphadenopathy from SARS-CoV-2 vaccination in Korea: a self-controlled case series analysis
Mi-Sook Kim, Bongyoung Kim, Jeong Pil Choi, Nam-Kyong Choi, Jung Yeon Heo, Jun Yong Choi, Joongyub Lee, Sang Il Kim
Epidemiology and Health.2023; 45: e2023090. CrossRef

Review Article

Strategies to combat Gram-negative bacterial resistance to conventional antibacterial drugs: a review: Priyanka Bhowmik, Barkha Modi, Parijat Roy, Antarika Chowdhury; Osong Public Health Res Perspect. 2023;14(5):333-346. Published online October 18, 2023; DOI: https://doi.org/10.24171/j.phrp.2022.0323

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Graphical Abstract Abstract PDF

The emergence of antimicrobial resistance raises the fear of untreatable diseases. Antimicrobial resistance is a multifaceted and dynamic phenomenon that is the cumulative result of different factors. While Gram-positive pathogens, such as methicillin-resistant Staphylococcus aureus and Clostridium difficile, were previously the most concerning issues in the field of public health, Gram-negative pathogens are now of prime importance. The World Health Organization’s priority list of pathogens mostly includes multidrug-resistant Gram-negative organisms particularly carbapenem-resistant Enterobacterales, carbapenem-resistant Pseudomonas aeruginosa, and extensively drug-resistant Acinetobacter baumannii. The spread of Gram-negative bacterial resistance is a global issue, involving a variety of mechanisms. Several strategies have been proposed to control resistant Gram-negative bacteria, such as the development of antimicrobial auxiliary agents and research into chemical compounds with new modes of action. Another emerging trend is the development of naturally derived antibacterial compounds that aim for targets novel areas, including engineered bacteriophages, probiotics, metal-based antibacterial agents, odilorhabdins, quorum sensing inhibitors, and microbiome-modifying agents. This review focuses on the current status of alternative treatment regimens against multidrug-resistant Gram-negative bacteria, aiming to provide a snapshot of the situation and some information on the broader context.

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Bioactive Potential and Chemical Composition of Vitex agnus-castus L. Leaf Extracts Collected in Algeria: A Combined In Vitro and In Silico Approach
Amina Bramki, Ghozlane Barboucha, Ouided Benslama, Anna Andolfi, Fatima Zohra Makhlouf, Maria Smati, Djamila Benouchenne, Mohamed Moussaoui, Chawki Bensouici, Alessio Cimmino, Jesús G. Zorrilla, Maria Michela Salvatore, Marco Masi
Molecules.2025; 30(3): 749. CrossRef
Viability and Surface Morphology of Human Erythrocytes upon Interaction with Chitosan Derivatives
Evgeniya A. Bezrodnykh, Marina G. Holyavka, Tatyana N. Belyaeva, Svetlana M. Pankova, Valery G. Artyukhov, Yurij A. Antonov, Boris B. Berezin, Inesa V. Blagodatskikh, Vladimir E. Tikhonov
ACS Applied Bio Materials.2025; 8(3): 1909. CrossRef
Progress in Characterization of Lipopolysaccharides and Lipid A by Mass Spectrometry
Amanda Helms, Jennifer S. Brodbelt
Mass Spectrometry Reviews.2025;[Epub] CrossRef
Efficacy of new generation biosorbents for the sustainable treatment of antibiotic residues and antibiotic resistance genes from polluted waste effluent
Barkha Madhogaria, Sangeeta Banerjee, Atreyee Kundu, Prasanta Dhak
Infectious Medicine.2024; 3(1): 100092. CrossRef
Evaluation of Plant-Based Silver Nanoparticles for Antioxidant Activity and Promising Wound-Healing Applications
Maria Qubtia, Shazia Akram Ghumman, Sobia Noreen, Huma Hameed, Shazia Noureen, Rizwana Kausar, Ali Irfan, Pervaiz Akhtar Shah, Hafsa Afzal, Misbah Hameed, Mohammad Raish, Maria Rana, Ajaz Ahmad, Katarzyna Kotwica-Mojzych, Yousef A. Bin Jardan
ACS Omega.2024; 9(10): 12146. CrossRef
Progress and potentialities in wood extractives-based materials for active food packaging applications
Eliana I. Fernández Sosa, Nanci Ehman, Fernando E. Felissia, M. Guadalupe Chaves, M. Cristina Area
Food Bioscience.2024; 60: 104489. CrossRef
Isolation, derivatization, and anti-microbial evaluation of secondary metabolites from Garcinia dryobalanoides
Nur Fazlin Zafirah Zaine, Nor Hisam Zamakshshari, Ainaa Nadiah Abd Halim, Vivien Jong Yi Mian, Ngieng Ngui Sing
Natural Product Research.2024; : 1. CrossRef
A comprehensive investigation of the anion inhibition profile of a β-carbonic anhydrase from Acinetobacter baumannii for crafting innovative antimicrobial treatments
Viviana De Luca, Simone Giovannuzzi, Claudiu T. Supuran, Clemente Capasso
Journal of Enzyme Inhibition and Medicinal Chemist.2024;[Epub] CrossRef

Original Article

Prevalence, multidrug resistance, and biofilm formation of Vibrio parahaemolyticus isolated from fish mariculture environments in Cat Ba Island, Vietnam: Kim Cuc Thi Nguyen, Phuc Hung Truong, Hoa Truong Thi, Xuan Tuy Ho, Phu Van Nguyen; Osong Public Health Res Perspect. 2024;15(1):56-67. Published online February 19, 2024; DOI: https://doi.org/10.24171/j.phrp.2023.0181

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Objectives
Vibrio parahaemolyticus is a major foodborne pathogen in aquatic animals and a threat to human health worldwide. This study investigated the prevalence, antimicrobial resistance, antimicrobial resistance genes (ARGs), and biofilm formation of V. parahaemolyticus strains isolated from fish mariculture environments in Cat Ba Island, Vietnam. Methods: In total, 150 rearing water samples were collected from 10 fish mariculture farms in winter and summer. A polymerase chain reaction assay was used to identify V. parahaemolyticus, its virulence factors, and ARGs. The antimicrobial resistance patterns and biofilm formation ability of V. parahaemolyticus strains were investigated using the disk diffusion test and a microtiter plate-based crystal violet method, respectively. Results: Thirty-seven V. parahaemolyticus isolates were recovered from 150 samples. The frequencies of the tdh and trh genes among V. parahaemolyticus isolates were 8.1% and 21.6%, respectively. More than 90% of isolates were susceptible to ceftazidime, cefotaxime, and chloramphenicol, but over 72% were resistant to ampicillin, tetracycline, and erythromycin. Furthermore, 67.57% of isolates exhibited multidrug resistance. The presence of ARGs related to gentamicin (aac(3)-IV), tetracycline (tetA) and ciprofloxacin (qnrA) in V. parahaemolyticus isolates was identified. Conversely, no ARGs related to ampicillin or erythromycin resistance were detected. Biofilm formation capacity was detected in significantly more multidrug-resistant isolates (64.9%) than non-multidrug-resistant isolates (18.9%). Conclusion: Mariculture environments are a potential source of antibiotic-resistant V. parahaemolyticus and a hotspot for virulence genes and ARGs diffusing to aquatic environments. Thus, the prevention of antibiotic-resistant foodborne vibriosis in aquatic animals and humans requires continuous monitoring.

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Exploring the antibiofilm efficacy of pyrimidines against Vibrio parahaemolyticus, mechanisms and their potential food processing applications
Olajide Sunday Faleye, Jin-Hyung Lee, Jintae Lee
LWT.2025; 215: 117229. CrossRef
The role of sea fish meat in the transmission of Vibrio parahaemolyticus to humans: An in-depth analysis of seasonal and species-specific variations
Maged A. Al-Garadi, Dhary Alewy Almashhadany, Rasha N. Aziz, Dheyazan M. Ali Al-Qabili, Ohoud S. Alhumaidan, Hanouf Alnuwaysir, Al-Hammadi Mohammed Ali, Essam Sayed, A. M. Alabsi
Veterinary World.2025; : 348. CrossRef
Multidrug Resistance, Biofilm-Forming Ability, and Molecular Characterization of Vibrio Species Isolated from Foods in Thailand
Watcharapong Mitsuwan, Ratchadaporn Boripun, Phirabhat Saengsawang, Sutsiree Intongead, Sumaree Boonplu, Rawiwan Chanpakdee, Yukio Morita, Sumalee Boonmar, Napapat Rojanakun, Natnicha Suksriroj, Chollathip Ruekaewma, Titima Tenitsara
Antibiotics.2025; 14(3): 235. CrossRef
Antimicrobial resistance of zoonotic bacteria isolated from shrimp aquaculture environments in Selangor, Malaysia
S. Devadas, Z. Zakaria, M. Shariff, S. Bhassu, M. Karim, I. Natrah
Aquaculture.2025; 604: 742480. CrossRef
Characterization of Virulence Genotypes and Prevalence of Vibrio parahaemolyticus from Fish Samples Collected from Thoothukudi Fish Landing Centres, India
Selvamathi Veerabhadran Ragul, Fathiraja Parthiban, Rajendran Shalini, Sivasankar Panchavarnam, Thandapani Muthulakshmi, Mohamed Mansoor, Stephen Jerusha, Selvam Krishnakumar
Thalassas: An International Journal of Marine Scie.2025;[Epub] CrossRef
A New Strategy: Antibiotic Circumstances for Rational Drug use Against Clinical Aeromonas hydrophila And Bacterial Properties of This Bacteria on Different Agars
Nurdan Filik, Fethi Filik, Ayşegül Kubilay
Acta Aquatica Turcica.2024; 20(4): 312. CrossRef
Passive immunoprophylaxis with Ccombodies against Vibrio parahaemolyticus in Pacific white shrimp (Penaeus vannamei)
Wanna Sirimanapong, Prawporn Thaijongrak, Chiranan Sudpraseart, Dennis Berbulla Bela-ong, Abigail Joy D. Rodelas-Angelia, Mark Rickard N. Angelia, Seungbeom Hong, Jaesung Kim, Kim D. Thompson, Tae Sung Jung
Fish & Shellfish Immunology.2024; 154: 109973. CrossRef

Review Articles

Global prevalence of enterobiasis in young children over the past 20 years: a systematic review and meta-analysis: Elham Kia Lashaki, Azadeh Mizani, Seyed Abdollah Hosseini, Bentolhoda Habibi, Khadijeh Taherkhani, Amir Javadi, AliReza Taremiha, Samira Dodangeh; Osong Public Health Res Perspect. 2023;14(6):441-450. Published online December 28, 2023; DOI: https://doi.org/10.24171/j.phrp.2023.0204

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Graphical Abstract Abstract PDF

Parasitic infections are the most common diseases worldwide, and enterobiasis is a common parasitic infection in children. Various studies have reported on the prevalence of Enterobius vermicularis in different regions of the world. However, no study has gathered and analyzed this data systematically. Our systematic review and meta-analysis investigated the overall prevalence of E. vermicularis among children globally. Data were extracted from 4 available databases for studies published from January 2002 to April 2022. The quality of the included studies was scored based on the standard Strengthening the Reporting of Observational Studies in Epidemiology. A random-effect model was chosen to calculate the pooled prevalence and corresponding 95% confidence interval (CI) according to the degree of heterogeneity in the included studies. Thus, 40 publications (42 data sets) that included 3,279 children with enterobiasis met all criteria and were included in the analysis. The meta-analysis showed that heterogeneity among the included studies was high (Q=4,399.35, I2=99.96%; df=41; p<0.001). The pooled global prevalence of enterobiasis among the studied children was 12.9% (95% CI, 8.2%–17.7%). Our systematic review and meta-analysis estimated that, for the past 20 years, 12.9% of children around the world have been infected with E. vermicularis.

Citations

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Modelling international travel as risk of acquiring Dientamoeba fragilis: Comparison to Giardia duodenalis data
Jukka-Pekka Pietilä, Tuuve A Häkkinen, Jukka Ollgren, Anu Kantele
Travel Medicine and Infectious Disease.2025; 65: 102836. CrossRef
A Case of Appendiceal Pinworms in an Adolescent Patient
Zachary S Kauffman, David L Stuart
Cureus.2025;[Epub] CrossRef
Development of a Machine Learning Model for the Classification of Enterobius vermicularis Egg
Natthanai Chaibutr, Pongphan Pongpanitanont, Sakhone Laymanivong, Tongjit Thanchomnang, Penchom Janwan
Journal of Imaging.2024; 10(9): 212. CrossRef
Global burden of soil-transmitted helminth infections, 1990–2021
Jin Chen, Yanfeng Gong, Qin Chen, Shizhu Li, Yibiao Zhou
Infectious Diseases of Poverty.2024;[Epub] CrossRef
Studies on the significance of secretory IgA antibodies in the pathogenesis and clinical course of enterobiasis in infected persons from Bulgaria: preliminary findings
E. Kaneva, R. Harizanov, D. Velcheva, N. Tsvetkova, M. Pavlova, I. Alexiev, R. Dimitrova, M. Videnova, R. Borisova, A. Ivanova
Helminthologia.2024; 61(4): 277. CrossRef

Effectiveness of virtual reality-supported exercise therapy in improving upper extremity function and activities of daily living among patients after stroke: a systematic review of randomized control trials: Priyanshi Dixit, Uma Phalswal, Nipin Kalal, Saumya P. Srivastava; Osong Public Health Res Perspect. 2024;15(3):189-200. Published online May 24, 2024; DOI: https://doi.org/10.24171/j.phrp.2023.0148

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Objectives
This systematic review describes the effectiveness of virtual reality (VR)-supported exercise therapy on upper limb motor function and activities of daily living after stroke. Methods: Studies published through January 24, 2022, were identified using CINAHL, Cochrane Library, Embase, Medline, and Web of Science. Randomized control trials comparing VR treatment with conventional therapy (CT) for upper extremity rehabilitation after stroke were included. Methodological quality was assessed using the Cochrane risk-of-bias tool. Results: Of 9 included studies, 5 concluded that the VR group outperformed control participants, 1 indicated the superiority of VR-supported exercises alone over CT, and 3 found VR comparable to CT in promoting upper limb motor function. Five studies analyzed independence in daily living, with 4 reporting no significant difference between VR and CT groups. No strong evidence indicated long-term benefits of VR-assisted exercise. All included studies demonstrated low risk of bias concerning random sequence generation, allocation concealment, outcome assessment blinding, incomplete outcome data, and selective reporting bias. However, a high risk of bias was observed regarding participant blinding due to the nature of the intervention. Conclusion: Most studies suggested that VR, used alongside CT, can improve motor function following stroke. However, the evidence was insufficient to conclude that VR outperforms conventional approaches.

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Advances in hemiplegia rehabilitation: modern therapeutic interventions to enhance activities of daily living
Jing Xiong, Jin-Tian Wang, Shu Lin, Bao-Yuan Xie
Frontiers in Neurology.2025;[Epub] CrossRef
Effect of virtual reality-based upper limb training on activity of daily living and quality of life among stroke survivors: a systematic review and meta-analysis
Diriba Dereje Olana, Teklu Gemechu Abessa, Dheeraj Lamba, Lisa Tedesco Triccas, Bruno Bonnechere
Journal of NeuroEngineering and Rehabilitation.2025;[Epub] CrossRef
Efficacy of a Virtual Reality Rehabilitation Protocol Based on Art Therapy in Patients with Stroke: A Single-Blind Randomized Controlled Trial
Gaetano Tieri, Marco Iosa, Antonio Fortini, Federica Aghilarre, Federico Gentili, Cristiano Rubeca, Tommaso Mastropietro, Gabriella Antonucci, Roberto De Giorgi
Brain Sciences.2024; 14(9): 863. CrossRef
Elevating patient experience: Transformative strategies in hand therapy
Jean Paul Brutus, Bianieff Tchiloemba, Anna Galstyan, Tom Lattré, Aviva Wolff, Alison Taylor
Hand Surgery and Rehabilitation.2024; 43(5): 101764. CrossRef

Brief Report

JYNNEOS vaccine safety monitoring in the Republic of Korea, 2022: a cross-sectional study: Jaeeun Lee, Seunghyun Lewis Kwon, Jinhee Park, Hyuna Bae, Hyerim Lee, Geun-Yong Kwon; Osong Public Health Res Perspect. 2023;14(5):433-438. Published online October 18, 2023; DOI: https://doi.org/10.24171/j.phrp.2023.0182

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Objectives
With the recent global mpox outbreak, the JYNNEOS vaccine (Modified Vaccinia Ankara-Bavarian Nordic) was developed as a third-generation smallpox vaccine and initially favored for mpox immunization. Vaccine-associated side effects contribute to vaccine hesitancy. Consequently, tracking adverse events post-immunization is crucial for safety management. This study used data from the national active vaccine safety surveillance conducted in Korea from August 25 to November 24, 2022 to detect potential safety signals and adverse events. Methods: Data on health conditions following vaccination were gathered from web-based surveys and reported via active surveillance through the Immunization Registry Information System. This follow-up system functioned via a text message link, surveying adverse events and health conditions beginning on the second day post-vaccination. Information about specific adverse events, including both local and systemic reactions, was collected. Results: The study included 86 healthcare workers who had received at least 1 dose of the JYNNEOS vaccine. Among the respondents, 79.1% reported experiencing at least 1 adverse event, with the majority being local reactions at the injection site. The incidence of adverse events was higher following the first dose (67.9%) than after the second dose (34.4%). The most frequently reported adverse event for both doses was mild pain at the injection site. Conclusion: The study provides crucial information on the safety of the JYNNEOS vaccine, demonstrating that most adverse events were manageable and predominantly localized to the injection site. Nonetheless, additional research is needed on the safety of various vaccine administration techniques and the vaccine’s effects on broader demographics.

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Enhanced Immunogenicity and Affinity with A35R-Fc-Based Chimeric Protein Compared to MPXV A35R Protein
Shimeng Bai, Yanxin Cui, Qibin Liao, Hongyang Yi, Zhonghui Liao, Gengwei Zhang, Fenfang Wu, Hongzhou Lu
Viruses.2025; 17(1): 116. CrossRef
Adverse Reactions After Intradermal Vaccination With JYNNEOS for Mpox in Korea
So Yun Lim, Yu Mi Jung, Yeonjae Kim, Gayeon Kim, Jaehyun Jeon, BumSik Chin, Min-Kyung Kim
Journal of Korean Medical Science.2024;[Epub] CrossRef
First Nationwide Mpox Vaccination Program in the Republic of Korea: Implications for an Enhanced Public Health Response
Seunghyun Lewis Kwon, Minju Song, Wonkyung Lee, Jeeyeon Shin, Su-Yeon Lee, Sang-Gu Yeo, Minjeong Kim, Sanggyun Jeong, Joonku Park, Dongwoo Lee, Sookyoung Lim
Journal of Korean Medical Science.2024;[Epub] CrossRef
Global perspectives on smallpox vaccine against monkeypox: a comprehensive meta-analysis and systematic review of effectiveness, protection, safety and cross-immunogenicity
Hao Liu, Wenjing Wang, Yang Zhang, Fuchun Wang, Junyi Duan, Tao Huang, Xiaojie Huang, Tong Zhang
Emerging Microbes & Infections.2024;[Epub] CrossRef

Original Article

Estimating the prevalence of oral manifestations in COVID-19 patients: a systematic review: Ankita Gupta, Kriti Shrivastav, Amit Agrawal, Abhishek Purohit, Roshan Chanchlani; Osong Public Health Res Perspect. 2023;14(5):388-417. Published online September 19, 2023; DOI: https://doi.org/10.24171/j.phrp.2023.0033

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Objectives
Patients with coronavirus disease 2019 (COVID-19) present with a variety of oral manifestations. Therefore, we conducted a systematic review to estimate the prevalence of oral lesions among COVID-19 patients. Methods: An extensive literature search of several electronic bibliographic databases (PubMed, Scopus, Science Direct, Litcovid) was conducted to retrieve all articles published in the English language from January 1, 2020 to March 31, 2023 that reported the prevalence of oral manifestations among COVID-19 patients. A meta-analysis of pooled prevalence was performed using Jamovi ver. 2.3 (2022). The I2 and Q statistics were used to assess heterogeneity between studies, and p-values <0.01 were considered statistically significant. Results: In total, 79 studies with data from 13,252 patients were included. The articles were predominantly published in 2020 (n=33), and Italy was the most common country (n=14). Most of the affected patients more than 50 years old and women (56.6%). The most common sites of involvement were the tongue (n=65), followed by the oral mucosa (n=37) and lips (n=19). High heterogeneity was found between studies. The most common oral manifestation was taste alteration, followed by xerostomia and ulceration, showing pooled prevalence rates of 48%, 35%, and 21%, respectively. Conclusion: COVID-19 patients show various oral manifestations that may help clinicians identify the disease promptly. Recognition of the signs and symptoms of COVID-19 is critical for an early diagnosis and better prognosis.

Citations

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Severe acute respiratory syndrome coronavirus 2 pathology and cell tropism in tongue tissues of COVID-19 autopsies
Longda Ma, Qian Liu, Manli Wang, Liang Liu, Zhihong Hu, Yiwu Zhou, Jia Liu
Frontiers in Cellular and Infection Microbiology.2024;[Epub] CrossRef
Impact of COVID-19 Disease on the Development of Osteomyelitis of Jaws: A Systematic Review
Emmanouil Vardas, Daniela Adamo, Federica Canfora, Maria Kouri, Konstantina Delli, Michele Davide Mignogna, Nikolaos Nikitakis
Journal of Clinical Medicine.2024; 13(15): 4290. CrossRef
Painful ulcerations associated with COVID-19 in an adolescent patient: a case report
David O. Danesh, Kyulim Lee, Rebecca G. Wallihan, Janice A. Townsend, Ira Mulo, Ashok Kumar
Frontiers in Dental Medicine.2024;[Epub] CrossRef
Characteristics of Oral Adverse Effects following COVID-19 Vaccination and Similarities with Oral Symptoms in COVID-19 Patients: Taste and Saliva Secretory Disorders
Hironori Tsuchiya, Maki Mizogami
Medical Principles and Practice.2024; 34(2): 101. CrossRef

Short Communication

Epidemiological characteristics of carbapenemase-producing Enterobacteriaceae outbreaks in the Republic of Korea between 2017 and 2022: Hyoseon Jeong, Junghee Hyun, Yeon-Kyeng Lee; Osong Public Health Res Perspect. 2023;14(4):312-320. Published online August 21, 2023; DOI: https://doi.org/10.24171/j.phrp.2023.0069

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Objectives
We aimed to describe the epidemiological characteristics of carbapenemase-producing Enterobacteriaceae (CPE) outbreaks in healthcare settings in the Republic of Korea between 2017 and 2022.
Methods
Under the national notifiable disease surveillance system, we obtained annual descriptive statistics regarding the isolated species, carbapenemase genotype, healthcare facility type, outbreak location and duration, and number of patients affected and recommended interventions. We used epidemiological investigation reports on CPE outbreaks reported to Korea Disease Control and Prevention Agency from June 2017 to September 2022.
Results
Among the 168 reports analyzed, Klebsiella pneumoniae (85.1%) was the most frequently reported species, while K. pneumoniae carbapenemase (KPC, 82.7%) was the most common carbapenemase genotype. Both categories increased from 2017 to 2022 (p<0.01). General hospitals had the highest proportion (54.8%), while tertiary general hospitals demonstrated a decreasing trend (p<0.01). The largest proportion of outbreaks occurred exclusively in intensive care units (ICUs, 44.0%), and the frequency of concurrent outbreaks in ICUs and general wards increased over time (p<0.01). The median outbreak duration rose from 43.5 days before the coronavirus disease 2019 (COVID-19) pandemic (2017–2019) to 79.5 days during the pandemic (2020–2022) (p=0.01), and the median number of patients associated with each outbreak increased from 5.0 to 6.0 (p=0.03). Frequently recommended interventions included employee education (38.1%), and 3 or more measures were proposed for 45.2% of outbreaks.
Conclusion
In the Republic of Korea, CPE outbreaks have been consistently dominated by K. pneumoniae and KPC. The size of these outbreaks increased during the COVID-19 pandemic. Our findings highlight the need for continuing efforts to control CPE outbreaks using a multimodal approach, while considering their epidemiology.

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Comparison of clinical outcomes of patients with serial negative surveillance cultures according to a subsequent polymerase chain reaction test for carbapenemase-producing Enterobacterales
H. Seo, S. Kim, Y.W. Lee, H.S. Oh, H-S. Kim, Y.K. Kim
Journal of Hospital Infection.2024; 146: 93. CrossRef
Identifying Contact Time Required for Secondary Transmission ofClostridioides difficileInfections by Using Real-Time Locating System
Min Hyung Kim, Jaewoong Kim, Heejin Ra, Sooyeon Jeong, Yoon Soo Park, Dongju Won, Hyukmin Lee, Heejung Kim
Emerging Infectious Diseases.2024;[Epub] CrossRef
Antimicrobial activity of ceftazidime-avibactam against KPC-2-producing Enterobacterales: a cross-combination and dose-escalation titration study with relebactam and vaborbactam
Min Seo Kang, Jin Yang Baek, Jae-Hoon Ko, Sun Young Cho, Keon Young Lee, Young Ho Lee, Jinyoung Yang, Tae Yeul Kim, Hee Jae Huh, Nam Yong Lee, Kyungmin Huh, Cheol-In Kang, Doo Ryeon Chung, Kyong Ran Peck, Bobby G. Warren
Microbiology Spectrum.2024;[Epub] CrossRef
Performance comparison of BD Phoenix CPO detect panel with Cepheid Xpert Carba-R assay for the detection of carbapenemase-producing Klebsiella pneumoniae isolates
Nazmiye Ülkü Tüzemen, Uğur Önal, Osman Merdan, Bekir Akca, Beyza Ener, Halis Akalın, Cüneyt Özakın
BMC Microbiology.2024;[Epub] CrossRef

Original Article

Mental health and its determinants among adolescents living in families with separated or divorced parents in an urban area of Vietnam: Binh Thang Tran, Minh Tu Nguyen, Minh Tam Nguyen, Thanh Gia Nguyen, Vo Nu Hong Duc, Thi Tra My Tran; Osong Public Health Res Perspect. 2023;14(4):300-311. Published online August 9, 2023; DOI: https://doi.org/10.24171/j.phrp.2023.0110

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Objectives
We assessed the prevalence of stress, anxiety, and depression among adolescents living in families with separated or divorced parents in Hue City, Vietnam and identified factors associated with these conditions.
Methods
This cross-sectional study enrolled 309 adolescents, aged 12 to 17 years, living in families with separated or divorced parents in Hue City, Vietnam. The depression anxiety stress scale-21 (DASS-21) was used to measure stress, anxiety, and depression. Predictors of overall and individual mental health problems were identified using ordered and binary logistic regression, respectively.
Results
The DASS-21 scale revealed a 49.2% prevalence of stress, while anxiety and depression had s prevalence rates of 61.5%. Among participants, 42.4% experienced all 3 mental health issues. Several factors were identified as significant predictors of mental health problems, including poor to average economic status (adjusted odds ratio [aOR], 2.00; 95% confidence interval [CI], 1.21–3.31; p=0.007); being in high school (aOR, 5.02; 95% CI, 2.93–8.60; p<0.001); maternal occupation of teacher, healthcare professional, or official (aOR, 2.39; 95% CI, 1.13–5.03; p=0.022); longer duration of family separation or divorce (aOR, 1.24; 95% CI, 1.05–1.45; p=0.009); living with one’s mother (aOR, 1.69; 95% CI, 1.03–2.76; p=0.04); alcohol consumption (aOR, 1.70; 95% CI, 0.99–2.92; p=0.050); and being bullied (aOR, 5.33; 95% CI, 1.10–25.69; p=0.037). Most of these factors were associated with stress, anxiety, and depression. Additionally, smoking was associated with stress.
Conclusion
Adolescents with separated or divorced parents were at increased risk of stress, anxiety, and depression. The findings of this study provide important implications for prevention programs.

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The impact of parental absence on the mental health of middle school students in rural areas of Western China
Xiaohong Ren, Cen Lin, Lu Pan, Qiuyue Fan, Dapeng Wu, JinLong He, Ping He, Jiaming Luo
Frontiers in Public Health.2025;[Epub] CrossRef
Mental health among ethnic minority adolescents in Vietnam and correlated factors: A cross-sectional study
Ngo Anh Vinh, Vu Thi My Hanh, Do Thi Bich Van, Duong Anh Tai, Do Minh Loan, Le Thi Thanh Thuy
Journal of Affective Disorders Reports.2024; 17: 100795. CrossRef
Subgrouping of anxiety symptoms and stress levels in Chinese adolescents: results of a latent profile analysis
Xuefeng Li, Jingyan Chen, Jinpeng Wang, Jinhong Ding, Jing Xiao
Current Psychology.2024; 43(36): 28685. CrossRef
Prevalence and risk factors associated with psychological distress among children in Penang, Malaysia: A stratified multistage cluster study
Xin Yee Foo, Nur Arzuar Abdul Rahim, Lai Kuan Lee
MethodsX.2024; 13: 103069. CrossRef

Brief Report

Temporal association between the age-specific incidence of Guillain-Barré syndrome and SARS-CoV-2 vaccination in Republic of Korea: a nationwide time-series correlation study: Hyunju Lee, Donghyok Kwon, Seoncheol Park, Seung Ri Park, Darda Chung, Jongmok Ha; Osong Public Health Res Perspect. 2023;14(3):224-231. Published online June 22, 2023; DOI: https://doi.org/10.24171/j.phrp.2023.0050

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Objectives
The incidence of Guillain-Barré syndrome (GBS) changed significantly during the coronavirus disease 2019 (COVID-19) pandemic. Emerging reports suggest that viral vector-based vaccines may be associated with an elevated risk of GBS.
Methods
In this nationwide time-series correlation study, we examined the age-specific incidence of GBS from January 2011 to August 2022, as well as data on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinations and infections from February 2021 to August 2022. We compared the forecasted estimates of age-specific GBS incidence, using the pre-SARS-CoV-2 period as a benchmark, with the actual incidence observed during the post-vaccination period of the pandemic. Furthermore, we assessed the temporal association between GBS, SARS-CoV-2 vaccinations, and COVID-19 for different age groups.
Results
In the age group of 60 and older, the rate ratio was significantly elevated during June-August and November 2021. A significant, strong positive association was observed between viral vector-based vaccines and GBS incidence trends in this age group (r=0.52, p=0.022). For the 30 to 59 years age group, the rate ratio was notably high in September 2021. A statistically significant, strong positive association was found between mRNA-based vaccines and GBS incidence in this age group (r=0.61, p=0.006).
Conclusion
Viral vector-based SARS-CoV-2 vaccines were found to be temporally associated with an increased risk of GBS, particularly in older adults. To minimize age-specific and biological mechanism-specific adverse events, future vaccination campaigns should adopt a more personalized approach, such as recommending homologous mRNA-based SARS-CoV-2 vaccines for older adults to reduce the heightened risk of GBS.

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mRNA-LNP COVID-19 Vaccine Lipids Induce Complement Activation and Production of Proinflammatory Cytokines: Mechanisms, Effects of Complement Inhibitors, and Relevance to Adverse Reactions
Tamás Bakos, Tamás Mészáros, Gergely Tibor Kozma, Petra Berényi, Réka Facskó, Henriette Farkas, László Dézsi, Carlo Heirman, Stefaan de Koker, Raymond Schiffelers, Kathryn Anne Glatter, Tamás Radovits, Gábor Szénási, János Szebeni
International Journal of Molecular Sciences.2024; 25(7): 3595. CrossRef
Guillain-barre syndrome following COVID-19 vaccination: A study of 70 case reports
Biki Kumar Sah, Zahra Fatima, Rajan Kumar Sah, Bushra Syed, Tulika Garg, Selia Chowdhury, Bikona Ghosh, Binita Kunwar, Anagha Shree, Vivek Kumar Sah, Anisha Raut
Annals of Medicine & Surgery.2024;[Epub] CrossRef
Deciphering changes in the incidence of hemorrhagic stroke and cerebral venous sinus thrombosis during the coronavirus disease 2019 pandemic: A nationwide time-series correlation study
Soo Hyeon Cho, Dong Kyu Kim, Min Cheol Song, Euiho Lee, Seoncheol Park, Darda Chung, Jongmok Ha, Sonu Bhaskar
PLOS ONE.2024; 19(10): e0301313. CrossRef
Before Diagnosing SARS-CoV-2 Vaccination-Related Funicular Myelosis, GBS and Other Differentials Must be Ruled Out
Josef Finsterer
Neurology India.2024; 72(5): 1100. CrossRef

Original Articles

The COVID-19 pandemic and healthcare utilization in Iran: evidence from an interrupted time series analysis: Monireh Mahmoodpour-Azari, Satar Rezaei, Nasim Badiee, Mohammad Hajizadeh, Ali Mohammadi, Ali Kazemi-Karyani, Shahin Soltani, Mehdi Khezeli; Osong Public Health Res Perspect. 2023;14(3):180-187. Published online June 22, 2023; DOI: https://doi.org/10.24171/j.phrp.2023.0041

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Objectives
This study aimed to examine the effect of the coronavirus disease 2019 (COVID-19) outbreak on the hospitalization rate, emergency department (ED) visits, and outpatient clinic visits in western Iran.
Methods
We collected data on the monthly hospitalization rate, rate of patients referred to the ED, and rate of patients referred to outpatient clinics for a period of 40 months (23 months before and 17 months after the COVID-19 outbreak in Iran) from all 7 public hospitals in the city of Kermanshah. An interrupted time series analysis was conducted to examine the impact of COVID-19 on the outcome variables in this study.
Results
A statistically significant decrease of 38.11 hospitalizations per 10,000 population (95% confidence interval [CI], 24.93–51.29) was observed in the first month of the COVID-19 outbreak. The corresponding reductions in ED visits and outpatient visits per 10,000 population were 191.65 (95% CI, 166.63–216.66) and 168.57 (95% CI, 126.41–210.73), respectively. After the initial reduction, significant monthly increases in the hospitalization rate (an increase of 1.81 per 10,000 population), ED visits (an increase of 2.16 per 10,000 population), and outpatient clinic visits (an increase of 5.77 per 10,000 population) were observed during the COVID-19 pandemic.
Conclusion
Our study showed that the utilization of outpatient and inpatient services in hospitals and clinics significantly declined after the COVID-19 outbreak, and use of these services did not return to pre-outbreak levels as of June 2021.

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The strongest predictors of compliance with health protocols among marketers and guilds based on the transtheoretical model
Shandiz Moslehi, Asghar Tavan, Sajjad Narimani, Fardin shahbazzadeh, Nadia Sedri, Sama Sabahi
BMC Public Health.2024;[Epub] CrossRef
Time series analysis of COVID-19's impact on physician and dentist visits in Iran
Satar Rezaei, Hesam Ghiasvand, Heather Brown
Scientific Reports.2024;[Epub] CrossRef
A tale of two times: an exploration of healthcare utilization patterns before and during COVID-19 in Iran
Satar Rezaei, Masoud Mohammadnezhad
BMC Public Health.2024;[Epub] CrossRef
From Routine to Crisis: The Impact of COVID‐19 Pandemic on Antibiotic Consumption in Iran
Satar Rezaei, Mohammad Bazyar, Sina Ahmadi, Abdolvahed Khodamoradi
Health Science Reports.2024;[Epub] CrossRef

Risk factors associated with death due to severe fever with thrombocytopenia syndrome in hospitalized Korean patients (2018–2022): Jia Kim, Hyo-jeong Hong, Ji-hye Hwang, Na-Ri Shin, Kyungwon Hwang; Osong Public Health Res Perspect. 2023;14(3):151-163. Published online June 8, 2023; DOI: https://doi.org/10.24171/j.phrp.2023.0048

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Objectives
Severe fever with thrombocytopenia syndrome (SFTS) has no vaccine or treatment and an extremely high fatality rate. We aimed to analyze and evaluate the risk factors for death associated with SFTS.
Methods
Among reports from 2018 to 2022, we compared and analyzed 1,034 inpatients aged 18 years or older with laboratory-confirmed SFTS who underwent complete epidemiological investigations.
Results
Most of the inpatients with SFTS were aged 50 years or older (average age, 67.6 years). The median time from symptom onset to death was 9 days, and the average case fatality rate was 18.5%. Risk factors for death included age of 70 years or older (odds ratio [OR], 4.82); agriculture-related occupation (OR, 2.01); underlying disease (OR, 7.20); delayed diagnosis (OR, 1.28 per day); decreased level of consciousness (OR, 5.53); fever/chills (OR, 20.52); prolonged activated partial thromboplastin time (OR, 4.19); and elevated levels of aspartate aminotransferase (OR, 2.91), blood urea nitrogen (OR, 2.62), and creatine (OR, 3.21).
Conclusion
The risk factors for death in patients with SFTS were old age; agriculture-related occupation; underlying disease; delayed clinical suspicion; fever/chills; decreased level of consciousness; and elevated activated partial thromboplastin time, aspartate aminotransferase, blood urea nitrogen, and creatine levels.

Citations

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Identification of early prognostic biomarkers in Severe Fever with Thrombocytopenia Syndrome using machine learning algorithms
Jie Zhu, Jianmei Zhou, Chunhui Tao, Guomei Xia, Bingyan Liu, Xiaowei Zheng, Xu Li, Zhenhua Zhang
Annals of Medicine.2025;[Epub] CrossRef
Deciphering the evolutionary landscape of severe fever with thrombocytopenia syndrome virus across East Asia
Dongbin Park, Kwan Woo Kim, Young-Il Kim, Mark Anthony B Casel, Hyunwoo Jang, Woohyun Kwon, Kanghee Kim, Se-Mi Kim, Monford Paul Abishek N, Eun-Ha Kim, Hobin Jang, Suhee Hwang, Seok-Min Yun, Joo-Yeon Lee, Hye Won Jeong, Su-Jin Park, Young Ki Choi
Virus Evolution.2024;[Epub] CrossRef
Acute kidney injury as a prognostic marker in severe fever with thrombocytopenia syndrome
Jin Mi Lee, Hae Lee Kim, Myoung-nam Lim, Changhyup Kim, Yeon Ju La, Yong Duk Jeon, Won Sup Oh, Seongmin Son, Sunhwa Lee, Hyunjeong Baek, Daniel Duck-Jin Hwang, Ji In Park
Scientific Reports.2024;[Epub] CrossRef
Double-Stranded RNA-Based Method for Diagnosing Severe Fever with Thrombocytopenia
Jung Wan Park, Jaemin Jeon, Yoosik Kim, Min Hyok Jeon
Journal of Clinical Medicine.2024; 14(1): 105. CrossRef

The incidence and clinical characteristics of myocarditis and pericarditis following mRNA-based COVID-19 vaccination in Republic of Korea adolescents from July 2021 to September 2022: Ju-Young Sim, Seung-Yun Kim, Eun-Kyoung Kim; Osong Public Health Res Perspect. 2023;14(2):76-88. Published online April 18, 2023; DOI: https://doi.org/10.24171/j.phrp.2023.0032

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Graphical Abstract Abstract PDF

Objectives
Age-specific information regarding myocarditis/pericarditis in adolescents following mRNA-based coronavirus disease 2019 (COVID-19) vaccination in Asia remains insufficient. This study investigated the incidence and clinical characteristics of myocarditis/pericarditis in Republic of Korea adolescents after mRNA-based COVID-19 vaccination.
Methods
This retrospective descriptive study utilized patient data from the Korea Immunization Management System. Incidence rates were calculated according to age and sex. Clinical characteristics (symptoms/signs, laboratory values, and imaging results) were compared between mild and severe cases.
Results
Between July 19, 2021 and September 30, 2022, 3,728,224 individuals aged 12 to 19 years received 6,484,165 mRNA-based COVID-19 vaccines, and 173 cases met the case definition for myocarditis/pericarditis: 151 mild (87.3%) and 22 severe (12.7%). The incidence was 3.8-fold higher in males than in females. Troponin I/ troponin T was elevated in 96% of myocarditis cases, demonstrating higher sensitivity than creatine kinase-myocardial band (67.6%) or C-reactive protein (75.2%). ST-segment or Twave on electrography abnormalities were found in 60.3% (85/141). Paroxysmal/sustained atrial/ventricular arrhythmias were more common in severe than in mild cases (45.5% vs. 16.8%, p=0.008). Edema on T2-weighted magnetic imaging occurred in 21.6% (8/37) and 62.5% (5/8) of mild and severe cases, respectively (p=0.03). Abnormal pericardial fluid collection or pericardial inflammation was found in 75.4% of pericarditis cases (49/65).
Conclusion
Myocarditis/pericarditis occurred in rare cases following mRNA-based COVID-19 vaccination. Most cases were mild, but the incidence was higher in adolescent males and after the second dose. As bivalent severe acute respiratory syndrome coronavirus 2 mRNA vaccination started in Republic of Korea in October 2022, the post-vaccination incidence of myocarditis/pericarditis should be closely monitored, considering clinical characteristics.

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Responses to Common Misconceptions Relating to COVID-19 Variant-Adapted mRNA Vaccines
George Kassianos, Pauline MacDonald, Ivan Aloysius, Shanti Pather
Vaccines.2024; 12(1): 57. CrossRef
Comparative safety of monovalent and bivalent mRNA COVID-19 booster vaccines in adolescents aged 12 to 17 years in the Republic of Korea
Mijeong Ko, Seontae Kim, Seok-Kyoung Choi, Seung Hwan Shin, Yeon-Kyeng Lee, Yunhyung Kwon
Osong Public Health and Research Perspectives.2024; 15(4): 364. CrossRef
Epidemiological Characteristics and Outcome of Myocarditis and Pericarditis Temporally Associated With BNT162b2 COVID-19 Vaccine in Adolescents: Korean National Surveillance
Bin Ahn, Seung Hwan Shin, Myung-Jae Hwang, HyoSug Choi, Sara Na, Sangshin Park, Jue Seong Lee, Young June Choe, Yoonsun Yoon, Kyoungsan Seo, Jong Hee Kim, Hyun Mi Kang
Journal of Korean Medical Science.2024;[Epub] CrossRef
To become a more stronger and safer country
Jong-Koo Lee
Osong Public Health and Research Perspectives.2023; 14(2): 67. CrossRef

Association between the empirical dietary inflammatory index and musculoskeletal pain in community-dwelling older adults: a cross-sectional study: Mahshid Rezaei, Zahra Tajary, Zahra Esmaeily, Atefeh Eyvazkhani, Shahrzad Daei, Marjan Mansouri Dara, Mohaddeseh Rezaei, Abolghassem Djazayeri, Ahmadreza Dorosty Motlagh; Osong Public Health Res Perspect. 2023;14(1):51-58. Published online February 20, 2023; DOI: https://doi.org/10.24171/j.phrp.2022.0194

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Graphical Abstract Abstract PDF

Objectives
Inflammation has been proposed to be one of the main causes of musculoskeletal pain. Diet is a lifestyle factor that plays an important role in managing inflammation; thus, we assessed the inflammatory potential of diets using the empirical dietary inflammatory index (EDII) to investigate the relationship between diet and musculoskeletal pain.
Methods
This cross-sectional study included 212 elderly individuals who were selected from health centers in Tehran, Iran. Dietary intake was evaluated using a valid and reliable 147-item food frequency questionnaire. To measure the intensity of pain, a visual analogue scale was used. Multiple linear regression was applied to assess the association between the EDII and musculoskeletal pain.
Results
In total, 62.7% and 37.3% of participants had mild and severe pain, respectively. The EDII values were 0.97±0.72 and 1.10±0.66, respectively, in those with mild and severe pain. A higher EDII score was associated with more intense musculoskeletal pain after adjusting for age and sex (β=0.20; 95% confidence interval [CI], 0.06–0.26; p<0.001), but not after adjustment for other confounders (β=–0.13; 95% CI, –1.54 to 0.60; p=0.39).
Conclusion
Our findings indicated that higher dietary inflammation might not be associated with musculoskeletal pain in older adults. However, further investigations are required to confirm these findings.

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Proinflammatory diet is associated with higher pain, disease severity and biochemical parameters associated with inflammation in fibromyalgia
Nursena Ersoy Söke, Hansa İnceöz, İlker Solmaz, Hülya Yardımcı
Pain Medicine.2025; 26(3): 131. CrossRef
Exploring the association between dietary Inflammatory Index and chronic pain in US adults using NHANES 1999–2004
Lunxue Qing, Yingying Zhu, Changhe Yu, Yang Zhang, Jinxia Ni
Scientific Reports.2024;[Epub] CrossRef
The dietary inflammatory index and cardiometabolic parameters in US firefighters
Andria Christodoulou, Costas A. Christophi, Mercedes Sotos-Prieto, Steven Moffatt, Longgang Zhao, Stefanos N. Kales, James R. Hébert
Frontiers in Nutrition.2024;[Epub] CrossRef
Association between dietary inflammatory index and musculoskeletal disorders in adults
Firoozeh Khamoushi, Davood Soleimani, Farid Najafi, Neshat Ahmadi, Neda Heidarzadeh-Esfahani, Bita Anvari, Ebrahim Shakiba, Yahya Pasdar
Scientific Reports.2023;[Epub] CrossRef

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