Objectives The purpose of this study was to explore the relationships among obstructive sleep apnea (OSA), dyspnea, and health-related quality of life (HRQOL), as well as the factors influencing HRQOL.
Methods A total of 129 lung cancer survivors (mean age, 53.4 years; 77 men and 52 women; mean time since diagnosis, 1.6 years; and cancer stage [1/2/3/4/relapse], 43/31/19/34/2, respectively) completed a questionnaire that included demographic and clinical information, as well as questions about the severity of sleep apnea, dyspnea, and HRQOL. The severity of OSA, dyspnea, and HRQOL were assessed using the Berlin questionnaire, the Dyspnea-10 item (FACIT-Dyspnea), and the European Organization for Research and Treatment of Cancer QLQ-C30, respectively.
Results The severity of OSA and dyspnea exhibited negative correlations with HRQOL (p<0.05). Multiple regression analysis revealed that several factors significantly impacted the HRQOL of lung cancer survivors. These included the extent of dyspnea (β=–0.369, p<0.01), weight loss (β=0.192, p<0.01), OSA score (β=−0.215, p<0.01), stage 2 cancer (β=−0.181, p<0.01), and poor perceived health status (β=−0.179, p<0.05).
Conclusion These findings suggest that breathing difficulties, including OSA and dyspnea, contribute to decreased HRQOL. This study offers valuable insights for researchers and clinicians, aiding in the development of effective strategies to manage these issues in daily life.
Citations
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Effects of pulmonary rehabilitation in people with lung cancer after lung resection: a systematic review and meta-analysis Qun Wang, Zhe Liu, Lei Qi, Sek Ying Chair, Ruitong Gao Journal of Cancer Survivorship.2026;[Epub] CrossRef
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<sec>
<title>Objectives</title>
<p>The aim of this study was to evaluate whether the waist circumference of patients with chronic obstructive pulmonary disease (COPD), had an impact on lung function.</p></sec>
<sec>
<title>Methods</title>
<p>There were 180 patients with COPD recruited into this prospective cross-sectional study. The age, weight, body mass index and waist circumference (WC) were measured. Spirometry parameters including forced vital capacity (FVC), and forced expiratory volume in the first second (FEV1), were measured and FEV1/FVC calculated.</p></sec>
<sec>
<title>Results</title>
<p>The mean FEV1/FVC in both normal weight and overweight patients, did not statistically significantly correlate with WC. The COPD assessment test, positively correlated with WC ( <italic>p</italic> = 0.031). A positive correlation with body mass index ( <italic>p</italic> < 0.001), smoking ( <italic>p</italic> = 0.027), and global initiative for chronic obstructive lung disease score ( <italic>p</italic> = 0.009), were observed to positively associate with WC. WC, age, C-reactive protein, duration of disease, and gender (male), were observed to be statistically significant risk factors for the severity of COPD.</p></sec>
<sec>
<title>Conclusion</title>
<p>WC was not observed to impact upon lung function in this study but it was a predictive factor for COPD severity in patients.</p></sec>
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Lung function parameters in overweight patients with COPD in relation to body mass index and waist circumference and impact on quality of life Zunaira Nawaz, Muhammad Ashraf Jahangir, Zille Huma Journal of International Medical Research.2024;[Epub] CrossRef
The role of abdominal obesity in the development of cardiopulmonary disorders in aluminum industry workers Egor S. Filimonov, Olga Yu. Korotenko, Evgeniya V. Ulanova Hygiene and sanitation.2023; 102(4): 328. CrossRef
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<sec>
<title>Objectives</title>
<p>Lung function impairment due to exposure to indoor air pollution of particulate matter size 2.5 micrometers (PM<sub>2.5</sub>) is not well documented in Jakarta.</p></sec>
<sec>
<title>Methods</title>
<p>To assess whether there is an association between indoor PM<sub>2.5</sub> concentration and lung function impairment among the adult population, a cross-sectional design was implemented. There were 109 adults selected aged between 20 years and 65 years from the Pulo Gadung industrial area, East Jakarta. Association and logistic regression analysis were implemented for statistical analysis of the data.</p></sec>
<sec>
<title>Results</title>
<p>The average exposure to indoor PM<sub>2.5</sub> was 308 μg/m<sup>3</sup>. There were 38.5% of participants that had lung function impairment. PM<sub>2.5</sub> concentration was found to be associated with lung function impairment among the adult population living in Pulo Gadung industrial area after controlling for gender, duration of exposure, ventilation, smoking status, and humidity.</p></sec>
<sec>
<title>Conclusion</title>
<p>The results of this study suggest that PM<sub>2.5</sub> concentrations in the Pulo Gadung industrial area may be the main contributor to the impairment of lung function for adults living in the surrounding residential area.</p></sec>
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Objectives
High-risk human papillomavirus (hrHPV) is known to be a representative cancer-causing agent in the genital and head and neck regions. Many studies have detected hrHPV DNA in nonsmall cell lung carcinoma. However, hrHPV–etiologic correlation in nonsmall cell lung carcinoma remains unclear. This study is designed to determine the prevalence of episomal or integrated hrHPV DNA in nonsmall cell lung carcinoma among the Korean population. Methods
Surgically resected nonsmall cell lung carcinoma tissues, including 134 cases of squamous cell carcinoma (SqCC) and 99 cases of adenocarcinoma (ADC), were examined. <i>In situ</i> hybridization (ISH) for detecting episomal or integrated hrHPV DNA was performed using the INFORM HPV III Family 16 Probe (B) in the Ventana-validated assay. Anyplex II HPV28 detection kit based on real-time polymerase chain reaction was used for HPV DNA detection and genotyping. Results
All members of the study population were of Korean ethnicity. Episomal or integrated hrHPV DNA ISH analysis result was negative in all 233 cases. One SqCC of 89 samples (42 SqCCs and 47 ADCs) was positive for an hrHPV genotype by Anyplex II HPV28 detection kit. Conclusion
Our finding did not demonstrate hrHPV–etiologic correlation in primary lung SqCC and ADC in the Korean population.
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HPV and Lung Cancer: A Systematic Review Telma Sequeira, Rui Pinto, Carlos Cardoso, Catarina Almeida, Rita Aragão, Teresa Almodovar, Manuel Bicho, Maria Clara Bicho, Cristina Bárbara Cancers.2024; 16(19): 3325. CrossRef
HPV and lung cancer: A systematic review and meta‐analysis Julia Karnosky, Wolfgang Dietmaier, Helge Knuettel, Viola Freigang, Myriam Koch, Franziska Koll, Florian Zeman, Christian Schulz Cancer Reports.2021;[Epub] CrossRef
Presence and activity of HPV in primary lung cancer Talita Helena Araujo de Oliveira, Carolina Medeiros do Amaral, Bianca de França São Marcos, Kamylla Conceição Gomes Nascimento, Ana Carine de Miranda Rios, Dafne Carolina Alves Quixabeira, Maria Tereza Cartaxo Muniz, Jacinto da Costa Silva Neto, Antonio C Journal of Cancer Research and Clinical Oncology.2018; 144(12): 2367. CrossRef
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