aWHO/WPRO Japanese Encephalitis Regional Refernce Laboratory, 187 Osongsaengmyeong2-ro, Chungbuk 363-951, Korea
bDivision of Arboviruses, National Institute of Health, Korea Centers for Disease Control and Prevention, 187 Osongsaengmyeong2-ro, Chungbuk 363-951, Korea
cDepartment of Pediatrics, Inha University Medical School, Incheon, Korea
dDepartment of Biomedical Sciences, Hallym University, Chuncheon, Korea
© 2014 Published by Elsevier B.V. on behalf of Korea Centers for Disease Control and Prevention.
This is an Open Access article distributed under the terms of the CC-BY-NC License (http://creativecommons.org/licenses/by-nc/3.0).
Characteristics | Group | Total | |
---|---|---|---|
Inactivated vaccine | Live vaccine | ||
Number of children | 15 | 14 | 29 |
Number of doses in primary schedule | 3 | 2 | – |
Mean (range) age at time of first dose (mo) | 16.4 (10.4–24.2) | 14.7 (11.9–24.3) | 15.6 (10.4–24.3) |
Mean (range) age at time of last dose (mo) | 31 (19.6–67.7) | 24.9 (18.4–31.6) | 28 (18.4–67.7) |
Interval between sampling and last dose (mo) | 27.9 (3.2–47.0) | 21.3 (3.0–47.1) | 24.7 (3.0–47.1) |
Test | Inactivated vaccine group (n = 15) | Live attenuated vaccine group (n = 14) | ||
---|---|---|---|---|
No. (%) positive | GMT | No. (%) positive | GMT | |
PRNT | 15 (100) | 1:292 | 14 (100) | 1:195 |
HI | 13 (86.7) | 1:20 | 10 (71.4) | 1:17 |
IFA (IgG) | 8 (53.3) | 1:99 | 5 (35.7) | 1:111 |
IFA (IgM) | 0 | – | 0 | – |
ELISA (IgG) | 0 | – | 0 | – |
ELISA (IgM) | 0 | – | 0 | – |
Inactivated vaccine = inactivated vaccines derived from mouse brain; live vaccine = live attenuated vaccine. Range was relatively wide because one child had a booster shot more than 1 year later than recommended in the schedule.
ELISA = enzyme-linked immunosorbent assay; GMT = geometric mean titer; HI = hemagglutination inhibition test; IFA = indirect immunofluorescence assay; Ig = immunoglobulin; PRNT = plaque reduction neutralization test.