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Volume 16(3); June 2025

Editorial

Citations

Citations to this article as recorded by  Crossref logo
  • Addressing low-value care (LVC) in Asia: a narrative review of Choosing Wisely and other initiatives across Asia
    Jia Xuan Yeo, Yasuharu Tokuda, Shu Sasaki, Jay Pan, Hanin Kamaruzaman, Priya Ranganathan, Liyong Lu, Aliza Mohamad Yusof, Azarinah Izaham, C S Pramesh, Hairil Rizal Abdullah
    BMJ Open Quality.2026; 15(2): e003806.     CrossRef
  • 1,985 View
  • 64 Download
  • 1 Web of Science
  • Crossref

Review Articles

Effectiveness of non-pharmacological school-based therapies for cigarette smoking cessation among adolescents in South and Southeast Asian countries: a systematic review and meta-analysis
Fahad Ali Mangrio, Penpaktr Uthis, Suwimon Rojnawee, Alicia K Matthews
Osong Public Health Res Perspect 2025;16(3):195-210.
Published online April 30, 2025
DOI: https://doi.org/10.24171/j.phrp.2024.0320
Effectiveness of non-pharmacological school-based therapies for cigarette smoking cessation among adolescents in South and Southeast Asian countries: a systematic review and meta-analysis
Objectives
This review and meta-analysis examined the effectiveness of non-pharmacological therapies delivered through school-based interventions for smoking cessation among adolescents in South and Southeast Asian countries.
Methods
A systematic search was conducted across PubMed, Scopus, Science Direct, BioMed Central, the Cochrane Library, and ProQuest Dissertations & Theses Global from inception to October 2024. Eligible studies comprised randomized controlled trials and quasi-experimental studies that compared non-pharmacological smoking cessation interventions delivered in schools or other educational institutions. Data on smoking abstinence outcomes were extracted from published studies, and odds ratios (ORs) with 95% confidence intervals (CIs) were pooled using a random-effects model via the Mantel-Haenszel estimator.
Results
Seven studies involving 1,260 participants were included. The meta-analysis demonstrated that non-pharmacological school-based therapies significantly increased smoking abstinence compared to controls (OR, 2.83; 95% CI, 1.83–4.40; p<0.001. Subgroup analyzes revealed benefits across both randomized controlled trials and quasi-experimental studies with varying abstinence rates. Studies utilizing biochemical verification showed significant positive effects despite substantial heterogeneity, and short-term (<3 months) abstinence was significantly higher in intervention groups compared to controls. Overall, no differences were found between subgroups regarding intervention effectiveness.
Conclusion
This meta-analysis indicates that non-pharmacological school-based interventions positively impact smoking abstinence rates, although effectiveness may vary based on study design, follow-up duration, and use of biochemical verification. The findings underscore the need for further research with larger sample sizes, extended follow-up periods, and improved methodological rigor in these regions.

Citations

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  • Global disease burden of laryngeal cancer attributable to smoking from 1990 to 2021
    Xiao Han, Shanchun Gong, Chao Wang, Yulin Zhang, Yufei Pan, Jing Li, Kai Liu, Zhenkun Yu
    European Journal of Cancer Prevention.2026; 35(4): 291.     CrossRef
  • Adapting and Implementing a School-Based “Implementation Intentions” Program Within FRESHAIR4Life to Prevent Smoking Initiation Among Adolescents in Greece: A Study Protocol
    Izolde Bouloukaki, Antonios Christodoulakis, Sevasti Peraki, Floor A. Van Den Brand, Faraz Siddiqui, Theodoros Krasanakis, Antonia Aravantinou-Karlatou, Purva Abhyankar, Siân Williams, Julia van Koeveringe, Rianne MJJ van der Kleij, Ioanna Tsiligianni
    Healthcare.2026; 14(7): 938.     CrossRef
  • 8,622 View
  • 214 Download
  • 3 Web of Science
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The role of vitamin D and the VDR gene polymorphism in sepsis risk and mortality: a systematic review and meta-analysis
Wiwi Jaya, Sumarno Reto Prawiro, Hani Susianti, Aswoco Andyk Asmoro
Osong Public Health Res Perspect 2025;16(3):211-222.
Published online April 29, 2025
DOI: https://doi.org/10.24171/j.phrp.2025.0006
The role of vitamin D and the VDR gene polymorphism in sepsis risk and mortality:  a systematic review and meta-analysis
Objectives
Vitamin D regulates immune function, cell proliferation, and differentiation. Its deficiency is linked to sepsis, although the causal relationship remains unclear. Studies suggest a strong correlation between FokI polymorphism and sepsis in the context of vitamin D deficiency. This study examined the association between vitamin D levels, the VDR FokI polymorphism, and sepsis risk through a systematic review and meta-analysis.
Methods
Relevant articles from 2014–2024 were identified from various databases, including PubMed, Scopus, and Cochrane. A meta-analysis was conducted to assess the difference in vitamin D levels between the sepsis and control groups, as well as the relationship between VDR FokI genotypes (TT, CT, CC) and sepsis risk.
Results
Vitamin D levels in sepsis patients were consistently lower than in the control group, with a mean difference of –4.17 ng/mL (95% confidence interval, –7.87 to –0.47; p=0.03). However, the relationship between VDR FokI genotype and sepsis risk was not statistically significant (p>0.05), although several individual studies showed a positive correlation. High heterogeneity was found in the analysis of vitamin D levels (I2=100%) and FokI genotypes (I2=91%), which affected the interpretation of the results.
Conclusion
Vitamin D deficiency is a potential risk factor for sepsis, while the relationship between the VDR FokI polymorphism and sepsis risk requires further investigation. These findings highlight the importance of early detection of vitamin D deficiency as a preventive strategy in at-risk populations, although additional studies with more standardized designs are needed to definitively confirm this relationship.

Citations

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  • Vitamin D Status and Sepsis Outcomes: A PRISMA-Compliant Umbrella Review and Meta-Analysis
    Gracia Castro-Luna, Henar Gómez Galera, Meritxell Sánchez Martínez, Cristina Gongora-Beltran
    Nutrients.2026; 18(5): 869.     CrossRef
  • 4,385 View
  • 130 Download
  • 1 Web of Science
  • Crossref
Effect of cognitive behavior therapy on abstinence among healthy smokers: a systematic review and meta-analysis of randomized controlled trials
Rajesh Kumar, Priyanka Malhotra, Vishwas AS, Kalpana Beniwal, Gopal Singh Charan
Osong Public Health Res Perspect 2025;16(3):223-235.
Published online June 9, 2025
DOI: https://doi.org/10.24171/j.phrp.2025.0019
Effect of cognitive behavior therapy on abstinence among healthy smokers: a systematic review and meta-analysis of randomized controlled trials
Objectives
The objectives of this review and meta-analysis were twofold: first, to critically evaluate the effectiveness of cognitive behavioral therapy (CBT)-based interventions relative to standard care or control conditions in promoting smoking abstinence at the end of treatment, and second, to determine abstinence rates at 3 and 6 months of follow-up.
Methods
A comprehensive search of electronic databases, including PubMed, Cochrane Library, PsycINFO, Embase, and ClinicalTrials.gov, was conducted for randomized controlled trials published from 2001 to September 2024. Studies evaluating the effect of CBT on abstinence rates among healthy smokers (aged ≥12 years) were included and analyzed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.
Results
Out of 1,514 study records screened, 7 studies (comprising 17 arms and 1,438 participants) met eligibility criteria for inclusion in the final analysis. The pooled analysis revealed that CBT significantly improved smoking abstinence rates, demonstrating a fourfold increase in effectiveness compared to controls (odds ratio [OR], 4.04; 95% confidence interval [CI], 2.73–5.99; I2=19%; p<0.00001). Additionally, CBT significantly impacted smoking cessation at 3-month follow-up (OR, 1.62; 95% CI, 1.11–2.38; I2=0%; p=0.01) and 6-month follow-up (OR, 2.19; 95% CI, 1.59–3.00; I2=0%; p<0.00001).
Conclusion
CBT has demonstrated efficacy in facilitating smoking abstinence, particularly immediately after treatment, with sustained but diminished effects over time. However, robust conclusions on the efficacy of CBT require further studies involving larger sample sizes, diverse geographical regions, and longer follow-up periods.

Citations

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  • The Development and Implementation of a Multimodal Preoperative-specific Smoking Cessation Project
    Mary Ann Z. de Vera, Rashmi J. Patel, Andrea H. Kline-Simon, Felicia W. Chi, Kelly C. Young-Wolff
    Journal of PeriAnesthesia Nursing.2026; 41(3): 564.     CrossRef
  • Effectiveness of Workplace-Based Tobacco Awareness Interventions on Quit Readiness Among Bus Drivers: A Randomized Comparative Pilot Trial
    Gagan Raj, Ankita Jain
    Cureus.2026;[Epub]     CrossRef
  • Protocol for a randomized controlled trial of a cognitive-behavioral therapy–based smoking cessation intervention in incarcerated individuals: The PRISANTABAC Study
    Mélanie Rome, Xavier Laqueille, Carine Meslot, Katia Illel, Delphine Bourdeau, Lucia Romo
    Contemporary Clinical Trials Communications.2026; 51: 101643.     CrossRef
  • 7,223 View
  • 191 Download
  • 2 Web of Science
  • Crossref

Original Articles

Design and evaluation of a multi-epitope subunit vaccine against human norovirus using an immunoinformatics approach
Zxcy L. Nonog, Edward C. Banico, Ma. Easter V. Sajo, Pablo V. Serrano, Fredmoore L. Orosco
Osong Public Health Res Perspect 2025;16(3):236-251.
Published online April 25, 2025
DOI: https://doi.org/10.24171/j.phrp.2024.0349
Design and evaluation of a multi-epitope subunit vaccine against human norovirus using an immunoinformatics approach
Objectives
This study aimed to identify safe, conserved, and highly immunogenic epitopes from all proteins of human-infecting norovirus (NoV) and to design a multi-epitope subunit vaccine construct from these epitopes using an immunoinformatics approach. Additionally, the vaccine construct was evaluated using both sequence- and structure-based assessments.
Methods
Conserved fragments were identified from all proteins of human-infecting NoV, and B and T lymphocyte epitopes were subsequently predicted using multiple epitope prediction tools. The selected epitopes were linked to form a multi-epitope construct, incorporating various adjuvants in the design. Vaccine constructs with different adjuvants were analyzed for their physicochemical properties and immune simulation profiles, and the optimal combination was selected as the final vaccine candidate for further study. Finally, molecular docking and dynamics simulations were performed to visualize the interaction between the construct and a host immune receptor.
Results
Twenty-two safe, conserved, and highly immunogenic epitopes were identified from all human-infecting NoV proteins. The construct adjuvanted with 50S ribosomal protein L7/L12 (50SrpL7/L12) was chosen as the final vaccine candidate due to its optimal physicochemical properties and favorable immune simulation profile. Furthermore, the construct exhibited high binding affinity and a stable interaction with toll-like receptor 4).
Conclusion
The multi-epitope subunit vaccine designed in this study shows promise as a potential NoV vaccine candidate for human immunization. Further in vitro and in vivo experiments are warranted to validate these findings.

Citations

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  • A multi-epitope pan-betacoronavirus vaccine construct predicted to induce broad-spectrum and durable immune responses: an immunoinformatics approach
    Anabella Margareth Arapa, Trina Ekawati Tallei, Rinaldi Idroes, Fatimawali, Elly Juliana Suoth, Maghfirah Savitri, Ahmad Akroman Adam, Beivy Jonathan Kolondam, Chika Yamada, Rosy Iara Maciel de Azambuja Ribeiro, Amama Rani, Moon Nyeo Park, Youdiil Ophinn
    Frontiers in Bioinformatics.2026;[Epub]     CrossRef
  • A Multi-Domain Approach for Designing of Novel Epitopes-Based Vaccine Against Chandipura Virus
    Alhanouf I. Al-Harbi, Raed Amer Ali Alsahoo, Asad Ullah, Sajjad Ahmad
    Journal of Pharmaceutical Innovation.2026;[Epub]     CrossRef
  • Immunoinformatics-based design of artificial chimeric proteins as universal vaccine candidates against foot-and-mouth disease virus serotypes A, O, and SAT2
    Alyaa Elrashedy, Mohamed Nayel, Akram Salama, Ahmed Zaghawa, Mohamed E. Hasan
    Scientific Reports.2026;[Epub]     CrossRef
  • Immunoinformatics-guided design of a multi-epitope mRNA vaccine candidate against Western Equine Encephalitis virus
    Elijah Kolawole Oladipo, Boluwatife Ayobami Irewolede, Stephen Toluwanimi Gbadero, Favour Adebimpe Adebisi, Noor-Al-Hudah Nurudeen, Emmanuel Ololade Oyediran, Rukayat Romoke Tajudeen, Taiwo Dorcas Akinpelu, Christiana Iyanuoluwa Kolapo, Balqis Ajoke Adeji
    The Veterinary Journal: Pharmacology & Toxicology.2026; 1(4): 100019.     CrossRef
  • 6,108 View
  • 143 Download
  • 3 Web of Science
  • Crossref
Metabolic and systemic inflammation status in rheumatoid arthritis—fasting blood glucose as a primary predictor of rheumatoid arthritis risk: a cross-sectional study in Iran
Objectives
This study investigated the relationship between metabolic factors (blood lipids and glucose) and inflammatory indicators (tumor necrosis factor-alpha [TNF-α] and high-sensitivity C-reactive protein [hs-CRP]), disease activity, and the rheumatoid arthritis (RA) risk.
Methods
Serum fasting blood glucose (FBG) and lipid profiles—including total cholesterol (Chol), triglycerides (TG), high-density lipoprotein (HDL), and low-density lipoprotein—were measured in 100 RA patients and 100 healthy individuals. Disease severity was assessed using the disease activity score 28. Inflammatory indicators (TNF-α and hs-CRP) were measured using the enzyme-linked immunosorbent assay method.
Results
In RA patients, serum FBG, TG, Chol/HDL, and TG/HDL were significantly elevated, whereas HDL levels reduced compared to healthy individuals. Multivariate analysis indicated that each unit increase in serum FBG, HDL, Chol/HDL, and TG/HDL was associated with a 64% increase (p<0.001), a 7% reduction (p=0.001), a 52% increase (p=0.007), and a 54% increase (p=0.001) in the odds of RA, respectively. Disease activity showed no correlation with metabolic factors (p>0.05). Among all metabolic factors studied, FBG had the largest area under the curve (0.981) (p<0.0001) for predicting RA. Across the total participant group, FBG, TG, and TG/HDL were positively associated with hs-CRP and TNF-α (p<0.05). HDL showed an inverse association with hs-CRP (p=0.008). Among RA patients specifically, TNF-α positively correlated with TG and TG/HDL, while hs-CRP correlated only with TG/HDL.
Conclusion
These findings indicate that increased FBG and Chol/HDL and decreased HDL may elevate RA risk by promoting systemic inflammation. Among these, elevated FBG may serve as the strongest predictor of RA risk.

Citations

Citations to this article as recorded by  Crossref logo
  • Roles of immune cell metabolism in rheumatoid arthritis
    Rui Xie, Zeping Chen, Shufang Deng, Xiaofeng Jiang, Yue Feng, Wei Zhao
    Frontiers in Immunology.2026;[Epub]     CrossRef
  • Rheumatoid Factor Beyond Rheumatoid Arthritis: A Potential Marker of Cardiometabolic and Hepatic Risk
    Simeon Egba, Innocent Orhonigbe, Ngozi Achi, Gavin Ikechukwu, Charles Chukwu, Chukwudi Omeoga
    Biologics: Targets and Therapy.2026; Volume 20: 1.     CrossRef
  • 3,478 View
  • 83 Download
  • 2 Web of Science
  • Crossref
The level of household food insecurity is associated with the risk of infectious diseases among toddlers in Indonesia: a cross-sectional study
Siti Masitoh, Tri Wurisastuti, Woro Riyadina, Sudarto Ronoatmodjo
Osong Public Health Res Perspect 2025;16(3):261-269.
Published online June 4, 2025
DOI: https://doi.org/10.24171/j.phrp.2025.0009
The level of household food insecurity is associated with the risk of infectious diseases among toddlers in Indonesia: a cross-sectional study
Objectives
This study investigated the correlation between food insecurity and infectious diseases among toddlers in Indonesia.
Methods
This research employed a cross-sectional study design using data from the 2021 Indonesian Nutrition Status Survey, which included a sample of 84,115 toddlers. Food insecurity levels were assessed using the food insecurity experience scale, developed by the Food and Agriculture Organization. The dependent variable, infectious disease, was defined as a toddler experiencing 1 or more of the following conditions: acute respiratory infections, diarrhea, pneumonia, measles, or worms. Multivariate analysis was conducted using multiple logistic regression to determine adjusted odds ratios (ORs).
Results
The findings indicate that 23.78% of toddlers experienced at least 1 infectious disease. While more than half of the respondents were food secure, 26.5% faced mild food insecurity, 13.6% moderate food insecurity, and 6.5% severe food insecurity. Toddlers from households experiencing mild, moderate, and severe food insecurity had higher risks of infectious diseases compared to those from food-secure households, with adjusted ORs of 1.367 (95% confidence interval [CI], 1.308–1.428), 1.490 (95% CI, 1.399–1.588), and 1.500 (95% CI, 1.374–1.638), respectively.
Conclusion
In conclusion, more severe food insecurity is correlated with an increased risk of toddlers suffering infectious diseases.

Citations

Citations to this article as recorded by  Crossref logo
  • From pantry to physiology: A narrative review linking food insecurity to biological dysfunction
    Liahm Blank, Joshua Khorsandi, Nicole Kang, Kaloyan Momchilov, Itai Blank, Kavita Batra
    Dialogues in Health.2026; 8: 100308.     CrossRef
  • Structural Equation Modelling of Socioeconomic Status on Malnutrition Among Urban Preschoolers: Multi-Group Analysis of Hungary and Indonesia
    Arie Dwi Alristina, Éva Kovács, Diyah Arini, Helga Judit Feith
    International Journal of Environmental Research an.2026; 23(7): 858.     CrossRef
  • Implementasi Gerakan Kebun Gizi Keluarga (GK2) Sebagai Upaya Ketahanan Pangan dan Gizi Keluarga di Desa Gading Watu, Kabupaten Gresik
    Noveansyah Maskur Nurgah, Dhuha Nuri Samsiyah, Shafa Dwi Candra Syahputra, Aisyah Rahmah Maulidiyah , Rambu Breathy Salwasty Ananda Tamu Rambu, Intan Adinda Putri, Nabil Habib Abdillah, Devita Astrid Renata, Nurul I.A. Cahyo Wibowo, Muchammad Bachrul Ulu
    Journal of Community Development.2026; 7(2): 1.     CrossRef
  • Prematurity and Low Birth Weight Among Food-Secure and Food-Insecure Households: A Comparative Study in Surabaya, Indonesia
    Arie Alristina, Nour Mahrouseh, Anggi Irawan, Rizky Laili, Alexandra Zimonyi-Bakó, Helga Feith
    Nutrients.2025; 17(15): 2479.     CrossRef
  • 6,919 View
  • 143 Download
  • 1 Web of Science
  • Crossref
Analysis of influenza-like illness trends in Saudi Arabia: a comparative study of statistical and deep learning techniques
Fathelrhman EL Guma
Osong Public Health Res Perspect 2025;16(3):270-284.
Published online June 12, 2025
DOI: https://doi.org/10.24171/j.phrp.2025.0080
Analysis of influenza-like illness trends in Saudi Arabia: a comparative study of statistical and deep learning techniques
Objectives
To develop and evaluate forecasting models using the Holt-Winters statistical approach and the long short-term memory (LSTM) deep learning method for weekly seasonal influenza-like illness (ILI) incidences in Saudi Arabia. The study compares model performance and assesses the predictive value added by incorporating region-specific exogenous variables within Middle Eastern epidemiological modeling.
Methods
This study compared the performance of Holt-Winters and LSTM models in forecasting weekly ILI cases in Saudi Arabia, using data collected from 2017 to 2022. Time series analysis integrated exogenous variables including climatic conditions and population mobility trends. The Holt-Winters model employed both additive and multiplicative seasonal components. Model performance was evaluated using root mean squared error (RMSE), mean absolute percentage error, and R2.
Results
The best-performing model, LSTM with exogenous variables, achieved an RMSE of 28.55, mean absolute error (MAE) of 0.14, R2 of 0.96, and percent bias (PBIAS) of +2.1%, indicating negligible systematic error. The LSTM model without exogenous variables demonstrated slightly lower accuracy (RMSE of 34.07, MAE of 0.18, R2 of 0.93, PBIAS of +5.8%), indicating strong predictive capability but less precision in determining peak ILI cases. The Holt-Winters model effectively captured seasonal and long-term trends, but showed a moderate performance with an RMSE of 82.57, MAE of 0.38, R2 of 0.58, and a high PBIAS of +14.2%, revealing significant unexplained variability during periods of high incidence fluctuation.
Conclusion
This study highlights the respective strengths and limitations of statistical and machine learning approaches for ILI forecasting.

Citations

Citations to this article as recorded by  Crossref logo
  • Early-warning prediction of visceral leishmaniasis mortality using a multivariate STL–deep learning hybrid approach on 20 years of monthly time series
    Fathelrhman El Guma, Maaweya Awadalla, Halah Z. Al Rawi, Bashayer Saeed, Huda M. Alshanbari, Alshaikh A. Shokeralla, Bandar Alosaimi
    Frontiers in Public Health.2026;[Epub]     CrossRef
  • A hybrid STL–LightGBM framework with probabilistic forecasting for Influenza A incidence in the post-pandemic Saudi Arabia
    Reham M. Alahmadi, Maaweya Awadalla, Bashayer Saeed, Huda M. Alshanbari, Alshaikh A. Shokeralla, Ali Atif Yassin, Bandar Alosaimi, Fathelrhman El Guma
    Frontiers in Public Health.2026;[Epub]     CrossRef
  • Bayesian inference for modeling seasonal influenza transmission under control measures
    Rania Saadeh, Naseam Al-Kuleab, Fathelrhman EL Guma, Alshaikh A. Shokeralla, Suliman Jamiel M. Abdalla, Mohamed A. Abdoon, Mohamed Hafez
    Results in Control and Optimization.2026; 23: 100714.     CrossRef
  • Machine Learning-Based Prediction of Seasonal Influenza Trends in Saudi Arabia: A Tool for Regional Public Health Planning
    Alshaikh A. Shokeralla, Fathelrhman El Guma, Ali H. Abdalla, Amal E.Y. Hagsddig, Rahma AbuBakr Musa, M.A.M. Eltaweel, Abdelaziz H. Elawad, Ibrahim Elshamy
    International Journal of Statistics in Medical Res.2025; 14: 688.     CrossRef
  • 3,605 View
  • 93 Download
  • 4 Web of Science
  • Crossref

Short Communications

Subacute sclerosing panencephalitis incidence following measles elimination efforts in the Republic of Korea
Young Hwa Lee, Jung Hye Byeon, Cho Ryok Kang, Young June Choe, Jong-Koo Lee
Osong Public Health Res Perspect 2025;16(3):285-291.
Published online June 9, 2025
DOI: https://doi.org/10.24171/j.phrp.2025.0067
Subacute sclerosing panencephalitis incidence following measles elimination efforts in the Republic of Korea
Objectives
Subacute sclerosing panencephalitis (SSPE) is a rare but fatal neurodegenerative disease caused by persistent measles virus infection. After a significant measles outbreak in 2000–2001, the Republic of Korea implemented a nationwide measles elimination program, which led to a dramatic reduction in measles incidence. This study aimed to evaluate the impact of these measles elimination efforts on the incidence of SSPE in the Republic of Korea.
Methods
This nationwide, population-based retrospective cohort study identified patients newly diagnosed with measles and SSPE between 2007 and 2022, registered in the Health Insurance Review and Assessment Service (HIRA) and Korea Disease Control and Prevention Agency (KDCA) databases. Population-based incidence rates of measles and SSPE were calculated and compared annually.
Results
A total of 236 measles cases (HIRA data) and 1,168 measles cases (KDCA data), along with 2,736 SSPE cases, were diagnosed during the study period. Measles incidence significantly declined, reaching zero cases in 2021, while SSPE incidence displayed an upward trend, peaking in 2014. The mean age at SSPE onset was 21.2 years, with a marked male-to-female ratio of 13.0:1.
Conclusion
SSPE incidence was remarkably low in the post-outbreak period, likely attributable to successful measles control. This study underscores the critical importance of maintaining low measles incidence through sustained vaccination efforts, preventing SSPE and other measles-related complications.

Citations

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  • Measles subacute sclerosing panencephalitis in children: past and present
    G. P. Ivanova, N. V. Skripchenko, E. Yu. Skripchenk, O. V. Goleva, A. V. Astapova
    Rossiyskiy Vestnik Perinatologii i Pediatrii (Russ.2026; 71(4): 14.     CrossRef
  • Long-term survival (≥2 years) in subacute sclerosing panencephalitis: a systematic review of prolonged survivors
    Ravindra Kumar Garg, Shweta Pandey, Imran Rizvi, Sanjay Singhal
    encephalitis.2026; 6(4): 91.     CrossRef
  • The Republic of Korea’s health system at a turning point: from infectious disease threats to comprehensive reform
    Jong-Koo Lee
    Osong Public Health and Research Perspectives.2025; 16(3): 193.     CrossRef
  • Pan-Immune Inflammation Value and Clinical Outcomes in Subacute Sclerosing Panencephalitis: A Retrospective Study
    Bilge Özgör, Murat Çağlar Şahin, Işınsu Bıçakcıoğlu, Gül Yücel, Meral Karadağ, Serdal Güngör
    Viruses.2025; 18(1): 18.     CrossRef
  • 3,860 View
  • 81 Download
  • 2 Web of Science
  • Crossref
First report of human Mycobacterium bovis infection in a veterinary laboratory worker in the Republic of Korea
Ji-Yeon Lee, Seong Wook Pyo, Jieun Kim, Young-Joon Park
Osong Public Health Res Perspect 2025;16(3):292-299.
Published online April 16, 2025
DOI: https://doi.org/10.24171/j.phrp.2024.0343
First report of human Mycobacterium bovis infection in a veterinary laboratory worker in the Republic of Korea
Objectives
In the Republic of Korea, the previous surveillance system for zoonotic tuberculosis (TB) involved the X-ray testing of humans in contact with Mycobacterium bovis-infected livestock. In contrast, the updated surveillance system incorporates the genotyping of cultured Mycobacterium isolates for high-risk occupational groups. This study aimed to systematically document the detection, diagnosis, assessment, and response in the epidemic investigation of zoonotic TB in a laboratory worker in the Republic of Korea.
Methods
M. bovis was confirmed using spoligotyping and whole genome sequencing. Clinical characteristics were reviewed through epidemiological investigation and interviews with the affected individual. Transmission routes and secondary spread were assessed via field epidemiological investigations and contact evaluations using chest X-ray and interferon gamma release assay for latent TB infection.
Results
A 56-year-old laboratory worker presented with chest X-ray findings compatible with TB and subsequently tested positive for M. bovis. She had no clinical or family history of TB and remained asymptomatic. She completed a 6 month treatment regimen of isoniazid, rifampin, ethambutol, and pyrazinamide without hospitalization. Although no direct transmission pathways for zoonotic TB were identified, her work in a laboratory, processing specimens for zoonotic TB, indicated potential laboratory related exposure.
Conclusion
This case underscores the importance of stringent use of personal protective equipment among high-risk occupational groups and the implementation of an enhanced surveillance system to report zoonotic TB. These findings highlight the need for a One Health approach and proactive surveillance, emphasizing the necessity of refining and strengthening surveillance systems for precise monitoring and an effective response.

Citations

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  • Recombinant proteins expressed in Mycolicibacterium smegmatis enhance antibody-based detection of bovine tuberculosis
    Eomseob Jang, Kilhan Kwak, Norikazu Isoda, Kazuhiro Matsuo, Jeewan Thapa, Chie Nakajima, Yasuhiko Suzuki
    Veterinary Research.2026;[Epub]     CrossRef
  • 4,974 View
  • 199 Download
  • 1 Web of Science
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Brief Report
Standardizing the approach to clinical-based human microbiome research: from clinical information collection to microbiome profiling and human resource utilization
Objectives
This study presents the standardized protocols developed by the Clinical-Based Human Microbiome Research and Development Project (cHMP) in the Republic of Korea.
Methods
It addresses clinical metadata collection, specimen handling, DNA extraction, sequencing methods, and quality control measures for microbiome research.
Results
The cHMP involves collecting samples from healthy individuals and patients across various body sites, including the gastrointestinal tract, oral cavity, respiratory system, urogenital tract, and skin. These standardized procedures ensure consistent data quality through controlled specimen collection, storage, transportation, DNA extraction, and sequencing. Sequencing encompasses both amplicon and whole metagenome methods, followed by stringent quality checks. The protocols conform to international guidelines, ensuring that the data generated are both reliable and comparable across microbiome studies.
Conclusion
The cHMP underscores the importance of methodological standardization in enhancing data integrity, reproducibility, and advancing microbiome-based research with potential applications for improving human health outcomes.

Citations

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  • Harnessing Dietary Tryptophan: Bridging the Gap Between Neurobiology and Psychiatry in Depression Management
    Amanda Chabrour Chehadi, Enzo Pereira de Lima, Cláudia Rucco Penteado Detregiachi, Rafael Santos de Argollo Haber, Virgínia Maria Cavallari Strozze Catharin, Lucas Fornari Laurindo, Vitor Engracia Valenti, Cristiano Machado Galhardi, Masaru Tanaka, Sandra
    International Journal of Molecular Sciences.2026; 27(1): 465.     CrossRef
  • Human Microbiota-Associated Pig Models for Translational Microbiome Research: A Scoping Review
    Seong-Jin Wang, Hao-Yang Nian, Zhi-Hao Chen, Li Cui
    International Journal of Molecular Sciences.2026; 27(4): 1987.     CrossRef
  • Gut microbiota-regulated tryptophan metabolism in breast cancer: mechanisms and therapeutic perspectives
    Jiaxi Yan, Linfeng Qian, Shiqi Chen, Maryam Mohammed Abbas Karekad, Xuanwei Wu, Musheng Xu, Xiaohong Xu
    Frontiers in Oncology.2026;[Epub]     CrossRef
  • Genome-based medicine in Korea: the Korea National Institute of Health infrastructure for precision medicine
    Hyun-Young Park
    Childhood Kidney Diseases.2026; 30(1): 15.     CrossRef
  • The gut microbiome as a biomarker and modifiable risk factor in Lynch Syndrome
    Verona Sarena Colaco, Annemarie Boleij
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