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Norovirus outbreaks occurred in different settings in the Republic of Korea
Hae-Wol Cho, Chaeshin Chu
Osong Public Health and Research Perspectives 2015;6(5):281-282.
Published online: December 2, 2015

Osong Public Health and Research Perspectives, Korea Centers for Disease Control and Prevention, Cheongju, Korea

College of Medicine, Eulji University, Daejeon, Korea

Osong Public Health and Research Perspectives, Korea Centers for Disease Control and Prevention, Cheongju, Korea

∗Corresponding author.
∗∗Corresponding author.

Copyright © 2015 Korea Centers for Disease Control and Prevention. Published by Elsevier Korea LLC. All rights reserved.

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Norovirus is major cause of epidemic acute nonbacterial gastroenteritis in human in the worldwide. Norovirus infection is common in all age groups and characterized by a low infection dose and efficient transmission with typical fecal-oral routes, besides airborne spread and environmental contamination 1, 2, 3. Human norovirus GII.4 was prominent in all genogroup and genotype and GII.4 variants were divided into 13 sub-cluster types along with epidemic year and genetic characterization. Especially, GII.4 Sydney strain, named as 2012 variant, was relatively new and predicted next prominent strain 4, 5, 6. There were several reports about GII.4 associated gastroenteritis but had been lack of environmental and molecular-epidemiological data.
In the current issue of Osong Public Health and Research Perspectives, a study was conducted to identify GII.4 variants in outbreaks in Korea, 2004-12. Partial VP1 sequence of NoV GII.4-related outbreaks was analyzed 2004 to 2012. Partial VP1 were detected with RT-PCR and semi-nested PCR, and nucleotide of 312-314 base pairs sequenced for phylogenetic comparison. Nine variants were emerged in outbreaks, with the Sydney variant showing predominance recently. The authors concluded that this predominance may persist for at least three years, although new variants may appear in Korea [7].
Another study reported epidemiological feature of 3 outbreak cases of norovirus in Korea, and described the clinical symptom and distribution of causative genotypes. In this study, authors described the investigation of three outbreaks caused by GII.4 Sydney variant, which traced contaminated groundwater to supply manufacturing company. In Korea, three outbreaks associated with norovirus GII.4 Sydney variant occurred in middle and high school setting in different city on November 21-30, 2011. The incidence rates of A, B, C outbreaks were 16.24% (326/2,007), 4.1% (27/656) and 16.8% (36/214), respectively. The patients in these three outbreaks were affected by acute gastroenteritis. These schools were provided from same manufacturing company to unheated-food. Two genotypes (GII.3 and GII.4) of norovirus were detected in these cases. Among them major causative strains GII.4 (Hu-jeju-47-2007KR-like), were identified in patients, food-handlers and groundwater from manufacturing company of unheated-foods. GII.4 (Hu-jeju-47-2007KR-like) strain of norovirus, the nucleotide sequences were identical and identified to GII.4 Sydney variant. The authors concluded that combined epidemiological and laboratory results were closely related with contaminated groundwater, and causative pathogen is GII.4 Sydney variant strains [8].

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License ( which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

  • 1. Rockx B., De Wit M., Vennema H., Vinjé J.. Natural history of human calicivirus infection: a prospective cohort study. Clin Infect Dis 35(3). 2002 Aug;246−253. PMID: 12115089.ArticlePubMed
  • 2. Maunula L., Miettinen I.T., von Bonsdorff C.H.. Norovirus outbreaks from drinking water. Emerg Infect Dis 11(11). 2005 Nov;1716−1721. PMID: 16318723.ArticlePubMed
  • 3. Hewitt J., Bell D., Simmons G.C.. Gastroenteritis outbreak caused by waterborne norovirus at a New Zealand ski resort. Appl Environ Microbiol 73(24). 2007 Dec;7853−7857. PMID: 17965205.ArticlePubMed
  • 4. Belliot G., Kamel A.H., Estienney M.. Evidence of emergence of new GGII.4 norovirus variants from gastroenteritis outbreak survey in France during the 2007-to-2008 and 2008-to-2009 winter seasons. J Clin Microbiol 48(3). 2010 Mar;994−998. PMID: 20042616.ArticlePubMed
  • 5. Vega E., Barclay L., Gregoricus N.. Novel surveillance network for norovirus gastroenteritis outbreaks, United States. Emerg Infect Dis 17(8). 2011 Aug;1389−1395. PMID: 21801614.ArticlePubMed
  • 6. van Beek J., Ambert-Balay K., Botteldoorn N.. Indications for worldwide increased norovirus activity associated with emergence of a new variant of genotype II.4, late 2012. Euro Surveill 18(1). 2013 Jan;8−9. PMID: 23305715.PubMed
  • 7. Jung S., Jeong H.J., Hwang B.-M.. Epidemics of norovirus GII.4 variants in outbreak cases in Korea, 2004–2012. Osong Public Health Res Perspect 6(5). 2015 Oct;325−328.
  • 8. Jung S., Hwang B.-M., Jeong H.J.. Occurrence of norovirus GII.4 Sydney variant-related three outbreaks in Korea. Osong Public Health Res Perspect 6(5). 2015 Oct;329−333. PMID: 26835241.ArticlePubMed

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