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- Genetic Variability of Methicillin Resistant
Staphylococcus Aureus Strains Isolated from Burns Patients - Mehdi Goudarzi, Nobumichi Kobayashi, Ali Hashemi, Maryam Fazeli, Masoumeh Navidinia
- Osong Public Health Res Perspect. 2019;10(3):170-176. Published online June 30, 2019
- DOI: https://doi.org/10.24171/j.phrp.2019.10.3.08
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Abstract
PDF Objectives Staphylococcus aureus is a nosocomial pathogen that provides a major challenge in the healthcare environment, especially in burns units where patients are particularly susceptible to infections. In this study, we sought to determine molecular types ofS. aureus isolates collected from burns patients, based on staphylococcal protein A and coagulase gene polymorphisms.Methods Antibiotic susceptibility testing of 89
S. aureus strains isolated from burn wounds of patients was assessed using the Kirby-Bauer disk diffusion method. Strains were characterized byspa typing,coa typing, and resistance and toxin gene profiling.Results A total of 12 different
spa types were identified with the majority being t790 (18%). Panton-Valentine leucocidin encoding genes were identified inspa types t044 (5.6%), t852 (2.2%) and t008 (2.2%). The most commonly detected antibiotic resistance gene wasant (4′)-Ia (60.7%). Ten differentcoa types were detected and the majority of the tested isolates belonged tocoa III (47.2%). All the high-level mupirocin-resistant and low-level mupirocin resistant strains belonged tocoa type III.Conclusion The present study illustrated that despite the high frequency of
coa III andspa t790 types, the genetic background ofS. aureus strains in Iranian burns patients was diverse. The findings obtained are valuable in creating awareness ofS. aureus infections within burns units.-
Citations
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Brazilian Journal of Microbiology.2023; 54(1): 159. CrossRef - Emerging Challenges in Staphylococcus aureus Bloodstream Infections: Insights from Coagulase Typing, Toxin Genes, and Antibiotic Resistance Patterns
Samira Zamani, Masoud Dadashi, Sara Bahonar, Mehrdad Haghighi, Sareh Kakavandi, Ali Hashemi, Mohammad Javad Nasiri, Bahareh Hajikhani, Mehdi Goudarzi, Veronica Folliero
Advances in Medicine.2023; 2023: 1. CrossRef - Characteristic, antibiotic resistance and molecular typing of Staphylococcus aureus isolated from intensive care unit and burn patients based on coagulase gene analysis
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Masoume Hallajzadeh, Ali Mojtahedi, Nour Amirmozafari, Vahid Pirhajati Mahabadi
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Vaccines.2020; 8(2): 314. CrossRef - Genotypic and Phenotypic Characterisation of Clinical Isolates of Methicillin-Resistant Staphylococcus aureus in Two Different Geographical Locations of Iran
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Indian Journal of Medical Microbiology.2020; 38(2): 162. CrossRef
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- Detection of Integrons and Staphylococcal Cassette Chromosome
mec Types in Clinical Methicillin-resistant Coagulase Negative Staphylococci Strains - Fahimeh Hajiahmadi, Elham Salimi Ghale, Mohammad Yousef Alikhani, Alireza Mordadi, Mohammad Reza Arabestani
- Osong Public Health Res Perspect. 2017;8(1):47-53. Published online February 28, 2017
- DOI: https://doi.org/10.24171/j.phrp.2017.8.1.06
- 4,397 View
- 29 Download
- 2 Crossref
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Abstract
PDF
Objectives Integrons are thought to play an important role in the spread of antibiotic resistance. This study investigates class 1 and 2 integron-positive methicillin-resistant coagulase-negative staphylococci strains isolated in Iran and characterizes their patterns of antimicrobial resistance.
Methods Hundred clinical isolates of coagulase-negative staphylococci were characterized for integron content and staphylococcal cassette chromosome
mec (SCCmec) type.Results Sixteen isolates carried class 1 (
intI1 ) integrons and four isolates carried class 2 (intI2 ) integrons. One resistance gene array was identified among the class 1 integrons (aadA1 cassette). The distribution of SCCmec types in 50 methicillin-resistant coagulase-negative staphylococci strains showed that SCCmec types III and V dominated among the tested strains.Conclusion This is the first report of methicillin-resistant coagulase-negative staphylococci strains that carry two mobile genetic elements, including class 1 and 2 integrons and SCCmec, in Iran.
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Edidah Ong’era, John Kagira, Naomi Maina, Daniel Kiboi, Kenneth Waititu, Lynda Michira, Maina Ngotho, Mejdi Snoussi
BioMed Research International.2023; 2023: 1. CrossRef - Investigation of SCCmec types I–IV in clinical isolates of methicillin-resistant coagulase-negative staphylococci in Ahvaz, Southwest Iran
Effat Abbasi Montazeri, Sakineh Seyed-Mohammadi, Aram Asarehzadegan Dezfuli, Azar Dokht Khosravi, Maryam Dastoorpoor, Mitra Roointan, Morteza Saki
Bioscience Reports.2020;[Epub] CrossRef
- Prevalence and Potential Risk Factors for the Acquisition of Antibiotic-Resistant Staphylococcus spp. Bacteria Among Pastoralist Farmers in Kajiado Central Subcounty, Kenya
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