<sec>
<title>Objectives</title>
<p>This study aimed to extend an epidemiological model (SEIHFR) to analyze epidemic trends, and evaluate intervention efficacy.</p></sec>
<sec>
<title>Methods</title>
<p>SEIHFR was modified to examine disease transmission dynamics after vaccination for the Ebola outbreak. Using existing data from Liberia, sensitivity analysis of various epidemic scenarios was used to inform the model structure, estimate the basic reproduction number ℜ<sub>0</sub> and investigate how the vaccination could effectively change the course of the epidemic.</p></sec>
<sec>
<title>Results</title>
<p>If a randomized mass vaccination strategy was adopted, vaccines would be administered prophylactically or as early as possible (depending on the availability of vaccines). An effective vaccination rate threshold for Liberia was estimated as 48.74% among susceptible individuals. If a ring vaccination strategy was adopted to control the spread of the Ebola virus, vaccines would be given to reduce the transmission rate improving the tracing rate of the contact persons of an infected individual.</p></sec>
<sec>
<title>Conclusion</title>
<p>The extended SEIHFR model predicted the total number of infected cases, number of deaths, number of recoveries, and duration of outbreaks among others with different levels of interventions such as vaccination rate. This model may be used to better understand the spread of Ebola and develop strategies that may achieve a disease-free state.</p></sec>
Citations
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A hybrid simulation model to study the impact of combined interventions on Ebola epidemic Peiyu Chen, Wenhui Fan, Xudong Guo, Constantinos Siettos PLOS ONE.2021; 16(7): e0254044. CrossRef
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Modeling the 2014–2015 Ebola Virus Disease Outbreaks in Sierra Leone, Guinea, and Liberia with Effect of High- and Low-risk Susceptible Individuals Qianying Lin, Salihu S. Musa, Shi Zhao, Daihai He Bulletin of Mathematical Biology.2020;[Epub] CrossRef
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