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PHRP : Osong Public Health and Research Perspectives

OPEN ACCESS. pISSN: 2210-9099. eISSN: 2233-6052

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"Behzad Badakhsh"

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"Behzad Badakhsh"

Original Article
Anti-biofilm Properties of Peganum harmala against Candida albicans
Elham Aboualigalehdari, Nourkhoda Sadeghifard, Morovat Taherikalani, Zaynab Zargoush, Zahra Tahmasebi, Behzad Badakhsh, Arman Rostamzad, Sobhan Ghafourian, Iraj Pakzad
Osong Public Health Res Perspect 2016;7(2):116-118.
Published online April 30, 2016
DOI: https://doi.org/10.1016/j.phrp.2015.12.010
Objectives
Vaginitis still remains as a health issue in women. It is notable that <i>Candida albicans</i> producing biofilm is considered a microorganism responsible for vaginitis with hard to treat. Also, <i>Peganum harmala</i> was applied as an anti fungal in treatment for many infections in Iran. Therefore, this study goal to investigate the role of <i>P. harmala</i> in inhibition of biofilm formation in <i>C. albicans</i>.
Methods
So, 27 <i>C. albicans</i> collected from women with Vaginitis, then subjected for biofilm formation assay. <i>P. harmala</i> was applied as antibiofilm formation in <i>C. albicans.</i>
Results
Our results demonstrated that <i>P. harmala</i> in concentration of 12 μg/ml easily inhibited strong biofilm formation; while the concentrations of 10 and 6 μg/ml inhibited biofilm formation in moderate and weak biofilm formation <i>C. albicans</i> strains, respectively.
Conclusion
Hence, the current study presented <i>P. harmala</i> as antibiofilm herbal medicine for <i>C. albicans</i>; but <i>in vivo</i> study suggested to be performed to confirm its effectiveness.

Citations

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