| Arman Rostamzad | 1 Article |
Objectives
Vaginitis still remains as a health issue in women. It is notable that <i>Candida albicans</i> producing biofilm is considered a microorganism responsible for vaginitis with hard to treat. Also, <i>Peganum harmala</i> was applied as an anti fungal in treatment for many infections in Iran. Therefore, this study goal to investigate the role of <i>P. harmala</i> in inhibition of biofilm formation in <i>C. albicans</i>. Methods So, 27 <i>C. albicans</i> collected from women with Vaginitis, then subjected for biofilm formation assay. <i>P. harmala</i> was applied as antibiofilm formation in <i>C. albicans.</i> Results Our results demonstrated that <i>P. harmala</i> in concentration of 12 μg/ml easily inhibited strong biofilm formation; while the concentrations of 10 and 6 μg/ml inhibited biofilm formation in moderate and weak biofilm formation <i>C. albicans</i> strains, respectively. Conclusion Hence, the current study presented <i>P. harmala</i> as antibiofilm herbal medicine for <i>C. albicans</i>; but <i>in vivo</i> study suggested to be performed to confirm its effectiveness. Citations
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