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1 "AmpC β–lactamases"
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Original Article
High Prevalence of AmpC β-Lactamases in Clinical Isolates of Escherichia coli in Ilam, Iran
Abbas Maleki, Afra Khosravi, Sobhan Ghafourian, Iraj Pakzad, Shiva Hosseini, Rashid Ramazanzadeh, Nourkhoda Sadeghifard
Osong Public Health Res Perspect. 2015;6(3):201-204.   Published online June 30, 2015
DOI: https://doi.org/10.1016/j.phrp.2015.02.001
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  • 8 Citations
AbstractAbstract PDF
Objectives
Widespread use of β-lactam antibiotics could cause resistance to this group of antibiotics in pathogenic bacteria through the production of the enzyme β-lactamases. The aim of this study is to determine the molecular detection of AmpC β-lactamases among clinical Escherichia coli isolated from Ilam hospitals in Ilam, Iran.
Methods
One hundred and twelve clinical isolates of E. coli were collected from hospitalized patients and were identified by biochemical tests. They were evaluated for extended spectrum beta-lactamases (ESBLs) production, and the positive strains were subjected to AmpC enzymes; for detection of AmpC cluster genes, multiplex polymerase chain reaction was applied.
Results
The analysis showed 62.5% of isolates were ESBLs positive and that five strains revealed the AmpC cluster genes. This is the first report of FOXM cluster genes in E. coli in Iran.
Conclusion
Based on our results, the prevalence of AmpC β-lactamases is increasing in Iran, which caused failure in antibiotic therapy. So, the current study recommended the revision of antibiotic policy in Iranian hospitals.

Citations

Citations to this article as recorded by  
  • Prevalence of ESBL and AmpC genes in E. coli isolates from urinary tract infections in the north of Iran
    M. Sadeghi, H. Sedigh Ebrahim-Saraie, A. Mojtahedi
    New Microbes and New Infections.2022; 45: 100947.     CrossRef
  • Amp-CKlebsiella-Induced Chorioamnionitis and Associated Abnormalities in Cardiotocography: A Case Report with a Narrative Review
    Sufia Athar, Anvar P. Vellamgot, Lolwa Mohammed Alansari, Mohd Adnan
    Case Reports in Infectious Diseases.2022; 2022: 1.     CrossRef
  • Molecular characteristics, antimicrobial resistance profiles, and antibiotic resistance determinants in uropathogenic fluoroquinolone resistant-Escherichia coli isolates
    Hassan Valadbeigi, Masoumeh HatamiLak, Abbas Maleki, Ebrahim Kouhsari, Nourkhoda Sadeghifard
    Gene Reports.2020; 18: 100584.     CrossRef
  • High prevalence of blaCMY AmpC beta-lactamase in ESBL co-producing Escherichia coli and Klebsiella spp. clinical isolates in the northeast of Iran
    Kobra Salimiyan Rizi, Arman Mosavat, Masoud Youssefi, Saeid Amel Jamehdar, Kiarash Ghazvini, Hadi Safdari, Yousef Amini, Hadi Farsiani
    Journal of Global Antimicrobial Resistance.2020; 22: 477.     CrossRef
  • Evaluating the antimicrobial resistance and frequency of AmpC β-lactamases bla gene in Gram-negative bacteria isolates collected from selected hospitals of Iran: A multicenter retrospective study
    Fatemeh Fallah, Taher Azimi, Leila Azimi, Abdollah Karimi, Mohammad Rahbar, Mehdi Shirdoust, Iraj Sedighi, Ata Saadat Sadeghi, Shahnaz Armin
    Gene Reports.2020; 21: 100868.     CrossRef
  • Plasmid-Mediated AmpC β-Lactamase CITM and DHAM Genes Among Gram-Negative Clinical Isolates


    Subhas Chandra Aryal, Milan Kumar Upreti, Anil Kumar Sah, Mehraj Ansari, Krishus Nepal, Binod Dhungel, Nabaraj Adhikari, Binod Lekhak, Komal Raj Rijal
    Infection and Drug Resistance.2020; Volume 13: 4249.     CrossRef
  • Isolation and molecular characterization of multidrug-resistant Escherichia coli from chicken meat
    Md. Masudur Rahman, Asmaul Husna, Hatem A. Elshabrawy, Jahangir Alam, Nurjahan Yasmin Runa, A. T. M. Badruzzaman, Nahid Arjuman Banu, Mohammad Al Mamun, Bashudeb Paul, Shobhan Das, Md. Mahfujur Rahman, A. T. M. Mahbub-E-Elahi, Ahmed S. Khairalla, Hossam M
    Scientific Reports.2020;[Epub]     CrossRef
  • Bacteraemia due to AmpC β-lactamase-producing Escherichia coli in hospitalized cancer patients: risk factors, antibiotic therapy, and outcomes
    Qing Zhang, Wenfang Zhang, Zheng Li, Changsen Bai, Ding Li, Shan Zheng, Peng Zhang, Sihe Zhang
    Diagnostic Microbiology and Infectious Disease.2017; 88(3): 247.     CrossRef

PHRP : Osong Public Health and Research Perspectives