Figure 1OP through different formulations (mean ± SD, n = 3). OP = oxygen permeability; SD = standard deviation.
Figure 2Profile of nitrofurazone permeability of different formulations.
Table 1Compositions of different formulation of films (v/v ratio).
Formula |
Chitosan (3%) |
Eudragit RL |
Propylene glycol |
Cs |
4 |
0 |
0.1 |
Cs Eu 0.5 |
4 |
1 (0.5%) |
0.1 |
Cs Eu 1 |
4 |
1 (1%) |
0.1 |
Cs Eu 1.5 |
4 |
1 (1.5%) |
0.1 |
Table 2Mechanical properties of Cs films (mean ± SD, n = 3).
Formula |
Thickness (μm) |
Tensile strength (MPa) |
Elongation (%) |
Cs |
94 ± 11.40 |
25 ± 4.25 |
20.873 ± 0.69 |
Cs Eu 0.5 |
104 ± 11.40 |
10.73 ± 1.54 |
12.18 ± 0.99 |
Cs Eu 1 |
130 ± 15.81 |
14.36 ± 0.80 |
9.634 ± 0.19 |
Cs Eu 1.5 |
156 ± 8.94 |
17.31 ± 2.56 |
7.93 ± 0.40 |
Table 3Value of water uptake and WVTR in different formulations.
Formula |
Water uptake 48 h (%) |
WVTR (g/m2 d) |
Cs |
108.18 ± 1.61 |
205.63 ± 9.90 |
Cs Eu 0.5 |
112.74 ± 0.90 |
201.30 ± 0.00 |
Cs Eu 1 |
111.56 ± 2.77 |
205.63 ± 9.92 |
Cs Eu 1.5 |
116.70 ± 2.39 |
214.29 ± 6.5 |
Table 4Values of flux (J), permeability coefficient (P), and drug release for each formulation after 24 hours (R24).
Formula |
J (mg/cm2 h) |
P (cm/h) |
R24 (%) |
Cs |
0.004 ± 0.0004 |
0.0019 ± 0.0002 |
19.874 ± 3.125 |
Cs Eu 0.5 |
0.022 ± 0.0001 |
0.0112 ± 0.000 |
44.478 ± 0.333 |
Cs Eu 1 |
0.009 ± 0.0001 |
0.0044 ± 0.000 |
27.435 ± 0.331 |
Cs Eu 1.5 |
0.008 ± 0.0001 |
0.0038 ± 0.000 |
26.125 ± 0.159 |