Table 1Association between clinical/patient factors and mortality in Candida-infected patients with cancer
Variable |
Survived (n = 385) |
Expired (n = 249) |
OR (95% CI) |
p-value |
HAI |
Yes |
4 (33.3) |
8 (66.7) |
3.162 (0.942–10.614) |
0.05*
|
|
No |
381 (61.3) |
241 (38.7) |
|
|
Sex |
Male |
285 (61.7) |
177 (38.3) |
0.863 (0.604–1.232) |
0.416 |
|
Female |
100 (58.1) |
72 (41.9) |
|
|
Age (y) |
< 65 |
209 (58.4) |
149 (41.6) |
0.797 (0.577–1.101) |
0.168 |
|
≥ 65 |
176 (63.8) |
100 (36.2) |
|
|
Cancer type |
Solid |
343 (61.9) |
211 (38.1) |
1.471 (0.918–2.356) |
0.107 |
|
Hematology |
42 (52.5) |
38 (47.5) |
|
|
Length of hospital stay (d) |
< 7 |
9 (33.3) |
18 (66.7) |
0.307 (0.136–0.695) |
0.003**
|
|
≥ 7 |
376 (61.9) |
231 (38.1) |
|
|
Surgery |
Yes |
226 (70.8) |
93 (29.2) |
0.419 (0.302–0.582) |
0.000**
|
|
No |
159 (50.5) |
156 (49.5) |
|
|
Chemotherapy |
Yes |
81 (52.6) |
73 (47.4) |
1.557 (1.079–2.246) |
0.018*
|
|
No |
304 (63.3) |
176 (36.7) |
|
|
Antifungal drug use |
Yes |
142 (54.4) |
119 (45.6) |
1.566 (1.133–2.165) |
0.006**
|
|
No |
243 (65.1) |
130 (34.9) |
|
|
Steroid use |
Yes |
132 (53.0) |
117 (47.0) |
1.699 (1.226–2.353) |
0.001**
|
|
No |
253 (65.7) |
132 (34.3) |
|
|
Antibiotic use |
Yes |
379 (60.7) |
245 (39.3) |
0.97 (0.271–3.471) |
0.962 |
|
No |
6 (60.0) |
4 (40.0) |
|
|
Central line |
Yes |
126 (47.4) |
140 (52.6) |
2.465 (1.901–3.667) |
0.000**
|
|
No |
259 (70.4) |
109 (29.6) |
|
|
Mechanical ventilator |
Yes |
182 (48.9) |
190 (51.1) |
3.596 (2.521–5.118) |
0.000**
|
|
No |
203 (77.5) |
59 (22.5) |
|
|
Specimen |
Blood |
19 (42.2) |
56 (57.8) |
2.246 (1.215–4.152) |
0.008**
|
|
Other |
366 (62.1) |
223 (37.9) |
|
|
Candida species |
Candida albicans
|
339 (62.3) |
205 (37.7) |
1.582 (1.010–2.476) |
0.044*
|
|
NCA |
46 (51.1) |
44 (48.9) |
|
|
Table 2Factors predicting mortality in Candida-infected patients with cancer
Variable |
B |
Wald |
OR |
p-value |
95% CI |
HAI |
0.385 |
0.356 |
1.469 |
0.551 |
0.415–5.196 |
Length of hospital stay |
−1.273 |
7.912 |
0.28 |
0.005**
|
0.115–0.68 |
Surgery |
−0.46 |
5.781 |
0.631 |
0.016*
|
0.434–0.918 |
Antifungal drugs |
0.086 |
0.19 |
1.09 |
0.663 |
0.74–1.607 |
Steroids |
0.386 |
4.248 |
1.471 |
0.039*
|
1.019–2.124 |
Chemotherapy |
0.291 |
1.892 |
1.338 |
0.169 |
0.884–2.025 |
Central Line |
0.566 |
9.105 |
1.761 |
0.003**
|
1.219–2.543 |
Mechanical ventilator |
0.872 |
18.351 |
2.391 |
0.000**
|
1.605–3.563 |
Specimen (blood) |
0.9 |
6.762 |
2.46 |
0.009**
|
1.248–4.849 |
Candida species |
0.135 |
0.273 |
1.144 |
0.601 |
0.69–1.898 |