Division of High-risk Pathogen Research, National Institute of Health Korea National Institute of Health, Osong, Korea.
Copyright ©2012, Korea Centers for Disease Control and Prevention
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PA(μg) dose | Survival percentage (alive/total) | Geometric mean ELISA titer (standard error) | Geometric mean ED50 TNA assay titer (standard error)a |
---|---|---|---|
50 | 50 (3/6) | 634.96 (1.89) | 59.01 (1.27) |
25 | 16.7 (1/6) | 400.00 (1.55) | 27.41 (1.31) |
12.5 | 0 (0/6) | 224.49 (1.45) | 18.66 (1.82) |
6.3 | 0 (0/6) | 1.0 (1.00) | 1.0 (1.00) |
3.1 | 0 (0/6) | 1.0 (1.00) | 1.0 (1.00) |
1.6 | 0 (0/6) | 1.0 (1.00) | 1.0 (1.00) |
0 (control) | 0 (0/6) | 1.0 (1.00) | 1.0 (1.00) |
PA(μg) dose | Survival percentage (alive/total) | Geometric mean ELISA titer (standard error) | Geometric mean ED50 TNA assay titer (standard error)a |
---|---|---|---|
50 | 100 (9/9) | 43890.9 (1.12) | 4063.8 (1.26) |
25 | 100 (9/9) | 25600.0 (1.22) | 3225.4 (1.26) |
12.5 | 88.9 (8/9) | 16126.9 (1.29) | 1097.3 (1.35) |
6.3 | 80.0 (8/10) | 5198.4 (1.26) | 685.9 (1.18) |
3.1 | 33.3 (3/9) | 696.4 (1.72) | 278.6 (1.38) |
1.6 | 30.0 (3/10) | 459.5 (1.09) | 113.1 (1.37) |
0 (control) | 0.0 (0/10) | 1.0 (1.00) | 1.0 (1.00) |
Guinea pigs received single i.m. injections (0.5 ml) of rPA vaccine containing various concentrations of rPA. Four weeks later, guinea pigs were challenged by the i.m. route with a targeted dose of 30LD50 spores of the
Guinea pigs received two i.m. injections at 0 and 4 weeks (0.5 ml each) of rPA vaccine containing various concentrations of rPA. Four weeks after the last injection (Week 8), guinea pigs were challenged by the i.m. route with a targeted dose of 30LD50 spores of the