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Volume 4(6); Dec 2013
Editorial
What is Next for HIV/AIDS in Korea?
Hae-Wol Cho, Chaeshin Chu
Osong Public Health Res Perspect. 2013;4(6):291-292.   Published online December 31, 2013
Original Article
Proteomic Analysis of Intracellular and Membrane Proteins From Voriconazole-Resistant Candida glabrata
Jae Il Yoo, Hwa Su Kim, Chi Won Choi, Jung Sik Yoo, Jae Yon Yu, Yeong Seon Lee
Osong Public Health Res Perspect. 2013;4(6):293-300.   Published online December 31, 2013
Objectives The proteomic analysis of voriconazole resistant Candida glabrata strain has not yet been investigated. In this study, differentially expressed proteins of intracellular and membrane fraction from voriconazole-susceptible, susceptible dose-dependent (S-DD), resistant C. glabrata strains were compared with each other and several proteins were identified. Methods The proteins of intracellular and membrane were isolated by disrupting cells with glass bead and centrifugation from...
Lon Mutant of Brucella abortus Induces Tumor Necrosis Factor-Alpha in Murine J774.A1 Macrophage
Sungdo Park, Young-Sill Choi, Sang-Hee Park, Young-Rok Kim, Hyuk Chu, Kyu-Jam Hwang, Mi-Yeoun Park
Osong Public Health Res Perspect. 2013;4(6):301-307.   Published online December 31, 2013
Objectives The objective of this study was to isolate a Brucella lon mutant and to analyze the cytokine response of B. lon mutant during macrophage infection. Methods A wild-type Brucella abortus strain was mutagenized by Tn5 transposition. From the mouse macrophage J774.A1 cells, total RNA was isolated at 0 hours, 6 hours, 12 hours, and 24 hours after infection with Brucella. Using mouse...
A Study on the Public-Private Partnership to Global Health Issues in Korea
Hyun Sook Lee
Osong Public Health Res Perspect. 2013;4(6):308-315.   Published online December 31, 2013
Objectives To find the fit that is most apt for the current situation in Korea and to find new ways of identifying potential partners for the purpose of public–private partnership (PPP). The research was conducted using domestic and international literature where the concept and definition of PPP was stated, and cases of PPP reported by the World Health Organization and cases...
Prevalent Multidrug-resistant Nonvaccine Serotypes in Pneumococcal Carriage of Healthy Korean Children Associated with the Low Coverage of the Seven-valent Pneumococcal Conjugate Vaccine
Sungkyoung Lee, Ji-Hye Kim, Seong-Han Kim, Misun Park, Songmee Bae
Osong Public Health Res Perspect. 2013;4(6):316-322.   Published online December 31, 2013
Objectives Our previous longitudinal multicenter-based carriage study showed that the average carriage rate of Streptococcus pneumoniae was 16.8% in 582 healthy children attending kindergarten or elementary school in Seoul, Korea. We assessed serotype-specific prevalence and antimicrobial resistance among colonizing pneumococcal isolates from young children in the era of low use of the seven-valent pneumococcal conjugate vaccine (PCV7). Methods Serotypes were determined by an...
Generation and Characterization of Recombinant Influenza A(H1N1) Viruses Resistant to Neuraminidase Inhibitors
WooYoung Choi, Jin-Young Shin, Hwan-Eui Jeong, Mi-Jin Jeong, Su-Jin Kim, Joo-Yeon Lee, Chun Kang
Osong Public Health Res Perspect. 2013;4(6):323-328.   Published online December 31, 2013
Objectives To examine the effect of neuraminidase (NA) mutations on the NA inhibitor (NAI) resistance phenotype, the recombinant influenza A/Chungbuk/4448/2008(H1N1) virus isolated in South Korea during the 2008–2009 season was generated by reverse genetics. Methods Site-directed mutagenesis was introduced on the NA gene of A/Chungbuk/4448/2008(H1N1) virus, and a total of 23 single, double, and triple mutants were generated. Resistance phenotype of these recombinant...
Determinants of the Length of Stay in Stroke Patients
Sang Mi Kim, Sung Wan Hwang, Eun-Hwan Oh, Jung-Kyu Kang
Osong Public Health Res Perspect. 2013;4(6):329-341.   Published online December 31, 2013
Objectives The study objective was to identify the factors that influence the length of stay (LOS) in hospital for stroke patients and to provide data for managing hospital costs by managing the LOS. Methods This study used data from the Discharge Injury Survey of the Korea Centers for Disease Control and Prevention, which included 17,364 cases from 2005 to 2008. Result The LOS for stroke,...
Development of a Specific and Rapid Diagnostic Method for Detecting Influenza A (H1N1) pdm09 Virus Infection Using Immunochromatographic Assay
Mi Jung Ji, Byung Ki Cho, Young Shik Cho, Young Jin Choi, Donghyok Kwon, Kyeongcheol Shin, Joo-Yeon Lee, Chun Kang, Byoung Su Yoon
Osong Public Health Res Perspect. 2013;4(6):342-346.   Published online December 31, 2013
Objectives The aim of this study was to develop an immunochromatographic assay (ICA) for the detection of influenza A (H1N1) pdm09 virus infection. Materials and methods Several monoclonal antibodies against influenza A (H1N1) pdm09 virus were generated and an ICA (pdm09-ICA) was developed for the rapid and specific detection of influenza A (H1N1) pdm09 virus infection. The specificity and sensitivity of the developed...
In Vitro Antibacterial Efficacy of 21 Indian Timber-Yielding Plants Against Multidrug-Resistant Bacteria Causing Urinary Tract Infection
Monali P. Mishra, Rabindra N. Padhy
Osong Public Health Res Perspect. 2013;4(6):347-357.   Published online December 31, 2013
Objectives To screen methanolic leaf extracts of 21 timber-yielding plants for antibacterial activity against nine species of uropathogenic bacteria isolated from clinical samples of a hospital (Enterococcus faecalis, Staphylococcus aureus, Acinetobacter baumannii, Citrobacter freundii, Enterobacter aerogenes, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, and Pseudomonas aeruginosa). Methods Bacterial strains were subjected to antibiotic sensitivity tests by the Kirby–Bauer's disc diffusion method. The antibacterial potentiality...
Forecasting the Number of Human Immunodeficiency Virus Infections in the Korean Population Using the Autoregressive Integrated Moving Average Model
Hye-Kyung Yu, Na-Young Kim, Sung Soon Kim, Chaeshin Chu, Mee-Kyung Kee
Osong Public Health Res Perspect. 2013;4(6):358-362.   Published online December 31, 2013
Objectives From the introduction of HIV into the Republic of Korea in 1985 through 2012, 9,410 HIV-infected Koreans have been identified. Since 2000, there has been a sharp increase in newly diagnosed HIV-infected Koreans. It is necessary to estimate the changes in HIV infection to plan budgets and to modify HIV/AIDS prevention policy. We constructed autoregressive integrated moving average (ARIMA) models...

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Print ISSN: 2210-9099
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