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Volume 2(3); Dec 2011
Articles
Is the Public Transportation System Safe from a Public Health Perspective?
Hae-Wol Cho, Chaeshin Chu
Osong Public Health Res Perspect. 2011;2(3):149-150.   Published online December 31, 2011
Neutralizing Antibody Responses and Evolution of the Viral Envelope in the Course of HIV-1 Korean Clade B Infection
Bo Gyeong Shin, Mi-Ran Yun, Sung Soon Kim, Gab Jung Kim
Osong Public Health Res Perspect. 2011;2(3):151-157.   Published online December 31, 2011
Objectives HIV is able to continuously adapt to and evade the evolving neutralizing antibody responses of the host. We investigated the ability of HIV variants to evade neutralizing antibodies in order to understand the distinct characteristics of HIV-1 Korean clade B. Methods Three drug-naive subjects were enrolled in this study who were infected with HIV-1 Korean clade B. Neutralizations were performed using autologous...
Longitudinal and Cross-Sectional Genetic Diversity in the Korean Peninsula Based on the P vivax Merozoite Surface Protein Gene
Jung-Yeon Kim, Eun-Jung Suh, Hyo-Soon Yu, Hyun-Sik Jung, In-Ho Park, Yien-Kyeoug Choi, Kyoung-Mi Choi, Shin-Hyeong Cho, Won-Ja Lee
Osong Public Health Res Perspect. 2011;2(3):158-163.   Published online December 31, 2011
Objectives Vivax malaria has reemerged and become endemic in Korea. Our study aimed to analyze by both longitudinal and cross-sectional genetic diversity of this malaria based on the P vivax Merozoite Surface Protein (PvMSP) gene parasites recently found in the Korean peninsula. Methods PvMSP-1 gene sequence analysis from P vivax isolates (n = 835) during the 1996-2010 period were longitudinally analyzed and the...
Alterations of gyrA, gyrB, and parC and Activity of Efflux Pump in Fluoroquinolone-resistant Acinetobacter baumannii
Sunok Park, Kyeong Min Lee, Yong Sun Yoo, Jung Sik Yoo, Jae Il Yoo, Hwa Su Kim, Yeong Seon Lee, Gyung Tae Chung
Osong Public Health Res Perspect. 2011;2(3):164-170.   Published online December 31, 2011
Objectives This study investigated the fluoroquinolone-resistant mechanism of 56 clinical cases of A baumannii infection from 23 non-tertiary hospitals, collected between 2004 and 2006. Methods Susceptibility testing was performed by broth microdilution and Epsilometer test. Analyses of quinolone resistance-determining region (QRDR) were done by sequencing. The activity of the efflux pump was measured using inhibitors. Results The sequences from selected 56 isolates were divided into...
Cyclophilin A Cpr1 Protein Modulates the Response of Antioxidant Molecules to Menadione-induced Oxidative Stress in Saccharomyces cerevisiae KNU5377Y
Il-Sup Kim, Haesun Yun, Ingnyol Jin, Ho-Sung Yoon
Osong Public Health Res Perspect. 2011;2(3):171-177.   Published online December 31, 2011
Objectives The cellular function of cyclophilin A (CypA) differs between organisms, even though CypA is conserved in both prokaryotes and eukaryotes. The purpose of this study was to elucidate the role of activated CypA isoform CPR1 in the antioxidative mechanisms of Saccharomyces cerevisiae under menadione (MD)-induced oxidative stress. Methods Four S. cerevisiae strains, KNU5377Y (kwt) and BY4741 (bwt), and their isogenic cpr1⊿ mutant...
The Emergence of Oseltamivir-Resistant Seasonal Influenza A (H1N1) Virus in Korea During the 2008-2009 Season
Woo-Young Choi, Inseok Yang, Sujin Kim, Namjoo Lee, Meehwa Kwon, Joo-Yeon Lee, Chun Kang
Osong Public Health Res Perspect. 2011;2(3):178-185.   Published online December 31, 2011
Objectives To monitor antiviral drug resistance among seasonal influenza viruses isolated in Korea during the 2008-2009 influenza season, we examined influenza isolates collected through Korea Influenza Surveillance Scheme for antiviral drug susceptibility. Methods For genetic analysis of antiviral drug resistance, the matrix (M2) and neuraminidase (NA) genes of each isolate were amplified by reverse transcription-polymerase chain reaction and followed by nucleotide sequencing. For...
Serum MicroRNA Expression Profiling in Mice Infected with Rabies Virus
Myung Guk Han, Jun-Sun Park, Cho Soon Lee, Young Eui Jeong, Jung Sang Ryou, Jung Eun Cho, Young Ran Ju, Kyoung-Ki Lee
Osong Public Health Res Perspect. 2011;2(3):186-191.   Published online December 31, 2011
Objectives Serum or plasma microRNAs (miRNAs) are potential biomarkers for the diagnosis for cancer and prenatal diseases. This study was conducted to investigate whether rabies virus causes a change in serum miRNA expression. Methods ICR mice were intramuscularly inoculated with rabies virus and were sacrificed weekly to collect serum and brain tissue for 4 weeks postinoculation. Mice were assigned to four groups based...
Food and Nutrient Intakes According to Income in Korean Men and Women
Inyoung Hur, Myoung-Jin Jang, Kyungwon Oh
Osong Public Health Res Perspect. 2011;2(3):192-197.   Published online December 31, 2011
Objectives The present study investigated associations between income and intake of nutrients and food in adults (n = 11,063) from the fourth Korea National Health and Nutrition Examination Survey 2007–2009. Methods To examine relationships between individual dietary intake and anthropometric measures and family income, multiple linear regression models were constructed for each outcome variable. All models were adjusted for age, education, energy intake,...
Prevalence of Farm and Slaughterhouse Workers Carrying Shiga Toxin-Producing Escherichia coli in Korea
Sahyun Hong, Seung Eun Song, Kyung Hwan Oh, Seung Hak Kim, Seok ju Yoo, Hyun Sul Lim, Mi Sun Park
Osong Public Health Res Perspect. 2011;2(3):198-201.   Published online December 31, 2011
Objectives The aim of this study was to investigate the distribution of Shiga toxin (Stx) gene-positive stool samples from dairy farmer and slaughterhouse workers in Gyeonggi-Do province. Methods A total of 621 samples from healthy farmers and 198 samples from slaughterhouse workers were screened by polymerase chain reaction (PCR) for Shiga toxigenic Escherichia coli (STEC) infection on stool samples. Results The PCR product of Stx-encoding...
A diversity of Antibiotic-resistant Staphylococcus spp. in a Public Transportation System
Pamela J. Yeh, Dawn M. Simon, Jess A. Millar, H. Forrest Alexander, Darleen Franklin
Osong Public Health Res Perspect. 2011;2(3):202-209.   Published online December 31, 2011
Objectives Our goal was to determine the diversity and abundance of Staphylococcus bacteria on different components of a public transportation system in a mid-sized US city (Portland, Oregon) and to examine the level of drug resistance in these bacteria. Methods We collected 70 samples from 2 cm × 4 cm sections from seven different areas on buses and trains in Portland, USA, taking...
Sensitivity Analysis of the Parameters of Korea’s Pandemic Influenza Preparedness Plan
Chaeshin Chu, Junehawk Lee, Dong Hoon Choi, Seung-Ki Youn, Jong-Koo Lee
Osong Public Health Res Perspect. 2011;2(3):210-215.   Published online December 31, 2011
Objectives Our aim was to evaluate Korea’s Pandemic Influenza Preparedness Plan. Methods We conducted a sensitivity analysis on the expected number of outpatients and hospital bed occupancy, with 1,000,000 parameter combinations, in a situation of pandemic influenza, using the mathematical simulation program InfluSim. Results Given the available resources in Korea, antiviral treatment and social distancing must be combined to reduce the number of outpatients and...
A Contribution of MdfA to Resistance to Fluoroquinolones in Shigella flexneri
Jun-Young Kim, Se-Mi Jeon, Hyungjun Kim, Mi-Sun Park, Seong-Han Kim
Osong Public Health Res Perspect. 2011;2(3):216-217.   Published online December 31, 2011
In this study, we measured the drug resistance conferred by mdfA mutations in two Shigella flexneri strains. A mutant in mdfA genes was constructed by polymerase chain reaction–based, one-step inactivation of chromosomal genes. The antimicrobial susceptibility of parent and mutant strains to fluoroquinolones was determined by minimal inhibitory concentration (MICs). The △mdfA mutants were somewhat more susceptible to fluoroquinolones than...

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Print ISSN: 2210-9099
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