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Volume 2(2); Sep 2011
Editorial
A Tale of Two Fields: Mathematical and Statistical Modeling of Infectious Diseases
Hae-Wol Cho, Chaeshin Chu
Osong Public Health Res Perspect. 2011;2(2):73-74.   Published online June 30, 2011
Original Article
Development of a Predictive Model for Type 2 Diabetes Mellitus Using Genetic and Clinical Data
Juyoung Lee, Bhumsuk Keam, Eun Jung Jang, Mi Sun Park, Ji Young Lee, Dan Bi Kim, Chang-Hoon Lee, Tak Kim, Bermseok Oh, Heon Jin Park, Kyu-Bum Kwack, Chaeshin Chu, Hyung-Lae Kim
Osong Public Health Res Perspect. 2011;2(2):75-82.   Published online June 30, 2011
Objectives

Recent genetic association studies have provided convincing evidence that several novel loci and single nucleotide polymorphisms (SNPs) are associated with the risk of developing type 2 diabetes mellitus (T2DM). The aims of this study were: 1) to develop a predictive model of T2DM using genetic and clinical data; and 2) to compare misclassification rates of different models.

Methods

We selected 212 individuals...

Plasma Calcium and Risk of Hypertension: Propensity Score Analysis Using Data From the Korean Genome and Epidemiology Study
Jong Wook Kim, Kwang-Pil Ko, Hee Jo Koo, Younjhin Ahn, Seon-Joo Park, Hyo-Mi Kim, Yeonjung Kim, Sung Soo Kim
Osong Public Health Res Perspect. 2011;2(2):83-88.   Published online June 30, 2011
Objective

To investigate associations between plasma calcium and future incidence of hypertension in a healthy population.

Methods

We used prospective data from Ansung and Ansan cohorts (n = 10,038) of the Korean Genome and Epidemiology Study. Data from baseline (2001–02) to the fourth study (2007–08) were used. After excluding hypertensive cases at baseline, missing data, and outliers, 5560 participants were analyzed. Propensity scores for having...

Modeling for Estimating Influenza Patients from ILI Surveillance Data in Korea
Joo-Sun Lee, Sun-Hee Park, Jin-Woong Moon, Jacob Lee, Yong Gyu Park, Yong Kyun Roh
Osong Public Health Res Perspect. 2011;2(2):89-93.   Published online June 30, 2011
Objective

Prediction of influenza incidence among outpatients from an influenza surveillance system is important for public influenza strategy.

Methods

We developed two influenza prediction models through influenza surveillance data of the Korea Centers for Disease Control and Prevention (each year, each province and metropolitan city; total reported patients with influenza-like illness stratified by age) for 6 years from 2005 to 2010 and disease-specific...

Increased Prevalence of low High-density Lipoprotein Cholesterol (HDL-C) Levels in Korean Adults: Analysis of the Three Korean National Health and Nutrition Examination Surveys (KNHANES 1998–2005)
Sun-Ja Choi, Sung-Hee Park, Hyun-Young Park
Osong Public Health Res Perspect. 2011;2(2):94-103.   Published online June 30, 2011
Objectives

High-density lipoprotein cholesterol (HDL-C) is an independent risk factor for cardiovascular diseases that has shown a remarkable increase, but little is known about the prevalence of low HDL-C in Korea. This study aimed to evaluate changing trends of low HDL-C prevalence, and indicate other risk factors associated with low HDL-C.

Methods

We selected subjects aged ≥20 years from the Korean National Health...

Estimation of HIV Seroprevalence in Colorectal Hospitals by Questionnaire Survey in Korea, 2002–2007
Mee-Kyung Kee, Do Yeon Hwang, Jong Kyun Lee, Seung Hyun Kim, Chaeshin Chu, Jin-Hee Lee, Sung Soon Kim
Osong Public Health Res Perspect. 2011;2(2):104-108.   Published online June 30, 2011
Objectives

The incidence of anal disease is higher among persons with human immunodeficiency virus (HIV) infection than among the general population. We surveyed the status of seroprevalence in colorectal hospitals in Korea.

Methods

The survey was conducted in colorectal hospitals in Korea from November to December 2008. The questionnaire was comprised of six topics about the status of HIV testing in colorectal hospitals....

Ingenol Protects Human T Cells From HIV-1 Infection
Kee-Jong Hong, Hak Sung Lee, Yeong-shik Kim, Sung Soon Kim
Osong Public Health Res Perspect. 2011;2(2):109-114.   Published online June 30, 2011
Objectives

Many natural compounds have been investigated as drug candidates to prevent human immunodeficiency virus (HIV) with low cytotoxicity. We tested whether ingenol from Euphorbia ingens exerts anti-HIV effects in human T cell lines.

Methods and Results

Ingenol effectively maintained high cell viability (CD50, >1 mM) in H9 and MT4 T cells. The efficacy of ingenol to inhibit HIV-1 infection was dose dependent. ED50 for 100...

Multilocus Sequence Analysis of Housekeeping Genes and Antigenic Determinant Genes in Bordetella pertussis Strains Isolated in Korea
Sang-Oun Jung, Yu Mi Moon, So-Hyeon Kim, Hwa Young Sung, Seung-Jik Kwon, Yeon Ho Kang, Jae Yon Yu
Osong Public Health Res Perspect. 2011;2(2):115-126.   Published online June 30, 2011
Objectives

To confirm genotype diversities of clinical isolates of Bordetella pertussis and to evaluate the risk of pertussis outbreak in Korea.

Methods

Seven housekeeping genes and 10 antigenic determinant genes from clinical B. pertussis isolates were analyzed by Multilocus sequence typing (MLST).

Results

More variant pattern was observed in antigenic determinant genes. Especially, PtxS1 gene was the most variant gene; five genotypes were observed from...

Improved HPLC Method Using 2,3-naphthalenedicarboxaldehyde as Fluorescent Labeling Agent for Quantification of Histamine in Human Immunoglobulin Preparations
Jung-Hwan Kim, In Soo Shin, Yoo Kyoung Lee, Ho Jung Oh, Sang Ja Ban
Osong Public Health Res Perspect. 2011;2(2):127-134.   Published online June 30, 2011
Objectives

To develop and optimize quantitative HPLC method using 2,3-naphthalenedicarboxaldehyde (NDA) after simple and efficient solid phase extraction to determine the histamine in a biopharmaceutical (Histobulin™).

Methods

The HPLC method was established using NDA-induced Histobulin and compared with the recently reported HPLC method using o-phthaldehyde (OPA). The validated NDA-applied HPLC method was adjusted to 15 lots of Histobulin and compared by the current...

A Note on Obesity as Epidemic in Korea
Mun Seok Kim, Chaeshin Chu, Yongkuk Kim
Osong Public Health Res Perspect. 2011;2(2):135-140.   Published online June 30, 2011
Objective

To analyze the incidence of obesity in adults aged 19–59 years in Korea and predict its trend in the future.

Methods

We considered a two-compartmental deterministic mathematical model Susceptible-Infected-Susceptible (SIS), a system of difference equations, to predict the evolution of obesity in the population and to propose strategies to reduce its incidence.

Results

The prevention strategy on normal-weight individuals produced a greater improvement than...

Brief Report
Registration of Human Embryonic Stem Cell Lines: Korea, 2010
Ji-Yoon Lee, Dae-Yeon Lee, Young-Sil Choi, Kyoung-Jae Lee, Yong-Ou Kim
Osong Public Health Res Perspect. 2011;2(2):141-147.   Published online June 30, 2011

In an effort to increase the credibility of human embryonic stem cell (hESC) lines established in Korea, obligatory registration was introduced by the Bioethics and Safety Act 2008, effective as of January 1, 2010.

The DNA fingerprint, chromosome stability, expression of pluripotency markers, and contamination of mycoplasma of the submitted lines were analyzed by Korea Centers for Disease Control and Prevention...

Osong Public
Health and
Research
Perspectives

Print ISSN: 2210-9099
Online ISSN: 2233-6052

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