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Review Article
Points to consider for COVID-19 vaccine quality control and national lot release in Republic of Korea: focus on a viral vector platform
Jung Hun Ju, Naery Lee, Sun-hee Kim, Seokkee Chang, Misook Yang, Jihyun Shin, Eunjo Lee, Sunhwa Sung, Jung-Hwan Kim, Jin Tae Hong, Ho Jung Oh
Osong Public Health Res Perspect. 2022;13(1):4-14.   Published online February 8, 2022
DOI: https://doi.org/10.24171/j.phrp.2021.0311
  • 3,317 View
  • 140 Download
Graphical AbstractGraphical Abstract AbstractAbstract PDF
Due to the global public health crisis caused by the coronavirus disease 2019 (COVID-19) pandemic, the importance of vaccine development has increased. In particular, a rapid supply of vaccines and prompt deployment of vaccination programs are essential to prevent and overcome the spread of COVID-19. As a part of the vaccine regulations, national lot release is regulated by the responsible authorities, and this process involves the assessment of the lot before a vaccine is marketed. A lot can be released for use when both summary protocol (SP) review and quality control testing are complete. Accelerated lot release is required to distribute COVID-19 vaccines in a timely manner. In order to expedite the process by simultaneously undertaking the verification of quality assessment and application for approval, it is necessary to prepare the test methods before marketing authorization. With the prolonged pandemic and controversies regarding the effectiveness of the COVID-19 vaccine against new variants, public interest for the development of a new vaccine are increasing. Domestic developers have raised the need to establish standard guidance on the requirements for developing COVID-19 vaccine. This paper presents considerations for quality control in the manufacturing process, test items, and SP content of viral vector vaccines.
Original Articles
Modeling Chagas Disease at Population Level to Explain Venezuela's Real Data
Gilberto González-Parra, Benito M. Chen-Charpentier, Moises Bermúdez
Osong Public Health Res Perspect. 2015;6(5):288-301.   Published online October 31, 2015
DOI: https://doi.org/10.1016/j.phrp.2015.09.001
  • 1,862 View
  • 15 Download
  • 2 Citations
AbstractAbstract PDF
Objectives
In this paper we present an age-structured epidemiological model for Chagas disease. This model includes the interactions between human and vector populations that transmit Chagas disease.
Methods
The human population is divided into age groups since the proportion of infected individuals in this population changes with age as shown by real prevalence data. Moreover, the age-structured model allows more accurate information regarding the prevalence, which can help to design more specific control programs. We apply this proposed model to data from the country of Venezuela for two periods, 1961–1971, and 1961–1991 taking into account real demographic data for these periods.
Results
Numerical computer simulations are presented to show the suitability of the age-structured model to explain the real data regarding prevalence of Chagas disease in each of the age groups. In addition, a numerical simulation varying the death rate of the vector is done to illustrate prevention and control strategies against Chagas disease.
Conclusion
The proposed model can be used to determine the effect of control strategies in different age groups.

Citations

Citations to this article as recorded by  
  • Mathematical modeling and numerical simulations of Zika in Colombia considering mutation
    Diego F. Aranda L., Gilberto González-Parra, Tommaso Benincasa
    Mathematics and Computers in Simulation.2019; 163: 1.     CrossRef
  • Modeling Chagas disease in Chile: From vector to congenital transmission
    Mauricio Canals, Dante Cáceres, Sergio Alvarado, Andrea Canals, Pedro E. Cattan
    Biosystems.2017; 156-157: 63.     CrossRef
Expression of Recombinant pET22b-LysK-Cysteine/Histidine-Dependent Amidohydrolase/Peptidase Bacteriophage Therapeutic Protein in Escherichia coli BL21 (DE3)
Hamed Haddad Kashani, Rezvan Moniri
Osong Public Health Res Perspect. 2015;6(4):256-260.   Published online August 31, 2015
DOI: https://doi.org/10.1016/j.phrp.2015.08.001
  • 1,952 View
  • 19 Download
  • 17 Citations
AbstractAbstract PDF
Objectives
Bacteriophage-encoded endolysins are a group of enzymes that act by digesting the peptidoglycan of bacterial cell walls. LysK has been reported to lyse live staphylococcal cultures. LysK proteins containing only the cysteine/histidine-dependent amidohydrolase/peptidase (CHAP) domain has the capability to show lytic activity against live clinical staphylococcal isolates, including methicillin-resistant Staphylococcus aureus (MRSA). The aim of this study was to clone and express LysK-CHAP domain in Escherichia coli BL21 (DE3) using pET22b as a secretion vector. The pET22b plasmid was used, which encoded a pelB secretion signal under the control of the strong bacteriophage T7 promoter.
Methods
The E. coli cloning strains DH5α and BL21 (DE3) were grown at 37°C with aeration in the Luria-Bertani medium. A plasmid encoding LysK-CHAP in a pET22b backbone was constructed. The pET22b vector containing LysK-CHAP sequences were digested with NcoI and HindIII restriction enzymes. Cloning accuracy was confirmed by electrophoresis. The pET22b-LysK plasmid was used to transform the E. coli strain BL21. Isopropyl β-d-1-thiogalactopyranoside (IPTG) was added to a final concentration of 1mM to induce T7 RNA polymerase-based expression. Finally, western blot confirmed the expression of target protein.
Results
In this study, after double digestion of pEX and pET22b vectors with HindIII and NcoI, LysK gene was cloned into two HindIII and NcoI sites in pET22b vector, and then transformed to E. coli DH5α. Cloning was confirmed with double digestion and analyzed with agarose gel. The recombinant pET22b-LysK plasmid was transformed to E. coli BL21 and the expression was induced by IPTG. The expression was confirmed by Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and western blotting method. Observation of a 28.5 kDa band confirmed LysK protein expression.
Conclusion
In the present study, LysK-CHAP domain was successfully cloned and expressed at the pET22b vector and E. coli BL21 (DE3).

Citations

Citations to this article as recorded by  
  • Chemotherapeutic Strategies for Combating Staphylococcus aureus Infections
    Namita Sharma, Anil Kumar Chhillar, Sweety Dahiya, Aruna Punia, Pooja Choudhary, Prity Gulia, Akanksha Behl, Mehak Dangi
    Mini-Reviews in Medicinal Chemistry.2022; 22(1): 26.     CrossRef
  • Antimicrobial peptides of the vaginal innate immunity and their role in the fight against sexually transmitted diseases
    H. Madanchi, M. Shoushtari, H.H. Kashani, S. Sardari
    New Microbes and New Infections.2020; 34: 100627.     CrossRef
  • Assessment of Relationship Between Expression of Survivin Protein and Histopathology Diagnosis and Malignancy Severity in Colon Specimen
    Amin Jourabchin, Tahereh Mazoochi, Hamed Haddad Kashani, Tahereh Khamechian
    Journal of Gastrointestinal Cancer.2020; 51(1): 76.     CrossRef
  • The effect of calcium on the adhesion of Streptococcus mutans to Human Gingival Epithelial Cells in the presence of probiotic bacteria Lactobacillus plantarum and Lactobacillus salivarius
    Mahboobeh Mehrabani Natanzi, Fatemeh Soleimanifard, Hamed Haddad Kashani, Mohammad Javad Azadchehr, Ahmadreza Mirzaei, Zohre Khodaii
    Gene Reports.2020; 20: 100710.     CrossRef
  • Expression and characterization of family 40 Carbohydrate Binding Module (CBM) from Vibrio cholerae Non-O1 sialidase
    Gogula Selvi Asang, Shadariah Mamat, Nadiawati Alias, Asmad Kari
    Asia Pacific Journal of Molecular Biology and Biot.2020; : 26.     CrossRef
  • Effect of intraoperative dexmedetomidine infusion during functional endoscopic sinus surgery: a prospective cohort study
    Mohammad Reza Fazel, Zeynab Sadat Ahmadi, Hossein Akbari, Fahimeh Abam
    Patient Safety in Surgery.2020;[Epub]     CrossRef
  • Comparison of a novel herbal skin care ointment with regular ointments to treat skin around the abdominal stoma: A clinical trial study
    Maryam Hajikari, Soheila Mojdeh, Mohsen Shariari
    Polish Annals of Medicine.2019;[Epub]     CrossRef
  • Evaluation of the serum sex hormones levels and alkaline phosphatase activity in rats’ testis after administering of berberine in experimental varicocele
    Hamed Najaran, Hassan Hassani Bafrani, Hamid Rashtbari, Fatemeh Izadpanah, Mohammad Reza Rajabi, Hamed Haddad Kashani, Abouzar Mohammadi
    Oriental Pharmacy and Experimental Medicine.2019; 19(2): 157.     CrossRef
  • Effect of melatonin in reducing second-generation antipsychotic metabolic effects: A double blind controlled clinical trial
    Mansour Agahi, Negar Akasheh, Afshin Ahmadvand, Hossein Akbari, Fatemeh Izadpanah
    Diabetes & Metabolic Syndrome: Clinical Research &.2018; 12(1): 9.     CrossRef
  • Dengue viruses and promising envelope protein domain III-based vaccines
    Hossein Fahimi, Mahshid Mohammadipour, Hamed Haddad Kashani, Farshid Parvini, Majid Sadeghizadeh
    Applied Microbiology and Biotechnology.2018; 102(7): 2977.     CrossRef
  • Recombinant Endolysins as Potential Therapeutics against Antibiotic-Resistant Staphylococcus aureus: Current Status of Research and Novel Delivery Strategies
    Hamed Haddad Kashani, Mathias Schmelcher, Hamed Sabzalipoor, Elahe Seyed Hosseini, Rezvan Moniri
    Clinical Microbiology Reviews.2018;[Epub]     CrossRef
  • A Novel Chimeric Endolysin with Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus
    Hamed Haddad Kashani, Hossein Fahimi, Yasaman Dasteh Goli, Rezvan Moniri
    Frontiers in Cellular and Infection Microbiology.2017;[Epub]     CrossRef
  • The lowering of bilirubin levels in patients with neonatal jaundice using massage therapy: A randomized, double-blind clinical trial
    Fatemeh Eghbalian, Haneyeh Rafienezhad, Javad Farmal
    Infant Behavior and Development.2017; 49: 31.     CrossRef
  • The effect of chronic noise stress on serum levels of cortisol, gonadotropins, and sexual hormones at implantation time of mice
    Alireza Shafiei, Hassan Ehteram, Hossein Akbari, Masoud Motalebi Kashani, Mandana Beigi, Javad Amini Mahabadi, Tahere Mazoochi
    Comparative Clinical Pathology.2017; 26(4): 779.     CrossRef
  • The Role of Probiotics in the Treatment of Dysentery: a Randomized Double-Blind Clinical Trial
    Alireza Sharif, Hamed Haddad Kashani, Elahe Nasri, Zahra Soleimani, Mohammad Reza Sharif
    Probiotics and Antimicrobial Proteins.2017; 9(4): 380.     CrossRef
  • Assessment of 25-hydroxy vitamin D in stroke patients based on severity and type: a cross-sectional study
    Ebrahim Kouchaki, Mansour Sayyah, Maryam Omidvari
    Comparative Clinical Pathology.2017; 26(4): 811.     CrossRef
  • Purification of Antibacterial CHAPK Protein Using a Self-Cleaving Fusion Tag and Its Activity Against Methicillin-Resistant Staphylococcus aureus
    Elahe Seyed Hosseini, Rezvan Moniri, Yasaman Dasteh Goli, Hamed Haddad Kashani
    Probiotics and Antimicrobial Proteins.2016; 8(4): 202.     CrossRef
Evaluation of Mycobacterium tuberculosis Early Secreted Antigenic Target 6 Recombinant Protein as a Diagnostic Marker in Skin Test
Jale Moradi, Nader Mosavari, Mahmoud Ebrahimi, Reza Arefpajohi, Majid Tebianian
Osong Public Health Res Perspect. 2015;6(1):34-38.   Published online February 28, 2015
DOI: https://doi.org/10.1016/j.phrp.2014.12.002
  • 1,952 View
  • 17 Download
  • 5 Citations
AbstractAbstract PDF
Objectives
Tuberculosis (TB) is the leading infectious disease in the developing world. Delayed-type hypersensitivity skin test diagnoses TB using tuberculin purified protein derivative (PPD), but this test is incapable of distinguishing Mycobacterium tuberculosis (MTB) infection from bacillus Calmette–Guérin (BCG) vaccination or an infection caused by nontuberculous mycobacteria (NTM). This study was performed to evaluate the use of recombinant early secretory antigenic target 6 (rESAT-6), a secretory protein found only in MTB, Mycobacterium bovis, and few other mycobacterial species, as a skin marker for MTB in guinea pigs.
Methods
We prepared recombinant MTB ESAT-6 and evaluated its use as a specific antigen for MTB in guinea pigs.
Results
Our results show that the purified MTB rESAT-6 antigen is capable of inducing a positive reaction only in guinea pigs sensitized to MTB. No such reaction was observed in the animals sensitized to M. bovis, BCG vaccination, or NTM (Mycobacterium avium).
Conclusion
Our study results confirm that the ESAT-6 antigen is more specific to MTB infection than PPD and could be used in more specific skin tests for detection of MTB in large animals and in humans.

Citations

Citations to this article as recorded by  
  • Biological evaluation of mimetic peptides as active molecules for a new and simple skin test in an animal model
    Deborah Carbonera Guedes, Aline Kuhn Sbruzzi Pasquali, João Carlos Minozzo, Craig Faulds, Ricardo Rasmussen Petterle, Carlos Ricardo Soccol, Vanete Thomaz Soccol
    Parasitology Research.2019; 118(1): 317.     CrossRef
  • Application of transdermal patches with new skin test reagents for detection of latent tuberculosis
    Songsri Kasempimolporn, Pannatat Areekul, Wichit Thaveekarn, Rattana Sutthisri, Supatsorn Boonchang, Artikaya Sawangvaree, Visith Sitprija
    Journal of Medical Microbiology.2019; 68(9): 1314.     CrossRef
  • Guinea pig infected with Mycobacterium tuberculosis via oral consumption
    Jianfeng Gao, Ming Guo, Li Teng, Rong Bao, Qiaoyang Xian, Xin Wang, Wenzhe Ho
    Journal of Applied Animal Research.2018; 46(1): 1323.     CrossRef
  • New strategy to improve quality control of Montenegro skin test at the production level
    Deborah Carbonera Guedes, João Carlos Minozzo, Aline Kuhn Sbruzzi Pasquali, Craig Faulds, Carlos Ricardo Soccol, Vanete Thomaz-Soccol
    Revista da Sociedade Brasileira de Medicina Tropic.2017; 50(6): 788.     CrossRef
  • Dissecting the mycobacterial cell envelope and defining the composition of the native mycomembrane
    Laura Chiaradia, Cyril Lefebvre, Julien Parra, Julien Marcoux, Odile Burlet-Schiltz, Gilles Etienne, Maryelle Tropis, Mamadou Daffé
    Scientific Reports.2017;[Epub]     CrossRef
Ovicidal and Oviposition Deterrent Activities of Medicinal Plant Extracts Against Aedes aegypti L. and Culex quinquefasciatus Say Mosquitoes (Diptera: Culicidae)
Appadurai Daniel Reegan, Munusamy Rajiv Gandhi, Micheal Gabriel Paulraj, Savarimuthu Ignacimuthu
Osong Public Health Res Perspect. 2015;6(1):64-69.   Published online February 28, 2015
DOI: https://doi.org/10.1016/j.phrp.2014.08.009
  • 2,486 View
  • 25 Download
  • 34 Citations
AbstractAbstract PDF
Objectives
To evaluate the ovicidal and oviposition deterrent activities of five medicinal plant extracts namely Aegle marmelos (Linn.), Limonia acidissima (Linn.), Sphaeranthus indicus (Linn.), Sphaeranthus amaranthoides (burm.f), and Chromolaena odorata (Linn.) against Culex quinquefasciatus and Aedes aegypti mosquitoes. Three solvents, namely hexane, ethyl acetate, and methanol, were used for the preparation of extracts from each plant.
Methods
Four different concentrations—62.5 parts per million (ppm), 125 ppm, 250 ppm, and 500 ppm—were prepared using acetone and tested for ovicidal and oviposition deterrent activities. One-way analysis of variance (ANOVA) was used to determine the significance of the treatments and means were separated by Tukey's test of comparison.
Results
Among the different extracts of the five plants screened, the hexane extract of L. acidissima recorded the highest ovicidal activity of 79.2% and 60% at 500 ppm concentration against the eggs of Cx. quinquefasciatus and Ae. aegypti, respectively. Similarly, the same hexane extract of L. acidissima showed 100% oviposition deterrent activity at all the tested concentrations against Cx. quinquefasciatus and Ae. aegypti adult females.
Conclusion
It is concluded that the hexane extract of L. acidissima could be used in an integrated mosquito management program.

Citations

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  • Mosquitocidal activities of Chenopodium botrys whole plant n-hexane extract against Culex quinquefasciatus
    I. Ilahi, A. M. Yousafzai, M. Attaullah, T. U. Haq, A. Rahim, W. Khan, A. A. Khan, S. Ullah, T. Jan, M. M. Khan, G. Rahim, N. Zaman
    Brazilian Journal of Biology.2023;[Epub]     CrossRef
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    Muthiah Chellappandian, Sengottayan Senthil-Nathan, Prabhakaran Vasantha-Srinivasan, Sengodan Karthi, Kandaswamy Kalaivani, Wayne Brian Hunter, Hayssam M. Ali, Mohamed Z. M. Salem, Ahmed Abdel-Megeed
    Toxin Reviews.2022; 41(1): 119.     CrossRef
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    Sivaji Sathiyaraj, Gunasekaran Suriyakala, Arumugam Dhanesh Gandhi, Ranganathan Babujanarthanam, K. Kaviyarasu, R. Rajakrishnan, Palaniselvam Kuppusamy, Belle Ebanda Kedi Philippe
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    K. Nakasen, A. Wongsrila, J. Prathumtet, P. Sriraj, T. Boonmars, T. Promsrisuk, N. Laikaew, R. Aukkanimart
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  • Ovicidal, larvicidal and pupicidal efficacy of silver nanoparticles synthesized by Bacillus marisflavi against the chosen mosquito species
    Thelma J., Balasubramanian C., Jiang-Shiou Hwang
    PLOS ONE.2021; 16(12): e0260253.     CrossRef
  • Insecticidal activity and phytochemical analysis of Pyrus communis L. extracts against malarial vector, Anopheles pharoensis Theobald, 1901 (Diptera: Culicidae)
    Ahmed Zeinhom Ibrahem Shehata, Rola Milad Labib, Mohammad Reda Kamel Abdel-Samad
    Polish Journal of Entomology.2021; 90(4 - Ahead ): 209.     CrossRef
  • Oviposition Deterrent Activity and Ovicidal Effect of Pometia pinnata Leaves Extract against Dengue Vector, Aedes aegypti (Diftera: Culicidae)
    Luthfi Suharyo, Rizqulla K. Arthari, Fitria S.N. Rochmah, G. Gholib, A. Sutriana, A. Engelhardt, J. Duboscq, R. Sahara Zamzami
    E3S Web of Conferences.2020; 151: 01013.     CrossRef
  • Toxicological screening of marine red algae Champia parvula (C. Agardh) against the dengue mosquito vector Aedes aegypti (Linn.) and its non-toxicity against three beneficial aquatic predators
    Parthiban Yogarajalakshmi, Thinnaur Venugopal Poonguzhali, Raja Ganesan, Sengodan Karthi, Sengottayan Senthil-Nathan, Patcharin Krutmuang, Narayanaswamy Radhakrishnan, Faruq Mohammad, Tae-Jin Kim, Prabhakaran Vasantha-Srinivasan
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    Gopalan Rajagopal, Jeyaraj Jeyavani, Sakkanan Ilango
    Pest Management Science.2020; 76(11): 3587.     CrossRef
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    Vika Ichsania Ninditya, Endah Purwati, Ajeng Tyas Utami, Aprillyani Sofa Marwaningtyaz, Nadia Khairunnisa Fairuz, Rini Widayanti, Penny Humaidah Hamid
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    Rajiv Ravi, Dinesh Rajendran, Wen-Da Oh, Mohd Sukhairi Mat Rasat, Zulhazman Hamzah, Intan H. Ishak, Mohamad Faiz Mohd Amin
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    Chinnasamy Ragavendran, Venkatesan Manigandan, Chinnaperumal Kamaraj, Govindasamy Balasubramani, Joy Sebastian Prakash, Pachiappan Perumal, Devarajan Natarajan
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    Raj K. Singh, Kuldeep Dhama, Rekha Khandia, Ashok Munjal, Kumaragurubaran Karthik, Ruchi Tiwari, Sandip Chakraborty, Yashpal S. Malik, Rubén Bueno-Marí
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    Prabhakaran Vasantha-Srinivasan, Muthiah Chellappandian, Sengottayan Senthil-Nathan, Athirstam Ponsankar, Annamalai Thanigaivel, Sengodan Karthi, Edward-Sam Edwin, Selvaraj Selin-Rani, Kandaswamy Kalaivani, Filippo Maggi, Giovanni Benelli
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    Souvic Sarker, Un Taek Lim, Miguel Lopez-Ferber
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  • Mosquito oviposition deterrents
    Essam Abdel-Saalam Shaalan, Deon Vahid Canyon
    Environmental Science and Pollution Research.2018; 25(11): 10207.     CrossRef
  • Suaeda maritima -based herbal coils and green nanoparticles as potential biopesticides against the dengue vector Aedes aegypti and the tobacco cutworm Spodoptera litura
    Udaiyan Suresh, Kadarkarai Murugan, Chellasamy Panneerselvam, Rajapandian Rajaganesh, Mathath Roni, Al Thabiani Aziz, Hatem Ahmed Naji Al-Aoh, Subrata Trivedi, Hasibur Rehman, Suresh Kumar, Akon Higuchi, Angelo Canale, Giovanni Benelli
    Physiological and Molecular Plant Pathology.2018; 101: 225.     CrossRef
  • Orchids as Sources of Novel Nanoinsecticides? Efficacy of Bacillus sphaericus and Zeuxine gracilis-Fabricated Silver Nanoparticles Against Dengue, Malaria and Filariasis Mosquito Vectors
    Kalimuthu Kovendan, Balamurugan Chandramohan, Marimuthu Govindarajan, Arulsamy Jebanesan, Siva Kamalakannan, Savariar Vincent, Giovanni Benelli
    Journal of Cluster Science.2018; 29(2): 345.     CrossRef
  • Impact of Terminalia chebula Retz. against Aedes aegypti L. and non-target aquatic predatory insects
    Annamalai Thanigaivel, Prabhakaran Vasantha-Srinivasan, Sengottayan Senthil-Nathan, Edward-Sam Edwin, Athirstam Ponsankar, Muthiah Chellappandian, Selvaraj Selin-Rani, Jalasteen Lija-Escaline, Kandaswamy Kalaivani
    Ecotoxicology and Environmental Safety.2017; 137: 210.     CrossRef
  • Biocontrol Properties of Basidiomycetes: An Overview
    Subramaniyan Sivanandhan, Ameer Khusro, Michael Paulraj, Savarimuthu Ignacimuthu, Naif AL-Dhabi
    Journal of Fungi.2017; 3(1): 2.     CrossRef
  • Adulticidal, larvicidal, pupicidal and oviposition deterrent activities of essential oil from Zanthoxylum limonella Alston (Rutaceae) against Aedes aegypti (L.) and Culex quinquefasciatus (Say)
    Mayura Soonwera, Siriporn Phasomkusolsil
    Asian Pacific Journal of Tropical Biomedicine.2017; 7(11): 967.     CrossRef
  • Larvicidal and Pupicidal Activities of Alizarin Isolated from Roots of Rubia cordifolia Against Culex quinquefasciatus Say and Aedes aegypti (L.) (Diptera: Culicidae)
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    Arshia Hematpoor, Sook Yee Liew, Wei Lim Chong, Mohd Sofian Azirun, Vannajan Sanghiran Lee, Khalijah Awang, Youjun Zhang
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Predicting 5-Year Survival Status of Patients with Breast Cancer based on Supervised Wavelet Method
Maryam Farhadian, Hossein Mahjub, Jalal Poorolajal, Abbas Moghimbeigi, Muharram Mansoorizadeh
Osong Public Health Res Perspect. 2014;5(6):324-332.   Published online December 31, 2014
DOI: https://doi.org/10.1016/j.phrp.2014.09.002
  • 1,854 View
  • 16 Download
  • 4 Citations
AbstractAbstract PDF
Objectives
Classification of breast cancer patients into different risk classes is very important in clinical applications. It is estimated that the advent of high-dimensional gene expression data could improve patient classification. In this study, a new method for transforming the high-dimensional gene expression data in a low-dimensional space based on wavelet transform (WT) is presented.
Methods
The proposed method was applied to three publicly available microarray data sets. After dimensionality reduction using supervised wavelet, a predictive support vector machine (SVM) model was built upon the reduced dimensional space. In addition, the proposed method was compared with the supervised principal component analysis (PCA).
Results
The performance of supervised wavelet and supervised PCA based on selected genes were better than the signature genes identified in the other studies. Furthermore, the supervised wavelet method generally performed better than the supervised PCA for predicting the 5-year survival status of patients with breast cancer based on microarray data. In addition, the proposed method had a relatively acceptable performance compared with the other studies.
Conclusion
The results suggest the possibility of developing a new tool using wavelets for the dimension reduction of microarray data sets in the classification framework.

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Articles
Surveillance and Vector Control of Lymphatic Filariasis in the Republic of Korea
Shin Hyeong Cho, Da Won Ma, Bo Ra Koo, Hee Eun Shin, Wook Kyo Lee, Byong Suk Jeong, Chaeshin Chu, Won Ja Lee, Hyeng Il Cheun
Osong Public Health Res Perspect. 2012;3(3):145-150.   Published online June 30, 2012
DOI: https://doi.org/10.1016/j.phrp.2012.07.008
  • 2,186 View
  • 12 Download
  • 7 Citations
AbstractAbstract PDF
Objectives
Until the early 2000s, lymphatic filariasis would commonly break out in the coastal areas in Korea. Through steady efforts combining investigation and treatment, filariasis was officially declared eradicated in 2008. This study surveyed the density of vector species of filariasis in past endemic areas, and inspected filariasis DNA from collected mosquitoes for protection against the reemergence of filariasis.
Methods
Between May and October 2009, mosquitoes were caught using the black night trap in past endemic coastal areas: Gyeongsangnam-do, Jeollanamdo, and Jeju-do. The collected mosquitoes were identified, and the extracted DNA from the collected vector mosquitoes was tested by polymerase chain reaction for Brugia malayi filariasis.
Results
Ochletotatus togoi, Anophel es (Hyrcanus) group and Culex pipiens were most frequently caught in Jeollanam-do (Geomun Island, Bogil Island, Heuksan Island), Jeju-do (Namone-ri, Wimi-ri). and Gyeongsangnam-do (Maemul Island). DNA of B malayi was not found in Och Togoi and An (Hyrcanus) group as main vectors of filariasis.
Conclusion
Lymphatic filariasis was not found in the vector mosquitoes collected in past endemic areas. However, considering that the proportion of vector species is quite high, there is a potential risk that filariasis could be reemerging through overseas travel or trade. Thus, there is a need to continuously monitor vector mosquitoes of lymphatic filariasis.

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Review Article
The Effect of Global Warming on Infectious Diseases
Ichiro Kurane
Osong Public Health Res Perspect. 2010;1(1):4-9.   Published online December 31, 2010
DOI: https://doi.org/10.1016/j.phrp.2010.12.004
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  • 21 Download
  • 46 Citations
AbstractAbstract PDF
Global warming has various effects on human health. The main indirect effects are on infectious diseases. Although the effects on infectious diseases will be detected worldwide, the degree and types of the effect are different, depending on the location of the respective countries and socioeconomical situations.Among infectious diseases, water- and foodborne infectious diseases and vector-borne infectious diseases are two main categories that are forecasted to be most affected. The effect on vector-borne infectious diseases such as malaria and dengue fever is mainly because of the expansion of the infested areas of vector mosquitoes and increase in the number and feeding activity of infected mosquitoes. There will be increase in the number of cases with water- and foodborne diarrhoeal diseases.Even with the strongest mitigation procedures, global warming cannot be avoided for decades. Therefore, implementation of adaptation measures to the effect of global warming is the most practical action we can take. It is generally accepted that the impacts of global warming on infectious diseases have not been apparent at this point yet in East Asia. However, these impacts will appear in one form or another if global warming continues to progress in future. Further research on the impacts of global warming on infectious diseases and on future prospects should be conducted.

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PHRP : Osong Public Health and Research Perspectives