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Seroprevalence of Brucellosis in Human Immunodeficiency Virus Infected Patients in Hamadan, Iran
Fariba Keramat, Mohammad Mehdi Majzobi, Jalal Poorolajal, Zohreh Zarei Ghane, Maryam Adabi
Osong Public Health Res Perspect. 2017;8(4):282-288.   Published online August 31, 2017
  • 3,719 View
  • 23 Download
  • 4 Crossref
AbstractAbstract PDF

Brucellosis is a systemic disease with a wide spectrum of clinical manifestations. This study aimed to determine the seroprevalence of brucellosis in human immunodeficiency virus (HIV) infected patients in Hamadan Province in the west of Iran.


A total of 157 HIV-infected patients were screened through standard serological tests, including Wright’s test, Coombs’ Wright test, and 2-mercaptoethanol Brucella agglutination test (2ME test), blood cultures in Castaneda media, and CD4 counting. Data were analyzed using Stata version 11.


Wright and Coombs’ Wright tests were carried out, and only 5 (3.2%) patients had positive serological results. However, all patients had negative 2ME results, and blood cultures were negative for Brucella spp. Moreover, patients with positive serology and a mean CD4 count of 355.8 ± 203.11 cells/μL had no clinical manifestations of brucellosis, and, and the other patients had a mean CD4 count of 335.55 ± 261.71 cells/μL.


Results of this study showed that HIV infection is not a predisposing factor of acquiring brucellosis.


Citations to this article as recorded by  
  • A case of brucellosis concomitant with HIV infection in China
    Shuai-Bing Dong, Li-Ping Wang, Chao-Xue Wu, Fan Li, Yong Yue, Dong-Ri Piao, Hong-Yan Zhao, Hai Jiang
    Infectious Diseases of Poverty.2020;[Epub]     CrossRef
  • Investigation of Linc-MAF-4 expression as an effective marker in brucellosis
    Reza Gheitasi, Fariba Keramat, Ghasem Solgi, Mehrdad Hajilooi
    Molecular Immunology.2020; 123: 60.     CrossRef
  • Human Brucellosis: Risks and Prevalence among Iranian Blood Donors Residing in Endemic Areas
    Maryam Zadsar, Mohammad Reza Shirzadi, Mohammad Zeynali, Mahboubeh Rasouli, Gharib Karimi
    Transfusion Medicine and Hemotherapy.2020; 47(2): 103.     CrossRef
  • Prevalence and risk factors of brucellosis among febrile patients attending a community hospital in south western Uganda
    Richard Migisha, Dan Nyehangane, Yap Boum, Anne-Laure Page, Amaia Zúñiga-Ripa, Raquel Conde-Álvarez, Fred Bagenda, Maryline Bonnet
    Scientific Reports.2018;[Epub]     CrossRef
Serological Detection of Lyme Borreliosis Agents in Patients From Korea, 2005–2009
Sang-Hee Park, Kyu-Jam Hwang, Hyuk Chu, Mi-Yeoun Park
Osong Public Health Res Perspect. 2011;2(1):29-33.   Published online June 30, 2011
  • 3,166 View
  • 17 Download
  • 13 Crossref
AbstractAbstract PDF
Laboratory tests are now being used to identify seropositive cases in patients suspected of having a Lyme borreliosis (LB) infection. From 2005 to 2009, we analyzed the serological and epidemiological characteristics of 53 LB positive cases in Korea using immunoblot assay.
During the five-year study period, a total of 1897 serum samples from suspected LB cases were referred to us for further laboratory diagnosis. The bacterial strains Borrelia afzeli pKo, Borrelia garinii 935T and Borrelia burgdorferi B31 were used for indirect immunofluorescent antibody assay. Immunoblot assay was performed using the recomBlot Borrelia.
Based on the information from the clinicians, the main symptoms of LB infection were rash and fever (66.0%), neurological symptoms (30.2%), and arthritis (5.7%). Of the 53 cases, 16 (30.2%) were infected abroad and the remaining 37 cases (69.8%) were suspected to have been infected in Korea. Immunoblot assays detected high levels of the antigens p41 (FlaB) of B. burgdorferi and OspC of B. garinii in infected samples.
The causative bacteria of LB were not isolated from humans yet but from vector ticks and rodents in Korea, and a few cases were reported with serological diagnosis. Our results suggest that LB is present in all areas of Korea and indicate that B. garinii and B. burgdorferi may be the predominant bacteria in patients with LB. However, further studies are needed to isolate and identify the causative bacteria for LB in patients.


Citations to this article as recorded by  
  • Surveillance and Molecular Identification ofBorreliaSpecies in Ticks Collected at U.S. Army Garrison Humphreys, Republic of Korea, 2018–2019
    Seung-Ho Lee, Sung-Tae Chong, Heung-Chul Kim, Terry A Klein, Kyungmin Park, Jingyeong Lee, Jeong-Ah Kim, Won-Keun Kim, Jin-Won Song, Sarah Hamer
    Journal of Medical Entomology.2022; 59(1): 363.     CrossRef
  • Seroepidemiologic Survey of Lyme Disease among Forestry Workers in National Park Offices in South Korea
    Dilaram Acharya, Ji-Hyuk Park
    International Journal of Environmental Research an.2021; 18(6): 2933.     CrossRef
  • Molecular Identification of Borrelia spp. from Ticks in Pastures Nearby Livestock Farms in Korea
    Haeseung Lee, Seung-Hun Lee, SungShik Shin, Dongmi Kwak
    Insects.2021; 12(11): 1011.     CrossRef
  • A case of Henoch-Schönlein purpura associated with scrub typhus
    Jae Hyoung Im, Suk Jin Choi, Moon-Hyun Chung, Seung Yun Lee, Young Kyoung Park, Hea Yoon Kwon, Ji Hyeon Baek, Jin-Soo Lee
    BMC Infectious Diseases.2020;[Epub]     CrossRef
  • Geographical Distribution of Borrelia burgdorferi sensu lato in Ticks Collected from Wild Rodents in the Republic of Korea
    Seong Yoon Kim, Tae-Kyu Kim, Tae Yun Kim, Hee Il Lee
    Pathogens.2020; 9(11): 866.     CrossRef
  • Molecular Detection and Characterization of Borrelia garinii (Spirochaetales: Borreliaceae) in Ixodes nipponensis (Ixodida: Ixodidae) Parasitizing a Dog in Korea
    Seung-Hun Lee, Youn-Kyoung Goo, Paul John L. Geraldino, Oh-Deog Kwon, Dongmi Kwak
    Pathogens.2019; 8(4): 289.     CrossRef
  • Development of a borreliosis assay: Mannan coated polyethylene sinter bodies as a new platform technology
    Mohammed Alasel, Nina Dassinger, Doru Vornicescu, Michael Keusgen
    Analytical Biochemistry.2018; 543: 55.     CrossRef
  • Promising alternatives for one-tier testing of Lyme borreliosis
    Mohammed Alasel, Michael Keusgen
    Clinica Chimica Acta.2018; 479: 148.     CrossRef
  • Borrelia Species Detected in Ticks Feeding on Wild Korean Water Deer (Hydropotes inermis) Using Molecular and Genotypic Analyses
    D. VanBik, S. H. Lee, M. G. Seo, B. R. Jeon, Y. K. Goo, S. J. Park, M. H. Rhee, O. D. Kwon, T. H. Kim, P.J.L. Geraldino, D. Kwak
    Journal of Medical Entomology.2017; 54(5): 1397.     CrossRef
  • Detection of SFTS Virus inIxodes nipponensisandAmblyomma testudinarium(Ixodida: Ixodidae) Collected From Reptiles in the Republic of Korea
    Jae-Hwa Suh, Heung-Chul Kim, Seok-Min Yun, Jae-Won Lim, Jin-Han Kim, Sung-Tae Chong, Dae-Ho Kim, Hyun-Tae Kim, Hyun Kim, Terry A. Klein, Jaree L. Johnson, Won-Ja Lee
    Journal of Medical Entomology.2016; 53(3): 584.     CrossRef
  • Epidemiological Features and Clinical Manifestations of Lyme Borreliosis in Korea during the Period 2005^|^ndash;2012
    Shinje Moon, Yeongseon Hong, Kyu-Jam Hwang, Suyeon Kim, Jihye Eom, Donghyok Kwon, Ji-Hyuk Park, Seung-Ki Youn, Aeree Sohn
    Japanese Journal of Infectious Diseases.2015; 68(1): 1.     CrossRef
  • Autochthonous Lyme Borreliosis in Humans and Ticks in Korea
    Shinje Moon, Jin Gwack, Kyu Jam Hwang, Donghyuk Kwon, Suyeon Kim, Yoontae Noh, Jongyul Roh, E-hyun Shin, Kyungjin Jeong, Wonseok Seok, Seung-Ki Youn
    Osong Public Health and Research Perspectives.2013; 4(1): 52.     CrossRef
  • The Road Less Traveled
    Chaeshin Chu
    Osong Public Health and Research Perspectives.2011; 2(1): 1.     CrossRef

PHRP : Osong Public Health and Research Perspectives