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Brief Report
The laboratory test procedure to confirm rotavirus vaccine infection in severe complex immunodeficiency patients
Su-Jin Chae, Seung-Rye Cho, Wooyoung Choi, Myung-Guk Han, Deog-Yong Lee
Osong Public Health Res Perspect. 2021;12(4):269-273.   Published online August 13, 2021
DOI: https://doi.org/10.24171/j.phrp.2021.0079
  • 2,615 View
  • 65 Download
AbstractAbstract PDF
The rotavirus vaccine is a live vaccine, and there is a possibility of infection by the virus strain used in the vaccine. We investigated the process of determining whether an infection was caused by the vaccine strain in a severe complex immunodeficiency (SCID) patient with rotavirus infection. The patient was vaccinated with RotaTeq prior to being diagnosed with SCID. The testing process was conducted in the following order: confirming rotavirus infection, determining its genotype, and confirming the vaccine strain. Rotavirus infection was confirmed through enzyme immunoassay and VP6 gene detection. G1 and P[8] were identified by multiplex polymerase chain reaction for the genotype, and G3 was further identified using a single primer. By detecting the fingerprint gene (WC3) of RotaTeq, it was confirmed that the detected virus was the vaccine strain. Genotypes G1 and P[8] were identified, and the infection was suspected of having been caused by rotavirus G1P[8]. G1P[8] is the most commonly detected genotype worldwide and is not included in the recombinant strains used in vaccines. Therefore, the infection was confirmed to have been caused by the vaccine strain by analyzing the genetic relationship between VP4 and VP7. Rotavirus infection by the vaccine strain can be identified through genotyping and fingerprint gene detection. However, genetic linkage analysis will also help to identify vaccine strains.
Original Article
Diversity of Rotavirus Strain Circulated in Gwangju, Republic of Korea
Min Ji Kim, Hye Sook Jeong, Seon Gyeong Kim, Se Mi Lee, Sun Hee Kim, Hye-Young Kee, Eun-hye Jo, Hye-jung Park, Dong-Ryong Ha, Eun Sun Kim, Kye-Won Seo, Jae Keun Chung
Osong Public Health Res Perspect. 2014;5(6):364-369.   Published online December 31, 2014
DOI: https://doi.org/10.1016/j.phrp.2014.10.004
  • 2,146 View
  • 18 Download
  • 3 Citations
AbstractAbstract PDF
Objectives
The introduction of new rotavirus vaccines into the public sphere makes it necessary to maintain constant surveillance and to heighten public awareness of the appearance of new rotavirus strains. We describe the molecular epidemiology of circulating rotavirus strains after vaccine introduction.
Methods
We collected a total of 1070 stool samples from children with gastroenteritis from January 2013 to June 2013. The antigenic prevalence of rotavirus group A was distinguished using enzyme immunoassay. The G and P genotypes of enzyme immunoassay-positive samples were determined with reverse transcription-polymerase chain reaction and nucleotide sequencing analysis.
Results
Of the 1070 samples collected, 277 (25.9%) tested positive for rotaviruses by enzyme-linked immunoabsorbent assay. The most prevalent circulating genotype G was G1 (51.3%), followed by G2 (34.7%) and G9 (10.8%). The predominant type of genotype P was P[8] (66.1%), followed by P[4] (31.4%). In this study, nine genotypes were found. G1P[8] was the most prevalent (51.8%), followed by G2P[4] (30.5%), G9P[8] (9.9%), and G2P[8] (4.0%). Several unusual combinations (G1P[4], G3P[9], G3P[8], G4P[6], and G9P[4]) were also identified.
Conclusion
Molecular epidemiological knowledge of rotaviruses is critical for the development of effective preventive measures, including vaccines. These data will help us monitor the effectiveness of current rotavirus vaccines.

Citations

Citations to this article as recorded by  
  • Rotavirus infection among hospitalized children under five years of age with acute watery diarrhea in Sri Lanka
    Paba Palihawadana, Gagandeep Kang, Janakan Navaratnasingam, Geethani Galagoda, Janaki Abeynayake, Madhava Gunasekera, Shilanthi Seneviratne
    Vaccine.2018; 36(51): 7846.     CrossRef
  • Complete genome sequence analysis of rare G4P[6] rotavirus strains from human and pig reveals the evidence for interspecies transmission
    Rungnapa Malasao, Pattara Khamrin, Kattareeya Kumthip, Hiroshi Ushijima, Niwat Maneekarn
    Infection, Genetics and Evolution.2018; 65: 357.     CrossRef
  • Post-marketing safety surveillance conducted in Korea (2008–2013) following the introduction of the rotavirus vaccine, RIX4414 (Rotarix™)
    Son Moon Shin, Chun Soo Kim, Naveen Karkada, Aixue Liu, Girish Jayadeva, Htay Htay Han
    Human Vaccines & Immunotherapeutics.2016; 12(10): 2590.     CrossRef
Articles
Phylogenetic Analysis of the Rotavirus Genotypes Originated from Children < 5 Years of Age in 16 Cities in South Korea, between 2000 and 2004
Ho-Kyung Oh, Seung-Hwa Hong, Byung-Yoon Ahn, Hye-Kyoung Min
Osong Public Health Res Perspect. 2012;3(1):36-42.   Published online December 31, 2011
DOI: https://doi.org/10.1016/j.phrp.2012.01.006
  • 1,824 View
  • 16 Download
  • 6 Citations
AbstractAbstract PDF
Objectives
The purpose of this study was to examine the diversity of the G and P types of human rotavirus strains isolated in South Korea during 2000 to 2004.
Methods
We selected 38 Group A rotavirus isolates among 652 fecal samples, which were collected from infants and children < 5 years of age with acute gastroenteritis or diarrhea admitted in 8 hospitals representative of five provinces of South Korea between 2000 and 2004. Rotavirus P- and G-genotypes were determined by nucleotide sequencing and phylogenetic analysis was performed.
Results
One G1P[4] consisted G1-Id-P[4]-V; one G1P[6] consisted G1-Id-P[6]-Ia; nine G1P[8] consisted G1-Ib-P[8]-Ia (n=3), G1-Ic-P[8]-Ia (n=1), and G1-Id-P[8]-Ia (n=5); 13 G2P[4] consisted G2-V-P[4]-V; two G3P[4] consisted G3-IIId-P[4]-V; five G3P[8] consisted G3-IIId-P[8]-Ia; four G4P[6] consisted G4-Ie-P[6]-Ia; two G4P[8] consisted G4-Ie-P[8]-II; one G9P[6] consisted G9-III-P[6]-Ia.
Conclusions
A considerable amount of rotavirus genotypic diversity was detected in South Korea from 2000 to 2004. These findings are important to develop the effective vaccines and to undertake epidemiologic studies.

Citations

Citations to this article as recorded by  
  • Long-term monitoring of G1P[8] rotaviruses circulating without vaccine pressure in Nizhny Novgorod, Russia, 1984-2019
    N. A. Novikova, T. A. Sashina, N. V. Epifanova, A. U. Kashnikov, O. V. Morozova
    Archives of Virology.2020; 165(4): 865.     CrossRef
  • Prevalence, risk factors, and clinical characteristics of rotavirus and adenovirus among Lebanese hospitalized children with acute gastroenteritis
    Rasha Zaraket, Ali Salami, Marwan Bahmad, Ali El Roz, Batoul Khalaf, Ghassan Ghssein, Hisham F. Bahmad
    Heliyon.2020; 6(6): e04248.     CrossRef
  • Prevalence and Genotypic Distribution of Rotavirus in Thailand: A Multicenter Study
    Pimmada Sakpaisal, Sasikorn Silapong, Amara Yowang, Gaysorn Boonyasakyothin, Boonyaorn Yuttayong, Umaporn Suksawad, Siriporn Sornsakrin, Paphavee Lertsethtakarn, Ladaporn Bodhidatta, John M. Crawford, Carl J. Mason
    The American Journal of Tropical Medicine and Hyg.2019; 100(5): 1258.     CrossRef
  • Monitoring Shedding of Five Genotypes of RotaTeq Vaccine Viruses by Genotype-Specific Real-Time Reverse Transcription-PCR Assays
    Yuki Higashimoto, Masaru Ihira, Yu Miyazaki, Ayumi Kuboshiki, Sayaka Yoshinaga, Hiroyuki Hiramatsu, Ryota Suzuki, Masafumi Miyata, Hiroki Miura, Satoshi Komoto, Jun Yukitake, Koki Taniguchi, Yoshiki Kawamura, Tetsushi Yoshikawa, Yi-Wei Tang
    Journal of Clinical Microbiology.2018;[Epub]     CrossRef
  • Molecular analysis of group A rotaviruses detected in hospitalized children from Rawalpindi, Pakistan during 2014
    Massab Umair, Bilal Haider Abbasi, Nadia Nisar, Muhammad Masroor Alam, Salmaan Sharif, Shahzad Shaukat, Muhammad Suleman Rana, Adnan Khurshid, Ghulam Mujtaba, Uzma Bashir Aamir, Syed Sohail Zahoor Zaidi
    Infection, Genetics and Evolution.2017; 53: 160.     CrossRef
  • Analysis of rotavirus genotypes in Korea during 2013: An increase in the G2P[4] genotype after the introduction of rotavirus vaccines
    Jae-Seok Kim, Hyun Soo Kim, Jungwon Hyun, Han-Sung Kim, Wonkeun Song, Kyu Man Lee, Seon-Hee Shin
    Vaccine.2014; 32(48): 6396.     CrossRef

PHRP : Osong Public Health and Research Perspectives