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Original Article
Anti-Human Rhinovirus 1B Activity of Dexamethasone viaGCR-Dependent Autophagy Activation
Jae-Sug Lee, Seong-Ryeol Kim, Jae-Hyoung Song, Yong-Pyo Lee, Hyun-Jeong Ko
Osong Public Health Res Perspect. 2018;9(6):334-339.   Published online December 31, 2018
DOI: https://doi.org/10.24171/j.phrp.2018.9.6.07
  • 4,803 View
  • 63 Download
  • 4 Crossref
AbstractAbstract PDF
Objectives

Human rhinoviruses (HRVs) are the major cause of the common cold. Currently there is no registered, clinically effective, antiviral chemotherapeutic agent to treat diseases caused by HRVs. In this study, the antiviral activity of dexamethasone (DEX) against HRV1B was examined.

Methods

The anti–HRV1B activity of DEX was assessed by sulforhodamine B assay in HeLa cells, and by RT-PCR in the lungs of HRV1B-infected mice. Histological evaluation of HRV1B-infected lungs was performed and a histological score was given. Anti-HRV1B activity of DEX via the glucocorticoid receptor (GCR)-dependent autophagy activation was assessed by blocking with chloroquine diphosphate salt or bafilomycin A1 treatment.

Results

In HRV1B-infected HeLa cells, treatment with DEX in a dose-dependent manner, resulted in a cell viability of > 70% indicating that HRV1B viral replication was reduced by DEX treatment. HRV1B infected mice treated with DEX, had evidence of reduced inflammation and a moderate histological score. DEX treatment showed antiviral activity against HRV1B via GCR-dependent autophagy activation.

Conclusion

This study demonstrated that DEX treatment showed anti-HRV1B activity via GCR-dependent autophagy activation in HeLa cells and HRV1B infected mice. Further investigation assessing the development of topical formulations may enable the development of improved DEX effectiveness.

Citations

Citations to this article as recorded by  
  • Intracellular translocation of HMGB1 is important for Zika virus replication in Huh7 cells
    Kim-Ling Chin, Nurhafiza Zainal, Sing-Sin Sam, Pouya Hassandarvish, Rafidah Lani, Sazaly AbuBakar
    Scientific Reports.2022;[Epub]     CrossRef
  • Pharmacological Modulators of Autophagy as a Potential Strategy for the Treatment of COVID-19
    Gustavo José da Silva Pereira, Anderson Henrique França Figueredo Leão, Adolfo Garcia Erustes, Ingrid Beatriz de Melo Morais, Talita Aparecida de Moraes Vrechi, Lucas dos Santos Zamarioli, Cássia Arruda Souza Pereira, Laís de Oliveira Marchioro, Letícia P
    International Journal of Molecular Sciences.2021; 22(8): 4067.     CrossRef
  • MSTN Attenuates Cardiac Hypertrophy through Inhibition of Excessive Cardiac Autophagy by Blocking AMPK /mTOR and miR-128/PPARγ/NF-κB
    Hanping Qi, Jing Ren, Lina Ba, Chao Song, Qianhui Zhang, Yonggang Cao, Pilong Shi, Bowen Fu, Yongsheng Liu, Hongli Sun
    Molecular Therapy - Nucleic Acids.2020; 19: 507.     CrossRef
  • Autophagy Augmentation to Alleviate Immune Response Dysfunction, and Resolve Respiratory and COVID-19 Exacerbations
    Garrett Pehote, Neeraj Vij
    Cells.2020; 9(9): 1952.     CrossRef
Brief Reports
In Vitro Antiviral Activity of Sakuranetin against Human Rhinovirus 3
Hwa-Jung Choi
Osong Public Health Res Perspect. 2017;8(6):415-420.   Published online December 31, 2017
DOI: https://doi.org/10.24171/j.phrp.2017.8.6.09
  • 3,887 View
  • 46 Download
  • 21 Crossref
AbstractAbstract PDF
Objectives

Rhinoviruses (RVs) cause common cold and are associated with exacerbation of chronic inflammatory respiratory diseases. Until now, no clinically effective antiviral chemotherapeutic agents to treat diseases caused by human rhinoviruses (HRVs) have been reported. We assessed the anti-HRV3 activity of sakuranetin isolated from Sorbus commixta Hedl. in human epithelioid carcinoma cervix (HeLa) cells, to evaluate its anti-rhinoviral potential in the clinical setting.

Methods

Antiviral activity and cytotoxicity as well as the effect of sakuranetin on HRV3-induced cytopathic effects (CPEs) were evaluated using the sulforhodamine B (SRB) method using CPE reduction. The morphology of HRV3-infected cells was studied using a light microscope.

Results

Sakuranetin actively inhibited HRV3 replication and exhibited antiviral activity of more than 67% without cytotoxicity in HeLa cells, at 100 μg/mL. Ribavirin showed anti-HRV3 activity similar to that of sakuranetin. Treatment of HRV-infected HeLa cells with sakuranetin visibly reduced CPEs.

Conclusion

The inhibition of HRV production by sakuranetin is mainly due to its general antioxidant activity through inhibition of viral adsorption. Therefore, the antiviral activity of sakuranetin should be further investigated to elucidate its mode of action and prevent HRV3-mediated diseases in pathological conditions.

Citations

Citations to this article as recorded by  
  • Interaction of sakuranetin with unsaturated lipids forming Langmuir monolayers at the air-water interface: A biomembrane model
    Matheus Lima de Souza, André Campos Machado, Henrique Barbosa, João Henrique Ghilardi Lago, Luciano Caseli
    Colloids and Surfaces B: Biointerfaces.2024; 234: 113747.     CrossRef
  • Sakuranetin and its therapeutic potentials – a comprehensive review
    Md. Junaid, Bristy Basak, Yeasmin Akter, Syeda Samira Afrose, Afsana Nahrin, Rashiduzzaman Emran, Md. Shahinozzaman, Shinkichi Tawata
    Zeitschrift für Naturforschung C.2023; 78(1-2): 27.     CrossRef
  • Comparative metabolomics of flavonoids in twenty vegetables reveal their nutritional diversity and potential health benefits
    Han Tao, Yao Zhao, Linying Li, Yuqing He, Xueying Zhang, Ying Zhu, Gaojie Hong
    Food Research International.2023; 164: 112384.     CrossRef
  • Rice Phytoalexins: Half a Century of Amazing Discoveries; Part I: Distribution, Biosynthesis, Chemical Synthesis, and Biological Activities
    Alessio Valletta, Lorenzo Maria Iozia, Laura Fattorini, Francesca Leonelli
    Plants.2023; 12(2): 260.     CrossRef
  • Ethanolamine phospholipids at the air-water interface as cell membranes models of microorganisms to study the nanotoxicology of sakuranetin
    Guilherme Henrique da Cruz Ramos Pires, Henrique Barbosa, Roberto Baptista Pereira Almeida, João Henrique Ghilardi Lago, Luciano Caseli
    Thin Solid Films.2023; 770: 139768.     CrossRef
  • Antiviral Activity of Flavonoids Against Non-polio Enteroviruses
    Hwa-Jung Choi
    Journal of Bacteriology and Virology.2023; 53(1): 29.     CrossRef
  • Novel anti‑hepatitis B virus flavonoids sakuranetin and velutin fromRhus retinorrhoea
    Sarfaraz Ahmed, Mohammad Parvez, Mohammed Al‑Dosari, Mazin Abdelwahid, Tawfeq Alhowiriny, Adnan Al‑Rehaily
    Molecular Medicine Reports.2023;[Epub]     CrossRef
  • Antiviral Activity of Flavonoids from Geopropolis of the Brazilian Jandaira Bee against Zika and Dengue Viruses
    Poliana Gomes da Silva, Elton José Ferreira Chaves, Tania Maria Sarmento Silva, Gerd Bruno Rocha, Willyenne Marília Dantas, Ronaldo Nascimento de Oliveira, Lindomar José Pena
    Pharmaceutics.2023; 15(10): 2494.     CrossRef
  • Metabolic engineering in Streptomyces albidoflavus for the biosynthesis of the methylated flavonoids sakuranetin, acacetin, and genkwanin
    Álvaro Pérez-Valero, Suhui Ye, Patricia Magadán-Corpas, Claudio J. Villar, Felipe Lombó
    Microbial Cell Factories.2023;[Epub]     CrossRef
  • Antiviral Activity of Quercetin-3-Glucoside Against Non-Polio Enterovirus
    Hwa-Jung Choi
    Journal of Bacteriology and Virology.2022; 52(1): 20.     CrossRef
  • Sakuranetin interacting with cell membranes models: Surface chemistry combined with molecular simulation
    Guilherme Henrique da Cruz Ramos Pires, Vitor Torres Freire, Rafael Guimarães Pereira, Leonardo José Amaral de Siqueira, Eric Umehara, João Henrique Ghilardi Lago, Luciano Caseli
    Colloids and Surfaces B: Biointerfaces.2022; 216: 112546.     CrossRef
  • Production of (2S)-sakuranetin from (2S)-naringenin in Escherichia coli by strengthening methylation process and cell resistance
    Qiumeng Sun, Song Gao, Shiqin Yu, Pu Zheng, Jingwen Zhou
    Synthetic and Systems Biotechnology.2022; 7(4): 1117.     CrossRef
  • Sakuranetin State of the Art: Physical Properties, Biological Effects, and Biotechnological Trends
    Leonardo Ribeiro Bernardo, Anna Rafaela Cavalcante Braga
    Industrial Biotechnology.2022; 18(6): 341.     CrossRef
  • Stevia Genus: Phytochemistry and Biological Activities Update
    Jimena Borgo, Laura C. Laurella, Florencia Martini, Cesar A. N. Catalán, Valeria P. Sülsen
    Molecules.2021; 26(9): 2733.     CrossRef
  • Phytochemistry and teratogenic potential of Mimosa tenuiflora (willd.) poir. (Fabaceae) in ruminants: A systematic review
    José Jailson Lima Bezerra, Anderson Angel Vieira Pinheiro, Ricardo Barbosa Lucena
    Toxicon.2021; 195: 78.     CrossRef
  • DO WE KNOW RHINOVIRUSES AND THEIR CLINICAL IMPACT?
    Irina Georgieva, Asya Stoyanova, Svetla Angelova, Savina Stoitsova, Silvia Voleva, Neli Korsun, Lubomira Nikolaeva-Glomb
    PROBLEMS of Infectious and Parasitic Diseases.2021; 49(1): 5.     CrossRef
  • Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71)
    Salima Lalani, Chit Laa Poh
    Viruses.2020; 12(2): 184.     CrossRef
  • A Review on Sources and Pharmacological Aspects of Sakuranetin
    Monika Stompor
    Nutrients.2020; 12(2): 513.     CrossRef
  • Ethnopharmacologically important but underestimated genus Sorbus: a comprehensive review
    Agnieszka Sołtys, Agnieszka Galanty, Irma Podolak
    Phytochemistry Reviews.2020; 19(2): 491.     CrossRef
  • The Sorbus spp.—Underutilised Plants for Foods and Nutraceuticals: Review on Polyphenolic Phytochemicals and Antioxidant Potential
    Viive Sarv, Petras Rimantas Venskutonis, Rajeev Bhat
    Antioxidants.2020; 9(9): 813.     CrossRef
  • Suppression of influenza B virus replication by sakuranetin and mode of its action
    Dur‐Han Kwon, Jeong‐Hun Ji, Soon‐Ho Yim, Byoung‐Soo Kim, Hwa‐Jung Choi
    Phytotherapy Research.2018; 32(12): 2475.     CrossRef
Evaluation of Antiviral Activity of Zanthoxylum Species Against Picornaviruses
Hwa-Jung Choi
Osong Public Health Res Perspect. 2016;7(6):400-403.   Published online December 31, 2016
DOI: https://doi.org/10.1016/j.phrp.2016.11.003
  • 2,576 View
  • 19 Download
  • 16 Crossref
AbstractAbstract PDF
Human rhinoviruses and enteroviruses (family Picornaviridae) infect millions of people worldwide each year, but little is known about effective therapeutical treatment for the infection caused by these viruses. We sought to determine whether or not Zanthoxylum (Rutaceae) species can exhibit antiviral activity against picornaviruses. The leaf parts of four Zanthoxylum species were extracted with methanol, and the extracts were investigated for their antiviral activity against picornaviruses using cytopathic effects by cytopathic effect reduction. Leaf extracts of Zanthoxylum piperitum among four Zanthoxylum species were found to possess only broad-spectrum antipicornavirus activity against human rhninovirus 2 with a 50% inhibitory concentration (IC50) value of 59.48 μg/mL, human rhinovirus 3 with an IC50 value of 39.94 μg/mL, coxsackie A16 virus with an IC50 value of 45.80 μg/mL, coxsackie B3 virus with an IC50 value of 68.53 μg/mL, coxsackie B4 virus with an IC50 value of 93.58 μg/mL, and enterovirus 71 virus with an IC50 value of 4.48 μg/mL. However, ribavirin did not possess antiviral activity against human rhinovirus 3 and four enteroviruses. Therefore, leaves of Z. piperitum showed broad-spectrum antipicornavirus activity, and may be useful as a candidate for studying picornavirus agents and development of pharmaceuticals.

Citations

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  • A mini review on the prospects of Fagara zanthoxyloides extract based composites: a remedy for COVID-19 and associated replica?
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    Physical Sciences Reviews.2023;[Epub]     CrossRef
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    Chang-Seob Seo
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    Falah Saleh Mohammed, İmran Uysal, Mustafa Sevindik
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PHRP : Osong Public Health and Research Perspectives