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Original Article
How Should Biobanks Collect Biosamples for Clinical Application? A 20-year Biomarker-related Publication and Patent Trend Analysis
Jae-Eun Lee
Osong Public Health Res Perspect. 2018;9(3):105-111.   Published online June 30, 2018
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  • 4 Citations
AbstractAbstract PDF

This study was designed to analyze biomarker-related publications and patent trends which biobanks could consider in planning biosample collections for biomarker research.


Publications and patents containing the term “biomarker” in the title published between 1998 to 2017 were retrieved using Scopus database and Google Patents search engine.


Over the last 20 years there has been a steady increase in biomarker-related publications and patents; however this has slowed for patents over the last few years. Publications in 2017 that contained blood, serum, and plasma search terms in the abstract accounted for 50%, and serum as a search term in the title and abstract was more numerous than those containing blood, plasma, tissue, or urine. Blood-related patents were the most common patent in the last 10 years, and accounted for 110 patents in 2017. Biomarker-related publications since 2010 containing RNA and protein search terms in the title and abstract, were more numerous than those containing DNA and metabolite search terms. More than 27% of biomarker-related publications in 2017 and 21% of biomarker-related patents were associated with cancer.


The results of this study will help biobanks establish a biosample collection strategy for clinical application.


Citations to this article as recorded by  
  • Nanodiamond Solid-Phase Extraction and Triton X-114 Cloud Point Separation for Robust Fractionation and Shotgun Proteomics Analysis of the Human Serum Proteome
    Hai Lam Khuong, Chein-Hung Chen, Jung-Lee Lin, Trong-Nghia Le, Thi Hue Pham, Thi Bich Thao Le, Xuan Canh Nguyen, Van Chi Phan, Hoang Ha Chu, Wesley Wei-Wen Hsiao, Thi Minh Phuong Nguyen, Dinh Minh Pham
    Journal of Proteome Research.2022; 21(1): 67.     CrossRef
  • Sampling strategies to evaluate the prognostic value of a new biomarker on a time-to-event end-point
    Francesca Graziano, Maria Grazia Valsecchi, Paola Rebora
    BMC Medical Research Methodology.2021;[Epub]     CrossRef
  • MicroRNA-181b Serves as a Circulating Biomarker and Regulates Inflammation in Heart Failure
    Hongxiao Yang, Lina Shan, Yunan Gao, Lin Li, Guifen Xu, Bin Wang, Xiaoxue Yin, Chengfang Gao, Jiaren Liu, Wei Yang, Gaetano Isola
    Disease Markers.2021; 2021: 1.     CrossRef
  • Enhancing Cooperation Between Academic Biobanks and Biomedical Industry: Better Mutual Understanding and New Collaborative Models Are Needed
    Daniel Simeon-Dubach, Michael H. Roehrl, Paul Hofman, Pascal Puchois
    Biopreservation and Biobanking.2020; 18(2): 144.     CrossRef

PHRP : Osong Public Health and Research Perspectives