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Original Articles
Yes-associated protein 1 as a prognostic biomarker and its correlation with telomerase in various cancers
Hye-Ran Kim, Choong-Won Seo, Keunje Yoo, Sang Jun Han, Jongwan Kim
Osong Public Health Res Perspect. 2021;12(5):324-332.   Published online September 17, 2021
DOI: https://doi.org/10.24171/j.phrp.2021.0207
  • 5,359 View
  • 98 Download
AbstractAbstract PDFSupplementary Material
Objectives
The aims of this study were to investigate the expression of Yes-associated protein 1 (YAP1), its prognostic significance, and the correlation between YAP1 and telomerase in various cancers.
Methods
The Gene Expression Profiling Interactive Analysis database was used to analyze RNA sequencing data and the survival rate of patients with various cancers in The Cancer Genome Atlas (TCGA) database. PrognoScan was used to analyze the prognostic value of YAP1 expression in various cancers. Tumor Immune Estimation Resource was used to determine the correlation between YAP1 expression and telomerase in various cancer types based on TCGA data.
Results
The analysis suggested that YAP1 was differentially expressed between tissues of various cancers and non-tumor tissues. High YAP1 expression was also related to a poor prognosis in adrenocortical carcinoma, bladder urothelial carcinoma, and pancreatic adenocarcinoma. Moreover, YAP1 expression was correlated with the expression of telomerase reverse transcriptase and telomerase RNA component in various cancer types.
Conclusion
These results suggest that YAP1 is a potential biomarker with prognostic significance and relevance for oncogene research in various cancer types. The correlation between the expression of YAP1 and telomere-associated genes will help to understand their cancer-promoting mechanisms and interactions.
Validity and reliability of the Health-Related Quality of Life Instrument with 8 Items (HINT-8) in Korean breast cancer patients
Juyoung Kim, Min-Woo Jo, Hyeon-Jeong Lee, Sei-Hyun Ahn, Byung Ho Son, Jong Won Lee, Sae Byul Lee
Osong Public Health Res Perspect. 2021;12(4):254-263.   Published online August 5, 2021
DOI: https://doi.org/10.24171/j.phrp.2021.0005
  • 6,990 View
  • 130 Download
  • 6 Web of Science
  • 9 Crossref
AbstractAbstract PDFSupplementary Material
Objectives
This study evaluated the validity and reliability of the Health-Related Quality of Life Instrument with 8 Items (HINT-8) in postoperative breast cancer patients in South Korea.
Methods
The study included 300 breast cancer patients visiting a tertiary hospital. We measured health-related quality of life (HRQoL) using the HINT-8, the 5-level EQ-5D version (EQ-5D-5L), and the Functional Assessment of Cancer Therapy-Breast (FACT-B). Discriminatory ability, known-group validity, and convergent validity were assessed. Reliability was evaluated with the Cohen kappa, weighted kappa, and intraclass correlation coefficient (ICC).
Results
The EQ-5D-5L indexes (p<0.001) and EQ visual analogue scale (VAS) scores (p<0.001) were significantly higher in subjects with no problems in each item of the HINT-8 than in those with problems. The FACT-B total scores were also higher in subjects without problems on the HINT-8. Older age, lower education level, and comorbidities were associated with a lower HINT-8 index. The HINT-8 index was correlated with the EQ-5D-5L index and the EQ VAS, with correlation coefficients of 0.671 (p<0.001) and 0.577 (p<0.001), respectively. The correlation coefficients between the HINT-8 and the FACT-B ranged from 0.390 to 0.714. The ICC was 0.690 (95% confidence interval, 0.580–0.780).
Conclusion
The HINT-8 showed appropriate validity for capturing HRQoL in postoperative breast cancer patients.

Citations

Citations to this article as recorded by  
  • Health-related quality of life of premenopausal young breast cancer survivors undergoing endocrine therapy
    Kyungmi Lee, Hye Suk Jun
    European Journal of Oncology Nursing.2024; 68: 102496.     CrossRef
  • Smartphone application-based rehabilitation in patients with chronic respiratory and cardiovascular diseases
    Chiwook Chung, Ah-Ram Kim, Dongbum Kim, Hee Kwon, Seong Ho Lee, Il-Young Jang, Min-Woo Jo, Do-Yoon Kang, Sei Won Lee
    Scientific Reports.2024;[Epub]     CrossRef
  • Willingness to pay for integrative healthcare services to treat sleep disturbances: Evidence from a nationwide survey
    Min Kyung Hyun
    European Journal of Integrative Medicine.2023; 58: 102223.     CrossRef
  • Internal Structure of the Health-Related Quality of Life Instrument with 8-Items in a Nationally Representative Population
    Eun-Hyun Lee
    Journal of Korean Academy of Nursing.2023; 53(3): 359.     CrossRef
  • Factors influencing health-related quality of life for young single-person households: the mediating effect of resilience
    Soo Jin Lee, Sujin Lee, Xianglan Jin
    Journal of Korean Biological Nursing Science.2023; 25(3): 160.     CrossRef
  • Smartphone application-based rehabilitation in patients with chronic respiratory and cardiovascular diseases: a randomised controlled trial study protocol
    Chiwook Chung, Ah-Ram Kim, Il-Young Jang, Min-Woo Jo, Seongho Lee, Dongbum Kim, Hee Kwon, Do-Yoon Kang, Sei Won Lee
    BMJ Open.2023; 13(9): e072698.     CrossRef
  • Health-related quality of life among cancer patients and survivors and its relationship with current employment status
    Woorim Kim, Kyu-Tae Han, Seungju Kim
    Supportive Care in Cancer.2022; 30(5): 4547.     CrossRef
  • Associations between Food Groups and Health-Related Quality of Life in Korean Adults
    Shamirah Nabbosa, Sunghee Lee
    Nutrients.2022; 14(17): 3643.     CrossRef
  • Validity of the Health-Related Quality of Life Instrument with 8 Items (HINT-8) in the Korean Elderly: A Cross-Sectional Study
    Seon-Ha Kim, Miok Kim
    Journal of Korean Gerontological Nursing.2022; 24(3): 248.     CrossRef
Impact of fatigue on quality of life among breast cancer patients receiving chemotherapy
Fares Mohammed Saeed Muthanna, Mahmathi Karuppannan, Bassam Abdul Rasool Hassan, Ali Haider Mohammed
Osong Public Health Res Perspect. 2021;12(2):115-125.   Published online April 29, 2021
DOI: https://doi.org/10.24171/j.phrp.2021.12.2.09
  • 8,206 View
  • 279 Download
  • 4 Web of Science
  • 6 Crossref
AbstractAbstract PDF
Objectives
Fatigue is the most frequently reported symptom experienced by cancer patients and has a profound effect on their quality of life (QOL). The study aimed to determine the impact of fatigue on QOL among breast cancer patients receiving chemotherapy and to identify the risk factors associated with severe fatigue incidence.
Methods
This was an observational prospective study carried out at multiple centers. In total, 172 breast cancer patients were included. The Functional Assessment of Chronic Illness Therapy-Fatigue Questionnaire was used to measure QOL, while the Brief Fatigue Inventory (BFI) was used to assess the severity of fatigue.
Results
The total average mean and standard deviation of QOL were 84.58±18.07 and 4.65±1.14 for BFI scores, respectively. A significant association between fatigue and QOL was found in linear and multiple regression analyses. The relationships between fatigue severity and cancer stage, chemotherapy dose delay, dose reduction, chemotherapy regimen, and ethnicity were determined using binary logistic regression analysis.
Conclusion
The findings of this study are believed to be useful for helping oncologists effectively evaluate, monitor, and treat fatigue related to QOL changes.

Citations

Citations to this article as recorded by  
  • Effectiveness of Therapeutic Exercise Models on Cancer-Related Fatigue in Patients With Cancer Undergoing Chemotherapy: A Systematic Review and Network Meta-analysis
    Aida Herranz-Gómez, Ferran Cuenca-Martínez, Luis Suso-Martí, Clovis Varangot-Reille, Miriam Prades-Monfort, Joaquín Calatayud, Jose Casaña
    Archives of Physical Medicine and Rehabilitation.2023; 104(8): 1331.     CrossRef
  • Anatomical Sites OF Superficial Basal Cell Cancers Demonstrate Higher Rates of Mixed Histology
    Zahid Sarfaraz Khan, Asim Muhammad, Muhammad Ataullah, Syeda Gulrukh Saba Shah, Tehmina Naushin, Hina Mir, Nabiha Naeem, Ziyad Ahmad, Sudhair Abbas Bangash, Irfan Ullah
    Pakistan BioMedical Journal.2022; : 44.     CrossRef
  • Glycated Albumin's Clinical Effectiveness in The Diabetes Diagnosis
    Summeira Jabeen Shah, Hajira Ishaq, Hina Hakeem, Saima Shaheen, Sikandar Ali Khan, Sosan Rauf, Hina Mir, Sudhair Abbas Bangash, Muhammad Ali, Irfan Ullah
    Pakistan BioMedical Journal.2022; : 176.     CrossRef
  • Post stroke intervention trial in fatigue (POSITIF): Randomised multicentre feasibility trial
    Gillian Mead, David Gillespie, Mark Barber, Allan House, Steff Lewis, Hannah Ensor, Simiao Wu, Trudie Chalder
    Clinical Rehabilitation.2022; 36(12): 1578.     CrossRef
  • Quality of Life and Its Associated Factors Among Cancer Patients Receiving Chemotherapy at Oncology Hospitals in Vietnam After the Third Wave of the COVID-19 Pandemic
    Hanh TH Nguyen, Khanh Linh Duong, Son T Nguyen, Quy Trinh, Hao TL Hoang, Toan Q Phung, Hsiang-Wen Lin, Huong TL Nguyen
    Cancer Management and Research.2022; Volume 14: 2429.     CrossRef
  • Effects of traditional Chinese medicine exercise therapy on cancer-related fatigue, anxiety and sleep quality in cancer patients
    Lihao Jiang, Ju Ouyang, Xianfeng Du
    Medicine.2021; 100(44): e27681.     CrossRef
Epidemiological Study on Candida Species in Patients with Cancer in the Intensive Care Unit
Young-ju Choi, Byeongyeo Lee, Sun-A Park
Osong Public Health Res Perspect. 2017;8(6):384-388.   Published online December 31, 2017
DOI: https://doi.org/10.24171/j.phrp.2017.8.6.05
  • 3,890 View
  • 26 Download
  • 1 Crossref
AbstractAbstract PDF
Objectives

Although cancer survival rates have increased, serious infection complications can arise in cancer patients. Candida can occur in various tissues and has significant effects on the prognosis of patients with cancer. Thus, we conducted an epidemiological study on Candida infections in patients with cancer admitted to the intensive care unit.

Methods

A retrospective study was conducted in adult patients with cancer admitted to the intensive care unit between January 1, 2013, and December 31, 2015. Candida infection status and predictive factors for mortality were examined in 634 patients.

Results

The predictive factors for mortality included the use of steroids, use of a central venous catheter or mechanical ventilator, and identification of Candida in the blood. Patients who stayed in the surgical and intensive care unit for more than 7 days had a lower risk of death than that in those with shorter days.

Conclusion

The present study shows that invasive procedures, bloodstream infections, and the use of steroids increase the risk of mortality in Candida-infected patients with cancer. To improve the quality of life and reduce mortality, further studies are needed on the factors affecting the risk of mortality associated with Candida infection.

Citations

Citations to this article as recorded by  
  • Ionic Liquids with Anti-Candida and Anticancer Dual Activity as Potential N-Myristoyltransferase Inhibitors
    Larysa Metelytsia, Maria Trush, Ivan Semenyuta, Sergiy Rogalsky, Oleksandr Kobzar, Larisa Kalashnikova, Volodymyr Blagodatny, Diana Hodyna
    Current Bioactive Compounds.2020; 16(7): 1036.     CrossRef
Influence of Socioeconomic Status, Comorbidity, and Disability on Late-stage Cancer Diagnosis
Bo Ram Park, So Young Kim, Dong Wook Shin, Hyung Kook Yang, Jong Hyock Park
Osong Public Health Res Perspect. 2017;8(4):264-270.   Published online August 31, 2017
DOI: https://doi.org/10.24171/j.phrp.2017.8.4.06
  • 4,249 View
  • 42 Download
  • 8 Crossref
AbstractAbstract PDF
Objectives

Understanding factors affecting advanced stage at diagnosis is vital to improve cancer outcomes and overall survival. We investigated the factors affecting later-stage cancer diagnosis.

Methods

Patients completed self-reported questionnaires. We collected cancer stage data from medical records review. Logistic regression analyses were performed to identify factors associated with later stage cancer at diagnosis by gender.

Results

In total, 1,870 cancer patients were included in the study; 55.8% were men, 31.1% had more than one comorbid condition, and 63.5% had disabilities. About half of the patients were smokers, and drank alcohol, and 58.0% were diagnosed at an advanced stage. By cancer type, lung and liver cancers (both genders), prostate (men), colorectal, cervical, and thyroid cancer (women) were more likely to be diagnosed at a later stage. After controlling for socioeconomic factors, comorbidity (odds ratio [OR], 1.48 in men) and disability (OR, 1.64 in men and 1.52 in women) remained significantly associated with late-stage diagnosis.

Conclusion

In this nationwide study, using combined information from patients and medical records, we found that male patients with comorbidities or disabilities, and female patients with disabilities were more likely to have advanced stage cancer at diagnosis. Targeted approaches by cancer type and health conditions are recommended.

Citations

Citations to this article as recorded by  
  • Factors associated with late diagnosis of cervical cancer at two national referral hospitals, Kenya 2017: A case control study
    Valerian Mwenda, Martin Mwangi, Gladwell Gathecha, Joseph Kibachio, Robert Too, Zeinab Gura, Marleen Temmerman
    Gynecologic Oncology Reports.2024; 52: 101355.     CrossRef
  • Obstacles dans le dépistage du cancer du sein chez les personnes ayant un handicap
    Sylvia Mazellier, Rajeev Ramanah, Catherine Guldenfels, Carole Mathelin
    Bulletin du Cancer.2022; 109(2): 185.     CrossRef
  • Cancer Disparities Experienced by People with Disabilities
    Rosemary B. Hughes, Susan Robinson-Whelen, Carly Knudson
    International Journal of Environmental Research an.2022; 19(15): 9187.     CrossRef
  • Prognostic factors and survival analysis of Hurthle cell carcinoma: A population-based study
    Bailey M. Humphreys, Kelvin O. Memeh, Alex Funkhouser, Tanaz M. Vaghaiwalla
    Surgery.2022; 172(5): 1379.     CrossRef
  • Disparities in the Diagnosis and Treatment of Bile Duct Cancer in People with Disabilities: A National Cohort Study in South Korea
    Seon Mee Park, So Young Kim, Kyoung Eun Yeob, Dong Wook Shin, Joung-Ho Han, Jong Heon Park, Jong Hyock Park
    International Journal of Environmental Research an.2022; 19(24): 16625.     CrossRef
  • Impact of comorbidity assessment methods to predict non-cancer mortality risk in cancer patients: a retrospective observational study using the National Health Insurance Service claims-based data in Korea
    Sanghee Lee, Yoon Jung Chang, Hyunsoon Cho
    BMC Medical Research Methodology.2021;[Epub]     CrossRef
  • Disparities in the Diagnosis, Treatment, and Survival Rate of Cervical Cancer among Women with and without Disabilities
    Jin Young Choi, Kyoung Eun Yeob, Seung Hwa Hong, So Young Kim, Eun-Hwan Jeong, Dong Wook Shin, Jong Heon Park, Gil-won Kang, Hak Soon Kim, Jong Hyock Park, Ichiro Kawachi
    Cancer Control.2021; 28: 107327482110552.     CrossRef
  • Gynecologic Care in Women With Down Syndrome
    Anna J. B. Smith, Jeremy Applebaum, Edward J. Tanner, George T. Capone
    Obstetrics & Gynecology.2020; 136(3): 518.     CrossRef
Analysis of Hospital Volume and Factors Influencing Economic Outcomes in Cancer Surgery: Results from a Population-based Study in Korea
Jung-A Lee, So-Young Kim, Keeho Park, Eun-Cheol Park, Jong-Hyock Park
Osong Public Health Res Perspect. 2017;8(1):34-46.   Published online February 28, 2017
DOI: https://doi.org/10.24171/j.phrp.2017.8.1.05
  • 4,234 View
  • 33 Download
  • 7 Crossref
AbstractAbstract PDF
Objectives

To evaluate associations between hospital volume, costs, and length of stay (LOS), and clinical and demographic outcome factors for five types of cancer resection. The main dependent variables were cost and LOS; the primary independent variable was volume.

Methods

Data were obtained from claims submitted to the Korean National Health Insurance scheme. We identified patients who underwent the following surgical procedures: pneumonectomy, colectomy, mastectomy, cystectomy, and esophagectomy. Hospital volumes were divided into quartiles.

Results

Independent predictors of high costs and long LOS included old age, low health insurance contribution, non-metropolitan residents, emergency admission, Charlson score > 2, public hospital ownership, and teaching hospitals. After adjusting for relevant factors, there was an inverse relationship between volume and costs/LOS. The highest volume hospitals had the lowest procedure costs and LOS. However, this was not observed for cystectomy.

Conclusion

Our findings suggest an association between patient and clinical factors and greater costs and LOS per surgical oncologic procedure, with the exception of cystectomy. Yet, there were no clear associations between hospitals’ cost of care and risk-adjusted mortality.

Citations

Citations to this article as recorded by  
  • Impact of hospital volume on failure to rescue for complications requiring reoperation after elective colorectal surgery: multicentre propensity score–matched cohort study
    Marie T Grönroos-Korhonen, Laura E Koskenvuo, Panu J Mentula, Taina P Nykänen, Selja K Koskensalo, Ari K Leppäniemi, Ville J Sallinen
    BJS Open.2024;[Epub]     CrossRef
  • Volume-outcome relationships in laryngeal trauma processes of care: a retrospective cohort study
    David Forner, Christopher W. Noel, Matthew P. Guttman, Barbara Haas, Danny Enepekides, Matthew H. Rigby, S. Mark Taylor, Avery B. Nathens, Antoine Eskander
    European Journal of Trauma and Emergency Surgery.2022; 48(5): 4131.     CrossRef
  • Association between Stroke Quality Assessments and Mortality within 30 Days among Patients Who Underwent Hemorrhagic Stroke Surgeries in South Korea
    Mi-Na Lee, Wonjeong Jeong, Sung-In Jang, Sohee Park, Eun-Cheol Park
    Cerebrovascular Diseases.2022; 51(1): 82.     CrossRef
  • Impact of surgeon and hospital factors on length of stay after colorectal surgery systematic review
    Zubair Bayat, Keegan Guidolin, Basheer Elsolh, Charmaine De Castro, Erin Kennedy, Anand Govindarajan
    BJS Open.2022;[Epub]     CrossRef
  • Crucial areas of the economic analysis of public cancer care
    D. A. Andreev, K. I. Polyakova, A. A. Zavyalov, T. N. Ermolaeva, A. G. Fisun, A. D. Ermolaeva, V. A. Dubovtseva, T. E. Maksimova
    FARMAKOEKONOMIKA. Modern Pharmacoeconomic and Phar.2020; 12(4): 310.     CrossRef
  • Initial Diagnosis of Colorectal Cancer through Colonoscopy or Emergent Surgery-Clinicopathological Features that Support Early Screening
    Konstantinos A Paschos, A Chatzigeorgiadis
    Hellenic Journal of Surgery.2020; 92(2): 51.     CrossRef
  • What Matters in the Performance of a Medial Institution?
    Hae-Wol Cho, Chaeshin Chu
    Osong Public Health and Research Perspectives.2017; 8(1): 1.     CrossRef

PHRP : Osong Public Health and Research Perspectives