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Original Article
Anti-Human Rhinovirus 1B Activity of Dexamethasone viaGCR-Dependent Autophagy Activation
Jae-Sug Lee, Seong-Ryeol Kim, Jae-Hyoung Song, Yong-Pyo Lee, Hyun-Jeong Ko
Osong Public Health Res Perspect. 2018;9(6):334-339.   Published online December 31, 2018
DOI: https://doi.org/10.24171/j.phrp.2018.9.6.07
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  • 4 Crossref
AbstractAbstract PDF
Objectives

Human rhinoviruses (HRVs) are the major cause of the common cold. Currently there is no registered, clinically effective, antiviral chemotherapeutic agent to treat diseases caused by HRVs. In this study, the antiviral activity of dexamethasone (DEX) against HRV1B was examined.

Methods

The anti–HRV1B activity of DEX was assessed by sulforhodamine B assay in HeLa cells, and by RT-PCR in the lungs of HRV1B-infected mice. Histological evaluation of HRV1B-infected lungs was performed and a histological score was given. Anti-HRV1B activity of DEX via the glucocorticoid receptor (GCR)-dependent autophagy activation was assessed by blocking with chloroquine diphosphate salt or bafilomycin A1 treatment.

Results

In HRV1B-infected HeLa cells, treatment with DEX in a dose-dependent manner, resulted in a cell viability of > 70% indicating that HRV1B viral replication was reduced by DEX treatment. HRV1B infected mice treated with DEX, had evidence of reduced inflammation and a moderate histological score. DEX treatment showed antiviral activity against HRV1B via GCR-dependent autophagy activation.

Conclusion

This study demonstrated that DEX treatment showed anti-HRV1B activity via GCR-dependent autophagy activation in HeLa cells and HRV1B infected mice. Further investigation assessing the development of topical formulations may enable the development of improved DEX effectiveness.

Citations

Citations to this article as recorded by  
  • Intracellular translocation of HMGB1 is important for Zika virus replication in Huh7 cells
    Kim-Ling Chin, Nurhafiza Zainal, Sing-Sin Sam, Pouya Hassandarvish, Rafidah Lani, Sazaly AbuBakar
    Scientific Reports.2022;[Epub]     CrossRef
  • Pharmacological Modulators of Autophagy as a Potential Strategy for the Treatment of COVID-19
    Gustavo José da Silva Pereira, Anderson Henrique França Figueredo Leão, Adolfo Garcia Erustes, Ingrid Beatriz de Melo Morais, Talita Aparecida de Moraes Vrechi, Lucas dos Santos Zamarioli, Cássia Arruda Souza Pereira, Laís de Oliveira Marchioro, Letícia P
    International Journal of Molecular Sciences.2021; 22(8): 4067.     CrossRef
  • MSTN Attenuates Cardiac Hypertrophy through Inhibition of Excessive Cardiac Autophagy by Blocking AMPK /mTOR and miR-128/PPARγ/NF-κB
    Hanping Qi, Jing Ren, Lina Ba, Chao Song, Qianhui Zhang, Yonggang Cao, Pilong Shi, Bowen Fu, Yongsheng Liu, Hongli Sun
    Molecular Therapy - Nucleic Acids.2020; 19: 507.     CrossRef
  • Autophagy Augmentation to Alleviate Immune Response Dysfunction, and Resolve Respiratory and COVID-19 Exacerbations
    Garrett Pehote, Neeraj Vij
    Cells.2020; 9(9): 1952.     CrossRef

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