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Behavioral therapy and pharmacotherapy for relapse prevention in abstinent smokers: a rapid review and meta-analysis for the Korea Preventive Service Task Force
Naae Lee, Eon Sook Lee, Jae Moon Yun, Cheol Min Lee, Seung-Won Oh, Younglee Choi, Belong Cho
Osong Public Health Res Perspect. 2021;12(4):244-253.   Published online July 6, 2021
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AbstractAbstract PDFSupplementary Material
This study aimed to assess the effectiveness of relapse prevention interventions involving behavioral and pharmacological treatment among abstinent smokers.
This rapid review was conducted using MEDLINE, Cochrane CENTRAL, CINAHL, Embase, KMbase, and KoreaMed to identify studies published until June 20, 2020. The participants were abstinent smokers who quit smoking on their own, due to pregnancy, hospitalization, or by participating in a smoking cessation program. We found a systematic review that fit the objective of this study and included 81 randomized controlled trials (RCTs). Studies that did not present information on smoking cessation status, had no control group, or used reward-based interventions were excluded. Random effect and fixed effect meta-analyses were used to estimate the relative risk (RR) and 95% confidence interval (CI). In subgroup analyses, differences between subgroups were verified based on the participant setting, characteristics, intervention type, and intensity.
Following screening, 44 RCTs were included in the meta-analysis. The review reported no differences in the success rate of relapse prevention between the behavioral interventions. Pharmacotherapy interventions showed higher success rates (RR, 1.15; 95% CI, 1.05−1.26; I2=40.71%), depending on prior abstinence duration and the drug type. Conclusions: The results indicated that pharmacotherapy has a significant effect on preventing relapse among abstinent smokers.


Citations to this article as recorded by  
  • A Survey of the Clinical Practice of Korean Medicine for Smoking Cessation in Public Health Centers: A Web-Based Survey of Public Health Doctors of Korean Medicine
    Gyoungeun Park, Jeong-Hyun Moon, Eun-Jung Kim, Byung-Kwan Seo, Yong-Hyeon Baek, Won-Suk Sung
    Perspectives on Integrative Medicine.2024; 3(1): 45.     CrossRef

PHRP : Osong Public Health and Research Perspectives