주메뉴 바로가기 본문 바로가기
  • KDCA
  • Contact us
  • E-Submission

PHRP : Osong Public Health and Research Perspectives

OPEN ACCESS. pISSN: 2210-9099. eISSN: 2233-6052
About
Browse articles
Editorial policies
For authors

Page Path

2
results for

"Inflammation"

Article category

Keywords

Publication year

Authors

Funded articles

"Inflammation"

Original Articles
<b>Objectives</b><br/>This study investigated the relationship between metabolic factors (blood lipids and glucose) and inflammatory indicators (tumor necrosis factor-alpha [TNF-α] and high-sensitivity C-reactive protein [hs-CRP]), disease activity, and the rheumatoid arthritis (RA) risk. <br/><b>Methods</b><br/>Serum fasting blood glucose (FBG) and lipid profiles—including total cholesterol (Chol), triglycerides (TG), high-density lipoprotein (HDL), and low-density lipoprotein—were measured in 100 RA patients and 100 healthy individuals. Disease severity was assessed using the disease activity score 28. Inflammatory indicators (TNF-α and hs-CRP) were measured using the enzyme-linked immunosorbent assay method. <br/><b>Results</b><br/>In RA patients, serum FBG, TG, Chol/HDL, and TG/HDL were significantly elevated, whereas HDL levels reduced compared to healthy individuals. Multivariate analysis indicated that each unit increase in serum FBG, HDL, Chol/HDL, and TG/HDL was associated with a 64% increase (p<0.001), a 7% reduction (p=0.001), a 52% increase (p=0.007), and a 54% increase (p=0.001) in the odds of RA, respectively. Disease activity showed no correlation with metabolic factors (p>0.05). Among all metabolic factors studied, FBG had the largest area under the curve (0.981) (p<0.0001) for predicting RA. Across the total participant group, FBG, TG, and TG/HDL were positively associated with hs-CRP and TNF-α (p<0.05). HDL showed an inverse association with hs-CRP (p=0.008). Among RA patients specifically, TNF-α positively correlated with TG and TG/HDL, while hs-CRP correlated only with TG/HDL. <br/><b>Conclusion</b><br/>These findings indicate that increased FBG and Chol/HDL and decreased HDL may elevate RA risk by promoting systemic inflammation. Among these, elevated FBG may serve as the strongest predictor of RA risk.
  • 707 View
  • 22 Download
Association between the empirical dietary inflammatory index and musculoskeletal pain in community-dwelling older adults: a cross-sectional study
Mahshid Rezaei, Zahra Tajary, Zahra Esmaeily, Atefeh Eyvazkhani, Shahrzad Daei, Marjan Mansouri Dara, Mohaddeseh Rezaei, Abolghassem Djazayeri, Ahmadreza Dorosty Motlagh
Osong Public Health Res Perspect 2023;14(1):51-58.
Published online February 20, 2023
DOI: https://doi.org/10.24171/j.phrp.2022.0194
<b>Objectives</b><br/>Inflammation has been proposed to be one of the main causes of musculoskeletal pain. Diet is a lifestyle factor that plays an important role in managing inflammation; thus, we assessed the inflammatory potential of diets using the empirical dietary inflammatory index (EDII) to investigate the relationship between diet and musculoskeletal pain. <br/><b>Methods</b><br/>This cross-sectional study included 212 elderly individuals who were selected from health centers in Tehran, Iran. Dietary intake was evaluated using a valid and reliable 147-item food frequency questionnaire. To measure the intensity of pain, a visual analogue scale was used. Multiple linear regression was applied to assess the association between the EDII and musculoskeletal pain. <br/><b>Results</b><br/>In total, 62.7% and 37.3% of participants had mild and severe pain, respectively. The EDII values were 0.97±0.72 and 1.10±0.66, respectively, in those with mild and severe pain. A higher EDII score was associated with more intense musculoskeletal pain after adjusting for age and sex (β=0.20; 95% confidence interval [CI], 0.06–0.26; p<0.001), but not after adjustment for other confounders (β=–0.13; 95% CI, –1.54 to 0.60; p=0.39). <br/><b>Conclusion</b><br/>Our findings indicated that higher dietary inflammation might not be associated with musculoskeletal pain in older adults. However, further investigations are required to confirm these findings.

Citations

Citations to this article as recorded by  Crossref logo
  • Proinflammatory diet is associated with higher pain, disease severity and biochemical parameters associated with inflammation in fibromyalgia
    Nursena Ersoy Söke, Hansa İnceöz, İlker Solmaz, Hülya Yardımcı
    Pain Medicine.2025; 26(3): 131.     CrossRef
  • Exploring the association between dietary Inflammatory Index and chronic pain in US adults using NHANES 1999–2004
    Lunxue Qing, Yingying Zhu, Changhe Yu, Yang Zhang, Jinxia Ni
    Scientific Reports.2024;[Epub]     CrossRef
  • The dietary inflammatory index and cardiometabolic parameters in US firefighters
    Andria Christodoulou, Costas A. Christophi, Mercedes Sotos-Prieto, Steven Moffatt, Longgang Zhao, Stefanos N. Kales, James R. Hébert
    Frontiers in Nutrition.2024;[Epub]     CrossRef
  • Association between dietary inflammatory index and musculoskeletal disorders in adults
    Firoozeh Khamoushi, Davood Soleimani, Farid Najafi, Neshat Ahmadi, Neda Heidarzadeh-Esfahani, Bita Anvari, Ebrahim Shakiba, Yahya Pasdar
    Scientific Reports.2023;[Epub]     CrossRef
  • 4,234 View
  • 102 Download
  • 4 Web of Science
  • Crossref