Osong Public Health and Research Perspectives

Original Article

Relationship between Serum Levels of Body Iron Parameters and Insulin Resistance and Metabolic Syndrome in Korean Children: Hye-Ja Lee, Han Byul Jang, Ji Eun Park, Kyung-Hee Park, Jae Heon Kang, Sang Ick Park, Jihyun Song; Osong Public Health Res Perspect. 2014;5(4):204-210. Published online August 31, 2014; DOI: https://doi.org/10.1016/j.phrp.2014.06.005

2,778 View
22 Download
16 Crossref

Objectives
An increase in serum ferritin and levels of the cleaved soluble form of transferrin receptor (sTfR) are related to several metabolic conditions. We evaluated the relationship between body iron status indicators, including ferritin and sTfR, and insulin resistance and metabolic syndrome (MetS) in Korean children.
Methods
A cross-sectional study was conducted on 1350 children in Korea. Anthropometrical parameters; lipid profiles; levels of glucose, insulin, and leptin; and iron status indicators, including sTfR, serum ferritin, serum iron, total iron-binding capacity (TIBC), and transferrin saturation (TS), were analyzed.
Results
Although serum sTfR levels were significantly higher in boys than in girls (2.20 vs. 2.06 mg/L, p < 0.0001), serum iron and TS were higher in girls than in boys (101.38 vs. 95.77 mg/L, p = 0.027 and 30.15 vs. 28.91%, p = 0.04, respectively). Waist circumference (WC) and leptin were most significantly associated with body iron indicators when adjusted for age and sex. After adjusting for age, sex, and WC, sTfR levels showed the strongest positive association with leptin levels (p = 0.0001). Children in the highest tertile for homeostasis model assessment-insulin resistance (HOMA-IR) had higher TIBC (p = 0.0005) and lower serum iron (p = 0.0341), and the lowest TS (p < 0.0001) after adjustment for confounders. Children with higher sTfR were most significantly associated with risk of MetS compared with those lower sTfR (p = 0.0077).
Conclusion
The associations of serum levels of iron metabolism markers with leptin levels, HOMA-IR, and MetS suggest that iron-related factors may involve insulin resistance and MetS.

Citations

Citations to this article as recorded by

Relationship between trajectories of dietary iron intake and risk of type 2 diabetes mellitus: evidence from a prospective cohort study
Ruoting Wang, Yingxin Liu, Lehana Thabane, Ivan Olier, Likang Li, Sandra Ortega-Martorell, Gregory Y.H. Lip, Guowei Li
Nutrition Journal.2024;[Epub] CrossRef
Serum iron concentration and leptin inversely relate, partially mediated by body mass index in American adults
Mi Chen, Yuebai Chen, Chao Li
Nutrition Research.2024; 124: 1. CrossRef
Association between serum ferritin level and lipid profile among diabetic patients: A retrospective cohort study
Saif Aboud M Alqahtani, Mohammed Abadi Alsaleem, Ramy Mohamed Ghazy
Medicine.2024; 103(13): e37631. CrossRef
Relationship between Serum Ferritin Level and Dyslipidemia in US Adults Based on Data from the National Health and Nutrition Examination Surveys 2017 to 2020
Guohua Li, Wenlu Yu, Hexiang Yang, Xinyue Wang, Tianyou Ma, Xiaoqin Luo
Nutrients.2023; 15(8): 1878. CrossRef
Iron status and cardiometabolic risk in children
Milton Fabian Suárez-Ortegón, Anna Prats-Puig, Judit Bassols, Gemma Carreras-Badosa, Stela McLachlan, Sarah H. Wild, Abel López-Bermejo, Jose Manuel Fernández-Real
Diabetes Research and Clinical Practice.2023; 202: 110795. CrossRef
Association between biomarkers of iron status and cardiometabolic risk in Spanish children aged 9–10 years. The ELOIN study
Honorato Ortiz-Marrón, Gloria Cabañas Pujadas, Encarnación Donoso Navarro, Mar Burreros García, María Isabel Herreros Álvaro, Alma María Mejía Fernández de Velasco, Ana Cornejo Gutiérrez, Iñaki Galán
European Journal of Pediatrics.2023; 182(12): 5649. CrossRef
Serum ferritin levels among schoolchildren and its correlation with lipid profile and adiposity
Mariana Orta-Duarte, Rosa del Carmen Vázquez-Zapien, Hugo Ventura-Cisneros, Mario del Toro-Equihua, Benjamin Trujillo-Hernández, Carmen Alicia Sánchez-Ramírez
Archivos Latinoamericanos de Nutrición.2021; 70(3): 155. CrossRef
Ferritin levels throughout childhood and metabolic syndrome in adolescent stage
M.F. Suárez-Ortegón, E. Blanco, S. McLachlan, J.M. Fernandez-Real, R. Burrows, S.H. Wild, B. Lozoff, S. Gahagan
Nutrition, Metabolism and Cardiovascular Diseases.2019; 29(3): 268. CrossRef
The immune-nutrition interplay in aging – facts and controversies
Iftikhar Alam, Ali M. Almajwal, Wajid Alam, Ibrar Alam, Niamat Ullah, Mahmoud Abulmeaaty, Suhail Razak, Saleem Khan, Graham Pawelec, Parvez Iqbal Paracha
Nutrition and Healthy Aging.2019; 5(2): 73. CrossRef
Iron metabolism and its association with dyslipidemia risk in children and adolescents: a cross-sectional study
Yanna Zhu, Baoting He, Yunjun Xiao, Yajun Chen
Lipids in Health and Disease.2019;[Epub] CrossRef
Standardized Aronia melanocarpa Extract as Novel Supplement against Metabolic Syndrome: A Rat Model
Vladimir Jakoviljevic, Petar Milic, Jovana Bradic, Jovana Jeremic, Vladimir Zivkovic, Ivan Srejovic, Tamara Nikolic Turnic, Isidora Milosavljevic, Nevena Jeremic, Sergey Bolevich, Milica Labudovic Borovic, Miroslav Mitrovic, Vesna Vucic
International Journal of Molecular Sciences.2018; 20(1): 6. CrossRef
High-fat diet–induced plasma protein and liver changes in obese rats can be attenuated by melatonin supplementation
Prapimpun Wongchitrat, Paul Klosen, Supitcha Pannengpetch, Kuntida Kitidee, Piyarat Govitrapong, Chartchalerm Isarankura-Na-Ayudhya
Nutrition Research.2017; 42: 51. CrossRef
Relationship between Serum Ferritin Levels and Dyslipidemia in Korean Adolescents
Young-Eun Kim, Do-Hoon Kim, Yong-Kyun Roh, Sang-Yhun Ju, Yeo-Joon Yoon, Ga-Eun Nam, Hyo-Yun Nam, Jun-Seok Choi, Jong-Eun Lee, Jung-Eun Sang, Kyungdo Han, Yong-Gyu Park, David O. Carpenter
PLOS ONE.2016; 11(4): e0153167. CrossRef
Investigation of the relationship between hemoglobin and serum iron levels and early-phase insulin secretion in non-diabetic subjects
Masanori Shimodaira, Shinji Okaniwa, Tomohiro Nakayama
Acta Diabetologica.2016; 53(5): 783. CrossRef
Hepcidin and iron metabolism associated with cardiometabolic risk factors in children: A case–control study
Y.N. Zhu, B.T. He, J. Jing, J. Ma, X.H. Li, W.H. Yang, Y. Jin, Y.J. Chen
Nutrition, Metabolism and Cardiovascular Diseases.2016; 26(6): 525. CrossRef
Biomarkers of iron metabolism are independently associated with impaired glucose metabolism and type 2 diabetes: the KORA F4 study
Cornelia Huth, Simon Beuerle, Astrid Zierer, Margit Heier, Christian Herder, Thorsten Kaiser, Wolfgang Koenig, Florian Kronenberg, Konrad Oexle, Wolfgang Rathmann, Michael Roden, Sigrid Schwab, Jochen Seissler, Doris Stöckl, Christa Meisinger, Annette Pet
European Journal of Endocrinology.2015; 173(5): 643. CrossRef

First
Prev
Page of 1
Next
Last

Search