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Original Articles
AIDS Awareness: Indispensible Prerequisite Among Fishermen Population
Swapna B. Shetty, Darshan D. Divakar, M.H.N. Dalati, Sajith Vellappally, Sukumaran Anil, Marey A. Alshehry, Baher Felemban, Al S. Mamdouh, Obaid A. Alshahrani
Osong Public Health Res Perspect. 2016;7(5):327-333.   Published online October 31, 2016
DOI: https://doi.org/10.1016/j.phrp.2016.09.003
  • 3,104 View
  • 30 Download
  • 2 Crossref
AbstractAbstract PDF
Objectives
Fishermen are among the most vulnerable groups for human immunodeficiency virus (HIV)/AIDS with reported high prevalence. Poor knowledge base has been evidenced by a few studies. The present study was conducted to assess the knowledge regarding HIV/AIDS among fishermen of the Kutch coast, Gujarat, India.
Methods
A descriptive cross-sectional study was conducted among 950 fishermen of the Kutch coast, in the months of January–February 2015. Knowledge of HIV/AIDS of fishermen was assessed using structured interview schedules with 12 questions. The information on socio-demographic characteristics was also obtained. Chi-square test and multivariate logistic regression analysis were used for statistical analysis. The confidence level and level of significance were fixed at 95% and 5%, respectively.
Results
A major proportion of participants (57.2%) had no access to any potential source of information and had never heard about HIV/AIDS (65.1%). Some of them were aware of modes of transmission of AIDS but only a few of them knew about the methods of prevention. Only 23.1% of participants were observed with appropriate knowledge regarding HIV/AIDS. Bivariate and multivariate analysis revealed significant variation in the proportion of participants with appropriate knowledge with age and educational status.
Conclusion
Overall, the knowledge of the fishermen community in the present study was evidenced to be poor creating an alarming situation demanding educative interventions as a part of AIDS control programs.

Citations

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  • Prolonged Release of Anti-Retroviral Efavirenz From System Using ZIF-8 as Carrier
    Alinne Élida Gonçalves Alves Tabosa, Aline Silva Ferreira, Natália Millena da Silva, Débora Dolores Souza da Silva Nascimento, Leslie Raphael de Moura Ferraz, José Yago Rodrigues Silva, Severino Alves Junior, Rosali Maria Ferreira da Silva, Larissa Araúj
    Current HIV Research.2020; 18(6): 396.     CrossRef
  • Prevalence of HIV infection and uptake of HIV/AIDS services among fisherfolk in landing Islands of Lake Victoria, north western Tanzania
    Anthony Kapesa, Namanya Basinda, Elias C. Nyanza, Martha F. Mushi, Ola Jahanpour, Sospatro E. Ngallaba
    BMC Health Services Research.2018;[Epub]     CrossRef
Identifying Barriers to Human Immunodeficiency Virus Testing for Men Who Have Sex with Men in South Korea
Aeree Sohn, Byonghee Cho, Harvey A. Kennedy
Osong Public Health Res Perspect. 2015;6(3):192-200.   Published online June 30, 2015
DOI: https://doi.org/10.1016/j.phrp.2015.06.003
  • 2,785 View
  • 21 Download
  • 7 Crossref
AbstractAbstract PDF
Objectives
The principal objective of this study was to identify the barriers to testing for men who have sex with men (MSM) in Korea, something that might prove useful in future studies of this nature.
Methods
This study was conducted at gay bars nationwide in Korea. After considering several offline locations (gay bars) where MSM candidates are commonly located, random recruitment was performed using time–location sampling. A total of 944 individuals participated in this survey. A total sample of 921 cases (23 cases were excluded) was used for analysis. A self-administered questionnaire measuring the individuals' demographics, human immunodeficiency virus (HIV)/AIDS knowledge, stigma, phobia, optimism bias, self-efficacy for condom use, and sexual practices was used.
Results
About 61.8% (N = 569) of respondents reported having been tested at least once in their lifetime, and 38.9% (N = 358) acknowledged being tested within the past 12 months. After adjusting for age, education, and number of partners in a logistic regression analysis, awareness of testing place [odds ratio (OR) = 4.04], exposure to HIV prevention campaign (1.54), fear (OR = 1.13), and discrimination toward people with HIV/AIDS (OR = 0.94) were the main factors associated with HIV testing.
Conclusion
To accomplish widespread HIV testing for Korean MSM, the accessibility of testing centers and advertisement of voluntary counseling and testing to MSM are needed.

Citations

Citations to this article as recorded by  
  • Behavioral predictors associated with HIV screening needs in gay Korean men during the COVID-19 pandemic
    Rang Hee Kwon, So-Hyun Kim, Minsoo Jung, Omid Dadras
    PLOS ONE.2023; 18(6): e0287061.     CrossRef
  • Trends in Human Immunodeficiency Virus-Related Knowledge and Stigma among Men Who Have Sex with Men in the Republic of Korea from 2012 to 2022
    Aeree Sohn
    Healthcare.2023; 11(24): 3135.     CrossRef
  • Cost-effectiveness analysis of pre-exposure prophylaxis for the prevention of HIV in men who have sex with men in South Korea: a mathematical modelling study
    Heun Choi, Jiyeon Suh, Woonji Lee, Jun Hyoung Kim, Jung Ho Kim, Hye Seong, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, Yoon Soo Park, Joon Sup Yeom, Changsoo Kim, Hee-Dae Kwon, Davey M. Smith, Jeehyun Lee, Jun Yong Choi
    Scientific Reports.2020;[Epub]     CrossRef
  • Users' Concerns Related to Online HIV Counseling in South Korea: A Descriptive Qualitative Study
    Han Ju Lee, Hee Sun Kang, Savitri Singh-Carlson, Kyung Sun Kim
    Journal of the Association of Nurses in AIDS Care.2020; 31(6): 646.     CrossRef
  • The use of social marketing campaigns to increase HIV testing uptake: a systematic review
    John O. Olawepo, Jennifer R. Pharr, Axenya Kachen
    AIDS Care.2019; 31(2): 153.     CrossRef
  • Non-adherence to anti-retroviral therapy among HIV infected adults in Mon State of Myanmar
    Win Lei Aye, Apa Puckpinyo, Karl Peltzer
    BMC Public Health.2017;[Epub]     CrossRef
  • Discrimination and Stigma
    Hae-Wol Cho, Chaeshin Chu
    Osong Public Health and Research Perspectives.2015; 6(3): 141.     CrossRef
Modification of AxSYM Human Immunodeficiency Virus Assay to Identify Recent Human Immunodeficiency Virus Infections in Korean Human Immunodeficiency Virus-Positive Individuals
Jin-Sook Wang, Mee-Kyung Kee, Byeong-Sun Choi, Sung Soon Kim
Osong Public Health Res Perspect. 2015;6(3):184-191.   Published online June 30, 2015
DOI: https://doi.org/10.1016/j.phrp.2015.06.002
  • 2,785 View
  • 19 Download
  • 1 Crossref
AbstractAbstract PDF
Objectives
To estimate human immunodeficiency virus (HIV) incidence using HIV avidity assays in Korea, we established a serological testing method to differentiate recent HIV infections from long-standing ones.
Methods
We adopted two incidence assays, the BED HIV-1 incidence test (Calypte Biomedical) and an HIV avidity assay (using Abbott AxSYM HIV Antigen/Antibody Combo), and performed them on Korean HIV samples obtained from 81 HIV seroconverters (n = 193), 135 HIV-positive samples, and three HIV commercial incidence panels (PRB965, PRB933, and PRB601 from SeaCare). To determine the most optimal concentration of the chaotropic agent (Guanidine) and the cutoff value for the avidity assay, we evaluated the sensitivity and specificity of the assay at different concentration levels.
Results
We determined that the concentration of Guanidine to be used in the avidity assay was 1.5M. The cutoff value of the avidity index (AI) was 0.8, and the sensitivity and specificity were 90.2% and 83.8%, respectively, under this condition. The gray zone for the avidity assay was 0.75–0.85 AI. The mean of coefficient of variation was low, at 5.43%.
Conclusion
An optimized avidity assay for the diagnosis of recent HIV infections using Korean samples was established. This assay will be applied to investigate the level of recent infection and will provide basic data to the HIV prevention policy in Korea.

Citations

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  • Characteristics of recent HIV infection among individuals newly diagnosed as HIV-positive in South Korea (2008–2015)
    Myeongsu Yoo, Jin-Sook Wang, Su-Jin Park, Jeong-ok Cha, Yoonhee Jung, Yoon-Seok Chung, Myung Guk Han, Byeong-Sun Choi, Sung-Soon Kim, Mee-Kyung Kee
    Scientific Reports.2022;[Epub]     CrossRef
The Recency Period for Estimation of Human Immunodeficiency Virus Incidence by the AxSYM Avidity Assay and BED-Capture Enzyme Immunoassay in the Republic of Korea
Hye-Kyung Yu, Tae-Young Heo, Na-Young Kim, Jin-Sook Wang, Jae-Kyeong Lee, Sung Soon Kim, Mee-Kyung Kee
Osong Public Health Res Perspect. 2014;5(4):187-192.   Published online August 31, 2014
DOI: https://doi.org/10.1016/j.phrp.2014.06.002
  • 2,754 View
  • 20 Download
  • 1 Crossref
AbstractAbstract PDF
Objectives
Measurement of the incidence of the human immunodeficiency virus (HIV) is very important for epidemiological studies. Here, we determined the recency period with the AxSYM avidity assay and the BED-capture enzyme immunoassay (BED-CEIA) in Korean seroconverters.
Methods
Two hundred longitudinal specimens from 81 seroconverters with incident HIV infections that had been collected at the Korea National Institute of Health were subjected to the AxSYM avidity assay (cutoff = 0.8) and BED-CEIA (cutoff = 0.8). The statistical method used to estimate the recency period in recent HIV infections was nonparametric survival analyses. Sensitivity and specificity were calculated for 10-day increments from 120 days to 230 days to determine the recency period.
Results
The mean recency period of the avidity assay and BED-CEIA using a survival method was 158 days [95% confidence interval (CI), 135–181 days] and 189 days (95% CI, 170–208 days), respectively. Based on the use of sensitivity and specificity, the mean recency period for the avidity assay and BED-CEIA was 150 days and 200 days, respectively.
Conclusion
We determined the recency period to estimate HIV incidence in Korea. These data showed that the nonparametric survival analysis often led to shorter recency periods than analysis of sensitivity and specificity as a new method. These findings suggest that more data from seroconverters and other methodologies are needed to determine the recency period for estimating HIV incidence.

Citations

Citations to this article as recorded by  
  • Western Blot-Based Logistic Regression Model for the Identification of Recent HIV-1 Infection: A Promising HIV-1 Surveillance Approach for Resource-Limited Regions
    Jiegang Huang, Minlian Wang, Chunyuan Huang, Bingyu Liang, Junjun Jiang, Chuanyi Ning, Ning Zang, Hui Chen, Jie Liu, Rongfeng Chen, Yanyan Liao, Li Ye, Hao Liang
    BioMed Research International.2018; 2018: 1.     CrossRef
Forecasting the Number of Human Immunodeficiency Virus Infections in the Korean Population Using the Autoregressive Integrated Moving Average Model
Hye-Kyung Yu, Na-Young Kim, Sung Soon Kim, Chaeshin Chu, Mee-Kyung Kee
Osong Public Health Res Perspect. 2013;4(6):358-362.   Published online December 31, 2013
DOI: https://doi.org/10.1016/j.phrp.2013.10.009
  • 2,892 View
  • 18 Download
  • 24 Crossref
AbstractAbstract PDF
Objectives
From the introduction of HIV into the Republic of Korea in 1985 through 2012, 9,410 HIV-infected Koreans have been identified. Since 2000, there has been a sharp increase in newly diagnosed HIV-infected Koreans. It is necessary to estimate the changes in HIV infection to plan budgets and to modify HIV/AIDS prevention policy. We constructed autoregressive integrated moving average (ARIMA) models to forecast the number of HIV infections from 2013 to 2017.
Methods
HIV infection data from 1985 to 2012 were used to fit ARIMA models. Akaike Information Criterion and Schwartz Bayesian Criterion statistics were used to evaluate the constructed models. Estimation was via the maximum likelihood method. To assess the validity of the proposed models, the mean absolute percentage error (MAPE) between the number of observed and fitted HIV infections from 1985 to 2012 was calculated. Finally, the fitted ARIMA models were used to forecast the number of HIV infections from 2013 to 2017.
Results
The fitted number of HIV infections was calculated by optimum ARIMA (2,2,1) model from 1985–2012. The fitted number was similar to the observed number of HIV infections, with a MAPE of 13.7%. The forecasted number of new HIV infections in 2013 was 962 (95% confidence interval (CI): 889–1,036) and in 2017 was 1,111 (95% CI: 805–1,418). The forecasted cumulative number of HIV infections in 2013 was 10,372 (95% CI: 10,308–10,437) and in 2017 was14,724 (95% CI: 13,893–15,555) by ARIMA (1,2,3).
Conclusion
Based on the forecast of the number of newly diagnosed HIV infections and the current cumulative number of HIV infections, the cumulative number of HIV-infected Koreans in 2017 would reach about 15,000.

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  • Intelligent Health Care and Diseases Management System: Multi-Day-Ahead Predictions of COVID-19
    Ahed Abugabah, Farah Shahid
    Mathematics.2023; 11(4): 1051.     CrossRef
  • Prevalence of HIV in Kazakhstan 2010–2020 and Its Forecasting for the Next 10 Years
    Kamilla Mussina, Shirali Kadyrov, Ardak Kashkynbayev, Sauran Yerdessov, Gulnur Zhakhina, Yesbolat Sakko, Amin Zollanvari, Abduzhappar Gaipov
    HIV/AIDS - Research and Palliative Care.2023; Volume 15: 387.     CrossRef
  • Integration models of demand forecasting and inventory control for coconut sugar using the ARIMA and EOQ modification methods
    Siti Wardah, Nunung Nurhasanah, Wiwik Sudarwati
    Jurnal Sistem dan Manajemen Industri.2023; 7(2): 127.     CrossRef
  • Deep learning-based forecasting model for COVID-19 outbreak in Saudi Arabia
    Ammar H. Elsheikh, Amal I. Saba, Mohamed Abd Elaziz, Songfeng Lu, S. Shanmugan, T. Muthuramalingam, Ravinder Kumar, Ahmed O. Mosleh, F.A. Essa, Taher A. Shehabeldeen
    Process Safety and Environmental Protection.2021; 149: 223.     CrossRef
  • Forecasting future HIV infection cases: evidence from Indonesia
    Maria Dyah Kurniasari, Andrian Dolfriandra Huruta, Hsiu Ting Tsai, Cheng-Wen Lee
    Social Work in Public Health.2021; 36(1): 12.     CrossRef
  • Forecasting Confirmed Malaria Cases in Northwestern Province of Zambia: A Time Series Analysis Using 2014–2020 Routine Data
    Dhally M. Menda, Mukumbuta Nawa, Rosemary K. Zimba, Catherine M. Mulikita, Jim Mwandia, Henry Mwaba, Karen Sichinga, Hamidreza Karimi-Sari
    Advances in Public Health.2021; 2021: 1.     CrossRef
  • An Adaptive Variational Mode Decomposition Technique with Differential Evolution Algorithm and Its Application Analysis
    Yuanxin Wang, Chaoqun Duan
    Shock and Vibration.2021; 2021: 1.     CrossRef
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    Zeming Li, Yanning Li
    BMC Medical Informatics and Decision Making.2020;[Epub]     CrossRef
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    Branislav Vuksanovic, Davoud Rahimi Ardali
    International Journal of Computer and Electrical E.2019; 11(1): 1.     CrossRef
  • Exploring an Ensemble of Methods that Combines Fuzzy Cognitive Maps and Neural Networks in Solving the Time Series Prediction Problem of Gas Consumption in Greece
    Papageorgiou, Poczeta, Papageorgiou, Gerogiannis, Stamoulis
    Algorithms.2019; 12(11): 235.     CrossRef
  • APLIKASI METODE DOUBLE EXPONENTIAL SMOOTHING HOLT DAN ARIMA UNTUK MERAMALKAN VOLUNTARY COUNSELING AND TESTING (VCT) ODHA DI PROVINSI JAWA TIMUR
    Suci Retno Ningtiyas
    The Indonesian Journal of Public Health.2019; 13(2): 158.     CrossRef
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    Qiu Ying Wang, Kaiyue Liu, Zhiguo Sun, Minghui Zhang
    Optik.2018; 172: 494.     CrossRef
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    Luca Basile, Manuel Oviedo de la Fuente, Nuria Torner, Ana Martínez, Mireia Jané, Jeffrey Shaman
    PLOS ONE.2018; 13(3): e0193651.     CrossRef
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    Tao Wang, Yunping Zhou, Ling Wang, Zhenshui Huang, Feng Cui, Shenyong Zhai
    Japanese Journal of Infectious Diseases.2016; 69(4): 279.     CrossRef
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    Xin Song, Jun Xiao, Jiang Deng, Qiong Kang, Yanyu Zhang, Jinbo Xu
    Medicine.2016; 95(26): e3929.     CrossRef
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    Mohamed A Daw
    World Journal of Virology.2016; 5(1): 14.     CrossRef
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    John Rubaihayo, Nazarius M. Tumwesigye, Joseph Konde-Lule, Fredrick Makumbi
    BMC Public Health.2016;[Epub]     CrossRef
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    Kewei Wang, Wentao Song, Jinping Li, Wu Lu, Jiangang Yu, Xiaofeng Han
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    Yilan Lin, Min Chen, Guowei Chen, Xiaoqing Wu, Tianquan Lin
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    Lin Wang, Yi Zeng, Tao Chen
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    Shengnan Wang, Max Petzold, Junshan Cao, Yue Zhang, Weibing Wang
    Medicine.2015; 94(20): e837.     CrossRef
  • Changing Patterns of HIV Epidemic in 30 Years in East Asia
    S. Pilar Suguimoto, Teeranee Techasrivichien, Patou Masika Musumari, Christina El-saaidi, Bhekumusa Wellington Lukhele, Masako Ono-Kihara, Masahiro Kihara
    Current HIV/AIDS Reports.2014; 11(2): 134.     CrossRef
  • What is Next for HIV/AIDS in Korea?
    Hae-Wol Cho, Chaeshin Chu
    Osong Public Health and Research Perspectives.2013; 4(6): 291.     CrossRef
Articles
Immune Status and Epidemiological Characteristics of Human Immunodeficiency Virus Seroconverters in Korea, 1999–2009
Jin-Sook Wang, Na-young Kim, Hyo Jung Sim, Byeong-Sun Choi, Mee-Kyung Kee
Osong Public Health Res Perspect. 2012;3(4):245-249.   Published online December 31, 2012
DOI: https://doi.org/10.1016/j.phrp.2012.11.001
  • 2,837 View
  • 24 Download
  • 3 Crossref
AbstractAbstract PDF
Objectives
The detection of HIV seroconverters increased annually since HIV antigen/antibody testing kits have been available widely in South Korea. This study aimed to identify the epidemiological characteristics of HIV seroconverters and their immune level at HIV diagnosis.
Method
We analyzed the epidemiological and immunological characteristics of 341 HIV seroconverters among 6,008 HIV-diagnosed individuals from 1999 and 2009. The analysis of immune level and epidemiological factors of HIV seroconverters was conducted by using chi-square test on SAS version 9.1.
Results
The seroconverters among newly-identified HIV cases each year increased from 0.5% in 1999 to over 5% or in 2009. The sex ratio of seroconverters was 18:1 (male:female), and 33% were in their 30s, and 28% were in their 20s. Reasons for HIV testing were involvement in voluntary test due to risky behaviors (43%), and health check-up (36%). Discovery of HIV infection occurred primarily in hospitals (84%). Among seroconverters, 55 percent had a CD4 T-cell count of more than 350/μl.
Conclusion
Korean HIV seroconverters tended to be younger at diagnosis, diagnosed during a voluntary test, and their CD4+ T-cell counts at HIV diagnosis were higher than those of non-seroconverters aall HIV-infected individuals. This study of HIV seroconverters will be important foundational in future studies on HIV incidence, disease progress, and survival rate.

Citations

Citations to this article as recorded by  
  • Characteristics of recent HIV infection among individuals newly diagnosed as HIV-positive in South Korea (2008–2015)
    Myeongsu Yoo, Jin-Sook Wang, Su-Jin Park, Jeong-ok Cha, Yoonhee Jung, Yoon-Seok Chung, Myung Guk Han, Byeong-Sun Choi, Sung-Soon Kim, Mee-Kyung Kee
    Scientific Reports.2022;[Epub]     CrossRef
  • Evaluation of the Bio-Rad Geenius HIV 1/2 Confirmation Assay as an Alternative to Western Blot in the Korean Population: A Multi-Center Study
    Hee-Won Moon, Hee Jin Huh, Gwi Young Oh, Sang Gon Lee, Anna Lee, Yeo-Min Yun, Mina Hur, Herman Tse
    PLOS ONE.2015; 10(9): e0139169.     CrossRef
  • Interferon-inducible protein 10 (IP-10) is associated with viremia of early HIV-1 infection in Korean patients
    SoYong Lee, Yoon-Seok Chung, Cheol-Hee Yoon, YoungHyun Shin, SeungHyun Kim, Byeong-Sun Choi, Sung Soon Kim
    Journal of Medical Virology.2015; 87(5): 782.     CrossRef
Knowledge, Attitudes, and Sexual Behaviors in HIV/AIDS and Predictors Affecting Condom Use among Men Who Have Sex with Men in South Korea
Aeree Sohn, Byonghee Cho
Osong Public Health Res Perspect. 2012;3(3):156-164.   Published online June 30, 2012
DOI: https://doi.org/10.1016/j.phrp.2012.07.001
  • 3,321 View
  • 25 Download
  • 30 Crossref
AbstractAbstract PDF
Objectives
In South Korea, men who have sex with men (MSM) are rather understudied, but are known to be at high risk for human immunodeficiency virus infection (HIV)/acquired immunodeficiency syndrome (AIDS). This study was to access HIV/AIDS knowledge, attitudes, and risk behaviors, and to identify the factors of condom use in HIV prevention.
Methods
We recruited 1070 MSM in Korea, using the Internet to maximize the confidentiality of the MSM.
Results
The prevalence of self-reported and sexually transmitted infections and HIV in the total sample was 10.7% and 2.7%, respectively. Factual knowledge and phobias regarding HIV/AIDS and self-efficacy were relatively high among the MSM. After controlling for age, education, marital status, and sexual identity, predictors of condom use at most recent anal sex included knowledge (OR = 1.25; p < 0.0001); self-efficacy (OR = 1.33; p = 0.02), additionally, having HIV testing (OR = 1.45; p = 0.02); and having a regular partner (OR = 0.53; p < 0.0001) were also positively associated with condom use.
Conclusion
The intervention programs for MSM in Korea may need to take the idiosyncratic societal and cultural pressures of the region into consideration in order to reduce infection risk.

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  • Mediating role of food insecurity in the relationship between perceived MSM related stigma and depressive symptoms among men who have sex with men in Nepal
    Kiran Paudel, Prashamsa Bhandari, Kamal Gautam, Jeffrey A. Wickersham, Toan Ha, Swagata Banik, Roman Shrestha, Cesar Infante Xibille
    PLOS ONE.2024; 19(1): e0296097.     CrossRef
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    Minsoo Jung
    Journal of Homosexuality.2024; : 1.     CrossRef
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    Isabel Tavitian-Exley, Ying Hao, Mark I-C. Chen, Chen Seong Wong, Chronos Kwok, Matthias Paul Han Sim Toh
    Frontiers in Public Health.2024;[Epub]     CrossRef
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    Seul Ki Choi, Jesse Golinkoff, Willey Y. Lin, Lisa Hightow-Weidman, Kathryn Muessig, José Bauermeister
    Archives of Sexual Behavior.2023; 52(2): 721.     CrossRef
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    Rang Hee Kwon, So-Hyun Kim, Minsoo Jung, Omid Dadras
    PLOS ONE.2023; 18(6): e0287061.     CrossRef
  • A Korean Post-Marketing Study of Abacavir/Dolutegravir/Lamivudine in Patients with HIV-1
    Sang-Kyu Shin, Jung-Eun Cho, Eun-Bin Lee, Yeon-Sook Kim, Sook-In Jung
    Infection & Chemotherapy.2023; 55(3): 337.     CrossRef
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    Aeree Sohn
    Healthcare.2023; 11(24): 3135.     CrossRef
  • A Korean Post-Marketing Surveillance Study of Dolutegravir Single-Agent Tablets in Patients with HIV-1
    Sungshin Kwon, Jung-Eun Cho, Eun-Bin Lee, Yeon-Sook Kim, Jang-Wook Sohn
    Infection & Chemotherapy.2022; 54(4): 711.     CrossRef
  • Scrutinizing the knowledge and stigma of HIV/AIDS in the community level in Indonesia and the correlation to risk groups aversion to screening
    Lee T Sen, Pavita M S Hutauruk, Mohammad R A Putra, Salsabila B Maulida, Areska Ramadhan, Agus Sugiharto
    IOP Conference Series: Earth and Environmental Sci.2021; 716(1): 012089.     CrossRef
  • The Relationship between Self-Efficacy and Spirituality in Condom use Behaviour among Msm-Plwha in Bandung, Indonesia
    Nirwanto K. Rahim, Agung Waluyo, Sri Yona
    Journal of Public Health Research.2021; 10(1_suppl): jphr.2021.2339.     CrossRef
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    Hye-Won Kim, Hyejin Yang
    The Journal of Korean Academic Society of Nursing .2021; 27(2): 163.     CrossRef
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    Geogina Charity Gumindega, Pranitha Maharaj
    African Journal of AIDS Research.2021; 20(3): 244.     CrossRef
  • Predictors of Condom Use among Gay and Bisexual Men in the Philippines
    Noriel P. Calaguas
    International Journal of Sexual Health.2020; 32(3): 188.     CrossRef
  • Cost-effectiveness analysis of pre-exposure prophylaxis for the prevention of HIV in men who have sex with men in South Korea: a mathematical modelling study
    Heun Choi, Jiyeon Suh, Woonji Lee, Jun Hyoung Kim, Jung Ho Kim, Hye Seong, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, Yoon Soo Park, Joon Sup Yeom, Changsoo Kim, Hee-Dae Kwon, Davey M. Smith, Jeehyun Lee, Jun Yong Choi
    Scientific Reports.2020;[Epub]     CrossRef
  • Prevalence and correlates of lifetime and recent HIV testing among men who have sex with men (MSM) who use mobile geo-social networking applications in Greater Tokyo
    Adam O. Hill, Benjamin R. Bavinton, Gregory Armstrong, Limin Mao
    PLOS ONE.2019; 14(1): e0209933.     CrossRef
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    Mark Drew Crosland Guimarães, Laio Magno, Maria das Graças Braga Ceccato, Raquel Regina de Freitas Magalhães Gomes, Andrea Fachel Leal, Daniela Riva Knauth, Maria Amélia de Sousa Mascena Veras, Inês Dourado, Ana Maria de Brito, Carl Kendall, Ligia Regina
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    Iván C. Balán, Javier Lopez-Rios, Curtis Dolezal, Christine Tagliaferri Rael, Cody Lentz
    Sexual Health.2019; 16(6): 580.     CrossRef
  • Differences in Risky Sexual Behavior According to Sexual Orientation in Korean Adolescents
    Ji-Su Kim, Kyunghee Kim, Yeunhee Kwak
    Journal of Homosexuality.2019; 66(1): 17.     CrossRef
  • Condom use social norms and self-efficacy with different kinds of male partners among Chinese men who have sex with men: results from an online survey
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    BMC Public Health.2018;[Epub]     CrossRef
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    Adam Hill, Benjamin Bavinton, Gregory Armstrong
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    주재홍
    Journal of Education & Culture.2017; 23(1): 175.     CrossRef
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    Natawan Khumsaen, Rob Stephenson
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    Hae-Wol Cho, Chaeshin Chu
    Osong Public Health and Research Perspectives.2016; 7(5): 279.     CrossRef
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    A. L. Bowring, V. Veronese, J. S. Doyle, M. Stoove, M. Hellard
    AIDS and Behavior.2016; 20(10): 2243.     CrossRef
  • How do Sexual Identity, and Coming Out Affect Stress, Depression, and Suicidal Ideation and Attempts Among Men Who Have Sex With Men in South Korea?
    Byonghee Cho, Aeree Sohn
    Osong Public Health and Research Perspectives.2016; 7(5): 281.     CrossRef
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    Aeree Sohn, Byonghee Cho, Harvey A. Kennedy
    Osong Public Health and Research Perspectives.2015; 6(3): 192.     CrossRef
  • Discrimination and Stigma
    Hae-Wol Cho, Chaeshin Chu
    Osong Public Health and Research Perspectives.2015; 6(3): 141.     CrossRef
  • Changing Patterns of HIV Epidemic in 30 Years in East Asia
    S. Pilar Suguimoto, Teeranee Techasrivichien, Patou Masika Musumari, Christina El-saaidi, Bhekumusa Wellington Lukhele, Masako Ono-Kihara, Masahiro Kihara
    Current HIV/AIDS Reports.2014; 11(2): 134.     CrossRef
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    Farhad Cooper, Tristan Barber
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  • What is Next for HIV/AIDS in Korea?
    Hae-Wol Cho, Chaeshin Chu
    Osong Public Health and Research Perspectives.2013; 4(6): 291.     CrossRef
Changes in Human Immunodeficiency Virusrelated Knowledge and Stigmatizing Attitudes among Korean Adolescents from 2006 to 2011
Aeree Sohn, SungBok Park
Osong Public Health Res Perspect. 2012;3(2):107-112.   Published online June 30, 2012
DOI: https://doi.org/10.1016/j.phrp.2012.04.006
  • 3,001 View
  • 21 Download
  • 8 Crossref
AbstractAbstract PDF
Objectives
This study assessed the prevalence and changes of human immunodeficiency virus (HIV) knowledge and stigmatizing attitudes in 2006, 2008, and 2011.
Methods
Three cross-sectional surveys were conducted in 2006, 2008, and 2011. A cross-sectional sample of high school students in Seoul, South Korea was targeted. A self-administered questionnaire measuring general and transmission and discriminatory attitudes was used.
Results
Misconceptions about casual contact were widespread, even though the proportion responding incorrectly decreased significantly over the 5-year period. The respondents in all surveys displayed a high level of discrimination against those with HIV/AIDS in some situations, particularly in the idea of HIV/AIDS making the respondent feel disgusted (63.3% in 2006, 57.5% in 2008, and 52.6% in 2011), avoiding sitting with people with HIV/AIDS (50.6% in 2006, 50.5% in 2008, and 48.5% in 2011), and blaming those with HIV for becoming infected (46.6% in 2006, 42.8% in 2008, and 43.0% in 2011). Even though respondents had a high level of stigmatizing attitudes, the survey showed that the stigma has declined over the 5-year period.
Conclusion
The survey results showed that public health policy should recognize that HIV stigmatizing attitudes persist in Korea. This finding has implications for the development of intervention programs focusing on reducing the levels of discrimination.

Citations

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  • Barriers and Facilitators toward HIV Testing and Health Perceptions among African-American Men Who Have Sex with Women at a South Side Chicago Community Health Center: A Pilot Study
    Ian J. Cooke, Rohan D. Jeremiah, Nataka J. Moore, Karriem Watson, Michael A. Dixon, Gregory L. Jordan, Marcus Murray, Mary K. Keeter, Courtney M. P. Hollowell, Adam B. Murphy
    Frontiers in Public Health.2017;[Epub]     CrossRef
  • Discrimination and Stigma
    Hae-Wol Cho, Chaeshin Chu
    Osong Public Health and Research Perspectives.2015; 6(3): 141.     CrossRef
  • Identifying Barriers to Human Immunodeficiency Virus Testing for Men Who Have Sex with Men in South Korea
    Aeree Sohn, Byonghee Cho, Harvey A. Kennedy
    Osong Public Health and Research Perspectives.2015; 6(3): 192.     CrossRef
  • Changing Patterns of HIV Epidemic in 30 Years in East Asia
    S. Pilar Suguimoto, Teeranee Techasrivichien, Patou Masika Musumari, Christina El-saaidi, Bhekumusa Wellington Lukhele, Masako Ono-Kihara, Masahiro Kihara
    Current HIV/AIDS Reports.2014; 11(2): 134.     CrossRef
  • HIV Stigmatization Harms Individuals and Public Health
    Jun Yong Choi
    Infection & Chemotherapy.2014; 46(2): 139.     CrossRef
  • What is Next for HIV/AIDS in Korea?
    Hae-Wol Cho, Chaeshin Chu
    Osong Public Health and Research Perspectives.2013; 4(6): 291.     CrossRef
  • Can Stigma Still Distort the Spectrum of a Disease?
    Hae-Wol Cho, Chaeshin Chu
    Osong Public Health and Research Perspectives.2012; 3(2): 65.     CrossRef
  • Knowledge, Attitudes, and Sexual Behaviors in HIV/AIDS and Predictors Affecting Condom Use among Men Who Have Sex with Men in South Korea
    Aeree Sohn, Byonghee Cho
    Osong Public Health and Research Perspectives.2012; 3(3): 156.     CrossRef
Epidemiological and Immunological Characteristics at the Time of HIV Diagnosis for HIV/AIDS Cohort Registrants Representative of HIV-Infected Populations in Korea
Jin-Hee Lee, Seung Hyun Kim, Jin-Sook Wang, Kyoung Mi Sung, Sung Soon Kim, Mee-Kyung Kee
Osong Public Health Res Perspect. 2012;3(2):100-106.   Published online June 30, 2012
DOI: https://doi.org/10.1016/j.phrp.2012.04.002
  • 2,882 View
  • 23 Download
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AbstractAbstract PDF
Objectives
The Korea HIV/AIDS cohort was constructed with 18 hospitals that care for HIV-infected individuals in 2006. We compared the epidemiological and immunological characteristics of the cohort registrants with those of the HIVinfected population at the time of HIV diagnosis.
Methods
This study was conducted on 5717 people living with HIV/AIDS from 1985 to 2009, of which 789 individuals registered with the Korea HIV/AIDS cohort study. Individuals who had data from initial CD4+ T-cell counts measured within 6 months following HIV diagnosis were selected as study participants to predict the status of disease progression at the time of HIV diagnosis. A total of 2886 patients (50%) were selected from people living with HIV/AIDS, of whom 424 individuals (54%) were cohort registrants. The χ2 test and Wilcoxon rank sum test were used for analysis.
Results
The distributions of age, marital status, diagnosed regions, reason for HIV testing, and screening site were similar between the HIV-infected population and the cohort registrants. In 1985–2004, the male ratio for the cohort registrants (94.3%) was significantly higher than that measured for the HIV-infected population (89.5%) (p = 0.0339). With regard to transmission route, homosexual contact of cohort registrants (46.6%) was higher than that of the HIV-infected population (40.1%) (p = 0.022) in 2005–2009. No statistical difference in CD4+ T-cell counts at the time of HIV diagnosis was found between the HIVinfected population and cohort registrants (p = 0.2195).
Conclusion
The Korea HIV/AIDS cohort registrants represent the HIV-infected population, and the data collected from this cohort could be used as a foundation for national statistics.

Citations

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  • Changing Patterns of HIV Epidemic in 30 Years in East Asia
    S. Pilar Suguimoto, Teeranee Techasrivichien, Patou Masika Musumari, Christina El-saaidi, Bhekumusa Wellington Lukhele, Masako Ono-Kihara, Masahiro Kihara
    Current HIV/AIDS Reports.2014; 11(2): 134.     CrossRef
  • Can Stigma Still Distort the Spectrum of a Disease?
    Hae-Wol Cho, Chaeshin Chu
    Osong Public Health and Research Perspectives.2012; 3(2): 65.     CrossRef
HIV/AIDS Knowledge, Stigmatizing Attitudes, and Related Behaviors and Factors that Affect Stigmatizing Attitudes against HIV/AIDS among Korean Adolescents
Aeree Sohn, SungBok Park
Osong Public Health Res Perspect. 2012;3(1):24-30.   Published online December 31, 2011
DOI: https://doi.org/10.1016/j.phrp.2012.01.004
  • 3,071 View
  • 16 Download
  • 30 Crossref
AbstractAbstract PDF
Objectives
This study examined the sex differentials for specific aspects of knowledge regarding HIV, stigmatizing attitudes toward people with HIV/AIDS (PWHAs) and sexual behavior. In addition, the factors that affect stigmatizing attitudes toward PWHAs were investigated.
Methods
The population of this study comprised of senior high students in Seoul, Korea. Eight high schools were selected randomly and 1566 adolescents participated in the survey. A total sample of 1548 cases (18 cases were excluded) was used for analysis. A self-administered questionnaire measuring their general and transmission and discriminatory attitudes was used.
Results
The level of HIV/AIDS knowledge among Korean adolescents was low, as indicated by a correct response rate of 54% (7.0 out of 13). The students answered correctly about HIV transmission by kissing at 50.2%, toilets at 59.4%, cup sharing at 57.4%, and daily school life at 60.5%. The level of discriminatory attitudes towards HIV-infected persons was high. Boys reported a higher proportion of sexual experience (7.0% vs. 2.6%, OR=2.89, p < 0.001). Only 39.0% used a condom during their last sexual encounter and more girls (53.3%) than boys (35.3%) reported using a condom.
Conclusions
These findings highlight the need for increasing HIV knowledge, reducing HIV stigma, and providing sex education focusing on safer sex practices.

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  • Socioeconomic Inequality in Knowledge About HIV and Its Contributing Factors Among Women of Reproductive Age in Sub-Saharan Africa: A Multicountry and Decomposition Analysis
    Achamyeleh Birhanu Teshale, Getayeneh Antehunegn Tesema
    HIV/AIDS - Research and Palliative Care.2023; Volume 15: 53.     CrossRef
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    Aeree Sohn
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    Fadi S. Qashqari, Radi T. Alsafi, Saeed M. Kabrah, Rayda'a A. AlGary, Sara A. Naeem, Malak S. Alsulami, Hatim Makhdoom
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    Herlin Fitriani Kurniawati, Herlin Fitriana Kurniawati
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    Marija Milic, Jelena Dotlic, Tatjana Gazibara, Milan Parlic, Desmond Nicholson, Katarina Mitic, Dragoslav Lazic, Jasmina Stevanovic
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    Hye-Won Kim, Hyejin Yang
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    FahadAbubakar Saulawa, ZaharaddeenShuaibu Babandi, Aminu Lawal, UmarMuhammad Umar, HalimaOmolara Olorukooba, AbdulhakeemAbayomi Olorukooba
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    Mutiara Tirta Prabandari Lintang Kusuma, Tandalayo Kidd, Nancy Muturi, Sandra Butin Procter, Linda Yarrow, Wei-Wen Hsu
    Journal of the International Association of Provid.2020; 19: 232595822093975.     CrossRef
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    Kibur Engdawork, Gail Davey, Desta Ayode, Colleen M McBride, Getnet Tadele
    Transactions of The Royal Society of Tropical Medi.2020; 114(12): 995.     CrossRef
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    Amporn Jirattikorn, Arunrat Tangmunkongvorakul, Patou Masika Musumari, Arratee Ayuttacorn, Kriengkrai Srithanaviboonchai, Cathy Banwell, Matthew Kelly
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    Minjin Kim, Haeok Lee, Peter Kiang, Deogwoon Kim
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  • Identifying Barriers to Human Immunodeficiency Virus Testing for Men Who Have Sex with Men in South Korea
    Aeree Sohn, Byonghee Cho, Harvey A. Kennedy
    Osong Public Health and Research Perspectives.2015; 6(3): 192.     CrossRef
  • Discrimination and Stigma
    Hae-Wol Cho, Chaeshin Chu
    Osong Public Health and Research Perspectives.2015; 6(3): 141.     CrossRef
  • Changing Patterns of HIV Epidemic in 30 Years in East Asia
    S. Pilar Suguimoto, Teeranee Techasrivichien, Patou Masika Musumari, Christina El-saaidi, Bhekumusa Wellington Lukhele, Masako Ono-Kihara, Masahiro Kihara
    Current HIV/AIDS Reports.2014; 11(2): 134.     CrossRef
  • What is Next for HIV/AIDS in Korea?
    Hae-Wol Cho, Chaeshin Chu
    Osong Public Health and Research Perspectives.2013; 4(6): 291.     CrossRef
  • Changes in Human Immunodeficiency Virus-related Knowledge and Stigmatizing Attitudes among Korean Adolescents from 2006 to 2011
    Aeree Sohn, SungBok Park
    Osong Public Health and Research Perspectives.2012; 3(2): 107.     CrossRef
  • Knowledge, Attitudes, and Sexual Behaviors in HIV/AIDS and Predictors Affecting Condom Use among Men Who Have Sex with Men in South Korea
    Aeree Sohn, Byonghee Cho
    Osong Public Health and Research Perspectives.2012; 3(3): 156.     CrossRef
  • Can Stigma Still Distort the Spectrum of a Disease?
    Hae-Wol Cho, Chaeshin Chu
    Osong Public Health and Research Perspectives.2012; 3(2): 65.     CrossRef
  • Human Diseases 101: Nature Versus Nurture
    Hae-Wol Cho, Chaeshin Chu
    Osong Public Health and Research Perspectives.2012; 3(1): 1.     CrossRef
Neutralizing Antibody Responses and Evolution of the Viral Envelope in the Course of HIV-1 Korean Clade B Infection
Bo Gyeong Shin, Mi-Ran Yun, Sung Soon Kim, Gab Jung Kim
Osong Public Health Res Perspect. 2011;2(3):151-157.   Published online December 31, 2011
DOI: https://doi.org/10.1016/j.phrp.2011.11.038
  • 2,886 View
  • 20 Download
  • 1 Crossref
AbstractAbstract PDF
Objectives
HIV is able to continuously adapt to and evade the evolving neutralizing antibody responses of the host. We investigated the ability of HIV variants to evade neutralizing antibodies in order to understand the distinct characteristics of HIV-1 Korean clade B.
Methods
Three drug-naive subjects were enrolled in this study who were infected with HIV-1 Korean clade B. Neutralizations were performed using autologous plasma and pseudovirion-based assays in order to analyze and compare changes in the env gene.
Results
In the early phase of infection, neutralizing activities against autologous virus variants gradually increased, which was followed by a decline in the humoral immune response against the subsequent viral escape variants. The amino acids lengths and number of potential N-linked glycosylation sites (PNGS) in HIV-1 env gene was positively correlated with neutralized antibody responses during the early stages of infection.
Conclusion
This study suggests that change within the env domains over the course of infection influences reactivities to neutralized antibodies and may also have an impact on host immune responses. This is the first longitudinal study of HIV-1 humoral immunity that took place over the entire course of HIV-1 Korean clade B infection.

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  • Blockage of CD59 Function Restores Activities of Neutralizing and Nonneutralizing Antibodies in Triggering Antibody-Dependent Complement-Mediated Lysis of HIV-1 Virions and Provirus-Activated Latently Infected Cells
    Kai Yang, Jie Lan, Nicole Shepherd, Ningjie Hu, Yanyan Xing, Daniel Byrd, Tohti Amet, Corlin Jewell, Samir Gupta, Carole Kounga, Jimin Gao, Qigui Yu, G. Silvestri
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Original Articles
Estimation of HIV Seroprevalence in Colorectal Hospitals by Questionnaire Survey in Korea, 2002–2007
Mee-Kyung Kee, Do Yeon Hwang, Jong Kyun Lee, Seung Hyun Kim, Chaeshin Chu, Jin-Hee Lee, Sung Soon Kim
Osong Public Health Res Perspect. 2011;2(2):104-108.   Published online June 30, 2011
DOI: https://doi.org/10.1016/j.phrp.2011.08.002
  • 3,283 View
  • 17 Download
  • 4 Crossref
AbstractAbstract PDF
Objectives
The incidence of anal disease is higher among persons with human immunodeficiency virus (HIV) infection than among the general population. We surveyed the status of seroprevalence in colorectal hospitals in Korea.
Methods
The survey was conducted in colorectal hospitals in Korea from November to December 2008. The questionnaire was comprised of six topics about the status of HIV testing in colorectal hospitals. We gathered the data by website (http://hivqa.nih.go.kr/risk) or fax.
Results
Among 774 colorectal hospitals contacted, 109 (14%) hospitals participated in the survey. Among these, 48 hospitals (44%) performed HIV tests in their own hospitals and 11 (23%) took HIV testing by rapid method. The main reason for recommending an HIV test was surgical operation (54%) followed by endoscope (11%) and health checkup (9%). The annual number of HIV tests increased from 58,647 (at 21 hospitals) in 2002 to 246,709 (at 58 hospitals) in 2007. HIV seroprevalence was >3.0 per 10,000 individuals during 2002–2005, decreased to 2.2 per 10,000 individuals in 2006 and rose to 2.8 per 10,000 individuals in 2007.
Conclusions
HIV seroprevalence of colorectal hospitals was more than twice that of general hospitals in Korea. HIV surveillance systems based on colorectal hospitals for HIV/AIDS transmission prevention by early HIV diagnosis are needed.

Citations

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  • Discrimination and Stigma
    Hae-Wol Cho, Chaeshin Chu
    Osong Public Health and Research Perspectives.2015; 6(3): 141.     CrossRef
  • Hospital-based HIV/HSV-2 seroprevalence among male patients with anal disease in Korea: cross sectional study
    Jin-Sook Wang, Do Yeon Hwang, Hye-Kyung Yu, Sung Soon Kim, Jong Kyun Lee, Mee-Kyung Kee
    BMC Infectious Diseases.2014;[Epub]     CrossRef
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    Hae-Wol Cho, Chaeshin Chu
    Osong Public Health and Research Perspectives.2013; 4(3): 125.     CrossRef
  • What is Next for HIV/AIDS in Korea?
    Hae-Wol Cho, Chaeshin Chu
    Osong Public Health and Research Perspectives.2013; 4(6): 291.     CrossRef
Ingenol Protects Human T Cells From HIV-1 Infection
Kee-Jong Hong, Hak Sung Lee, Yeong-shik Kim, Sung Soon Kim
Osong Public Health Res Perspect. 2011;2(2):109-114.   Published online June 30, 2011
DOI: https://doi.org/10.1016/j.phrp.2011.07.001
  • 2,999 View
  • 22 Download
  • 10 Crossref
AbstractAbstract PDF
Objectives
Many natural compounds have been investigated as drug candidates to prevent human immunodeficiency virus (HIV) with low cytotoxicity. We tested whether ingenol from Euphorbia ingens exerts anti-HIV effects in human T cell lines.
Methods
and Results Ingenol effectively maintained high cell viability (CD50, >1 mM) in H9 and MT4 T cells. The efficacy of ingenol to inhibit HIV-1 infection was dose dependent. ED50 for 100 and 200 TCID50 of HIV-1 was 5.06 and 16.87 μM, respectively. Gag p24 antigen production in ingenol-treated MT4 cells was reduced by 24.5% on day 6 post-infection. While p24 antigen was reduced in ingenol-treated cells, levels of cytokines such as TNF-α and IL-6 and chemokines such as RANTES and MCP-1 were increased. dUTP level related to late apoptotic events was increased on day 2 post-infection of HIV by ingenol treatment, whereas expression of annexin V was unchanged. Reduced levels of iNOS and ZAP-70 after HIV infection were recovered by ingenol treatment.
Conclusion
Ingenol helps T cells to survive longer against viremia after HIV-1 infection, without exerting cytotoxic effects. Ingenol can be considered a safe and efficacious candidate for immune-boosting therapy for AIDS patients.

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    E.J. Mavundza, R. Street, H. Baijnath
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    Diego Pandeló José, Koen Bartholomeeusen, Rodrigo Delvecchio da Cunha, Celina Monteiro Abreu, Jan Glinski, Thais Barbizan Ferreira da Costa, Ana Flávia Mello Bacchi Rabay, Luiz Francisco Pianowski Filho, Lech W. Dudycz, Udaykumar Ranga, Boris Matija Peter
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  • Dual Role of Novel Ingenol Derivatives from Euphorbia tirucalli in HIV Replication: Inhibition of De Novo Infection and Activation of Viral LTR
    Celina M. Abreu, Sarah L. Price, Erin N. Shirk, Rodrigo D. Cunha, Luiz F. Pianowski, Janice E. Clements, Amilcar Tanuri, Lucio Gama, Cheryl A. Stoddart
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Infectivity of Homologous Recombinant HIV-1 Pseudo-virus with Reverse Transcriptase Inhibitor-related Mutations from Highly Active Antiretroviral Therapy Experienced Patients
Oh-Kyung Kwon, Ju-yeon Choi, Eun-Jin Kim, Sung Soon Kim
Osong Public Health Res Perspect. 2011;2(1):23-28.   Published online June 30, 2011
DOI: https://doi.org/10.1016/j.phrp.2011.04.006
  • 2,820 View
  • 15 Download
  • 3 Crossref
AbstractAbstract PDF
Objectives
In this study, the viral fitness of pseudo-viruses with a drug-resistant site in the reverse transcriptase (RT) region of the genome was investigated. The pseudo-viruses were derived from highly active antiretroviral therapy (HAART)-experienced HIV/AIDS patients.
Methods
HIV-1 RNA was extracted from the plasma of HAART-experienced (KRB9149, KRB7021, KRC1097) and HAART-naïve (KRC5180, KRC5123) HIV-1 patients. The RT gene from the extracted viral RNA was amplified and the polymerase chain reaction product was cloned from the pHXB2Δ2-261 RT vector. C8166 and TZM-bl cell lines were used as the HIV-1 replication capacity measurement system. To quantify the infectivity of homologous recombinant HIV-1, the infectivity derived from each pseudo-virus was compared with the infectivity of the reference strain HXB2.
Results
Patient-derived HIV-1 was cotransfected into C8166 cells and the expression level of the p24 antigen was measured. The expression was high in the HIV-1 isolates from patients KRC5180 and KRB9149 and low in patients KRB7021, KRC5123, and KRC1097, when compared with the reference strain. The infectivity of the pseudo-virus measured in TZM-bl cells decreased in the order, reference strain HXB2 > KRC5180 > KRC5123 > KRB9149 > KRB7021 > KRC1097.
Conclusion
In this study, HIV-1 infectivity of the drug-resistant strain isolated from HAART-experienced patients with HIV/AIDS was found to be lower than the infectivity of the reference strain HXB2. This study provides useful data for the phenotypic susceptibility assay in HAART-experienced patients infected with HIV-1.

Citations

Citations to this article as recorded by  
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PHRP : Osong Public Health and Research Perspectives