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Original Article
Relationships between Virulence Factors and Antimicrobial Resistance among Escherichia coli Isolated from Urinary Tract Infections and Commensal Isolates in Tehran, Iran
Mohammad Reza Asadi Karam, Mehri Habibi, Saeid Bouzari
Osong Public Health Res Perspect. 2018;9(5):217-224.   Published online October 31, 2018
DOI: https://doi.org/10.24171/j.phrp.2018.9.5.02
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  • 104 Download
  • 19 Citations
AbstractAbstract PDF
Objectives

Uropathogenic Escherichia coli (UPEC) are the major cause of urinary tract infections (UTIs). Here, we determined whether sensitivity to antibiotics was related to the prevalence of iron scavenging genes, or to biofilm and hemolysis formation.

Methods

A total of 110 UPEC and 30 E coli isolates were collected from the urine of UTI patients and feces of healthy individuals without UTI, respectively. The presence of iron receptor genes and phenotypic properties were evaluated by polymerase chain reaction and phenotypic methods, respectively. Susceptibility to routine antibiotics was evaluated using the disc diffusion method.

Results

The prevalence of iron scavenging genes ranged from 21.8% (ireA) to 84.5% (chuA) in the UPEC. Resistance to ceftazidime and cefotaxime was significantly correlated with the presence of fyuA and iutA iron genes. Biofilm production was significantly associated with the prevalence of fyuA and hma iron genes. A higher degree of antibiotic resistance was exhibited by isolates that produced biofilms than by their non-biofilm producing counterparts.

Conclusion

Our study clearly indicates that biofilm production is associated with antibiotic resistance, and that iron receptors and hemolysin production also contribute to reduced antibiotic sensitivity. These results further our understanding of the role that these virulence factors play during UPEC pathogenesis, which in turn may be valuable for the development of novel treatment strategies against UTIs.

Citations

Citations to this article as recorded by  
  • Characterization of virulence determinants and phylogenetic background of multiple and extensively drug resistant Escherichia coli isolated from different clinical sources in Egypt
    Rana El-baz, Heba Shehta Said, Eman Salama Abdelmegeed, Rasha Barwa
    Applied Microbiology and Biotechnology.2022; 106(3): 1279.     CrossRef
  • A global systematic review and meta-analysis on correlation between biofilm producers and non-biofilm producers with antibiotic resistance in Uropathogenic Escherichia coli
    Mitra Garousi, Sina Monazami Tabar, Hosein Mirazi, Parnia Asgari, Paniz Sabeghi, Astireh Salehi, Azad Khaledi, Mohammad Ghenaat Pisheh Sanani, Hossein Karballaei Mirzahosseini
    Microbial Pathogenesis.2022; 164: 105412.     CrossRef
  • Virulence factors, antimicrobial resistance and the relationship between these characteristics in uropathogenic Escherichia coli
    Farzaneh Firoozeh, Mohammad Zibaei, Farzad Badmasti, Azad Khaledi
    Gene Reports.2022; 27: 101622.     CrossRef
  • Association between Virulence Factors and Antimicrobial Resistance of Klebsiella pneumoniae Clinical Isolates from North Kerala
    Ramya Kumaran, R.V. Geetha, Sabitha Baby
    Journal of Pure and Applied Microbiology.2022; 16(2): 867.     CrossRef
  • Characterization of virulence factors and antibiotic resistance pattern of uropathogenic Escherichia coli strains in a tertiary care center
    Naveen Kumar M, Sevitha Bhat, Archana Bhat K, Vishwas Saralaya, Shalini Shenoy Mulki
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    Naveen Kumar M, Sevitha Bhat, Archana Bhat K, Vishwas Saralaya, Shalini Shenoy Mulki
    F1000Research.2022; 11: 1163.     CrossRef
  • Insects, Rodents, and Pets as Reservoirs, Vectors, and Sentinels of Antimicrobial Resistance
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    Antibiotics.2021; 10(1): 68.     CrossRef
  • Virulence genes and phylogenetic groups of uropathogenic Escherichia coli isolates from patients with urinary tract infection and uninfected control subjects: a case-control study
    Seyedeh Elham Rezatofighi, Mahsa Mirzarazi, Mansour Salehi
    BMC Infectious Diseases.2021;[Epub]     CrossRef
  • Virulence characterization and clonal analysis of uropathogenic Escherichia coli metallo-beta-lactamase-producing isolates
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    Annals of Clinical Microbiology and Antimicrobials.2021;[Epub]     CrossRef
  • Antimicrobial Susceptibility and Detection of Virulence-Associated Genes in Escherichia coli Strains Isolated from Commercial Broilers
    Tímea Kocúreková, Lívia Karahutová, Dobroslava Bujňáková
    Antibiotics.2021; 10(11): 1303.     CrossRef
  • Evaluation of Biofilm Formation and Virulence Genes and Association with Antibiotic Resistance Patterns of Uropathogenic Escherichia coli Strains in Southwestern Iran
    Mostafa Boroumand, Asghar Sharifi, Mohammad Amin Ghatei, Mohsen Sadrinasab
    Jundishapur Journal of Microbiology.2021;[Epub]     CrossRef
  • Differences of virulence factors, and antimicrobial susceptibility according to phylogenetic group in uropathogenic Escherichia coli strains isolated from Korean patients
    Miri Hyun, Ji Yeon Lee, Hyun ah Kim
    Annals of Clinical Microbiology and Antimicrobials.2021;[Epub]     CrossRef
  • Changes in Bacterial Spectrum and Resistance Patterns Over Time in the Urine of Patients with Neurogenic Lower Urinary Tract Dysfunction Due to Spinal Cord Injury
    Jürgen Pannek, Carmen Kurmann, Jörg Krebs, Valentin Habermacher, Jens Wöllner
    Urologia Internationalis.2021; 105(5-6): 483.     CrossRef
  • A systematic review and meta-analysis of antibiotic resistance patterns, and the correlation between biofilm formation with virulence factors in uropathogenic E. coli isolated from urinary tract infections
    Fei Zhao, Huanxin Yang, Dezhong Bi, Azad Khaledi, Mingqi Qiao
    Microbial Pathogenesis.2020; 144: 104196.     CrossRef
  • A survey for phylogenetic relationship; presence of virulence genes and antibiotic resistance patterns of avian pathogenic and uropathogenic Escherichia coli isolated from poultry and humans in Yazd, Iran
    Mansoureh Bakhshi, Hengameh Zandi, Mehdi Fatahi Bafghi, Akram Astani, Vahid Reza Ranjbar, Mahmood Vakili
    Gene Reports.2020; 20: 100725.     CrossRef
  • Biofilm formation, antimicrobial susceptibility and virulence genes of Uropathogenic Escherichia coli isolated from clinical isolates in Uganda
    Paul Katongole, Fatuma Nalubega, Najjuka Christine Florence, Benon Asiimwe, Irene Andia
    BMC Infectious Diseases.2020;[Epub]     CrossRef
  • Relationship between Virulence and Resistance among Gram-Negative Bacteria
    Virginio Cepas, Sara M. Soto
    Antibiotics.2020; 9(10): 719.     CrossRef
  • Virulence factors of uropathogenic Escherichia coli (UPEC) and correlation with antimicrobial resistance
    Chhaya Shah, Ratna Baral, Bijay Bartaula, Lok Bahadur Shrestha
    BMC Microbiology.2019;[Epub]     CrossRef

PHRP : Osong Public Health and Research Perspectives