Osong Public Health and Research Perspectives

Original Articles

Seroprevalence of immunoglobulin G antibodies against SARS-CoV-2 in children and adolescents in Delhi, India, from January to October 2021: a repeated cross-sectional analysis: Pragya Sharma, Saurav Basu, Suruchi Mishra, Mongjam Meghachandra Singh; Osong Public Health Res Perspect. 2022;13(3):184-190. Published online June 10, 2022; DOI: https://doi.org/10.24171/j.phrp.2022.0014

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Objectives
The aim of this study was to assess changes in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) seroprevalence among children and adolescents in Delhi, India from January 2021 to October 2021. Methods: This was a repeated cross-sectional analysis of participants aged 5 to 17 years from 2 SARS-CoV-2 seroprevalence surveys conducted in Delhi, India during January 2021 and September to October 2021. Anti-SARS-CoV-2 IgG antibodies were detected by using the VITROS assay (90% sensitivity, 100% specificity). Results: The seroprevalence among 5- to 17-year-old school-age children and adolescents increased from 52.8% (95% confidence interval [CI], 51.3%−54.3%) in January 2021 to 81.8% (95% CI, 80.9%−82.6%) in September to October 2021. The assay-adjusted seroprevalence was 90.8% (95% CI, 89.8%−91.7%). Seropositivity positively correlated with participants’ age (p<0.001), but not sex (p=0.388). A signal to cut-off ratio ≥4.00, correlating with the presence of neutralization antibodies, was observed in 4,814 (57.9%) participants. Conclusion: The high percentage of seroconversion among children and adolescents indicates the presence of natural infection-induced immunity from past exposure to the SARS-CoV-2 virus. However, the lack of hybrid immunity and the concomitant likelihood of lower levels of neutralization antibodies than in adults due to the absence of vaccination warrants careful monitoring and surveillance of infection risk and disease severity from newer and emergent variants.

Citations

Citations to this article as recorded by

SARS-CoV-2 in Mozambican primary school-aged children at Maputo City and Province: a cross-sectional study from a low-income country
Adilson Fernando Loforte Bauhofer, Édio Ussivane, Assucênio Chissaque, Fátima Iahaia, Ramígio Pololo, Fernanda Campos, Emerson Miranda, Luciana António, Plácida Maholela, Aline Gatambire, Marlene Djedje, Fátima Ráice, Luzia Gonçalves, Nilsa de Deus, Osval
BMC Pediatrics.2024;[Epub] CrossRef
Pediatric antibody responses to SARS-CoV-2 after infection and vaccination in Calgary, Canada
Leah J. Ricketson, Emily J. Doucette, Isabella Alatorre, Tarannum Tarannum, Joslyn Gray, William Booth, Graham Tipples, Carmen Charlton, Jamil N. Kanji, Kevin Fonseca, James D. Kellner
BMC Infectious Diseases.2024;[Epub] CrossRef
Seroprevalence of SARS-CoV-2 IgG antibodies among rural children aged 6-14 years in a selected block of West Bengal, India
Vineeta Shukla, Vivek Shukla, Mausumi Basu, Aparajita Mondal, Mamunur Rashid, Ripan Saha
IMC Journal of Medical Science.2024; : 1. CrossRef
Severe Acute Hepatitis of Unknown Etiology Presenting as Pediatric Acute Liver Failure: Analysis of Likely Etiology, Clinical Course and Outcome
Bikrant B. Lal, Vikrant Sood, Ekta Gupta, Reshu Agarwal, Rajeev Khanna, Seema Alam
Journal of Clinical and Experimental Hepatology.2023; 13(5): 912. CrossRef
Anti-SARS-CoV-2 antibody kinetics up to 6 months of follow-up: Result from a nation-wide population-based, age stratified sero-epidemiological prospective cohort study in India
Puneet Misra, Arvind Kumar Singh, Baijayantimala Mishra, Bijayini Behera, Binod Kumar Patro, Guruprasad R. Medigeshi, Hari Shanker Joshi, Mohammad Ahmad, Pradeep Kumar Chaturvedi, Palanivel Chinnakali, Partha Haldar, Mohan Bairwa, Pradeep Kharya, Rahul Dh
PLOS ONE.2023; 18(12): e0287807. CrossRef
Seroprevalence of SARS CoV-2 among children after the second surge (June 2021) in a rural district of South India: Findings and lessons from a population-based survey
Carolin Elizabeth George, Leeberk Raja Inbaraj, Shon Rajukutty, Roshni Florina Joan, Sangeetha Muthuraj, Sindhulina Chandrasingh
Frontiers in Pediatrics.2022;[Epub] CrossRef

Seroprevalence of antibodies to SARS-CoV-2 and predictors of seropositivity among employees of a teaching hospital in New Delhi, India: Pragya Sharma, Rohit Chawla, Ritika Bakshi, Sonal Saxena, Saurav Basu, Pradeep Kumar Bharti, Meera Dhuria, S. K. Singh, Panna Lal; Osong Public Health Res Perspect. 2021;12(2):88-95. Published online April 29, 2021; DOI: https://doi.org/10.24171/j.phrp.2021.12.2.06

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Abstract PDF Supplementary Material

Objectives
Healthcare workers (HCWs) are at a high risk of contracting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) due to the increased likelihood of clinical exposure during patient management. The study objective was to determine the seroprevalence of antibodies to SARS-CoV-2 and its predictors among hospital employees.
Methods
The cross-sectional study was conducted at a teaching hospital from August 2020 to September 2020 among 1,401 employees, including 1,217 HCWs, in New Delhi, India. The serum samples were examined for immunoglobulin G (IgG) antibodies to SARS-CoV-2 using the COVID Kavach-Anti-SARS-CoV-2 IgG Antibody Detection enzyme-linked immunosorbent assay kit. Data were collected electronically using the EpiCollect mobile platform. A p<0.05 was considered to indicate statistical significance.
Results
A total of 169 participants (12.1%) had detectable IgG antibodies to SARS-CoV-2. The highest seropositivity rate was observed in the administrative staff (20.1%), while it was lowest among medical doctors (5.5%, p<0.001). Male sex and ever having lived in a containment zone were independently associated with past infection with SARS-CoV-2.
Conclusion
The seroprevalence of SARS-CoV-2 infection in health workers may be lower than in the general population in New Delhi. However, non-pharmaceutical interventions were not associated with a reduction in the risk of acquisition of SARS-CoV-2.

Citations

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Serosurveillance of COVID-19 amongst health care workers in a teaching institution – A prospective cohort study in Puducherry district
Muhamed Kamaludeen, Pajanivel Ranganadin, Agieshkumar Balakrishna Pillai, Arun Sugumaran
Journal of Family Medicine and Primary Care.2024; 13(5): 1917. CrossRef
Assessment of potential risk factors for COVID-19 among health care workers in a health care setting in Delhi, India -a cohort study
Mridu Dudeja, Aqsa Shaikh, Farzana Islam, Yasir Alvi, Mohammad Ahmad, Varun Kashyap, Vishal Singh, Anisur Rahman, Meely Panda, Neetu Shree, Shyamasree Nandy, Vineet Jain, Amitava Mukherjee
PLOS ONE.2023; 18(1): e0265290. CrossRef
Seroprevalence of IgG antibodies against SARS-CoV-2 in India, March 2020 to August 2021: a systematic review and meta-analysis
Nuzrath Jahan, Adarsha Brahma, Muthusamy Santhosh Kumar, Bhavani Shankara Bagepally, Manickam Ponnaiah, Tarun Bhatnagar, Manoj V Murhekar
International Journal of Infectious Diseases.2022; 116: 59. CrossRef
Risk Factors for COVID-19 Infection Among Healthcare Workers. A First Report From a Living Systematic Review and meta-Analysis
Tafadzwa Dzinamarira, Sphamandla Josias Nkambule, Mbuzeleni Hlongwa, Malizgani Mhango, Patrick Gad Iradukunda, Itai Chitungo, Mathias Dzobo, Munyaradzi Paul Mapingure, Innocent Chingombe, Moreblessing Mashora, Roda Madziva, Helena Herrera, Pelagia Makanda
Safety and Health at Work.2022; 13(3): 263. CrossRef
Seroprevalence of SARS-CoV-2 and Risk Assessment Among Healthcare Workers at a Dedicated Tertiary Care COVID-19 Hospital in Delhi, India: A Cohort Study
Pragya Sharma, Rohit Chawla, Saurav Basu, Sonal Saxena, Warisha Mariam, Pradeep Kumar Bharti, Shivani Rao, Neha Tanwar, Anisur Rahman, Mohammad Ahmad
Cureus.2021;[Epub] CrossRef

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