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2 "Jong Tae Choi"
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Characterization of Clostridium difficile Strains Isolated from Patients with C. difficile-associated Disease in Korea
Seung-Hak Cho, Jung-Whan Chon, Kun-Ho Seo, Young Kwon Kim, Jung-Beom Kim, Young-Seok Bak, Woon-Won Jung, Cheorl-Ho Kim, Jong Tae Choi
Osong Public Health Res Perspect. 2017;8(5):325-331.   Published online October 31, 2017
  • 4,565 View
  • 34 Download
  • 1 Crossref
AbstractAbstract PDF

Studies on Clostridium difficile are rare in Korea. We investigated the epidemiological characteristics of C. difficile isolates from patients with C. difficile-associated disease (CDAD) in Korea.


Multiplex polymerase chain reaction was performed to detect the presence of tcdA and tcdB toxin genes. Antimicrobial susceptibility test was carried out by the disk-dilution method. C. difficile strains were subtyped by automated repetitive-element palindromic PCR (rep-PCR).


Among patients with CDAD, 73 (25.8%), 32 (11.3%), 32 (11.3%), and 26 (9.2%) suffered from pneumonia, cancer or neoplasm, diabetes, and colitis, respectively. Of all stool samples, 43 samples (15.2%) were positive for C. difficile strains. We observed two expression patterns of toxin genes: tcdA+/tcdB+ (86% isolates) and tcdA−/tcdB+ (14% isolates), with all isolates expressing tcdB. Furthermore, some isolates were resistant to clindamycin (65%), ampicillin (56%), and cefazolin (40%), but all were susceptible to vancomycin and metronidazole. The tested samples were classified into diverse clusters using automated rep-PCR.


Our findings revealed the characteristics and antibiotic resistance of C. difficile isolates from patients in Korea. The epidemiological data may provide valuable insight into development of treatment strategies for C. difficile infections in Korea.


Citations to this article as recorded by  
  • Metronidazole therapy as initial treatment of Clostridium difficile infection in patients with chronic kidney disease in Korea
    Jaeuk Shin, Yu Mi Wi, Yu-Ji Lee
    Epidemiology and Infection.2019;[Epub]     CrossRef
Epidemiological Characterization of Skin Fungal Infections Between the Years 2006 and 2010 in Korea
Sang-Ha Kim, Seung-Hak Cho, Seung-Ki Youn, Je-Seop Park, Jong Tae Choi, Young-Seok Bak, Young-Bin Yu, Young Kwon Kim
Osong Public Health Res Perspect. 2015;6(6):341-345.   Published online December 31, 2015
  • 3,931 View
  • 31 Download
  • 11 Crossref
AbstractAbstract PDF
The purpose of this study was to build and provide a basic database of skin fungal infections for the effective management of skin fungal infections in the future.
We collected health insurance data between the years 2006 and 2010 from the Health Insurance Corporation (Seoul, Korea) and analyzed the data to determine the prevalence and treatment management of skin fungal infections.
Skin fungal infections were divided into two groups: namely dermatophytosis and other superficial mycoses. Dermatophytosis showed a higher prevalence (16,035,399 cases) than the other superficial mycoses (794,847 cases) within the study period. The prevalence rate decreased consecutively by 0.01% to 0.19% every year. The prevalence according to region showed that Jeolla-do had a high prevalence distribution. The prevalences in men and women were similar (7.01% vs. 6.26%). It is interesting to note that adults from the 50–79-year age group showed a higher prevalence than children and young adults. The average convalescence time (days) of dermatophytosis was longer than that of other superficial mycoses. The total medical expenses were also much higher in dermatophytosis than in the other superficial mycoses.
This study provides useful data for study trends of skin fungal infections.


Citations to this article as recorded by  
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    Rondinelli Donizetti Herculano, Camila Eugênia dos Reis, Silvia Maria Batista de Souza, Giovana Sant'Ana Pegorin Brasil, Mateus Scontri, Satoru Kawakita, Bruna Gregatti Carvalho, Camila Calderan Bebber, Yanjin Su, Ana Paula de Sousa Abreu, Marvin M Mecwan
    Journal of Controlled Release.2024; 365: 744.     CrossRef
  • Microsurgical Debridement for Persistent Ulcers Due to Rare Fungus Infection: Case Report and Literature Review
    Yu-Wen Tsui, Chia-Yu Tsai, Hung-Chi Chen
    Archives of Plastic Surgery.2024; 51(01): 135.     CrossRef
  • Prevalence and antifungal drug resistance of dermatophytes in the clinical samples from Pakistan
    Bakhtawar Usman, Abdul Rehman, Iffat Naz, Muhammad Anees
    Acta Microbiologica et Immunologica Hungarica.2021;[Epub]     CrossRef
  • Discovery of a novel and selective fungicide that targets fungal cell wall to treat dermatomycoses: 1,3‐bis(3,4‐dichlorophenoxy)propan‐2‐aminium chloride
    Daiane Flores Dalla Lana, Stefânia Neiva Lavorato, Laura Minussi Giuliani, Letícia Cruz, William Lopes, Marilene Henning Vainstein, Igor Camargo Fontana, Aline Rigon Zimmer, Murillo de Araújo Freitas, Saulo Fernandes de Andrade, Ricardo José Alves, Alexan
    Mycoses.2020; 63(2): 197.     CrossRef
  • Voriconazole-Natural Latex Dressings for Treating Infected Candida Spp. Skin Ulcers
    Thainá V da Silva, Natan R de Barros, Caroline B Costa-Orlandi, Jean L Tanaka, Lincoln G Moro, Giovana S Pegorin, Kassandra SM Oliveira, Maria JS Mendes-Gianinni, Ana M Fusco-Almeida, Rondinelli D Herculano
    Future Microbiology.2020; 15(15): 1439.     CrossRef
  • The Pathogenesis of Fungal-Related Diseases and Allergies in the African Population: The State of the Evidence and Knowledge Gaps
    Lorraine Tsitsi Pfavayi, Elopy Nimele Sibanda, Francisca Mutapi
    International Archives of Allergy and Immunology.2020; 181(4): 257.     CrossRef
  • Medicinal Importance of Azo and Hippuric Acid Derivatives
    Tehreem Tahir, Muhammad Ashfaq, Humna Asghar, Mirza I. Shahzad, Rukhsana Tabassum, Areeba Ashfaq
    Mini-Reviews in Medicinal Chemistry.2019; 19(9): 708.     CrossRef
  • Evaluation of antifungal activity of blended cinnamon oil and usnic acid nanoemulsion using candidiasis and dermatophytosis models
    Peeyush kumar, P.W. Ramteke, Avinash C. Pandey, Himanshu Pandey
    Biocatalysis and Agricultural Biotechnology.2019; 18: 101062.     CrossRef
  • A novel approach for skin infections: Controlled release topical mats of poly(lactic acid)/poly(ethylene succinate) blends containing Voriconazole
    Neslihan Üstündağ Okur, Maria Filippousi, Mehmet Evren Okur, Şule Ayla, Emre Şefik Çağlar, Ayşegül Yoltaş, Panoraia I. Siafaka
    Journal of Drug Delivery Science and Technology.2018; 46: 74.     CrossRef
  • Serious fungal infections in Korea
    K. Huh, Y. E. Ha, D. W. Denning, K. R. Peck
    European Journal of Clinical Microbiology & Infect.2017; 36(6): 957.     CrossRef
  • Epidemiology of Fungal Infections in Patients Admitted via Emergency Department in Korea (2011~2013)
    서영우, 장태창, 박준수
    Korean Journal of Medical Mycology.2016; 21(4): 111.     CrossRef

PHRP : Osong Public Health and Research Perspectives