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Original Article
- Plasma Calcium and Risk of Hypertension: Propensity Score Analysis Using Data From the Korean Genome and Epidemiology Study
- Jong Wook Kim, Kwang-Pil Ko, Hee Jo Koo, Younjhin Ahn, Seon-Joo Park, Hyo-Mi Kim, Yeonjung Kim, Sung Soo Kim
- Osong Public Health Res Perspect. 2011;2(2):83-88. Published online June 30, 2011
- DOI: https://doi.org/10.1016/j.phrp.2011.07.004
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Abstract
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Supplementary Material - Objective
To investigate associations between plasma calcium and future incidence of hypertension in a healthy population.
Methods
We used prospective data from Ansung and Ansan cohorts (n = 10,038) of the Korean Genome and Epidemiology Study. Data from baseline (2001–02) to the fourth study (2007–08) were used. After excluding hypertensive cases at baseline, missing data, and outliers, 5560 participants were analyzed. Propensity scores for having higher plasma calcium (≥2.37 mmol/L) were created for each participant. After propensity score matching (1:1 nearest neighbor matching within caliper), 2153 pairs were left for analysis. Factors that were significantly different between the lower and higher plasma calcium groups before matching either became nonsignificant or the difference decreased in size.
Results
Using multivariable Cox proportional hazard models with robust standard errors accounting for clustering of matched pairs, higher plasma calcium was associated with higher incidence of hypertension (adjusted HR, 1.24; robust 95%CI, 1.07–1.43). Among those with higher plasma calcium, low dietary calcium intake increased the development of hypertension, but the effect was not significant. Sensitivity analysis showed that our results were robust to hidden bias.
Conclusions
Plasma calcium was positively associated with incidence of hypertension. These results expand on cross-sectional associations between hypercalcemia and the metabolic syndrome, and extend the link to future risk of hypertension. -
Citations
Citations to this article as recorded by
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Shu Hui Lim, Weiying Lim, Serene Pei Ting Thain
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Anggun Rafisa, Sri Tjahajawati, Anggita Regiana Friandina, Intan Nur Atsila Putri Laksana, Cucu Zubaedah
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Diabetes & Metabolic Syndrome: Clinical Research &.2021; 15(1): 337. CrossRef - Plasma total calcium concentration is associated with blood pressure and systemic vascular resistance in normotensive and never-treated hypertensive subjects
Lasse Oinonen, Jenni Koskela, Arttu Eräranta, Antti Tikkakoski, Mika Kähönen, Onni Niemelä, Jukka Mustonen, Ilkka Pörsti
Blood Pressure.2020; 29(3): 137. CrossRef - Hipercalcemia como causa de hipertensión arterial presentación de un caso
Carlos Harrison Gómez, Derek Harrison Ragle, Francisco Sánchez Lezama, Adalberto Arceo Navarro, Víctor Manuel Arredondo Arzola, Luis Gerardo Domínguez Carrillo
Atención Familiar.2017;[Epub] CrossRef
- Challenges in the management of hypercalcemia in pregnancy – Case report of two cases
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