Skip Navigation
Skip to contents

PHRP : Osong Public Health and Research Perspectives



Page Path
HOME > Search
3 "Fatemeh Eghbalian"
Article category
Publication year
Review Article
Effect of clofibrate on reducing neonatal jaundice: a systematic review and meta-analysis
Fatemeh Eghbalian, Lotfollah Karimi, Roya Raeisi, Ayda Hasanpour Dehkordi, Hamid Bouraghi
Osong Public Health Res Perspect. 2022;13(3):174-183.   Published online June 30, 2022
  • 3,030 View
  • 112 Download
AbstractAbstract PDF
In neonates, bilirubin tends to be deposited in body tissues, especially the skin and mucous membranes. Jaundice is an early symptom of bilirubin excretion disorders. Therefore, the aim of this study was to investigate the effect of clofibrate on reducing neonatal jaundice. In this systematic review, international databases, including PubMed, Scopus, Web of Science, Embase, Cochrane, and Google Scholar, were searched without time and language restrictions. The reference lists of all studies ultimately included were manually searched. In the 17 articles reviewed, with a sample size of 665 people published between 2005 and 2019, the average weight of the neonates varied from 2,186 g to 4,000 g. Furthermore, the average age of neonates varied from 2 days to 9 days. Four doses of clofibrate (25, 30, 50, 100 mg/kg of neonatal body weight) were used. The bilirubin level of neonates significantly decreased in the intervention group 24, 36, 48, and 72 hours after the start of treatment. Clofibrate administration decreased total serum bilirubin, especially from the second day onwards, and also reduced hospitalization time, hospital costs, and side effects from hospitalization.
Original Article
Comparison of Purgative Manna Drop and Phototherapy with Phototherapy Treatment of Neonatal Jaundice: A Randomized Double-Blind Clinical Trial
Amirreza Monsef, Fatemeh Eghbalian, Neda Rahimi
Osong Public Health Res Perspect. 2019;10(3):152-157.   Published online June 30, 2019
Correction in: Osong Public Health Res Perspect 2020;11(4):265
  • 5,970 View
  • 181 Download
  • 3 Crossref
AbstractAbstract PDF

Herbal remedies such as purgative manna are used to treat neonatal jaundice. In this study Bilineaster drop (purgative manna) and phototherapy, and phototherapy treatment alone were compared by assessing phototherapy duration and number of days in hospital.


There were 150 consecutive term neonates with jaundice, weighting from 2,500 g to 4,000 g enrolled in this randomized double blind clinical trial. The neonates were randomly assigned to intervention and control groups. The control patients received only phototherapy and the intervention group underwent phototherapy treatment and purgative manna drop (5 drops per kg of body weight, 3 times a day). Direct and total measurements of bilirubin concentration in the serum were measured and the reduction in concentration of bilirubin was calculated.


There were 28% of patients whose hospital duration following phototherapy was 2 days, for Bilineaster and phototherapy treatment this was 49.3% of patients. At 48 hours and 72 hours the reduction in the concentration of total bilirubin in the serum was statistically significantly different across groups (p < 0.05) but at 24 hours and 96 hours there were no significant differences between groups (p > 0.05). The reduction in direct bilirubin concentration in the serum was significantly different between groups at 72 hours and 96 hours (p > 0.001).


Purgative manna and phototherapy, can statistically significantly reduce total bilirubin concentration at 48 hours and 72 hours compared with phototherapy alone, and reduce the length of hospital stay for jaundiced neonates at 2 days compared with phototherapy treatment.


Citations to this article as recorded by  
  • Recent Advances in Adjuvant Pharmacotherapy for Neonatal Indirect Hyperbilirubinemia: A Narrative Review
    Seyyedeh Azade Hoseini Nouri, Marjaneh Zarkesh
    Journal of Comprehensive Pediatrics.2023;[Epub]     CrossRef
  • The effect of oral use of concentrated pomegranate juice by mothers on hyperbilirubinemia in neonates under phototherapy: A randomized clinical trial
    Masomeh Rezapour, Yadollah Zahedpasha, Mohammad Kamalinejad, Zahra Memariani, Morteza Alijanpour, Mousa Ahmadpour-Kacho, SeyyedAli Mozaffarpur, Hoda Shirafkan
    Journal of Research in Medical Sciences.2023; 28(1): 46.     CrossRef
  • The effects of clofibrate on neonatal jaundice: A systematic review
    Fathemeh Eghbalian, Ali Hasanpour- Dehkordi, Roya Raeisi
    International Journal of Preventive Medicine.2022; 13(1): 3.     CrossRef

PHRP : Osong Public Health and Research Perspectives