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Review Article
Management of Hospital Infection Control in Iran: A Need for Implementation of Multidisciplinary Approach
Setareh Mamishi, Babak Pourakbari, Mostafa Teymuri, Abdolreza Babamahmoodi, Shima Mahmoudi
Osong Public Health Res Perspect. 2014;5(4):179-186.   Published online August 31, 2014
DOI: https://doi.org/10.1016/j.phrp.2014.06.001
  • 3,843 View
  • 22 Download
  • 17 Crossref
AbstractAbstract PDF
Nosocomial, or hospital-acquired, infections are considered the most common complications affecting hospitalized patients. According to results obtained from studies conducted in the Children Medical Center Hospital, a teaching children's hospital and a tertiary care referral unit in Tehran, Iran, improvements in infection control practices in our hospital seem necessary. The aim of this study was to identify risk management and review potential hospital hazards that may pose a threat to the health as well as safety and welfare of patients in an Iranian referral hospital. Barriers to compliance and poor design of facilities, impractical guidelines and policies, lack of a framework for risk management, failure to apply behavioral-change theory, and insufficient obligation and enforcement by infection control personnel highlight the need of management systems in infection control in our hospital. In addition, surveillance and early reporting of infections, evaluation of risk-based interventions, and production of evidence-based guidelines in our country are recommended.

Citations

Citations to this article as recorded by  
  • Hospital design principles implementation: Reflections from practitioners in Thailand
    Traiwat Viryasiri, Vikrom Laovisutthichai, Kullathida Sangnin, Kawin Dhanakoses, Pakwan Roopkaew, Pundharee Viryasiri
    Journal of Asian Architecture and Building Enginee.2024; 23(1): 43.     CrossRef
  • Linezolid and vancomycin for nosocomial infections in pediatric patients: a systematic review
    Bruno Russo Porchera, Carolina Moraes da Silva, Rayssa Pinheiro Miranda, Antônio Rafael Quadros Gomes, Pedro Henrique dos Santos Fernandes, Camili Giseli Oliveira de Menezes, Paula do Socorro de Oliveira da Costa Laurindo, Maria Fani Dolabela, Heliton Pat
    Jornal de Pediatria.2024; 100(3): 242.     CrossRef
  • Changing Epidemiology and Antimicrobial Resistance of Bacterial Childhood Diarrhea: Insights from a 7-Year Study in an Iranian Referral Hospital
    Forough Mohamadi, Babak Pourakbari, Reihaneh Hosseinpour Sadeghi, Maryam Sotoudeh, Shima Mahmoudi, Setareh Mamishi
    Foodborne Pathogens and Disease.2024;[Epub]     CrossRef
  • Bacterial etiology and antimicrobial resistance pattern of pediatric bloodstream infections: a 5-year experience in an Iranian referral hospital
    Sadaf Sajedi Moghaddam, Setareh Mamishi, Babak Pourakbari, Shima Mahmoudi
    BMC Infectious Diseases.2024;[Epub]     CrossRef
  • High prevalence of carbapenem resistance and clonal expansion of blaNDM gene in Klebsiella pneumoniae isolates in an Iranian referral pediatric hospital
    Babak Pourakbari, Setareh Mamishi, Shiva Poormohammadi, Reihaneh Hosseinpour Sadeghi, Shima Mahmoudi
    Gut Pathogens.2024;[Epub]     CrossRef
  • Evaluation of Antimicrobial Properties of Bam Date Kernel Extract and Investigation of the Structure of Extract
    Ali Monajjemi, Maryam Tabibi, Fateme Kheiri, Alireza Rasouli, Amir Arsalan Asgari, Gholam Ali Jafari
    Archives of Hygiene Sciences.2024; 13(1): 10.     CrossRef
  • Antimicrobial susceptibility and genotyping of microorganisms isolated from sputum culture of children with cystic fibrosis in an Iranian referral children’s hospital
    Setareh Mamishi, Arezu Akhlaghi, Babak Pourakbari, Mohammadreza Modaresi, Mohammad Taghi Haghi Ashtiani, Reihaneh Hosseinpour Sadeghi, Rohola Shirzadi, Zohreh Shalchi, Shima Mahmoudi
    Wiener Medizinische Wochenschrift.2023; 173(7-8): 182.     CrossRef
  • Three-year evaluation of the nosocomial infections in pediatrics: bacterial and fungal profile and antimicrobial resistance pattern
    Mehrnoush Afsharipour, Shima Mahmoudi, Hojatollahh Raji, Babak Pourakbari, Setareh Mamishi
    Annals of Clinical Microbiology and Antimicrobials.2022;[Epub]     CrossRef
  • SARS-CoV-2 Transmission Among Healthcare Workers in Iran: An Urgent Need for Early Identification and Management
    Mohammad Reza Abdolsalehi, Shima Mahmoudi, Reza Shervin Badv, Babak Pourakbari, Kayvan Mirnia, Yasmine Mahmoudieh, Setareh Mamishi
    Infectious Disorders - Drug Targets.2022;[Epub]     CrossRef
  • Prevalence of methicillin-resistant Staphylococcus aureus in Iranian children: a systematic review and meta-analysis
    Farhad Sarrafzadeh, Seyed Mojtaba Sohrevardi, Hamid Abousaidi, Hossein Mirzaei
    Clinical and Experimental Pediatrics.2021; 64(8): 415.     CrossRef
  • Antimicrobial Resistance and Genotyping of Bacteria Isolated from Urinary Tract Infection in Children in an Iranian Referral Hospital


    Setareh Mamishi, Zohreh Shalchi, Shima Mahmoudi, Reihaneh Hosseinpour Sadeghi, Mohammad Taghi Haghi Ashtiani, Babak Pourakbari
    Infection and Drug Resistance.2020; Volume 13: 3317.     CrossRef
  • An Outbreak of ESBL-producing Klebsiella pneumoniae in an Iranian Referral Hospital: Epidemiology and Molecular Typing
    Shima Mahmoudi, Babak Pourakbari, Aliakbar Rahbarimanesh, Mohammad Reza Abdosalehi, Keyghobad Ghadiri, Setareh Mamishi
    Infectious Disorders - Drug Targets.2019; 19(1): 46.     CrossRef
  • Model of Healthcare-Associated Infection Control in Primary Health Care Institutions: A Structural Equation Modeling
    Zi-nan Zhang, Xin-ping Zhang, Xiao-quan Lai
    Current Medical Science.2019; 39(1): 153.     CrossRef
  • Prevalence of methicillin-resistant Staphylococcus aureus isolated from burn patients in Iran: A systematic review and meta-analysis
    Mohammad Emaneini, Reza Beigverdi, Willem B. van Leeuwen, Hosseinali Rahdar, Morteza Karami-Zarandi, Faride Hosseinkhani, Fereshteh Jabalameli
    Journal of Global Antimicrobial Resistance.2018; 12: 202.     CrossRef
  • Health care-associated infections in Iran: A national update for the year 2015
    Babak Eshrati, Hossein Masoumi Asl, Shirin Afhami, Zahra Pezeshki, Arash Seifi
    American Journal of Infection Control.2018; 46(6): 663.     CrossRef
  • Molecular epidemiology of Staphylococcus aureus nasal colonization among patients and their parents /guardian in an Iranian referral hospital
    Babak Pourakbari, Mahmoud Khodabandeh, Shima Mahmoudi, Farah Sabouni, Alireza Aziz-Ahari, Abbas Bahador, Sepideh Keshavarz Valian, Reihaneh Hosseinpour Sadeghi, Setareh Mamishi
    Microbial Pathogenesis.2017; 107: 75.     CrossRef
  • Prevalence of vancomycin-resistant Enterococcus in Iran: a systematic review and meta-analysis
    M. Emaneini, F. Hosseinkhani, F. Jabalameli, M. J. Nasiri, M. Dadashi, R. Pouriran, R. Beigverdi
    European Journal of Clinical Microbiology & Infect.2016; 35(9): 1387.     CrossRef
Original Article
Virulence Factors of Staphylococcus aureus Isolates in an Iranian Referral Children's Hospital
Farah Sabouni, Shima Mahmoudi, Abbas Bahador, Babak Pourakbari, Reihaneh Hosseinpour Sadeghi, Mohammad Taghi Haghi Ashtiani, Bahram Nikmanesh, Setareh Mamishi
Osong Public Health Res Perspect. 2014;5(2):96-100.   Published online April 30, 2014
DOI: https://doi.org/10.1016/j.phrp.2014.03.002
  • 4,540 View
  • 24 Download
  • 34 Crossref
AbstractAbstract PDF
Objectives
The clinical importance of Staphylococcus aureus (S. aureus) is attributed to notable virulence factors, surface proteins, toxins, and enzymes as well as the rapid development of drug resistance. The aim of this study was to compare the occurrence of virulence factors produced by S. aureus strains isolated from children in an Iranian referral children's hospital.
Methods
The presence of genes encoding for the enterotoxins A (sea), B (seb), C (sec), D (sed), TSST-1 (tsst), exfoliative toxin A (eta), and exfoliative toxin B (etb) were detected by Multiplex polymerase chain reaction (PCR) using specific primers. In addition, the standardized Kirby-Bauer disc-diffusion method was performed on Mueller-Hinton agar.
Results
In total, 133 S. aureus isolates were obtained from different patients. Of these S. aureus isolates, 64 (48%) were methicillin-resistant S. aureus (MRSA), and all of these tested positive for the mecA gene. Regarding the classical enterotoxin genes, sea gene (40.6%) was the most prevalent followed by seb (19.6%), tsst (12.8%), eta (11.3%), etb (9%), sed (4.5%), and sec (3%). Among methicillin-susceptible S. aureus (MSSA) isolates, seb and tsst were the more prevalent toxins in comparison with MRSA isolates (p < 0.05), while the frequency of sea, sed, eta, and etb genes were higher among MRSA isolates (p > 0.05).
Conclusion
In our study enterotoxin A was produced by 40.6% of the isolates (48% from MRSA and 33% from MSSA isolates) which was higher than in previous reports. According to our results, strict hygiene and preventative measures during food processing are highly recommended.

Citations

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  • MRSA and VRSA isolated from patients hospitalized in the ICU, NICU and surgical departments of hospitals
    Monireh Rahimkhani, Zahra Rajabi
    Proceedings of the National Academy of Sciences, I.2024; 94(3): 653.     CrossRef
  • Antimicrobial susceptibility and genotyping of microorganisms isolated from sputum culture of children with cystic fibrosis in an Iranian referral children’s hospital
    Setareh Mamishi, Arezu Akhlaghi, Babak Pourakbari, Mohammadreza Modaresi, Mohammad Taghi Haghi Ashtiani, Reihaneh Hosseinpour Sadeghi, Rohola Shirzadi, Zohreh Shalchi, Shima Mahmoudi
    Wiener Medizinische Wochenschrift.2023; 173(7-8): 182.     CrossRef
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    Journal of Laboratory Physicians.2023; 15(03): 450.     CrossRef
  • A Retrospective Cross-sectional Study on Prevalence and Susceptibility Pattern of Bacterial Pathogens Causing Urinary Tract Infections at a Teaching Hospital in Tehran, Iran
    Maryam Noori, Shadi Aghamohammad, Fatemeh Ashrafian, Mehrdad Gholami, Hossein Dabiri, Hossein Goudarzi
    Archives of Pediatric Infectious Diseases.2023;[Epub]     CrossRef
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  • Molecular epidemiology of Staphylococcus aureus nasal colonization among patients and their parents /guardian in an Iranian referral hospital
    Babak Pourakbari, Mahmoud Khodabandeh, Shima Mahmoudi, Farah Sabouni, Alireza Aziz-Ahari, Abbas Bahador, Sepideh Keshavarz Valian, Reihaneh Hosseinpour Sadeghi, Setareh Mamishi
    Microbial Pathogenesis.2017; 107: 75.     CrossRef
  • The effect of antimicrobial photodynamic therapy on the expression of novel methicillin resistance markers determined using cDNA-AFLP approach in Staphylococcus aureus
    Mohammad Neshvan Hoorijani, Hosein Rostami, Maryam Pourhajibagher, Nasim Chiniforush, Mansour Heidari, Babak Pourakbari, Hossein Kazemian, Kambiz Davari, Vahid Amini, Reza Raoofian, Abbas Bahador
    Photodiagnosis and Photodynamic Therapy.2017; 19: 249.     CrossRef
  • Antimicrobial susceptibility of microorganisms isolated from sputum culture of patients with cystic fibrosis: Methicillin-resistant Staphylococcus aureus as a serious concern
    Narges Mazloomi Nobandegani, Shima Mahmoudi, Babak Pourakbari, Reihaneh Hosseinpour Sadeghi, Mehri Najafi Sani, Fateme Farahmand, Farzaneh Motamed, Raheleh Nabavizadeh Rafsanjani, Setareh Mamishi
    Microbial Pathogenesis.2016; 100: 201.     CrossRef
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    Jean-Soo Kim, Chul Park
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