Osong Public Health and Research Perspectives

Volume 9(3); June 2018

Editorial

Paradigm Shift in Life Sciences: Kisoon Kim; Osong Public Health Res Perspect. 2018;9(3):93-94. Published online June 30, 2018; DOI: https://doi.org/10.24171/j.phrp.2018.9.3.01

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Original Articles

Study on Cardiopulmonary Function, Maximal Oxygen Uptake, and Obesity Index according to Smoking Status in Middle-Aged and Older Office Workers: Deok-Ju Kim; Osong Public Health Res Perspect. 2018;9(3):95-100. Published online June 30, 2018; DOI: https://doi.org/10.24171/j.phrp.2018.9.3.02

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Abstract PDF

Objectives

To investigate the effect of smoking upon cardiopulmonary function, maximal oxygen uptake, and obesity index, in middle-aged and older workers to propose guidelines on healthcare for these age groups.

Methods

This study analyzed medical data from 2,753 white-collar workers aged 50 years or older from workplaces located in Seoul, South Korea. Blood pressure (BP), resting heart rate, maximal oxygen uptake (VO₂max), and body mass index (BMI) of each subject were measured. The collected data were analyzed using SPSS 21.0.

Results

In the smoking group BP and resting heart rate were significantly higher than in the non-smoking and smoking-cessation groups (p < 0.05). In addition, VO₂max was lower in the smoking group compared to the other 2 groups. BP closely correlated with resting heart rate, abdominal fat ratio, and BMI. BMI was the highest in the group that stopped smoking and, BMI and abdominal fat ratio negatively correlated with VO₂max.

Conclusion

Smoking increases the risk of cardiopulmonary disease but obesity may be caused by stopping smoking. Therefore, healthcare guidelines on smoking cessation should also include nutritional advice.

Citations

Citations to this article as recorded by

Smoking Status on Bone Health and Osteoporosis Prevalence
Vu H. Nguyen
Osong Public Health and Research Perspectives.2018; 9(4): 213. CrossRef

Seroprevalence of Toxocara in Children from Urban and Rural Areas of Ilam Province, West Iran: Sahar Shokouhi, Jahangir Abdi; Osong Public Health Res Perspect. 2018;9(3):101-104. Published online June 30, 2018; DOI: https://doi.org/10.24171/j.phrp.2018.9.3.03

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Abstract PDF

Objectives

The present study was performed to determine the seroprevalence of Toxocara in children ≤ 10 years old, from rural and urban areas of Ilam.

Methods

Serum samples from 383 children ≤ 10 years old, were selected randomly from rural and urban areas of Ilam province and surveyed using enzyme-linked immunosorbent assays.

Results

The total rate of infection with Toxocara was 22% (31% with a history of contact with dogs and cats, and 14% without a history of contact). Of those infected, 23% were male and 18% were female, 36% lived a rural life and 20% had an urban life. A significant correlation was found between the incidence of disease, and urban and rural life, as well as exposure to dogs and cats. There was no correlation between prevalence and gender or age.

Conclusion

Given the high prevalence of infection with Toxocara amongst children in Ilam province, preventive work in the community such as education in risk management and periodic treatment with anti-parasitic drugs and elimination of stray dogs and cats is an appropriate measure.

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Seroprevalence and Potential Risk Factors of Toxocariasis among General Population in Southwest Iran: Implications on the One Health Approach
Masoud Foroutan, Aida Vafae Eslahi, Shahrzad Soltani, Naser Kamyari, Ehsan Moradi-Joo, Jean-Francois Magnaval, Milad Badri, Rahul Shivahare
Journal of Immunology Research.2024; 2024: 1. CrossRef
Maternal COVID-19 infection and the fetus: Immunological and neurological perspectives
Shahab Falahi, Amir Abdoli, Azra Kenarkoohi
New Microbes and New Infections.2023; 53: 101135. CrossRef
Seroprevalence of Toxocariasis and Its Associated Risk Factors among Adult Population in Kavar District, Fars Province, South of Iran: A Cross-Sectional Community-Based Seroepidemiological Survey
Fatemehsadat Pezeshkian, Ali Pouryousef, Mostafa Omidian, Fattaneh Mikaeili, Ali Reza Safarpour, Sara Shojaei-Zarghani, Bahador Sarkari, Payam Behzadi
Interdisciplinary Perspectives on Infectious Disea.2023; 2023: 1. CrossRef
Real‐time impact of COVID‐19 pandemic on cutaneous leishmaniasis case finding and strategic planning, preventive interventions, control and epidemiology in a region with a high burden of cutaneous leishmaniasis and COVID‐19: A cross‐sectional descriptive
Morteza Shams, Ayoub Rashidi, Jasem Mohamadi, Mohamad Moradi, Reza Pakzad, Razi Naserifar, Jahangir Abdi, Fariba Ghelichi, Arezoo Bozorgomid, Nahid Maspi, Azra Kenarkoohi, Yasin Mohammadi, Amir Abdoli, Shahab Falahi
Health Science Reports.2023;[Epub] CrossRef
Presence of CRISPR CAS‐Like Sequences as a Proposed Mechanism for Horizontal Genetic Exchanges between Trichomonas vaginalis and Its Associated Virus: A Comparative Genomic Analysis with the First Report of a Putative CRISPR CAS Structures in Eukaryotic C
Azra Kenarkoohi, Amir Abdoli, Arman Rostamzad, Mahmoud Rashnavadi, Razi Naserifar, Jahangir Abdi, Morteza Shams, Arezoo Bozorgomid, Sepideh Saeb, Dhurgham Al-Fahad, Kosar Khezri, Shahab Falahi, Shibiao Wan
BioMed Research International.2023;[Epub] CrossRef
Seroprevalence and risk factors of Toxocara canis infection in children aged 2–15 years from the southwest Iran
Masoud Foroutan, Shahrzad Soltani, Samaneh Bahadoram, Fatemeh Maghsoudi, Naser Kamyari, Shekoufe Haddadi
Comparative Immunology, Microbiology and Infectiou.2022; 85: 101801. CrossRef
Seroprevalence of Toxocara spp. in children (3–13 years old) in Zahedan, Southeast of Iran
Alireza Salimi Khorashad, Majid Shahraki, Mansour Rahmati Balaghaleh, Samaneh Abdolahi Khabisi, Sangeetha Rala, Reza Shafiei, Hadi Mirahmadi
Journal of Parasitic Diseases.2021; 45(2): 449. CrossRef
The global prevalence of Toxocara spp. in pediatrics: a systematic review and meta-analysis
Behnam Abedi, Mehran Akbari, Sahar KhodaShenas, Alireza Tabibzadeh, Ali Abedi, Reza Ghasemikhah, Marzieh Soheili, Shnoo Bayazidi, Yousef Moradi
Clinical and Experimental Pediatrics.2021; 64(11): 575. CrossRef
Seroprevalence and associated risk factors of toxocariasis among nomads in Boyer-Ahmad County, southwest Iran
Nasir Arefkhah, Mohammad Reza Shadzi, Fattaneh Mikaeili, Bahador Sarkari, Farideh Esfandiari, Fatemeh Goudarzi
Transactions of The Royal Society of Tropical Medi.2020; 114(5): 372. CrossRef
Seroprevalence of anti-Toxocara antibody among multiple sclerosis patients: a case–control study
Nastaran Khalili, Neda Khalili, Ali Nickhah, Bahman Khalili
Journal of Parasitic Diseases.2020; 44(1): 145. CrossRef
Seroprevalence of toxocariasis and its related risk factors among municipal street sweepers in Shiraz District in Fars Province, southern Iran
Amirhossein Erfani, Ali Pouryousef, Nasir Arefkhah, Reza Shahriarirad, Mohammad Rastegarian, Ali Zeighami, Fattaneh Mikaeili, Seyed Younes Hosseini, Bahador Sarkari
Clinical Epidemiology and Global Health.2020; 8(2): 643. CrossRef
Toxocara infection: seroprevalence and associated risk factors among primary school children in central China
Shuai Wang, Haoran Li, Zhijun Yao, Pengju Li, Dong Wang, Haizhu Zhang, Qing Xie, Zhenchao Zhang, Xiangrui Li
Parasite.2020; 27: 30. CrossRef
Status of human toxocariasis, a neglected parasitic zoonosis in Iran: a systematic review from past to current
Reza Shafiei, Mohammad T Rahimi, Reza Zolfaghari Emameh, Mehdi Mirzaei, Gregorio Perez-Cordon, Ehsan Ahmadpour
Tropical Doctor.2020; 50(4): 285. CrossRef

How Should Biobanks Collect Biosamples for Clinical Application? A 20-year Biomarker-related Publication and Patent Trend Analysis: Jae-Eun Lee; Osong Public Health Res Perspect. 2018;9(3):105-111. Published online June 30, 2018; DOI: https://doi.org/10.24171/j.phrp.2018.9.3.04

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Abstract PDF

Objectives

This study was designed to analyze biomarker-related publications and patent trends which biobanks could consider in planning biosample collections for biomarker research.

Methods

Publications and patents containing the term “biomarker” in the title published between 1998 to 2017 were retrieved using Scopus database and Google Patents search engine.

Results

Over the last 20 years there has been a steady increase in biomarker-related publications and patents; however this has slowed for patents over the last few years. Publications in 2017 that contained blood, serum, and plasma search terms in the abstract accounted for 50%, and serum as a search term in the title and abstract was more numerous than those containing blood, plasma, tissue, or urine. Blood-related patents were the most common patent in the last 10 years, and accounted for 110 patents in 2017. Biomarker-related publications since 2010 containing RNA and protein search terms in the title and abstract, were more numerous than those containing DNA and metabolite search terms. More than 27% of biomarker-related publications in 2017 and 21% of biomarker-related patents were associated with cancer.

Conclusion

The results of this study will help biobanks establish a biosample collection strategy for clinical application.

Citations

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Nanodiamond Solid-Phase Extraction and Triton X-114 Cloud Point Separation for Robust Fractionation and Shotgun Proteomics Analysis of the Human Serum Proteome
Hai Lam Khuong, Chein-Hung Chen, Jung-Lee Lin, Trong-Nghia Le, Thi Hue Pham, Thi Bich Thao Le, Xuan Canh Nguyen, Van Chi Phan, Hoang Ha Chu, Wesley Wei-Wen Hsiao, Thi Minh Phuong Nguyen, Dinh Minh Pham
Journal of Proteome Research.2022; 21(1): 67. CrossRef
Sampling strategies to evaluate the prognostic value of a new biomarker on a time-to-event end-point
Francesca Graziano, Maria Grazia Valsecchi, Paola Rebora
BMC Medical Research Methodology.2021;[Epub] CrossRef
MicroRNA-181b Serves as a Circulating Biomarker and Regulates Inflammation in Heart Failure
Hongxiao Yang, Lina Shan, Yunan Gao, Lin Li, Guifen Xu, Bin Wang, Xiaoxue Yin, Chengfang Gao, Jiaren Liu, Wei Yang, Gaetano Isola
Disease Markers.2021; 2021: 1. CrossRef
Enhancing Cooperation Between Academic Biobanks and Biomedical Industry: Better Mutual Understanding and New Collaborative Models Are Needed
Daniel Simeon-Dubach, Michael H. Roehrl, Paul Hofman, Pascal Puchois
Biopreservation and Biobanking.2020; 18(2): 144. CrossRef

Estimating the Incidence of Cases and Deaths Resulting from Hand, Foot and Mouth Disease and Its Related Socioeconomic Disease Burden in Republic of Korea (2010 – 2014): Donghee Seo; Osong Public Health Res Perspect. 2018;9(3):112-117. Published online June 30, 2018; DOI: https://doi.org/10.24171/j.phrp.2018.9.3.05

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Abstract PDF

Objectives

Hand, Foot and Mouth disease (HFMD) is a highly contagious viral disease that affects young children and frequently causes epidemics. A vaccine is available in China (enterovirus 71) and, the Republic of Korea took the first step to develop a new vaccine. New vaccine development requires that disease burden is calculated in advance so the financial cost, morbidity and mortality can be measured.

Methods

Data from National Sentinel Surveillance and health insurance systems of 1 million claimants were used. Direct medical and non-medical costs, indirect (caregiving and premature death) costs, cases and related deaths were summarized.

Results

From 2010 to 2014, there were an estimated 3,605 to 9,271 cases of HFMD, with 1 to 3 deaths. The estimated socioeconomic disease burden ranged from 80.5 to 164.2 million USD and was similar to that of hepatitis A (93.6–103.8 million USD). Among each costs, costs of caregiving consisted of highest proportion mainly due to hiring caregivers (50% – 60%) or opportunity costs from day off (62% – 69%).

Conclusion

Considering the social impact of HFMD, the estimated socioeconomic disease burden is not high and government policies need to focus on reducing the loss of work in caregivers.

Citations

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Progress in research and development of preventive vaccines for children in China
XuYang Zheng, Ge Jin
Frontiers in Pediatrics.2024;[Epub] CrossRef
The Hand, Foot, and Mouth Disease Sentinel Surveillance System in South Korea: Retrospective Evaluation Study
Bryan Inho Kim, Chiara Achangwa, Seonghui Cho, Jisoo Ahn, Jisu Won, Hyunkyung Do, Dayeong Lee, Bohye Yoon, Joohee Kim, Sukhyun Ryu
JMIR Public Health and Surveillance.2024; 10: e59446. CrossRef
Association of public health and social measures on the hand-foot-mouth epidemic in South Korea
Sukhyun Ryu, Changhee Han, Sheikh Taslim Ali, Chiara Achangwa, Bingyi Yang, Sen Pei
Journal of Infection and Public Health.2023; 16(6): 859. CrossRef
Dynamical analysis for a reaction-diffusion HFMD model with nonsmooth saturation treatment function
Lei Shi, Hongyong Zhao, Daiyong Wu
Communications in Nonlinear Science and Numerical .2021; 95: 105593. CrossRef
A stage structure HFMD model with temperature-dependent latent period
Hongyong Zhao, Lei Shi, Jing Wang, Kai Wang
Applied Mathematical Modelling.2021; 93: 745. CrossRef
A reaction-diffusion HFMD model with nonsmooth treatment function
Lei Shi, Hongyong Zhao, Daiyong Wu
Advances in Difference Equations.2021;[Epub] CrossRef
Development and comparison of forecast models of hand-foot-mouth disease with meteorological factors
Tao Fu, Ting Chen, Zhen-Bin Dong, Shu-Ying Luo, Ziping Miao, Xiu-Ping Song, Ru-Ting Huang, Ji-Min Sun
Scientific Reports.2019;[Epub] CrossRef
Application of a combined model with seasonal autoregressive integrated moving average and support vector regression in forecasting hand-foot-mouth disease incidence in Wuhan, China
Jiao-Jiao Zou, Gao-Feng Jiang, Xiao-Xu Xie, Juan Huang, Xiao-Bing Yang
Medicine.2019; 98(6): e14195. CrossRef

Assessment of Weight Shift Direction in Chronic Stroke Patients: So Hyun Park; Osong Public Health Res Perspect. 2018;9(3):118-121. Published online June 30, 2018; DOI: https://doi.org/10.24171/j.phrp.2018.9.3.06

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Abstract PDF

Background

In patients who have suffered a stroke, the measurement of center of pressure excursion in all directions including oblique direction, anterior-medial, anterior-lateral, posterior-medial, and posterior-lateral side is important for determining balance instability but no research has been reported.

Objectives

This study investigated weight shift in all directions to determine balance instability in stroke patients, including the oblique direction, using the multi-directional functional reach test.

Methods

Eleven subjects participated. Multi-directional functional reach test consisted of moving the unaffected arm as far as possible in 8 directions. The directions were as follows; anterior, middle of anterior and lateral in unaffected side, lateral in unaffected side, and middle of the posterior and lateral in unaffected side, posterior, middle of posterior and lateral in affected side, lateral in affected side, middle of anterior and lateral in affected side.

Results

Movement was the lowest in the affected posterior-lateral side, followed by affected posterior, affected anterior-lateral, non-affected posterior lateral, affected lateral, non-affected lateral, non-affected anterior-lateral and anterior side (p < 0.05).

Conclusion

Center of pressure excursion of the affected posterior-lateral side was the most challenging for stroke patients and their reach was lowest from posterior, to lateral, and anterior directions, whilst patients could move less on the affected side compared with the non-affected side.

Citations

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Immediate effects of circular trunk movements on reach distance and centre of pressure distance during a multidirectional seated reach task in participants with post-stroke hemiparesis: a non-randomised controlled trial
Ryohei Nabeya, Hiromi Fujii, Toshiaki Sato
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Analysis of Forward Sitting Functional Reach Test in Hemiplegic Stroke
Hirofumi HIRANO, Shinichirou ISHII, Taku YONEYAMA, Sumiko YAMAMOTO
The Japanese Journal of Ergonomics.2024; 60(2): 134. CrossRef
Effects of galvanic vestibular stimulation on postural righting reactions in hemiplegia
Akari Horikawa, Kazu Amimoto, Shota Horikawa, Ken Hiramoto, Masaki Nishio, Jun Yoshino, Yumi Ikeda
Neuroscience Letters.2024; 827: 137735. CrossRef
Oblique direction reach test: evaluating psychometric properties in stroke population
Rinita Mascarenhas, Akshatha Nayak, Abraham M. Joshua, Shyam K. Krishnan, Vani Lakshmi R. Iyer, Jaya Shanker Tedla, Ravi Shankar Reddy
PeerJ.2023; 11: e16562. CrossRef
Effects of the different intensities of task-oriented training on the upper extremity motor function and self-care ability of stroke survivors: study protocol for a multiarm parallel-group randomised controlled trial in a tertiary hospital in China
Shengfeng Liu, Kai Zhang, Xuecha Li, Chunxiang Li, Mengsi Peng
BMJ Open.2023; 13(12): e074106. CrossRef
Efficacy of sitting balance training with delayed visual feedback among patients with stroke: a randomized crossover clinical trial
Kota Sawa, Kazu Amimoto, Abdul Chalik Meidian, Keisuke Ishigami, Takuya Miyamoto, Chika Setoyama, Rikuya Suzuki, Miko Tamura, Mitsusuke Miyagami
Journal of Physical Therapy Science.2022; 34(8): 540. CrossRef
Evaluation of the Effect of SPIDER System Therapy on Weight Shifting Symmetry in Chronic Stroke Patients—A Randomized Controlled Trial
Paulina Magdalena Ostrowska, Rafał Studnicki, Marcin Rykaczewski, Dawid Spychała, Rita Hansdorfer-Korzon
International Journal of Environmental Research an.2022; 19(23): 16214. CrossRef
Normative reference values for functional, lateral, and oblique direction reach tests in Saudi children aged six to 15 years old and psychometric properties of the oblique direction reach test
JS Tedla, DR Sangadala, K Gular, RS Reddy, MS Alshahrani, I Ahmad, M Abohashrh
Nigerian Journal of Clinical Practice.2021; 24(4): 576. CrossRef

Short Communication

Case of Rickettsia typhi-induced Brain Abscess Mimicking Brain Tumor: Yoonhyuk Jang, Jangsup Moon, Jin-Sun Jun, Tae-joon Kim, Kyung-Il Park, Soon-Tae Lee, Keun-Hwa Jung, Sang Kun Lee, Kon Chu; Osong Public Health Res Perspect. 2018;9(3):122-125. Published online June 30, 2018; DOI: https://doi.org/10.24171/j.phrp.2018.9.3.07

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Abstract PDF

Murine typhus is one of the most prevalent rickettsial infections in the world, caused by the bacterial genus Rickettsia. Though the disease manifests a relatively benign clinical course with fever, rash, and headache being the 3 classic symptoms, neurological complications may arise in patients that could become permanent. In this case study, a patient with a brain abscess caused by R typhi infection is described. Based upon the recent reemergence of arthropod-borne disease, the findings in this case are significant; R typhi can cause a brain abscess that mimics a brain tumor, which delays the diagnosis and appropriate management of the disease. Murine typhus should always be considered when performing the differential diagnosis of brain abscesses in South Korea.

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Meningoencephalitis and retinal vasculitis due to rickettsial infection
Louisa Lehner, Stephan Thurau, Konstantin Pusl, Steffen Tiedt, Florian Schöberl, Robert Forbrig, Günter Höglinger, Michael Strupp
Journal of Neurology.2024; 271(3): 1469. CrossRef
Giant Actinomyces brain abscess in an immunocompetent child: A management strategy
Nicole H. Chicoine, Jackson Griffith-Linsley, Joling Goh, John J. Manaloor, Jeffrey S. Raskin
Surgical Neurology International.2021; 12: 325. CrossRef

Brief Report

Review of the Incidence of Japanese Encephalitis in Foreign-Born and Korean Nationals Living in the Republic of Korea, 2007–2016: Een-Suk Shin, Ok Park, In-Sik Kong; Osong Public Health Res Perspect. 2018;9(3):126-129. Published online June 30, 2018; DOI: https://doi.org/10.24171/j.phrp.2018.9.3.08

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Abstract PDF

The Japanese encephalitis (JE) vaccine was introduced to the national immunization program in 1985, which has led to a dramatic decrease in the number of reported cases, but JE continues to occur in foreign nationals residing in or traveling to Korea. Although the incidence is low, this study demonstrated that more Koreans were infected with JE than foreign-born expatriates. The incidence rates of Korean-born nationals were between 0.01 and 0.08 cases per 100,000. In contrast, the incidence rates of foreign-born nationals ranged between 0 and 0.26 cases per 100,000. The incidence rates clearly showed that foreign-born expatriates were more at risk, which underscores the importance of vaccination. We recommend heightened surveillance among JE-susceptible individuals and promote vaccination among foreign-born nationals living in Korea.

Citations

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Zachary C. Janatpour, M. Andrew Boatwright, Sara M. Yousif, Maria-Fernanda Bonilla, Kelly A. Fitzpatrick, Susan L. Hills, Catherine F. Decker
Travel Medicine and Infectious Disease.2023; 52: 102536. CrossRef
Travel vaccines—priorities determined by incidence and impact
Robert Steffen, Lin H Chen, Peter A Leggat
Journal of Travel Medicine.2023;[Epub] CrossRef
Molecular Mechanism and Role of Japanese Encephalitis Virus Infection in Central Nervous System-Mediated Diseases
Pardeep Yadav, Pratik Chakraborty, Niraj Kumar Jha, Saikat Dewanjee, Abhimanyu Kumar Jha, Siva Prasad Panda, Prabhu Chandra Mishra, Abhijit Dey, Saurabh Kumar Jha
Viruses.2022; 14(12): 2686. CrossRef
Retention of neutralizing antibodies to Japanese encephalitis vaccine in age groups above fifteen years in Korea
Hee-Jung Lee, Hanul Choi, Ki Hoon Park, Yuyeon Jang, Young-jin Hong, Young Bong Kim
International Journal of Infectious Diseases.2020; 100: 53. CrossRef
Japanese Encephalitis Vaccine: Recommendations of the Advisory Committee on Immunization Practices
Susan L. Hills, Emmanuel B. Walter, Robert L. Atmar, Marc Fischer, Emmanuel Walter, Robert L. Atmar, Elizabeth Barnett, Alan Barrett, Joseph A. Bocchini, Lin Chen, Eric Deussing, Doran Fink, Michael Holbrook, Myron Levin, Anthony Marfin, Cody Meissner, Ro
MMWR. Recommendations and Reports.2019; 68(2): 1. CrossRef

Letter

Impact of Time Delay in Processing Blood Sample on Next Generation Sequencing for Transcriptome Analysis: Jae-Eun Lee, So-Young Jung, So-Youn Shin, Young-Youl Kim; Osong Public Health Res Perspect. 2018;9(3):130-132. Published online June 30, 2018; DOI: https://doi.org/10.24171/j.phrp.2018.9.3.09

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Scientific Reports.2020;[Epub] CrossRef

Meeting Report

The 2^nd Meeting of National Control Laboratories for Vaccines and Biologicals in the Western Pacific: Hokyung Oh, Jinho Shin, Chung Keel Lee, Masaki Ochiai, Kiyoko Nojima, Chang Kweng Lim, Sanj Raut, Irene Lisovsky, Stella Williams, Ki Young Yoo, Dong-Yeop Shin, Manabu Ato, Qiang Ye, Kiwon Han, Chulhyun Lee, Naery Lee, Ji Young Hong, Kikyung Jung, Pham Van Hung, Jayoung Jeong; Osong Public Health Res Perspect. 2018;9(3):133-139. Published online June 30, 2018; DOI: https://doi.org/10.24171/j.phrp.2018.9.3.10

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Abstract PDF

The Second Meeting of the National Control Laboratories for Vaccines and Biologicals in the Western Pacific, was jointly organized by the National Institute of Food and Drug Safety Evaluation of the Ministry of Food and Drug Safety in the Republic of Korea, and by the World Health Organization Regional Office for the Western Pacific.

In the National Lot Release Systems session countries including Canada, China, Japan, Malaysia, Vietnam, and the Republic of Korea, all shared information on their current Lot Release Systems, including current practices and developments in risk-based official lot release of vaccines.

In the session on Quality Control of Blood Products, experts from the National Institute for Biological Standards and Control shared quality control and research results for; blood coagulation factor VIII products, and the measurement of procoagulant activity in immunoglobulin products. Representatives from Japan proposed a regional collaborative study to test aggregated immunoglobulin free from complement activity. A cell-based Japanese encephalitis vaccine potency assay was proposed by representatives from Korea and they also called for voluntary participation of other National Control Laboratories in a collaborative study, on the first Korean Gloydius anti-venom standard. Participants agreed in general to continue communicating, and coordinate presentation of the study results.

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A collaborative study to establish the second national standard for hepatitis B immunoglobulin in Korea
Chan Woong Choi, Su Kyoung Seong, Ki Won Han, Hyun Jeong Kim, Kyung Hee Sohn, Sun Bo Shim, Yun Su Bang, JungHwan Cho, In Soo Shin
Biologicals.2023; 82: 101679. CrossRef
Report on the seventh meeting of national control laboratories for vaccines and biologicals of the WHO Western Pacific and South-East Asia member states
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Biologicals.2023; 84: 101712. CrossRef

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