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Volume 9(3); June 2018
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Editorial
Paradigm Shift in Life Sciences
Kisoon Kim
Osong Public Health Res Perspect. 2018;9(3):93-94.   Published online June 30, 2018
DOI: https://doi.org/10.24171/j.phrp.2018.9.3.01
  • 1,723 View
  • 61 Download
PDF
Original Articles
Study on Cardiopulmonary Function, Maximal Oxygen Uptake, and Obesity Index according to Smoking Status in Middle-Aged and Older Office Workers
Deok-Ju Kim
Osong Public Health Res Perspect. 2018;9(3):95-100.   Published online June 30, 2018
DOI: https://doi.org/10.24171/j.phrp.2018.9.3.02
  • 2,253 View
  • 105 Download
  • 1 Citations
AbstractAbstract PDF
Objectives

To investigate the effect of smoking upon cardiopulmonary function, maximal oxygen uptake, and obesity index, in middle-aged and older workers to propose guidelines on healthcare for these age groups.

Methods

This study analyzed medical data from 2,753 white-collar workers aged 50 years or older from workplaces located in Seoul, South Korea. Blood pressure (BP), resting heart rate, maximal oxygen uptake (VO2max), and body mass index (BMI) of each subject were measured. The collected data were analyzed using SPSS 21.0.

Results

In the smoking group BP and resting heart rate were significantly higher than in the non-smoking and smoking-cessation groups (p < 0.05). In addition, VO2max was lower in the smoking group compared to the other 2 groups. BP closely correlated with resting heart rate, abdominal fat ratio, and BMI. BMI was the highest in the group that stopped smoking and, BMI and abdominal fat ratio negatively correlated with VO2max.

Conclusion

Smoking increases the risk of cardiopulmonary disease but obesity may be caused by stopping smoking. Therefore, healthcare guidelines on smoking cessation should also include nutritional advice.

Seroprevalence of Toxocara in Children from Urban and Rural Areas of Ilam Province, West Iran
Sahar Shokouhi, Jahangir Abdi
Osong Public Health Res Perspect. 2018;9(3):101-104.   Published online June 30, 2018
DOI: https://doi.org/10.24171/j.phrp.2018.9.3.03
  • 2,367 View
  • 95 Download
  • 8 Citations
AbstractAbstract PDF
Objectives

The present study was performed to determine the seroprevalence of Toxocara in children ≤ 10 years old, from rural and urban areas of Ilam.

Methods

Serum samples from 383 children ≤ 10 years old, were selected randomly from rural and urban areas of Ilam province and surveyed using enzyme-linked immunosorbent assays.

Results

The total rate of infection with Toxocara was 22% (31% with a history of contact with dogs and cats, and 14% without a history of contact). Of those infected, 23% were male and 18% were female, 36% lived a rural life and 20% had an urban life. A significant correlation was found between the incidence of disease, and urban and rural life, as well as exposure to dogs and cats. There was no correlation between prevalence and gender or age.

Conclusion

Given the high prevalence of infection with Toxocara amongst children in Ilam province, preventive work in the community such as education in risk management and periodic treatment with anti-parasitic drugs and elimination of stray dogs and cats is an appropriate measure.

How Should Biobanks Collect Biosamples for Clinical Application? A 20-year Biomarker-related Publication and Patent Trend Analysis
Jae-Eun Lee
Osong Public Health Res Perspect. 2018;9(3):105-111.   Published online June 30, 2018
DOI: https://doi.org/10.24171/j.phrp.2018.9.3.04
  • 2,319 View
  • 104 Download
  • 4 Citations
AbstractAbstract PDF
Objectives

This study was designed to analyze biomarker-related publications and patent trends which biobanks could consider in planning biosample collections for biomarker research.

Methods

Publications and patents containing the term “biomarker” in the title published between 1998 to 2017 were retrieved using Scopus database and Google Patents search engine.

Results

Over the last 20 years there has been a steady increase in biomarker-related publications and patents; however this has slowed for patents over the last few years. Publications in 2017 that contained blood, serum, and plasma search terms in the abstract accounted for 50%, and serum as a search term in the title and abstract was more numerous than those containing blood, plasma, tissue, or urine. Blood-related patents were the most common patent in the last 10 years, and accounted for 110 patents in 2017. Biomarker-related publications since 2010 containing RNA and protein search terms in the title and abstract, were more numerous than those containing DNA and metabolite search terms. More than 27% of biomarker-related publications in 2017 and 21% of biomarker-related patents were associated with cancer.

Conclusion

The results of this study will help biobanks establish a biosample collection strategy for clinical application.

Estimating the Incidence of Cases and Deaths Resulting from Hand, Foot and Mouth Disease and Its Related Socioeconomic Disease Burden in Republic of Korea (2010 – 2014)
Donghee Seo
Osong Public Health Res Perspect. 2018;9(3):112-117.   Published online June 30, 2018
DOI: https://doi.org/10.24171/j.phrp.2018.9.3.05
  • 2,197 View
  • 58 Download
  • 5 Citations
AbstractAbstract PDF
Objectives

Hand, Foot and Mouth disease (HFMD) is a highly contagious viral disease that affects young children and frequently causes epidemics. A vaccine is available in China (enterovirus 71) and, the Republic of Korea took the first step to develop a new vaccine. New vaccine development requires that disease burden is calculated in advance so the financial cost, morbidity and mortality can be measured.

Methods

Data from National Sentinel Surveillance and health insurance systems of 1 million claimants were used. Direct medical and non-medical costs, indirect (caregiving and premature death) costs, cases and related deaths were summarized.

Results

From 2010 to 2014, there were an estimated 3,605 to 9,271 cases of HFMD, with 1 to 3 deaths. The estimated socioeconomic disease burden ranged from 80.5 to 164.2 million USD and was similar to that of hepatitis A (93.6–103.8 million USD). Among each costs, costs of caregiving consisted of highest proportion mainly due to hiring caregivers (50% – 60%) or opportunity costs from day off (62% – 69%).

Conclusion

Considering the social impact of HFMD, the estimated socioeconomic disease burden is not high and government policies need to focus on reducing the loss of work in caregivers.

Assessment of Weight Shift Direction in Chronic Stroke Patients
So Hyun Park
Osong Public Health Res Perspect. 2018;9(3):118-121.   Published online June 30, 2018
DOI: https://doi.org/10.24171/j.phrp.2018.9.3.06
  • 2,097 View
  • 34 Download
AbstractAbstract PDF
Background

In patients who have suffered a stroke, the measurement of center of pressure excursion in all directions including oblique direction, anterior-medial, anterior-lateral, posterior-medial, and posterior-lateral side is important for determining balance instability but no research has been reported.

Objectives

This study investigated weight shift in all directions to determine balance instability in stroke patients, including the oblique direction, using the multi-directional functional reach test.

Methods

Eleven subjects participated. Multi-directional functional reach test consisted of moving the unaffected arm as far as possible in 8 directions. The directions were as follows; anterior, middle of anterior and lateral in unaffected side, lateral in unaffected side, and middle of the posterior and lateral in unaffected side, posterior, middle of posterior and lateral in affected side, lateral in affected side, middle of anterior and lateral in affected side.

Results

Movement was the lowest in the affected posterior-lateral side, followed by affected posterior, affected anterior-lateral, non-affected posterior lateral, affected lateral, non-affected lateral, non-affected anterior-lateral and anterior side (p < 0.05).

Conclusion

Center of pressure excursion of the affected posterior-lateral side was the most challenging for stroke patients and their reach was lowest from posterior, to lateral, and anterior directions, whilst patients could move less on the affected side compared with the non-affected side.

Short Communication
Case of Rickettsia typhi-induced Brain Abscess Mimicking Brain Tumor
Yoonhyuk Jang, Jangsup Moon, Jin-Sun Jun, Tae-joon Kim, Kyung-Il Park, Soon-Tae Lee, Keun-Hwa Jung, Sang Kun Lee, Kon Chu
Osong Public Health Res Perspect. 2018;9(3):122-125.   Published online June 30, 2018
DOI: https://doi.org/10.24171/j.phrp.2018.9.3.07
  • 2,078 View
  • 110 Download
  • 1 Citations
AbstractAbstract PDF

Murine typhus is one of the most prevalent rickettsial infections in the world, caused by the bacterial genus Rickettsia. Though the disease manifests a relatively benign clinical course with fever, rash, and headache being the 3 classic symptoms, neurological complications may arise in patients that could become permanent. In this case study, a patient with a brain abscess caused by R typhi infection is described. Based upon the recent reemergence of arthropod-borne disease, the findings in this case are significant; R typhi can cause a brain abscess that mimics a brain tumor, which delays the diagnosis and appropriate management of the disease. Murine typhus should always be considered when performing the differential diagnosis of brain abscesses in South Korea.

Brief Report
Review of the Incidence of Japanese Encephalitis in Foreign-Born and Korean Nationals Living in the Republic of Korea, 2007–2016
Een-Suk Shin, Ok Park, In-Sik Kong
Osong Public Health Res Perspect. 2018;9(3):126-129.   Published online June 30, 2018
DOI: https://doi.org/10.24171/j.phrp.2018.9.3.08
  • 2,280 View
  • 99 Download
  • 2 Citations
AbstractAbstract PDF

The Japanese encephalitis (JE) vaccine was introduced to the national immunization program in 1985, which has led to a dramatic decrease in the number of reported cases, but JE continues to occur in foreign nationals residing in or traveling to Korea. Although the incidence is low, this study demonstrated that more Koreans were infected with JE than foreign-born expatriates. The incidence rates of Korean-born nationals were between 0.01 and 0.08 cases per 100,000. In contrast, the incidence rates of foreign-born nationals ranged between 0 and 0.26 cases per 100,000. The incidence rates clearly showed that foreign-born expatriates were more at risk, which underscores the importance of vaccination. We recommend heightened surveillance among JE-susceptible individuals and promote vaccination among foreign-born nationals living in Korea.

Letter
Impact of Time Delay in Processing Blood Sample on Next Generation Sequencing for Transcriptome Analysis
Jae-Eun Lee, So-Young Jung, So-Youn Shin, Young-Youl Kim
Osong Public Health Res Perspect. 2018;9(3):130-132.   Published online June 30, 2018
DOI: https://doi.org/10.24171/j.phrp.2018.9.3.09
  • 2,083 View
  • 24 Download
  • 1 Citations
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Meeting Report
The 2nd Meeting of National Control Laboratories for Vaccines and Biologicals in the Western Pacific
Hokyung Oh, Jinho Shin, Chung Keel Lee, Masaki Ochiai, Kiyoko Nojima, Chang Kweng Lim, Sanj Raut, Irene Lisovsky, Stella Williams, Ki Young Yoo, Dong-Yeop Shin, Manabu Ato, Qiang Ye, Kiwon Han, Chulhyun Lee, Naery Lee, Ji Young Hong, Kikyung Jung, Pham Van Hung, Jayoung Jeong
Osong Public Health Res Perspect. 2018;9(3):133-139.   Published online June 30, 2018
DOI: https://doi.org/10.24171/j.phrp.2018.9.3.10
  • 2,229 View
  • 94 Download
AbstractAbstract PDF

The Second Meeting of the National Control Laboratories for Vaccines and Biologicals in the Western Pacific, was jointly organized by the National Institute of Food and Drug Safety Evaluation of the Ministry of Food and Drug Safety in the Republic of Korea, and by the World Health Organization Regional Office for the Western Pacific.

In the National Lot Release Systems session countries including Canada, China, Japan, Malaysia, Vietnam, and the Republic of Korea, all shared information on their current Lot Release Systems, including current practices and developments in risk-based official lot release of vaccines.

In the session on Quality Control of Blood Products, experts from the National Institute for Biological Standards and Control shared quality control and research results for; blood coagulation factor VIII products, and the measurement of procoagulant activity in immunoglobulin products. Representatives from Japan proposed a regional collaborative study to test aggregated immunoglobulin free from complement activity. A cell-based Japanese encephalitis vaccine potency assay was proposed by representatives from Korea and they also called for voluntary participation of other National Control Laboratories in a collaborative study, on the first Korean Gloydius anti-venom standard. Participants agreed in general to continue communicating, and coordinate presentation of the study results.


PHRP : Osong Public Health and Research Perspectives