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Young-Kwon Kim 4 Articles
The effect of photodynamic therapy using Radachlorin on biofilm-forming multidrug-resistant bacteria
Choong-Won Seo, Young-Kwon Kim, Jeong-Lib An, Jong-Sook Kim, Pil-Seung Kwon, Young-Bin Yu
Osong Public Health Res Perspect. 2022;13(4):290-297.   Published online August 10, 2022
  • 2,507 View
  • 48 Download
  • 4 Web of Science
  • 4 Crossref
AbstractAbstract PDF
This study aimed to test the effect of photodynamic therapy (PDT) on the inhibition and removal of biofilms containing multidrug-resistant Acinetobacter baumannii.
Using multidrug-resistant A. baumannii strains, an antibiotic susceptibility test was performed using the Gram-negative identification card of the Vitek 2 system (bioMérieux Inc., France), as well as an analysis of resistance genes, the effects of treatment with a light-emitting diode (LED) array using Radachlorin (RADA-PHARMA Co., Ltd., Russia), and transmission and scanning electron microscopy to confirm the biofilm-inhibitory effect of PDT.
The antibiotic susceptibility test revealed multiple resistance to the antibiotics imipenem and meropenem in the carbapenem class. A class-D–type β-lactamase was found, and OXA-23 and OXA-51 were found in 100% of 15 A. baumannii strains. After PDT using Radachlorin, morphological observations revealed an abnormal structure due to the loss of the cell membrane and extensive morphological changes, including low intracellular visibility and small vacuoles attached to the cell membrane.
PDT involving a combination of LED and Radachlorin significantly eliminated the biofilm of multidrug-resistant A. baumannii. Observations made using electron microscopy showed that PDT combining LED and Radachlorin was effective. Additional studies on the effective elimination of biofilms containing multidrug-resistant bacteria are necessary, and we hope that a treatment method superior to sterilization with antibiotics will be developed in the future.


Citations to this article as recorded by  
  • Photophysical properties of Radachlorin photosensitizer in solutions of different pH, viscosity and polarity
    A.V. Belashov, A.A. Zhikhoreva, I.A. Gorbunova, M.E. Sasin, Sh.S. Shayakhmedov, I.V. Semenova
    Spectrochimica Acta Part A: Molecular and Biomolec.2024; 305: 123480.     CrossRef
  • Applications of Antimicrobial Photodynamic Therapy in Aquaculture: Effect on Fish Pathogenic Bacteria
    Edith Dube, Grace Emily Okuthe
    Fishes.2024; 9(3): 99.     CrossRef
  • Understanding the biofilm development of Acinetobacter baumannii and novel strategies to combat infection
    Naji Naseef Pathoor, Akshaya Viswanathan, Gulshan Wadhwa, Pitchaipillai Sankar Ganesh
    APMIS.2024; 132(5): 317.     CrossRef
  • PDT-Induced Variations of Radachlorin Fluorescence Lifetime in Living Cells In Vitro
    Andrey V. Belashov, Anna A. Zhikhoreva, Anna V. Salova, Tatiana N. Belyaeva, Ilia K. Litvinov, Elena S. Kornilova, Irina V. Semenova
    Photonics.2023; 10(11): 1262.     CrossRef
Corrigendum to “Epidemiological Characterization of Imported Systemic Mycoses Occurred in Korea” [Osong Public Health Res Perspect 2018;9(5):255–60]
Seung-Hak Cho, Young-Bin Yu, Je-Seop Park, Keun-Dol Yook, Young-Kwon Kim
Osong Public Health Res Perspect. 2018;9(6):362-362.   Published online December 31, 2018
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  • 34 Download
Epidemiological Characterization of Imported Systemic Mycoses Occurred in Korea
Seung-Hak Cho, Young-Bin Yu, Je-Seop Park, Keun-Dol Yook, Young-Kwon Kim
Osong Public Health Res Perspect. 2018;9(5):255-260.   Published online October 31, 2018
  • 10,960 View
  • 125 Download
  • 4 Crossref
AbstractAbstract PDF

Imported systemic mycoses is a severe fungal infection that can cause diseases in healthy people. However, there is a serious lack of epidemiological data about imported systemic mycoses. Therefore, an epidemiological characterization of imported systemic mycoses in Korea was performed.


We collected health insurance data between 2008 and 2012 from the Health Insurance Corporation and analyzed the data to determine the prevalence and treatment management of imported systemic mycoses.


The prevalence of imported systemic mycoses between 2008 and 2012 increased slowly by 0.49/100,000 to 0.53/100,000 persons. The prevalence of coccidioidomycosis increased from 0.28/100,000 in 2008 to 0.36/100,000 persons in 2012. A mean of 229.6 cases occurred each year. Children and the elderly showed higher prevalence than adults in the 20- to 59-year-old age group. The rate of infection according to region ranged from 0.18/100,000 persons in Ulsan, to 0.59/100,000 persons in Gyeonggi. The prevalence in females was higher than that in males. Inpatient treatment was 3.3% (38 cases), with 96.7% treated as outpatients. Hospitalizations cost 272.7 million won and outpatient treatments cost 111.7 million won. The treatment cost for coccidioidomycosis from 2008 to 2012 was 330.9 million won, with personal charges of 79.2 million won and insurance charges of 251.7 million won. Most of the expenses for the coccidioidomycosis treatment were for inpatient treatment.


The results in this study may be a useful resource for determining the changes in the trend of imported systemic mycoses.


Citations to this article as recorded by  
  • Invasive Fungal Infections in Acute Decompensation of Cirrhosis: Epidemiology, Predictors of 28-Day Mortality, and Outcomes
    Yu Wang, Chen Li, Haibin Su, Jinhua Hu
    Indian Journal of Microbiology.2024;[Epub]     CrossRef
  • The clinical laboratory evolution in coccidioidomycosis detection: Future perspectives
    José María Gastélum-Cano, Mitzuko Dautt-Castro, Alfonso García-Galaz, Katya Felix-Murray, Antonio Rascón-Careaga, Manuel A. Cano-Rangel, María A. Islas-Osuna
    Journal of Medical Mycology.2021; 31(3): 101159.     CrossRef
  • Emerging Invasive Fungal Infections: Clinical Features and Controversies in Diagnosis and Treatment Processes

    Hongliang Zhang, Aiqun Zhu
    Infection and Drug Resistance.2020; Volume 13: 607.     CrossRef
  • Timely Diagnosis of Histoplasmosis in Non-endemic Countries: A Laboratory Challenge
    María José Buitrago, M. Teresa Martín-Gómez
    Frontiers in Microbiology.2020;[Epub]     CrossRef
Trends in the Incidence of Scrub Typhus: The Fastest Growing Vector-Borne Disease in Korea
Mi Ae Jeong, Seung-Ki Youn, Young-Kwon Kim, Hyungmin Lee, Sun-Ja Kim, Aeree Sohn
Osong Public Health Res Perspect. 2013;4(3):166-169.   Published online June 30, 2013
  • 3,068 View
  • 23 Download
  • 17 Crossref
AbstractAbstract PDF
Scrub typhus, also called tsutsugamushi disease, is classified as a Group 3 disease in Korea according to the National Notifiable Diseases Surveillance Systems. It is an infectious disease transmitted to humans through the bite of mites that are infected with an intracellular parasite called Orientia tsutsugamushi (Family: Rickettsiaceae). This study aims to identify the demographic characteristics of the infected cases according to profession, region, gender, and onset period and provide a basic data for prevention and control of the disease in the infected patients. Between 2001 and 2010, 16,741 men (36.3%) and 29,373 women (63.7%) were reported to have been infected with scrub typhus, with men being 1.6 times less infected than women. When classified according to age, it was found that 4421 persons (9.6%) were under 40 years of age; 6601 (13.1%) in their 40s; 9714 (21.1%) in their 50s; 13,067 (28.3%) in 60s; 10,128 (22.0%) in their 70s; and 2723 (5.9%) aged 80 or more. The elderly (60 years or older) represented more than half of the infected cases. When the infections were classified according to region, it was found that the county residents had the major share of infection, with a total of 1583 infected cases (59.85).


Citations to this article as recorded by  
  • Epidemiologic changes of a longitudinal surveillance study spanning 51 years of scrub typhus in mainland China
    Pei-Ying Peng, Hui-Ying Duan, Lei Xu, Lin-Tao Zhang, Ji-Qin Sun, Ya Zu, Li-Juan Ma, Yan Sun, Ting-Liang Yan, Xian-Guo Guo
    Scientific Reports.2024;[Epub]     CrossRef
  • Identification of Bacteria and Viruses Associated with Patients with Acute Febrile Illness in Khon Kaen Province, Thailand
    Rungrat Jitvaropas, Vorthon Sawaswong, Yong Poovorawan, Nutthanun Auysawasdi, Viboonsak Vuthitanachot, Sirima Wongwairot, Wuttikon Rodkvamtook, Erica Lindroth, Sunchai Payungporn, Piyada Linsuwanon
    Viruses.2024; 16(4): 630.     CrossRef
  • Scrub typhus seroprevalence from an eastern state of India: findings from the state-wide serosurvey
    Debaprasad Parai, Matrujyoti Pattnaik, Jaya Singh Kshatri, Usha Kiran Rout, Annalisha Peter, Rashmi Ranjan Nanda, Subrat Kumar Sahoo, Asit Mansingh, Hari Ram Choudhary, Girish Chandra Dash, Ira Praharaj, Debdutta Bhattacharya, Sanghamitra Pati
    Transactions of The Royal Society of Tropical Medi.2023; 117(1): 22.     CrossRef
  • Epidemiological characteristics of cases with scrub typhus and their correlation with chigger mite occurrence (2019–2021): A focus on case occupation and activity locations
    Se‐Jin Jeong, Jin‐Hwan Jeon, Kyung won Hwang
    Entomological Research.2023; 53(7): 247.     CrossRef
  • Epidemiological Aspects of Tsutsugamushi Disease (Scrub Typhus) Outbreaks in Republic of Korea and Japan
    Myeong-Jin Lee, Bok Soon Han, Won-Chang Lee, Young Hwan Kwon
    The Korean Journal of Aerospace and Environmental .2022; 32(2): 65.     CrossRef
  • Scrub typhus and antibiotic-resistant Orientia tsutsugamushi
    Chin-Te Lu, Lih-Shinn Wang, Po-Ren Hsueh
    Expert Review of Anti-infective Therapy.2021; 19(12): 1519.     CrossRef
  • Seropositivity of Scrub Typhus Inpatients Attending a Tertiary Care Hospital in Western Odisha
    Shuvankar Mukherjee, Anshuman Dash, Shreekant Tiwari
    Journal of Evolution of Medical and Dental Science.2020; 9(04): 178.     CrossRef
  • Clinical and Laboratory Predictors associated with Complicated Scrub Typhus
    Mi-Hee Kim, Si-Hyun Kim, Jung-Hyun Choi, Seong-Heon Wie
    Infection & Chemotherapy.2019; 51(2): 161.     CrossRef
  • Molecular Epidemiology of an Orientia tsutsugamushi Gene Encoding a 56-kDa Type-Specific Antigen in Chiggers, Small Mammals, and Patients from the Southwest Region of Korea
    Jung Wook Park, Sun Hee Kim, Duck Woong Park, So Hyang Jung, Hye Jung Park, Mi Hee Seo, Hyeon Je Song, Jung Yoon Lee, Dong Min Kim, Choon-Mee Kim, Byong Chul Gill, Hang Jin Jeong, Jeong Min Lee, Dong Ryong Ha, Eun Sun Kim, Jae Keun Chung
    The American Journal of Tropical Medicine and Hygi.2018; 98(2): 616.     CrossRef
  • Clinical Aspects of Scrub Typhus Initially Misdiagnosed as Kawasaki Disease
    Sung Hoon Kim, Hae Jeong Lee, Ju Suk Lee
    Iranian Journal of Pediatrics.2018;[Epub]     CrossRef
  • Prevalence and risk factors for scrub typhus in South India
    Paul Trowbridge, Divya P., Prasanna S. Premkumar, George M. Varghese
    Tropical Medicine & International Health.2017; 22(5): 576.     CrossRef
  • Central Nervous System Infection Associated with Orientia tsutsugamushi in South Korea
    Kon Chu, Seon-Jae Ahn, Woo-Jin Lee, Jin-Sun Jun, Jung-Ah Lim, Keun-Hwa Jung, Kyung-Il Park, Jun-Sang Sunwoo, Han Sang Lee, Sang Kun Lee, Ki-Young Jung, Jangsup Moon, Soon-Tae Lee
    The American Journal of Tropical Medicine and Hygi.2017; 97(4): 1094.     CrossRef
  • Generation of protective immunity against Orientia tsutsugamushi infection by immunization with a zinc oxide nanoparticle combined with ScaA antigen
    Na-Young Ha, Hyun Mu Shin, Prashant Sharma, Hyun Ah Cho, Chan-Ki Min, Hong-il Kim, Nguyen Thi Hai Yen, Jae-Seung Kang, Ik-Sang Kim, Myung-Sik Choi, Young Keun Kim, Nam-Hyuk Cho
    Journal of Nanobiotechnology.2016;[Epub]     CrossRef
  • Immunization with an Autotransporter Protein of Orientia tsutsugamushi Provides Protective Immunity against Scrub Typhus
    Na-Young Ha, Prashant Sharma, Gwanghun Kim, Yuri Kim, Chan-Ki Min, Myung-Sik Choi, Ik-Sang Kim, Nam-Hyuk Cho, David H Walker
    PLOS Neglected Tropical Diseases.2015; 9(3): e0003585.     CrossRef
  • Current situation of scrub typhus in South Korea from 2001–2013
    Hyeong-Woo Lee, Pyo Yun Cho, Sung-Ung Moon, Byoung-Kuk Na, Yoon-Joong Kang, Youngjoo Sohn, Seung-Ki Youn, Yeongseon Hong, Tong-Soo Kim
    Parasites & Vectors.2015;[Epub]     CrossRef
  • 18F-FDG PET/CT Findings of Scrub Typhus
    Jahae Kim, Seong Young Kwon, Sae-Ryung Kang, Sang-Geon Cho, Ho-Chun Song
    Clinical Nuclear Medicine.2015; 40(10): e484.     CrossRef
  • Epidemiology of Scrub Typhus and the Eschars Patterns in South Korea from 2008 to 2012
    Ji-Hyuk Park, Sun-Ja Kim, Seung-Ki Youn, Kisoo Park, Jin Gwack
    Japanese Journal of Infectious Diseases.2014; 67(6): 458.     CrossRef

PHRP : Osong Public Health and Research Perspectives