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Yeong-Ae Yang 1 Article
The Effect of a Complex Intervention Program for Unilateral Neglect in Patients with Acute-Phase Stroke: A Randomized Controlled Trial
Hyun-Se Choi, Deok-Ju Kim, Yeong-Ae Yang
Osong Public Health Res Perspect. 2019;10(5):265-273.   Published online October 31, 2019
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AbstractAbstract PDF

The purpose of this study was to examine the combined effects of Prism Adaptation (PA) plus functional electrical stimulation (FES) on stroke patients with unilateral neglect, and suggest a new intervention method for acute-phase stroke patients.


There were 30 patients included in this study from April to October 2016 that had unilateral neglect whilst hospitalized following a stroke (diagnosed by a professional). The participants, who were patients receiving occupational therapy, understood the purpose of the study and agreed to participate. The patients were randomly divided into 3 groups: PA plus FES group (Group A), PA group (Group B), and FES group (Group C). Treatments lasted for 50 minutes per day, 5 times per week, for 3 weeks in total. Reevaluation was conducted after 3 weeks of intervention.


All 3 groups showed unilateral neglect reduction after the intervention, but PA plus FES (complex intervention method) was more effective than PA or FES alone [effect size: Motor-free Visual Perception Test (0.80), Albert test (0.98), CBS (0.92)].


The results of this study support further studies to examine complex intervention for the treatment of unilateral neglect.


Citations to this article as recorded by  
  • Inclusion of People With Aphasia in Stroke Trials: A Systematic Search and Review
    Ciara Shiggins, Brooke Ryan, Farhana Dewan, Julie Bernhardt, Robyn O'Halloran, Emma Power, Richard I. Lindley, Gordon McGurk, Miranda L. Rose
    Archives of Physical Medicine and Rehabilitation.2024; 105(3): 580.     CrossRef
  • Prism adaptation combined with eye movement training for unilateral spatial neglect after stroke: Study protocol for a single-blind prospective, randomized controlled trial
    Yu-xuan Yang, Ling-ling Wang, Juan Du, Yao-min Luo, Yu-lei Xie, Bo Zhang, Han Zhang
    Frontiers in Neurology.2023;[Epub]     CrossRef
  • No short-term treatment effect of prism adaptation for spatial neglect: An inclusive meta-analysis
    Orsolya Székely, Antonia F. Ten Brink, Alexandra G. Mitchell, Janet H. Bultitude, Robert D. McIntosh
    Neuropsychologia.2023; 189: 108566.     CrossRef
  • A Complex Intervention Integrating Prism Adaptation and Neck Vibration for Unilateral Neglect in Patients of Chronic Stroke: A Randomised Controlled Trial
    Hyun-Se Choi, Bo-Min Lee
    International Journal of Environmental Research an.2022; 19(20): 13479.     CrossRef
  • Non-pharmacological interventions for spatial neglect or inattention following stroke and other non-progressive brain injury
    Verity Longley, Christine Hazelton, Calvin Heal, Alex Pollock, Kate Woodward-Nutt, Claire Mitchell, Gorana Pobric, Andy Vail, Audrey Bowen
    Cochrane Database of Systematic Reviews.2021;[Epub]     CrossRef

PHRP : Osong Public Health and Research Perspectives