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Won Keun Seong 2 Articles
Enteric Bacteria Isolated from Diarrheal Patients in Korea in 2014
Nan-Ok Kim, Su-Mi Jung, Hae-Young Na, Gyung Tae Chung, Cheon-Kwon Yoo, Won Keun Seong, Sahyun Hong
Osong Public Health Res Perspect. 2015;6(4):233-240.   Published online August 31, 2015
DOI: https://doi.org/10.1016/j.phrp.2015.07.005
  • 2,222 View
  • 18 Download
  • 11 Citations
AbstractAbstract PDFSupplementary Material
Objectives
The aim of this study was to characterize the pathogens responsible for causing diarrhea according to season, region of isolation, patient age, and sex as well as to provide useful data for the prevention of diarrheal disease.
Methods
Stool specimens from 14,886 patients with diarrhea were collected to identify pathogenic bacteria from January 2014 to December 2014 in Korea. A total of 3,526 pathogenic bacteria were isolated and analyzed according to season, region of isolation, and the age and sex of the patient.
Results
The breakdown of the isolated pathogenic bacteria were as follows: Salmonella spp. 476 (13.5%), pathogenic Escherichia coli 777 (22.0%), Vibrio parahaemolyticus 26 (0.74%), Shigella spp. 13 (0.37%), Campylobacter spp. 215 (6.10%), Clostridium perfringens 508 (14.4%), Staphylococcus aureus 1,144 (32.4%), Bacillus cereus 356 (10.1%), Listeria monocytogenes 1 (0.03%), and Yersinia enterocolitica 10 (0.3%). The isolation rate trend showed the highest ratio in the summer season from June to September for most of the pathogenic bacteria except the Gram-positive bacteria. The isolation rate of most of the pathogenic bacteria by patient age showed highest ratio in the 0–19 year age range. For isolation rate by region, 56.2% were isolated from cities and 43.8% were isolated from provinces.
Conclusion
Hygiene education should be addressed for diarrheal disease-susceptible groups, such as those younger than 10 years, aged 10–19 years, and older than 70 years, and monitoring for the pathogens is still required. In addition, an efficient laboratory surveillance system for infection control should be continued.

Citations

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  • Plant-derived nanoparticles as alternative therapy against Diarrheal pathogens in the era of antimicrobial resistance: A review
    Tesleem Olatunde Abolarinwa, Daniel Jesuwenu Ajose, Bukola Opeyemi Oluwarinde, Justine Fri, Kotsoana Peter Montso, Omolola Esther Fayemi, Adeyemi Oladapo Aremu, Collins Njie Ateba
    Frontiers in Microbiology.2022;[Epub]     CrossRef
  • Prevalence, co-infection and seasonality of fecal enteropathogens from diarrheic cats in the Republic of Korea (2016–2019): a retrospective study
    Ye-In Oh, Kyoung-Won Seo, Do-Hyung Kim, Doo-Sung Cheon
    BMC Veterinary Research.2021;[Epub]     CrossRef
  • Genotyping and antimicrobial susceptibility of Clostridium perfringens isolated from dromedary camels, pastures and herders
    Mahmoud Fayez, Ibrahim Elsohaby, Theeb Al-Marri, Kamal Zidan, Ali Aldoweriej, Elham El-Sergany, Ahmed Elmoslemany
    Comparative Immunology, Microbiology and Infectiou.2020; 70: 101460.     CrossRef
  • Comparative Analysis of Aerotolerance, Antibiotic Resistance, and Virulence Gene Prevalence in Campylobacter jejuni Isolates from Retail Raw Chicken and Duck Meat in South Korea
    Jinshil Kim, Hyeeun Park, Junhyung Kim, Jong Hyun Kim, Jae In Jung, Seongbeom Cho, Sangryeol Ryu, Byeonghwa Jeon
    Microorganisms.2019; 7(10): 433.     CrossRef
  • Guideline for the Antibiotic Use in Acute Gastroenteritis
    Youn Jeong Kim, Ki-Ho Park, Dong-Ah Park, Joonhong Park, Byoung Wook Bang, Seung Soon Lee, Eun Jung Lee, Hyo-Jin Lee, Sung Kwan Hong, Yang Ree Kim
    Infection & Chemotherapy.2019; 51(2): 217.     CrossRef
  • Winning the War against Multi-Drug Resistant Diarrhoeagenic Bacteria
    Chizoba Mercy Enemchukwu, Angus Nnamdi Oli, Ebere Innocent Okoye, Nonye Treasure Ujam, Emmanuel O. Osazuwa, George Ogonna Emechebe, Kenneth Nchekwube Okeke, Christian Chukwuemeka Ifezulike, Obiora Shedrack Ejiofor, Jude Nnaemeka Okoyeh
    Microorganisms.2019; 7(7): 197.     CrossRef
  • Molecular Characterization of Enterotoxigenic Escherichia coli in Foodborne Outbreak
    Sang-Hun Park, Hyun-Jung Seung, Hyo-Won Jeong, So-Yun Park, Ji-Hun Jung, Young-Hee Jin, Sung-Hee Han, Hee-Soon Kim, Jin-Seok Kim, Joo-Hyun Park, Ye-Ji Gong, Chae Kyu Hong, Jib-Ho Lee, Il-Young Kim, Kweon Jung
    Journal of Bacteriology and Virology.2018; 48(4): 113.     CrossRef
  • Epidemiology of Listeria monocytogenes prevalence in foods, animals and human origin from Iran: a systematic review and meta-analysis
    Reza Ranjbar, Mehrdad Halaji
    BMC Public Health.2018;[Epub]     CrossRef
  • The Epidemiological Influence of Climatic Factors on Shigellosis Incidence Rates in Korea
    Yeong-Jun Song, Hae-Kwan Cheong, Myung Ki, Ji-Yeon Shin, Seung-sik Hwang, Mira Park, Moran Ki, Jiseun Lim
    International Journal of Environmental Research an.2018; 15(10): 2209.     CrossRef
  • Molecular characterization and antimicrobial resistance profile of Clostridium perfringens type A isolates from humans, animals, fish and their environment
    Jay Prakash Yadav, Suresh Chandra Das, Pankaj Dhaka, Deepthi Vijay, Manesh Kumar, Asish Kumar Mukhopadhyay, Goutam Chowdhury, Pranav Chauhan, Rahul Singh, Kuldeep Dhama, Satya Veer Singh Malik, Ashok Kumar
    Anaerobe.2017; 47: 120.     CrossRef
  • Molecular characterization of antimicrobial resistant non-typhoidal Salmonella from poultry industries in Korea
    Jin Eui Kim, Young ju Lee
    Irish Veterinary Journal.2017;[Epub]     CrossRef
Serological Correlate of Protection in Guinea Pigs for a Recombinant Protective Antigen Anthrax Vaccine Produced from Bacillus brevis
Jeong-Hoon Chun, On-Jee Choi, Min-Hee Cho, Kee-Jong Hong, Won Keun Seong, Hee-Bok Oh, Gi-Eun Rhie
Osong Public Health Res Perspect. 2012;3(3):170-176.   Published online June 30, 2012
DOI: https://doi.org/10.1016/j.phrp.2012.07.006
  • 2,368 View
  • 23 Download
  • 10 Citations
AbstractAbstract PDF
Objective Recombinant protective antigen (rPA) is the active pharmaceutical ingredient of a second generation anthrax vaccine undergoing clinical trials both in Korea and the USA. By using the rPA produced from Bacillus brevis pNU212 expression system, correlations of serological immune response to anthrax protection efficacy were analyzed in a guinea pig model.
Methods
Serological responses of rPA anthrax vaccine were investigated in guinea pigs that were given single or two injections (interval of 4 weeks) of various amounts of rPA combined with aluminumhydroxide adjuvant. Guinea pigs were subsequently challenged by the intramuscular injection with 30 half-lethal doses (30LD50) of virulent Bacillus anthracis spores. Serumantibody titerswere determined by anti-PA IgGELISA and the ability of antibodies to neutralize the cytotoxicity of lethal toxin on J774A.1 cell was measured through the toxin neutralizing antibody (TNA) assay.
Results
To examine correlations between survival rate and antibody titers, correlation between neutralizing antibody titers and the extent of protection was determined. Toxin neutralization titers of at least 1176 were sufficient to confer protection against a dose of 30LD50 of virulent anthrax spores of the H9401 strain. Such consistency in the correlation was not observed from those antibody titers determined by ELISA.
Conclusion
Neutralizing-antibody titers can be used as a surrogate marker.

Citations

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  • A putative exosporium lipoprotein GBAA0190 of Bacillus anthracis as a potential anthrax vaccine candidate
    Jun Ho Jeon, Yeon Hee Kim, Kyung Ae Kim, Yu-Ri Kim, Sun-Je Woo, Ye Jin Choi, Gi-eun Rhie
    BMC Immunology.2021;[Epub]     CrossRef
  • Construction of a bivalent vaccine against anthrax and smallpox using the attenuated vaccinia virus KVAC103
    Deok Bum Park, Bo-Eun Ahn, Hosun Son, Young-Ran Lee, Yu-Ri Kim, Su Kyoung Jo, Jeong-Hoon Chun, Jae-Yon Yu, Myung-Min Choi, Gi-eun Rhie
    BMC Microbiology.2021;[Epub]     CrossRef
  • Single-dose combination nanovaccine induces both rapid and durable humoral immunity and toxin neutralizing antibody responses against Bacillus anthracis
    Sean M. Kelly, Kristina R. Larsen, Ross Darling, Andrew C. Petersen, Bryan H. Bellaire, Michael J. Wannemuehler, Balaji Narasimhan
    Vaccine.2021; 39(29): 3862.     CrossRef
  • Current Status and Trends in Prophylaxis and Management of Anthrax Disease
    Vladimir Savransky, Boris Ionin, Joshua Reece
    Pathogens.2020; 9(5): 370.     CrossRef
  • Anthrax prevention through vaccine and post-exposure therapy
    Manish Manish, Shashikala Verma, Divya Kandari, Parul Kulshreshtha, Samer Singh, Rakesh Bhatnagar
    Expert Opinion on Biological Therapy.2020; 20(12): 1405.     CrossRef
  • A therapeutic human antibody against the domain 4 of the Bacillus anthracis protective antigen shows protective efficacy in a mouse model
    Bo-Eun Ahn, Hee-Won Bae, Hae-Ri Lee, Sun-Je Woo, Ok-Kyu Park, Jun Ho Jeon, Jungchan Park, Gi-eun Rhie
    Biochemical and Biophysical Research Communication.2019; 509(2): 611.     CrossRef
  • Vaccines against anthrax based on recombinant protective antigen: problems and solutions
    Olga A. Kondakova, Nikolai A. Nikitin, Ekaterina A. Evtushenko, Ekaterina M. Ryabchevskaya, Joseph G. Atabekov, Olga V. Karpova
    Expert Review of Vaccines.2019; 18(8): 813.     CrossRef
  • A novel live attenuated anthrax spore vaccine based on an acapsular Bacillus anthracis Sterne strain with mutations in the htrA, lef and cya genes
    Theodor Chitlaru, Ma'ayan Israeli, Shahar Rotem, Uri Elia, Erez Bar-Haim, Sharon Ehrlich, Ofer Cohen, Avigdor Shafferman
    Vaccine.2017; 35(44): 6030.     CrossRef
  • Expression and refolding of the protective antigen of Bacillus anthracis: A model for high-throughput screening of antigenic recombinant protein refolding
    María Elisa Pavan, Esteban Enrique Pavan, Fabián Martín Cairó, María Julia Pettinari
    Revista Argentina de Microbiología.2016; 48(1): 5.     CrossRef
  • Protein- and DNA-based anthrax toxin vaccines confer protection in guinea pigs against inhalational challenge withBacillus cereusG9241
    John Palmer, Matt Bell, Christian Darko, Roy Barnewall, Andrea Keane-Myers
    Pathogens and Disease.2014; : n/a.     CrossRef

PHRP : Osong Public Health and Research Perspectives