- Enteric Bacteria Isolated from Diarrheal Patients in Korea in 2014
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Nan-Ok Kim, Su-Mi Jung, Hae-Young Na, Gyung Tae Chung, Cheon-Kwon Yoo, Won Keun Seong, Sahyun Hong
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Osong Public Health Res Perspect. 2015;6(4):233-240. Published online August 31, 2015
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DOI: https://doi.org/10.1016/j.phrp.2015.07.005
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3,897
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 Abstract
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- Objectives
The aim of this study was to characterize the pathogens responsible for causing diarrhea according to season, region of isolation, patient age, and sex as well as to provide useful data for the prevention of diarrheal disease.
Methods
Stool specimens from 14,886 patients with diarrhea were collected to identify pathogenic bacteria from January 2014 to December 2014 in Korea. A total of 3,526 pathogenic bacteria were isolated and analyzed according to season, region of isolation, and the age and sex of the patient.
Results
The breakdown of the isolated pathogenic bacteria were as follows: Salmonella spp. 476 (13.5%), pathogenic Escherichia coli 777 (22.0%), Vibrio parahaemolyticus 26 (0.74%), Shigella spp. 13 (0.37%), Campylobacter spp. 215 (6.10%), Clostridium perfringens 508 (14.4%), Staphylococcus aureus 1,144 (32.4%), Bacillus cereus 356 (10.1%), Listeria monocytogenes 1 (0.03%), and Yersinia enterocolitica 10 (0.3%). The isolation rate trend showed the highest ratio in the summer season from June to September for most of the pathogenic bacteria except the Gram-positive bacteria. The isolation rate of most of the pathogenic bacteria by patient age showed highest ratio in the 0–19 year age range. For isolation rate by region, 56.2% were isolated from cities and 43.8% were isolated from provinces.
Conclusion
Hygiene education should be addressed for diarrheal disease-susceptible groups, such as those younger than 10 years, aged 10–19 years, and older than 70 years, and monitoring for the pathogens is still required. In addition, an efficient laboratory surveillance system for infection control should be continued.
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Citations
Citations to this article as recorded by  - Antimicrobial Susceptibility Patterns and Genetic Diversity of Campylobacter spp. Isolates from Patients with Diarrhea in South Korea
So Yeon Kim, Dongheui An, Hyemi Jeong, Jonghyun Kim
Microorganisms.2024; 12(1): 94. CrossRef - Comparative evaluation of two molecular multiplex syndromic panels with acute gastroenteritis
Kuenyoul Park, Bo-Moon Shin
Diagnostic Microbiology and Infectious Disease.2024; 109(1): 116211. CrossRef - Antimicrobial Resistance Profiles and Molecular Characteristics of Salmonella enterica Serovar Agona Isolated from Food-Producing Animals During 2010–2020 in South Korea
Hyun-Ju Song, Sekendar Ali, Bo-Youn Moon, Hee Young Kang, Eun Jeong Noh, Tae-Sun Kim, Su-Jeong Kim, Ji-In Kim, Yun Jin Lee, Soon-Seek Yoon, Suk-Kyung Lim
Foodborne Pathogens and Disease.2024;[Epub] CrossRef - An Outbreak of Campylobacter Jejuni Involving Healthcare Workers Detected by COVID-19 Healthcare Worker Symptom Surveillance
Hye Jin Shi, Jae Baek Lee, Shinhee Hong, Joong Sik Eom, Yoonseon Park
Korean Journal of Healthcare-Associated Infection .2023; 28(1): 172. CrossRef - Plant-derived nanoparticles as alternative therapy against Diarrheal pathogens in the era of antimicrobial resistance: A review
Tesleem Olatunde Abolarinwa, Daniel Jesuwenu Ajose, Bukola Opeyemi Oluwarinde, Justine Fri, Kotsoana Peter Montso, Omolola Esther Fayemi, Adeyemi Oladapo Aremu, Collins Njie Ateba
Frontiers in Microbiology.2022;[Epub] CrossRef - Prevalence, co-infection and seasonality of fecal enteropathogens from diarrheic cats in the Republic of Korea (2016–2019): a retrospective study
Ye-In Oh, Kyoung-Won Seo, Do-Hyung Kim, Doo-Sung Cheon
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Mahmoud Fayez, Ibrahim Elsohaby, Theeb Al-Marri, Kamal Zidan, Ali Aldoweriej, Elham El-Sergany, Ahmed Elmoslemany
Comparative Immunology, Microbiology and Infectiou.2020; 70: 101460. CrossRef - Comparative Analysis of Aerotolerance, Antibiotic Resistance, and Virulence Gene Prevalence in Campylobacter jejuni Isolates from Retail Raw Chicken and Duck Meat in South Korea
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Microorganisms.2019; 7(10): 433. CrossRef - Guideline for the Antibiotic Use in Acute Gastroenteritis
Youn Jeong Kim, Ki-Ho Park, Dong-Ah Park, Joonhong Park, Byoung Wook Bang, Seung Soon Lee, Eun Jung Lee, Hyo-Jin Lee, Sung Kwan Hong, Yang Ree Kim
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Chizoba Mercy Enemchukwu, Angus Nnamdi Oli, Ebere Innocent Okoye, Nonye Treasure Ujam, Emmanuel O. Osazuwa, George Ogonna Emechebe, Kenneth Nchekwube Okeke, Christian Chukwuemeka Ifezulike, Obiora Shedrack Ejiofor, Jude Nnaemeka Okoyeh
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Sang-Hun Park, Hyun-Jung Seung, Hyo-Won Jeong, So-Yun Park, Ji-Hun Jung, Young-Hee Jin, Sung-Hee Han, Hee-Soon Kim, Jin-Seok Kim, Joo-Hyun Park, Ye-Ji Gong, Chae Kyu Hong, Jib-Ho Lee, Il-Young Kim, Kweon Jung
Journal of Bacteriology and Virology.2018; 48(4): 113. CrossRef - Epidemiology of Listeria monocytogenes prevalence in foods, animals and human origin from Iran: a systematic review and meta-analysis
Reza Ranjbar, Mehrdad Halaji
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- Serological Correlate of Protection in Guinea Pigs for a Recombinant Protective Antigen Anthrax Vaccine Produced from Bacillus brevis
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Jeong-Hoon Chun, On-Jee Choi, Min-Hee Cho, Kee-Jong Hong, Won Keun Seong, Hee-Bok Oh, Gi-Eun Rhie
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Osong Public Health Res Perspect. 2012;3(3):170-176. Published online June 30, 2012
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DOI: https://doi.org/10.1016/j.phrp.2012.07.006
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3,805
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30
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10
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Abstract
PDF
- Objective
Recombinant protective antigen (rPA) is the active pharmaceutical ingredient of a second generation anthrax vaccine undergoing clinical trials both in Korea and the USA. By using the rPA produced from Bacillus brevis pNU212 expression system, correlations of serological immune response to anthrax protection efficacy were analyzed in a guinea pig model.
Methods
Serological responses of rPA anthrax vaccine were investigated in guinea pigs that were given single or two injections (interval of 4 weeks) of various amounts of rPA combined with aluminumhydroxide adjuvant. Guinea pigs were subsequently challenged by the intramuscular injection with 30 half-lethal doses (30LD50) of virulent Bacillus anthracis spores. Serumantibody titerswere determined by anti-PA IgGELISA and the ability of antibodies to neutralize the cytotoxicity of lethal toxin on J774A.1 cell was measured through the toxin neutralizing antibody (TNA) assay.
Results
To examine correlations between survival rate and antibody titers, correlation between neutralizing antibody titers and the extent of protection was determined. Toxin neutralization titers of at least 1176 were sufficient to confer protection against a dose of 30LD50 of virulent anthrax spores of the H9401 strain. Such consistency in the correlation was not observed from those antibody titers determined by ELISA.
Conclusion
Neutralizing-antibody titers can be used as a surrogate marker.
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Citations
Citations to this article as recorded by - A putative exosporium lipoprotein GBAA0190 of Bacillus anthracis as a potential anthrax vaccine candidate
Jun Ho Jeon, Yeon Hee Kim, Kyung Ae Kim, Yu-Ri Kim, Sun-Je Woo, Ye Jin Choi, Gi-eun Rhie
BMC Immunology.2021;[Epub] CrossRef - Construction of a bivalent vaccine against anthrax and smallpox using the attenuated vaccinia virus KVAC103
Deok Bum Park, Bo-Eun Ahn, Hosun Son, Young-Ran Lee, Yu-Ri Kim, Su Kyoung Jo, Jeong-Hoon Chun, Jae-Yon Yu, Myung-Min Choi, Gi-eun Rhie
BMC Microbiology.2021;[Epub] CrossRef - Single-dose combination nanovaccine induces both rapid and durable humoral immunity and toxin neutralizing antibody responses against Bacillus anthracis
Sean M. Kelly, Kristina R. Larsen, Ross Darling, Andrew C. Petersen, Bryan H. Bellaire, Michael J. Wannemuehler, Balaji Narasimhan
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Vladimir Savransky, Boris Ionin, Joshua Reece
Pathogens.2020; 9(5): 370. CrossRef - Anthrax prevention through vaccine and post-exposure therapy
Manish Manish, Shashikala Verma, Divya Kandari, Parul Kulshreshtha, Samer Singh, Rakesh Bhatnagar
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Bo-Eun Ahn, Hee-Won Bae, Hae-Ri Lee, Sun-Je Woo, Ok-Kyu Park, Jun Ho Jeon, Jungchan Park, Gi-eun Rhie
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Theodor Chitlaru, Ma'ayan Israeli, Shahar Rotem, Uri Elia, Erez Bar-Haim, Sharon Ehrlich, Ofer Cohen, Avigdor Shafferman
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María Elisa Pavan, Esteban Enrique Pavan, Fabián Martín Cairó, María Julia Pettinari
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John Palmer, Matt Bell, Christian Darko, Roy Barnewall, Andrea Keane-Myers
Pathogens and Disease.2014; : n/a. CrossRef
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