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Tayebe Ghiasvand 1 Article
The Occurrence and Risk Assessment of Exposure to Aflatoxin M1 in Ultra-High Temperature and Pasteurized Milk in Hamadan Province of Iran
Amir Sasan Mozaffari Nejad, Ali Heshmati, Tayebe Ghiasvand
Osong Public Health Res Perspect. 2019;10(4):228-233.   Published online August 31, 2019
DOI: https://doi.org/10.24171/j.phrp.2019.10.4.05
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  • 16 Citations
AbstractAbstract PDF
Objectives

Aflatoxins are a category of poisonous compounds found in most plants, milk and dairy products. The present research was carried out to detect the presence of aflatoxin M1 (AFM1) in samples of milk collected from Hamadan province, Iran.

Methods

Twenty five samples of ultra-high temperature (UHT) and 63 samples of pasteurized milk were collected and the amount of AFM1 was measured by an Enzyme-Linked Immunosorbent Assay method. In addition, the estimated daily intake (EDI) and hazard index (HI) of AFM1 was determined by the following equations:(EDI= mean concentration of AFM1 × daily consumption of milk/body weight; HI= EDI/Tolerance Daily Intake).

Results

AFM1 was detected in 21 (84%) UHT milk samples and in 55 (87.30%) pasteurized milk samples. Seven (28%) samples of UHT and 21 (33.33%) pasteurized milk samples had higher AFM1 content than the limit allowed in the European Union and Iranian National Standard Limits (0.05 μg/kg). None of the samples exceeded the US Food and Drug Administration limit (0.5 μg/kg) for AFM1. EDI and HI for AM1 through milk were 0.107 ng/kg body weight/day, and 0.535, respectively.

Conclusion

A significant percentage of milk produced by different factories in Iran (84% of UHT and 87.3% of pasteurized milk) was contaminated with AFM1. Therefore, more control and monitoring of livestock feeding in dairy companies may help reduce milk contamination with AFM1. As the HI value was lower than 1, it can be assumed that there was no risk of developing liver cancer due to milk consumption.

Citations

Citations to this article as recorded by  
  • Aflatoxin M1 in milk and dairy products: global occurrence and potential decontamination strategies
    Khurram Muaz, Muhammad Riaz, Carlos Augusto Fernandes de Oliveira, Saeed Akhtar, Shinawar Waseem Ali, Habibullah Nadeem, Sungkwon Park, Balamuralikrishnan Balasubramanian
    Toxin Reviews.2022; 41(2): 588.     CrossRef
  • Feed to fork risk assessment of mycotoxins under climate change influences - recent developments
    Rhea Sanjiv Chhaya, John O'Brien, Enda Cummins
    Trends in Food Science & Technology.2022; 126: 126.     CrossRef
  • Exposure assessment on aflatoxin M1 from milk and dairy products-relation to public health
    Eleni Malissiova, Georgia Soultani, Konstantina Tsokana, Mary Alexandraki, Athanasios Manouras
    Clinical Nutrition ESPEN.2022; 47: 189.     CrossRef
  • Aflatoxin M1 in distributed milks in northwestern Iran: occurrence, seasonal variation, and risk assessment
    Seyyed Ahmad Mokhtari, Ali Nemati, Mehdi Fazlzadeh, Eslam Moradi-Asl, Vahid Taefi Ardabili, Anoshirvan Seddigh
    Environmental Science and Pollution Research.2022; 29(27): 41429.     CrossRef
  • Brucellosis in Humans with the Approach of Brucella Species Contamination in Unpasteurized Milk and Dairy Products from Hamadan, Iran
    Mohammad Mahdi Majzobi, Pejman Karami, Amir Khodavirdipour, Mohammad Yousef Alikhani
    Iranian Journal of Medical Microbiology.2022; 16(4): 282.     CrossRef
  • Review, meta-analysis and carcinogenic risk assessment of aflatoxin M1 in different types of milks in Iran
    Fatemeh Mortezazadeh, Fathollah Gholami-Borujeni
    Reviews on Environmental Health.2022;[Epub]     CrossRef
  • Probabilistic modeling and risk characterization of the chronic aflatoxin M1 exposure of Hungarian consumers
    Zsuzsa Farkas, Kata Kerekes, Árpád Ambrus, Miklós Süth, Ferenc Peles, Tünde Pusztahelyi, István Pócsi, Attila Nagy, Péter Sipos, Gabriella Miklós, Anna Lőrincz, Szilveszter Csorba, Ákos Bernard Jóźwiak
    Frontiers in Microbiology.2022;[Epub]     CrossRef
  • The occurrence of aflatoxin M1 in doogh, kefir, and kashk in Hamadan, Iran
    Mina KHORSHIDI, Ali HESHMATI, Zahra HADIAN, Slim SMAOUI, Amin MOUSAVI KHANEGHAH
    Food Science and Technology.2022;[Epub]     CrossRef
  • Characterization and mechanism of aflatoxin degradation by a novel strain of Trichoderma reesei CGMCC3.5218
    Xiaofeng Yue, Xianfeng Ren, Jiayun Fu, Na Wei, Claudio Altomare, Miriam Haidukowski, Antonio F. Logrieco, Qi Zhang, Peiwu Li
    Frontiers in Microbiology.2022;[Epub]     CrossRef
  • Simultaneous multi-determination of pesticide residues in black tea leaves and infusion: a risk assessment study
    Ali Heshmati, Fereshteh Mehri, Amin Mousavi Khaneghah
    Environmental Science and Pollution Research.2021; 28(11): 13725.     CrossRef
  • Development of a specific anti-idiotypic nanobody for monitoring aflatoxin M1 in milk and dairy products
    Chong Cai, Qi Zhang, Seyni Nidiaye, Honglin Yan, Wen Zhang, Xiaoqian Tang, Peiwu Li
    Microchemical Journal.2021; 167: 106326.     CrossRef
  • The behavior of aflatoxin M1 during lactic cheese production and storage
    Mahtab Einolghozati, Ali Heshmati, Freshteh Mehri
    Toxin Reviews.2021; : 1.     CrossRef
  • Prevalence of aflatoxin M1 in pasteurized and ultra-high temperature (UHT) milk marketed in Dar es Salaam, Tanzania
    F. Mwakosya Hilda, K. Mugula Jovin
    African Journal of Microbiology Research.2021; 15(9): 461.     CrossRef
  • Multi-mycotoxin occurrence in feed, metabolism and carry-over to animal-derived food products: A review
    J. Tolosa, Y. Rodríguez-Carrasco, M.J. Ruiz, P. Vila-Donat
    Food and Chemical Toxicology.2021; 158: 112661.     CrossRef
  • Presence of Aflatoxin M1 in Commercial Milk in Paraguay
    ANDREA ALEJANDRA ARRUA, PABLO DAVID ARRÚA, JULIANA MOURA-MENDES, CINTHIA CAZAL, FRANCISCO PAULO FERREIRA, CRISTHIAN JAVIER GRABOWSKI, HORACIO DANIEL LOPEZ-NICORA, DANILO FERNÁNDEZ RIOS
    Journal of Food Protection.2021; 84(12): 2128.     CrossRef
  • The Occurrence and Risk Assessment of Aflatoxin M1 in Yoghurt Samples from Hamadan, Iran
    Ali Heshmati, Amir Sasan Mozaffari Mozaffari Nejad, Tayebeh Ghyasvand
    The Open Public Health Journal.2020; 13(1): 512.     CrossRef

PHRP : Osong Public Health and Research Perspectives