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Sun Hee Kim 1 Article
Diversity of Rotavirus Strain Circulated in Gwangju, Republic of Korea
Min Ji Kim, Hye Sook Jeong, Seon Gyeong Kim, Se Mi Lee, Sun Hee Kim, Hye-Young Kee, Eun-hye Jo, Hye-jung Park, Dong-Ryong Ha, Eun Sun Kim, Kye-Won Seo, Jae Keun Chung
Osong Public Health Res Perspect. 2014;5(6):364-369.   Published online December 31, 2014
DOI: https://doi.org/10.1016/j.phrp.2014.10.004
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AbstractAbstract PDF
Objectives
The introduction of new rotavirus vaccines into the public sphere makes it necessary to maintain constant surveillance and to heighten public awareness of the appearance of new rotavirus strains. We describe the molecular epidemiology of circulating rotavirus strains after vaccine introduction.
Methods
We collected a total of 1070 stool samples from children with gastroenteritis from January 2013 to June 2013. The antigenic prevalence of rotavirus group A was distinguished using enzyme immunoassay. The G and P genotypes of enzyme immunoassay-positive samples were determined with reverse transcription-polymerase chain reaction and nucleotide sequencing analysis.
Results
Of the 1070 samples collected, 277 (25.9%) tested positive for rotaviruses by enzyme-linked immunoabsorbent assay. The most prevalent circulating genotype G was G1 (51.3%), followed by G2 (34.7%) and G9 (10.8%). The predominant type of genotype P was P[8] (66.1%), followed by P[4] (31.4%). In this study, nine genotypes were found. G1P[8] was the most prevalent (51.8%), followed by G2P[4] (30.5%), G9P[8] (9.9%), and G2P[8] (4.0%). Several unusual combinations (G1P[4], G3P[9], G3P[8], G4P[6], and G9P[4]) were also identified.
Conclusion
Molecular epidemiological knowledge of rotaviruses is critical for the development of effective preventive measures, including vaccines. These data will help us monitor the effectiveness of current rotavirus vaccines.

PHRP : Osong Public Health and Research Perspectives