Skip Navigation
Skip to contents

PHRP : Osong Public Health and Research Perspectives


Author index

Page Path
HOME > Articles and issues > Author index
Suhad Abumweis 1 Article
Associations of pre-existing cardiovascular morbidity with severity and the fatality rate in COVID-19 patients: a systematic review and meta-analysis
Foad Alzoughool, Suhad Abumweis, Lo’ai Alanagreh, Manar Atoum
Osong Public Health Res Perspect. 2022;13(1):37-50.   Published online February 18, 2022
  • 4,852 View
  • 118 Download
  • 5 Web of Science
  • 5 Crossref
Graphical AbstractGraphical Abstract AbstractAbstract PDFSupplementary Material
The aim of this study was to evaluate the association of pre-existing cardiovascular comorbidities, including hypertension and coronary heart disease, with coronavirus disease 2019 (COVID-19) severity and mortality. Methods: PubMed, ScienceDirect, and Scopus were searched between January 1, 2020, and July 18, 2020, to identify eligible studies. Random-effect models were used to estimate the pooled event rates of pre-existing cardiovascular disease comorbidities and odds ratio (OR) with 95% confidence intervals (95% CIs) of disease severity and mortality associated with the exposures of interest. Results: A total of 34 studies involving 19,156 patients with COVID-19 infection met the inclusion criteria. The prevalence of pre-existing cardiovascular disease in the included studies was 14.0%. Pre-existing cardiovascular disease in COVID-19 patients was associated with severe outcomes (OR, 4.1; 95% CI, 2.9 to 5.7) and mortality (OR, 6.1; 95% CI, 2.9 to 12.7). Hypertension and coronary heart disease increased the risk of severe outcomes by 2.6 times (OR, 2.6; 95% CI, 1.9 to 3.6) and 2.5 times (OR, 2.5; 95% CI, 1.7 to 3.8), respectively. No significant publication bias was indicated. Conclusion: COVID-19 patients with pre-existing cardiovascular comorbidities have a higher risk of severe outcomes and mortality. Awareness of pre-existing cardiovascular comorbidity is important for the early management of COVID-19.


Citations to this article as recorded by  
  • Asthma and clinical outcomes of COVID-19 in a community setting
    L. Jiao, D. Bujnowski, P. Liu, E. Bakota, L. Liu, Y. Ye, A. Dewangan, C.N. Duong, E. Kviten, S. Zaheer, A. Zangeneh, R. Roy, J. Floyd, J. Monroy, D. Wiltz-Beckham
    Public Health.2024; 226: 84.     CrossRef
  • Understanding factors affecting implementation success and sustainability of a comprehensive prevention program for cardiovascular disease in primary health care: a qualitative process evaluation study combining RE-AIM and CFIR
    Naomi Aerts, Kathleen Van Royen, Peter Van Bogaert, Lieve Peremans, Hilde Bastiaens
    Primary Health Care Research & Development.2023;[Epub]     CrossRef
  • New Scenarios in Heart Transplantation and Persistency of SARS-CoV-2 (Case Report)
    Lubov Mitrofanova, Igor Makarov, Andrey Gorshkov, Olga Vorobeva, Maria Simonenko, Anna Starshinova, Dmitry Kudlay, Tatiana Karonova
    Life.2023; 13(7): 1551.     CrossRef
  • Prognostic Factors of COVID‐19: An Umbrella Review Endorsed by the International Society for Pharmacoepidemiology
    Grammati Sarri, Wei Liu, Luke Zabotka, Andreas Freitag, Ravinder Claire, Grace Wangge, Jamie Elvidge, Dalia Dawoud, Dimitri Bennett, Xuerong Wen, Xiaojuan Li, Christopher T. Rentsch, Md Jamal Uddin, M. Sanni Ali, Mugdha Gokhale, Anouk Déruaz‐Luyet, Daniel
    Clinical Pharmacology & Therapeutics.2023; 114(3): 604.     CrossRef
  • Comorbidities in congenital heart disease: different patterns in childhood and adulthood
    Zhibao Ding, Jingai Zhu, Ye Ding, Chun Zhu
    BMC Cardiovascular Disorders.2023;[Epub]     CrossRef

PHRP : Osong Public Health and Research Perspectives