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Songhee Cheon 1 Article
Hippocampus-dependent Task Improves the Cognitive Function after Ovariectomy in Rats
Songhee Cheon
Osong Public Health Res Perspect. 2017;8(3):227-234.   Published online June 30, 2017
DOI: https://doi.org/10.24171/j.phrp.2017.8.3.10
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  • 24 Download
  • 4 Citations
AbstractAbstract PDF
Objectives

Estrogen is an important hormone for cell growth, development, and differentiation by transcriptional regulation and modulation of intracellular signaling via second messengers. The reduction in the estrogen level after ovariectomy may lead to cognitive impairments associated with morphological changes in areas of the brain mediate memory. The aim of the present study was to find out the effect of tasks on the cognitive function after ovariectomy in rats.

Methods

The animals used in the experiment were 50 Sprague-Dawley female rats. This study applied a hippocampus-independent task (wheel running) and a hippocampus-dependent task (Morris water maze) after ovariectomy in rats and measured the cognitive performance (object-recognition and object-location test) and growth-associated protein 43 (GAP-43) and neurotrophin 3 (NT-3) expression in the hippocampus, which is an important center for memory and learning.

Results

There were meaningful differences between the hippocampus-independent and hippocampus-dependent task groups for the object-location test and GAP-43 and NT-3 expression in the hippocampus, but not the object-recognition test. However, the hippocampus-independent task group showed a significant improvement in the object-recognition test, compared to the control group.

Conclusion

These results suggest that hippocampus-dependent task training after ovariectomy enhances the hippocampus-related memory and cognitive function that are associated with morphological and functional changes in the cells of the hippocampus.

Citations

Citations to this article as recorded by  
  • Targeting the TLR4/NF-κΒ Axis and NLRP1/3 Inflammasomes by Rosuvastatin: A Role in Impeding Ovariectomy-Induced Cognitive Decline Neuropathology in Rats
    Muhammed A. Saad, Muhammad Y. Al-Shorbagy, Hany H. Arab
    Molecular Neurobiology.2022; 59(7): 4562.     CrossRef
  • Estrogen Exerts Neuroprotective Effects in Vascular Dementia Rats by Suppressing Autophagy and Activating the Wnt/β-Catenin Signaling Pathway
    Yanyan Yang, Lei Zhao, Na Li, Congwei Dai, Nan Yin, Zhaoping Chu, Xiaoyan Duan, Xiaoli Niu, Ping Yan, Peiyuan Lv
    Neurochemical Research.2020; 45(9): 2100.     CrossRef
  • Modulation of aromatase by natural compounds—A pharmacophore guided molecular modelling simulations
    S. Rampogu, C. Park, M. Son, A. Baek, A. Zeb, G. Lee, K.W. Lee
    South African Journal of Botany.2019; 120: 230.     CrossRef
  • Early Stage Glycosylation Biomarkers in Alzheimer’s Disease
    Patricia Regan, Paula L. McClean, Thomas Smyth, Margaret Doherty
    Medicines.2019; 6(3): 92.     CrossRef

PHRP : Osong Public Health and Research Perspectives