- Management of Hospital Infection Control in Iran: A Need for Implementation of Multidisciplinary Approach
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Setareh Mamishi, Babak Pourakbari, Mostafa Teymuri, Abdolreza Babamahmoodi, Shima Mahmoudi
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Osong Public Health Res Perspect. 2014;5(4):179-186. Published online August 31, 2014
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DOI: https://doi.org/10.1016/j.phrp.2014.06.001
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- Nosocomial, or hospital-acquired, infections are considered the most common complications affecting hospitalized patients. According to results obtained from studies conducted in the Children Medical Center Hospital, a teaching children's hospital and a tertiary care referral unit in Tehran, Iran, improvements in infection control practices in our hospital seem necessary. The aim of this study was to identify risk management and review potential hospital hazards that may pose a threat to the health as well as safety and welfare of patients in an Iranian referral hospital. Barriers to compliance and poor design of facilities, impractical guidelines and policies, lack of a framework for risk management, failure to apply behavioral-change theory, and insufficient obligation and enforcement by infection control personnel highlight the need of management systems in infection control in our hospital. In addition, surveillance and early reporting of infections, evaluation of risk-based interventions, and production of evidence-based guidelines in our country are recommended.
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- Virulence Factors of Staphylococcus aureus Isolates in an Iranian Referral Children's Hospital
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Farah Sabouni, Shima Mahmoudi, Abbas Bahador, Babak Pourakbari, Reihaneh Hosseinpour Sadeghi, Mohammad Taghi Haghi Ashtiani, Bahram Nikmanesh, Setareh Mamishi
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Osong Public Health Res Perspect. 2014;5(2):96-100. Published online April 30, 2014
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DOI: https://doi.org/10.1016/j.phrp.2014.03.002
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3,317
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- Objectives
The clinical importance of Staphylococcus aureus (S. aureus) is attributed to notable virulence factors, surface proteins, toxins, and enzymes as well as the rapid development of drug resistance. The aim of this study was to compare the occurrence of virulence factors produced by S. aureus strains isolated from children in an Iranian referral children's hospital.
Methods
The presence of genes encoding for the enterotoxins A (sea), B (seb), C (sec), D (sed), TSST-1 (tsst), exfoliative toxin A (eta), and exfoliative toxin B (etb) were detected by Multiplex polymerase chain reaction (PCR) using specific primers. In addition, the standardized Kirby-Bauer disc-diffusion method was performed on Mueller-Hinton agar.
Results
In total, 133 S. aureus isolates were obtained from different patients. Of these S. aureus isolates, 64 (48%) were methicillin-resistant S. aureus (MRSA), and all of these tested positive for the mecA gene. Regarding the classical enterotoxin genes, sea gene (40.6%) was the most prevalent followed by seb (19.6%), tsst (12.8%), eta (11.3%), etb (9%), sed (4.5%), and sec (3%). Among methicillin-susceptible S. aureus (MSSA) isolates, seb and tsst were the more prevalent toxins in comparison with MRSA isolates (p < 0.05), while the frequency of sea, sed, eta, and etb genes were higher among MRSA isolates (p > 0.05).
Conclusion
In our study enterotoxin A was produced by 40.6% of the isolates (48% from MRSA and 33% from MSSA isolates) which was higher than in previous reports. According to our results, strict hygiene and preventative measures during food processing are highly recommended.
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Citations
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Wiener Medizinische Wochenschrift.2023; 173(7-8): 182. CrossRef - Spectrum of Virulence Factors in Clinical Isolates of Staphylococcus aureus and Prevalence of SCCmec Types in Methicillin-Resistant Staphylococcus aureus in a Tertiary Care Center
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Folia Medica Indonesiana.2021; 57(2): 121. CrossRef - Molecular Genotyping of Tsst-1 Gene Staphylococcus Aureus from Clinical Specimen
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Folia Medica Indonesiana.2021; 57(2): 129. CrossRef - Prevalence of enterotoxin genes (SEA to SEE) and antibacterial resistant pattern of Staphylococcus aureus isolated from clinical specimens in Assiut city of Egypt
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Egyptian Journal of Medical Human Genetics.2021;[Epub] CrossRef - Contemporary systematic review and meta-analysis of exfoliative toxin-producing Staphylococcus aureus strains isolated from patients in Iran
Mojtaba Memariani, Hamed Memariani, Mohammad Shahidi-Dadras, Zohreh Tehranchinia, Fariba Ghalamkarpour, Hamideh Moravvej
Reviews in Medical Microbiology.2020; 31(1): 1. CrossRef - Strategies to Prevent Biofilm Infections on Biomaterials: Effect of Novel Naturally-Derived Biofilm Inhibitors on a Competitive Colonization Model of Titanium by Staphylococcus aureus and SaOS-2 Cells
Inés Reigada, Ramón Pérez-Tanoira, Jayendra Z. Patel, Kirsi Savijoki, Jari Yli-Kauhaluoma, Teemu J. Kinnari, Adyary Fallarero
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PLOS ONE.2020; 15(8): e0237714. CrossRef - Inhibition of growth and gene expression in Staphylococcus aureus by anti-gyrA peptide nucleic acid
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Future Microbiology.2019; 14(13): 1123. CrossRef - Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases
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BioMed Research International.2019; 2019: 1. CrossRef - Survey of Staphylococcus aureus in a general pediatric population and focus on isolates with three clinically relevant toxin-encoding genes
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World Journal of Pediatrics.2018; 14(1): 35. CrossRef - Characterization of Virulence Factors and Prophage Profiles of Methicillin-Resistant Staphylococcus aureus Strains Isolated from a Referral Hospital in Tehran, Iran
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Journal of Pure and Applied Microbiology.2018; 12(1): 95. CrossRef - Relationships among superantigen toxin gene profiles, genotypes, and pathogenic characteristics of Staphylococcus aureus isolates from bovine mastitis
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Journal of Dairy Science.2017; 100(6): 4276. CrossRef - Molecular epidemiology of Staphylococcus aureus nasal colonization among patients and their parents /guardian in an Iranian referral hospital
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Microbial Pathogenesis.2017; 107: 75. CrossRef - The effect of antimicrobial photodynamic therapy on the expression of novel methicillin resistance markers determined using cDNA-AFLP approach in Staphylococcus aureus
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Microbial Pathogenesis.2016; 100: 201. CrossRef - The Correlation between Toxin Genotype and Antibiotic Resistance in Methicillin ResistantStaphylococcus aureusIsolated from Clinical Specimen of Intensive Care Unit
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Korean Journal of Clinical Laboratory Science.2016; 48(3): 202. CrossRef - Studies on Enterotoxins and Antimicrobial Resistance in <i>Staphylococcus aureus</i> Isolated from Various Sources
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Advances in Microbiology.2016; 06(04): 263. CrossRef - Genotype Analyses of Methicillin Resistant Staphylococcus aureus Isolated from clinical specimens
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