- Management of Hospital Infection Control in Iran: A Need for Implementation of Multidisciplinary Approach
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Setareh Mamishi, Babak Pourakbari, Mostafa Teymuri, Abdolreza Babamahmoodi, Shima Mahmoudi
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Osong Public Health Res Perspect. 2014;5(4):179-186. Published online August 31, 2014
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DOI: https://doi.org/10.1016/j.phrp.2014.06.001
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- Nosocomial, or hospital-acquired, infections are considered the most common complications affecting hospitalized patients. According to results obtained from studies conducted in the Children Medical Center Hospital, a teaching children's hospital and a tertiary care referral unit in Tehran, Iran, improvements in infection control practices in our hospital seem necessary. The aim of this study was to identify risk management and review potential hospital hazards that may pose a threat to the health as well as safety and welfare of patients in an Iranian referral hospital. Barriers to compliance and poor design of facilities, impractical guidelines and policies, lack of a framework for risk management, failure to apply behavioral-change theory, and insufficient obligation and enforcement by infection control personnel highlight the need of management systems in infection control in our hospital. In addition, surveillance and early reporting of infections, evaluation of risk-based interventions, and production of evidence-based guidelines in our country are recommended.
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- Virulence Factors of Staphylococcus aureus Isolates in an Iranian Referral Children's Hospital
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Farah Sabouni, Shima Mahmoudi, Abbas Bahador, Babak Pourakbari, Reihaneh Hosseinpour Sadeghi, Mohammad Taghi Haghi Ashtiani, Bahram Nikmanesh, Setareh Mamishi
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Osong Public Health Res Perspect. 2014;5(2):96-100. Published online April 30, 2014
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DOI: https://doi.org/10.1016/j.phrp.2014.03.002
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2,548
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- Objectives
The clinical importance of Staphylococcus aureus (S. aureus) is attributed to notable virulence factors, surface proteins, toxins, and enzymes as well as the rapid development of drug resistance. The aim of this study was to compare the occurrence of virulence factors produced by S. aureus strains isolated from children in an Iranian referral children's hospital.
Methods
The presence of genes encoding for the enterotoxins A (sea), B (seb), C (sec), D (sed), TSST-1 (tsst), exfoliative toxin A (eta), and exfoliative toxin B (etb) were detected by Multiplex polymerase chain reaction (PCR) using specific primers. In addition, the standardized Kirby-Bauer disc-diffusion method was performed on Mueller-Hinton agar.
Results
In total, 133 S. aureus isolates were obtained from different patients. Of these S. aureus isolates, 64 (48%) were methicillin-resistant S. aureus (MRSA), and all of these tested positive for the mecA gene. Regarding the classical enterotoxin genes, sea gene (40.6%) was the most prevalent followed by seb (19.6%), tsst (12.8%), eta (11.3%), etb (9%), sed (4.5%), and sec (3%). Among methicillin-susceptible S. aureus (MSSA) isolates, seb and tsst were the more prevalent toxins in comparison with MRSA isolates (p < 0.05), while the frequency of sea, sed, eta, and etb genes were higher among MRSA isolates (p > 0.05).
Conclusion
In our study enterotoxin A was produced by 40.6% of the isolates (48% from MRSA and 33% from MSSA isolates) which was higher than in previous reports. According to our results, strict hygiene and preventative measures during food processing are highly recommended.
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Citations
Citations to this article as recorded by - New update on molecular diversity of clinical Staphylococcus aureus isolates in Iran: antimicrobial resistance, adhesion and virulence factors, biofilm formation and SCCmec typing
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Molecular Biology Reports.2022; 49(4): 3099. CrossRef - Investigation of Virulence Genes of the Predominant Bacteria Associated with Renal Stones and their Correlation with Postoperative Septic Complications
Asmaa E Ahmed, Hassan Abol-Enein, Amira Awadalla, Heba El degla, Omar A El-Shehaby
Infection and Drug Resistance.2022; Volume 15: 3643. CrossRef - Virulence genes distributed among Staphylococcus aureus causing wound infections and their correlation to antibiotic resistance
Asia Helmi Rasmi, Eman Farouk Ahmed, Abdou Mohammed Abdullah Darwish, Gamal Fadl Mahmoud Gad
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PLOS ONE.2021; 16(2): e0246478. CrossRef - Distribution of virulence genes and SCCmec types among methicillin-resistant Staphylococcus aureus of clinical and environmental origin: a study from community of Assam, India
Deepshikha Bhowmik, Shiela Chetri, Bhaskar Jyoti Das, Debadatta Dhar Chanda, Amitabha Bhattacharjee
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Farhad Sarrafzadeh, Seyed Mojtaba Sohrevardi, Hamid Abousaidi, Hossein Mirzaei
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Min Lu, Jean-Marie Parel, Darlene Miller, Abdelazeem Mohamed Algammal
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Folia Medica Indonesiana.2021; 57(2): 121. CrossRef - Molecular Genotyping of Tsst-1 Gene Staphylococcus Aureus from Clinical Specimen
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Folia Medica Indonesiana.2021; 57(2): 129. CrossRef - Prevalence of enterotoxin genes (SEA to SEE) and antibacterial resistant pattern of Staphylococcus aureus isolated from clinical specimens in Assiut city of Egypt
Ahmed A. Baz, Elsayed K. Bakhiet, Usama Abdul-Raouf, Ahmed Abdelkhalek
Egyptian Journal of Medical Human Genetics.2021;[Epub] CrossRef - Contemporary systematic review and meta-analysis of exfoliative toxin-producing Staphylococcus aureus strains isolated from patients in Iran
Mojtaba Memariani, Hamed Memariani, Mohammad Shahidi-Dadras, Zohreh Tehranchinia, Fariba Ghalamkarpour, Hamideh Moravvej
Reviews in Medical Microbiology.2020; 31(1): 1. CrossRef - Strategies to Prevent Biofilm Infections on Biomaterials: Effect of Novel Naturally-Derived Biofilm Inhibitors on a Competitive Colonization Model of Titanium by Staphylococcus aureus and SaOS-2 Cells
Inés Reigada, Ramón Pérez-Tanoira, Jayendra Z. Patel, Kirsi Savijoki, Jari Yli-Kauhaluoma, Teemu J. Kinnari, Adyary Fallarero
Microorganisms.2020; 8(3): 345. CrossRef - Characterization of different virulent factors in methicillin-resistant Staphylococcus aureus isolates recovered from Iraqis and Syrian refugees in Duhok city, Iraq
Narin A. Rasheed, Nawfal R. Hussein, Herminia de Lencastre
PLOS ONE.2020; 15(8): e0237714. CrossRef - Inhibition of growth and gene expression in Staphylococcus aureus by anti-gyrA peptide nucleic acid
Mahnaz Tavakoli, Ali Hashemi, Maryam Vaezjalali, Mohammad Mohammadzadeh, Hossein Goudarzi
Future Microbiology.2019; 14(13): 1123. CrossRef - Quorum Sensing: A Prospective Therapeutic Target for Bacterial Diseases
Qian Jiang, Jiashun Chen, Chengbo Yang, Yulong Yin, Kang Yao
BioMed Research International.2019; 2019: 1. CrossRef - Survey of Staphylococcus aureus in a general pediatric population and focus on isolates with three clinically relevant toxin-encoding genes
Anne Filleron, Sarah Beauregard-Birba, Thibault Mura, Fabien Aujoulat, Anne Laure Michon, Michel Rodière, Tu Anh Tran, Eric Jeziorski, Hélène Marchandin
World Journal of Pediatrics.2018; 14(1): 35. CrossRef - Characterization of Virulence Factors and Prophage Profiles of Methicillin-Resistant Staphylococcus aureus Strains Isolated from a Referral Hospital in Tehran, Iran
Fateh Rahimi, Leili Shokoohizadeh
Archives of Clinical Infectious Diseases.2018;[Epub] CrossRef - Inhibitory Effects of Curcumin on the Expression of NorA Efflux Pump and Reduce Antibiotic Resistance in Staphylococcus aureus
Samin Jaberi, Fateme Fallah, Ali Hashemi, Ahmad Karimi, Leila Azimi
Journal of Pure and Applied Microbiology.2018; 12(1): 95. CrossRef - Relationships among superantigen toxin gene profiles, genotypes, and pathogenic characteristics of Staphylococcus aureus isolates from bovine mastitis
Dong Wang, Limei Zhang, Changfu Yong, Mingliang Shen, Tariq Ali, Muhammad Shahid, Kun Han, Xuezhang Zhou, Bo Han
Journal of Dairy Science.2017; 100(6): 4276. CrossRef - Molecular epidemiology of Staphylococcus aureus nasal colonization among patients and their parents /guardian in an Iranian referral hospital
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Microbial Pathogenesis.2017; 107: 75. CrossRef - The effect of antimicrobial photodynamic therapy on the expression of novel methicillin resistance markers determined using cDNA-AFLP approach in Staphylococcus aureus
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Photodiagnosis and Photodynamic Therapy.2017; 19: 249. CrossRef - Antimicrobial susceptibility of microorganisms isolated from sputum culture of patients with cystic fibrosis: Methicillin-resistant Staphylococcus aureus as a serious concern
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Microbial Pathogenesis.2016; 100: 201. CrossRef - The Correlation between Toxin Genotype and Antibiotic Resistance in Methicillin ResistantStaphylococcus aureusIsolated from Clinical Specimen of Intensive Care Unit
Chul Park, Chi Nam Seong
Korean Journal of Clinical Laboratory Science.2016; 48(3): 202. CrossRef - Studies on Enterotoxins and Antimicrobial Resistance in <i>Staphylococcus aureus</i> Isolated from Various Sources
Enas Yasser Mohammed, Shaymaa Hassan Abdel-Rhman, Rasha Barwa, Mohammed Adel El-Sokkary
Advances in Microbiology.2016; 06(04): 263. CrossRef - Genotype Analyses of Methicillin Resistant Staphylococcus aureus Isolated from clinical specimens
Jean-Soo Kim, Chul Park
Journal of the Korea Academia-Industrial cooperati.2015; 16(5): 3315. CrossRef - Frequency of the toxic shock syndrome toxin-1 gene in methicillin-susceptible and -resistant Staphylococcus aureus isolates from teaching hospitals in Shiraz, Iran
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Revista da Sociedade Brasileira de Medicina Tropic.2015; 48(1): 90. CrossRef
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