Osong Public Health and Research Perspectives

Pradeep Kumar Bharti

1 Article

Seroprevalence of antibodies to SARS-CoV-2 and predictors of seropositivity among employees of a teaching hospital in New Delhi, India: Pragya Sharma, Rohit Chawla, Ritika Bakshi, Sonal Saxena, Saurav Basu, Pradeep Kumar Bharti, Meera Dhuria, S. K. Singh, Panna Lal; Osong Public Health Res Perspect. 2021;12(2):88-95. Published online April 29, 2021; DOI: https://doi.org/10.24171/j.phrp.2021.12.2.06

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Objectives
Healthcare workers (HCWs) are at a high risk of contracting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) due to the increased likelihood of clinical exposure during patient management. The study objective was to determine the seroprevalence of antibodies to SARS-CoV-2 and its predictors among hospital employees.
Methods
The cross-sectional study was conducted at a teaching hospital from August 2020 to September 2020 among 1,401 employees, including 1,217 HCWs, in New Delhi, India. The serum samples were examined for immunoglobulin G (IgG) antibodies to SARS-CoV-2 using the COVID Kavach-Anti-SARS-CoV-2 IgG Antibody Detection enzyme-linked immunosorbent assay kit. Data were collected electronically using the EpiCollect mobile platform. A p<0.05 was considered to indicate statistical significance.
Results
A total of 169 participants (12.1%) had detectable IgG antibodies to SARS-CoV-2. The highest seropositivity rate was observed in the administrative staff (20.1%), while it was lowest among medical doctors (5.5%, p<0.001). Male sex and ever having lived in a containment zone were independently associated with past infection with SARS-CoV-2.
Conclusion
The seroprevalence of SARS-CoV-2 infection in health workers may be lower than in the general population in New Delhi. However, non-pharmaceutical interventions were not associated with a reduction in the risk of acquisition of SARS-CoV-2.

Citations

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Seroprevalence of IgG antibodies against SARS-CoV-2 in India, March 2020 to August 2021: a systematic review and meta-analysis
Nuzrath Jahan, Adarsha Brahma, Muthusamy Santhosh Kumar, Bhavani Shankara Bagepally, Manickam Ponnaiah, Tarun Bhatnagar, Manoj V Murhekar
International Journal of Infectious Diseases.2022; 116: 59. CrossRef
Risk Factors for COVID-19 Infection Among Healthcare Workers. A First Report From a Living Systematic Review and meta-Analysis
Tafadzwa Dzinamarira, Sphamandla Josias Nkambule, Mbuzeleni Hlongwa, Malizgani Mhango, Patrick Gad Iradukunda, Itai Chitungo, Mathias Dzobo, Munyaradzi Paul Mapingure, Innocent Chingombe, Moreblessing Mashora, Roda Madziva, Helena Herrera, Pelagia Makanda
Safety and Health at Work.2022; 13(3): 263. CrossRef
Seroprevalence of SARS-CoV-2 and Risk Assessment Among Healthcare Workers at a Dedicated Tertiary Care COVID-19 Hospital in Delhi, India: A Cohort Study
Pragya Sharma, Rohit Chawla, Saurav Basu, Sonal Saxena, Warisha Mariam, Pradeep Kumar Bharti, Shivani Rao, Neha Tanwar, Anisur Rahman, Mohammad Ahmad
Cureus.2021;[Epub] CrossRef

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