- Serum Homocysteine and Folate Levels are Associated With Late-life Dementia in a Korean Population
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Ju Hee Song, Moon Ho Park, Changsu Han, Sangmee A. Jo, Kyungsook Ahn
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Osong Public Health Res Perspect. 2010;1(1):17-22. Published online December 31, 2010
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DOI: https://doi.org/10.1016/j.phrp.2010.12.006
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 Abstract
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- Objectives
We aimed to determine whether serum levels of homocysteine (Hcy) and its biological determinants, folate and vitamin B12, are related to cognitive decline in elderly people.
Methods
The concentrations of total Hcy, folate, and vitamin B12 were measured in serum samples from 424 cognitively normal controls, 382 mild cognitive impairment patients, and 56 dementia patients from Ansan Geriatric cohort. The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) neuropsychological battery was used to evaluate cognitive functions.
Results
The dementia patients had higher serum Hcy (dementia, 17.6 ± 6.9 μmol/L; control, 12.9 ± 5.0 μmol/L; p < 0.001) and lower serum folate (dementia, 7.9 ± 4.8 ng/mL; control, 10.0 ± 7.1 ng/mL; p = 0.034) levels compared with controls. There was an inverse relationship between Hcy levels and serum folate or vitamin B12 concentrations. The cognitive status as measured by the (CERAD) score was inversely related to Hcy levels. The adjusted odds ratio of dementia was 5.18 (95% confidence interval: 1.91–14.10; p = 0.001) for moderate (30 ≥ Hcy > 15) hyperhomocysteinemia compared with normal Hcy levels (≤15 μmol/L). In addition, there was weak association between low serum folate (<3.0 ng/mL) and the risk for dementia (crude odds ratio = 3.68; 95% confidence interval: 1.07–12.69; p = 0.039).
Conclusion
Elevated serum Hcy and decreased serum folate concentrations are associated with the risk of dementia in Korean elders.
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Citations
Citations to this article as recorded by  - B vitamins and prevention of cognitive decline and incident dementia: a systematic review and meta-analysis
Zhibin Wang, Wei Zhu, Yi Xing, Jianping Jia, Yi Tang
Nutrition Reviews.2022; 80(4): 931. CrossRef - Biochemical and Hematological Correlates of Elevated Homocysteine in National Surveys and a Longitudinal Study of Urban Adults
May A. Beydoun, Hind A. Beydoun, Peter H. MacIver, Sharmin Hossain, Jose A. Canas, Michele K. Evans, Alan B. Zonderman
Nutrients.2020; 12(4): 950. CrossRef - Hyperhomocysteinemia is key for increased susceptibility to PND in aged mice
Guangchao Zhao, Jiao Deng, Yuan Shen, Peng Zhang, Hailong Dong, Zhongcong Xie, Lize Xiong
Annals of Clinical and Translational Neurology.2019; 6(8): 1435. CrossRef - The effects and potential mechanisms of folic acid on cognitive function: a comprehensive review
Athena Enderami, Mehran Zarghami, Hadi Darvishi-Khezri
Neurological Sciences.2018; 39(10): 1667. CrossRef
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