| Mehdi Goudarzi | 1 Article |
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<b>Objectives</b>
<p><italic>Staphylococcus aureus</italic> is a nosocomial pathogen that provides a major challenge in the healthcare environment, especially in burns units where patients are particularly susceptible to infections. In this study, we sought to determine molecular types of <italic>S. aureus</italic> isolates collected from burns patients, based on staphylococcal protein A and coagulase gene polymorphisms.</p></sec>
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<b>Methods</b>
<p>Antibiotic susceptibility testing of 89 <italic>S. aureus</italic> strains isolated from burn wounds of patients was assessed using the Kirby-Bauer disk diffusion method. Strains were characterized by <italic>spa</italic> typing, <italic>coa</italic> typing, and resistance and toxin gene profiling.</p></sec>
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<b>Results</b>
<p>A total of 12 different <italic>spa</italic> types were identified with the majority being t790 (18%). Panton-Valentine leucocidin encoding genes were identified in <italic>spa</italic> types t044 (5.6%), t852 (2.2%) and t008 (2.2%). The most commonly detected antibiotic resistance gene was <italic>ant (4′)-Ia</italic> (60.7%). Ten different <italic>coa</italic> types were detected and the majority of the tested isolates belonged to <italic>coa</italic> III (47.2%). All the high-level mupirocin-resistant and low-level mupirocin resistant strains belonged to <italic>coa</italic> type III.</p></sec>
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<b>Conclusion</b>
<p>The present study illustrated that despite the high frequency of <italic>coa</italic> III and <italic>spa</italic> t790 types, the genetic background of <italic>S. aureus</italic> strains in Iranian burns patients was diverse. The findings obtained are valuable in creating awareness of <italic>S. aureus</italic> infections within burns units.</p></sec>
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