Skip Navigation
Skip to contents

PHRP : Osong Public Health and Research Perspectives

OPEN ACCESS
SEARCH
Search

Author index

Page Path
HOME > Articles and issues > Author index
Search
Mehdi Goudarzi 1 Article
Genetic Variability of Methicillin Resistant Staphylococcus Aureus Strains Isolated from Burns Patients
Mehdi Goudarzi, Nobumichi Kobayashi, Ali Hashemi, Maryam Fazeli, Masoumeh Navidinia
Osong Public Health Res Perspect. 2019;10(3):170-176.   Published online June 30, 2019
DOI: https://doi.org/10.24171/j.phrp.2019.10.3.08
  • 3,729 View
  • 113 Download
  • 9 Citations
AbstractAbstract PDF
Objectives

Staphylococcus aureus is a nosocomial pathogen that provides a major challenge in the healthcare environment, especially in burns units where patients are particularly susceptible to infections. In this study, we sought to determine molecular types of S. aureus isolates collected from burns patients, based on staphylococcal protein A and coagulase gene polymorphisms.

Methods

Antibiotic susceptibility testing of 89 S. aureus strains isolated from burn wounds of patients was assessed using the Kirby-Bauer disk diffusion method. Strains were characterized by spa typing, coa typing, and resistance and toxin gene profiling.

Results

A total of 12 different spa types were identified with the majority being t790 (18%). Panton-Valentine leucocidin encoding genes were identified in spa types t044 (5.6%), t852 (2.2%) and t008 (2.2%). The most commonly detected antibiotic resistance gene was ant (4′)-Ia (60.7%). Ten different coa types were detected and the majority of the tested isolates belonged to coa III (47.2%). All the high-level mupirocin-resistant and low-level mupirocin resistant strains belonged to coa type III.

Conclusion

The present study illustrated that despite the high frequency of coa III and spa t790 types, the genetic background of S. aureus strains in Iranian burns patients was diverse. The findings obtained are valuable in creating awareness of S. aureus infections within burns units.

Citations

Citations to this article as recorded by  
  • Characteristic, antibiotic resistance and molecular typing of Staphylococcus aureus isolated from intensive care unit and burn patients based on coagulase gene analysis
    Bahareh Hajikhani, Anis Mohammadi, Mohammad Javad Nasiri, Masoud Dadashi, Ali Hashemi, Mehrdad Haghighi, Mirmohammad Miri, Mehdi Goudarzi
    Gene Reports.2022; 26: 101542.     CrossRef
  • Vancomycin heteroresistance among methicillin-resistant clinical isolates S. haemolyticus, S. hominis, S. simulans, and S. warneri
    Magdalena Szemraj, Paweł Lisiecki, Paulina Glajzner, Eligia M. Szewczyk
    Brazilian Journal of Microbiology.2022;[Epub]     CrossRef
  • Efficacy of Phage- and Bacteriocin-Based Therapies in Combatting Nosocomial MRSA Infections
    Lauren Walsh, Crystal N. Johnson, Colin Hill, R. Paul Ross
    Frontiers in Molecular Biosciences.2021;[Epub]     CrossRef
  • Hospital clones of Panton-Valentine leukocidin-positive and methicillin-resistant Staphylococcus aureus circulating in the Tehran community
    Samira Tajik, Shahin Najar-Peerayeh, Bita Bakhshi
    Journal of Global Antimicrobial Resistance.2020; 22: 177.     CrossRef
  • Characterizing a Lytic Bacteriophage Infecting Methicillin-Resistant Staphylococcus aureus (MRSA) Isolated From Burn Patients
    Masoume Hallajzadeh, Ali Mojtahedi, Nour Amirmozafari, Vahid Pirhajati Mahabadi
    Archives of Clinical Infectious Diseases.2020;[Epub]     CrossRef
  • Methicillin-Resistant Staphylococcus aureus ST80 Clone: A Systematic Review
    Assia Mairi, Abdelaziz Touati, Jean-Philippe Lavigne
    Toxins.2020; 12(2): 119.     CrossRef
  • The prevalence and molecular mechanisms of mupirocin resistance in Staphylococcus aureus isolates from a Hospital in Cape Town, South Africa
    Shima M. Abdulgader, Tshepiso Lentswe, Andrew Whitelaw, Mae Newton-Foot
    Antimicrobial Resistance & Infection Control.2020;[Epub]     CrossRef
  • Search of Potential Vaccine Candidates against Trueperella pyogenes Infections through Proteomic and Bioinformatic Analysis
    Ángela Galán-Relaño, Lidia Gómez-Gascón, Antonio Rodríguez-Franco, Inmaculada Luque, Belén Huerta, Carmen Tarradas, Manuel J. Rodríguez-Ortega
    Vaccines.2020; 8(2): 314.     CrossRef
  • Genotypic and Phenotypic Characterisation of Clinical Isolates of Methicillin-Resistant Staphylococcus aureus in Two Different Geographical Locations of Iran
    Shiva Ahmadishoar, Nadia Kazemi Pour, Javid Sadeghi, Mohammad Reza Nahaei, Babak Kheirkhah
    Indian Journal of Medical Microbiology.2020; 38(2): 162.     CrossRef

PHRP : Osong Public Health and Research Perspectives