- Drug Resistance Pattern of Mycobacterium tuberculosis Isolates From Patients Referred to TB Reference Laboratory in Ahvaz
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Fereshteh Badie, Maniya Arshadi, Maryam Mohsenpoor, Soodabeh S. Gharibvand
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Osong Public Health Res Perspect. 2016;7(1):32-35. Published online February 28, 2016
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DOI: https://doi.org/10.1016/j.phrp.2015.10.010
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 Abstract
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- Objectives
Tuberculosis remains one of the top three infectious disease killers. The prevalence of multidrug-resistant tuberculosis (MDR-TB) has increased substantially in the past 20 years. When drug resistance is not detected, MDR-TB patients cannot access life-saving treatment; this puts their communities at risk of ongoing MDR-TB transmission. We aimed to determine the patterns of resistance to antituberculosis drugs among Mycobacterium tuberculosis isolates from Khuzestan province in Iran.
Methods
A total of 850 clinical specimens from patients suspected of active TB were cultured in 2015. Drug susceptibility testing to the first line antiTB drugs for culture positive MTB was performed on Lowenstein–Jensen medium using the proportion method.
Results
Of 850 cultured specimens, 272 (32%) were culture positive for mycobacteria. Of 64 MTB isolates that were analyzed by the proportion method, 62 (96.8%) were pan-susceptible and two (3.1%) were MDR.
Conclusion
An important way to prevent the emergence of MDR and XDR TB, and the principles of full implementation of the strategy is directly observed treatment, short-course (DOTS). The efficient diagnosis and timely treatment of MDR-TB patients can prevent disease transmission, reduce the risk of drug resistance developing, and avoid further lung damage.
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Citations
Citations to this article as recorded by  - The Structural Basis of Mycobacterium tuberculosis RpoB Drug-Resistant Clinical Mutations on Rifampicin Drug Binding
Arnold Amusengeri, Asifullah Khan, Özlem Tastan Bishop
Molecules.2022; 27(3): 885. CrossRef - Molecular Evidence of Drug-Resistant Tuberculosis in the Balimo Region of Papua New Guinea
Tanya Diefenbach-Elstob, Vanina Guernier, Graham Burgess, Daniel Pelowa, Robert Dowi, Bisato Gula, Munish Puri, William Pomat, Emma McBryde, David Plummer, Catherine Rush, Jeffrey Warner
Tropical Medicine and Infectious Disease.2019; 4(1): 33. CrossRef - Genetic diversity of multidrug‐resistant Mycobacterium tuberculosis strains isolated from tuberculosis patients in Iran using MIRU‐VNTR technique
Azar Dokht Khosravi, Abdolrazagh Hashemi Shahraki, Soolmaz Khandan Dezfuli, Mohammad Hashemzadeh, Hamed Goodarzi, Parviz Mohajeri
The Kaohsiung Journal of Medical Sciences.2017; 33(11): 550. CrossRef
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