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Kyu Jam Hwang 3 Articles
Autochthonous Lyme Borreliosis in Humans and Ticks in Korea
Shinje Moon, Jin Gwack, Kyu Jam Hwang, Donghyuk Kwon, Suyeon Kim, Yoontae Noh, Jongyul Roh, E-hyun Shin, Kyungjin Jeong, Wonseok Seok, Seung-Ki Youn
Osong Public Health Res Perspect. 2013;4(1):52-56.   Published online February 28, 2013
DOI: https://doi.org/10.1016/j.phrp.2012.12.001
  • 1,980 View
  • 15 Download
  • 16 Citations
AbstractAbstract PDF
Objective: This study aimed at finding epidemiological and clinical features of autochthonous Lyme borreliosis in humans through epidemiological investigations and identifying its vectors and pathogens through analysis of ticks.
Method
Epidemiological investigations, including review of the retrospective medical records and patient interviews, were conducted in two cases that occurred in 2012. To identify the vectors and pathogens, ticks were collected between September 23 and October 6, 2012 from the area where the tick bite in the first patient occurred. The ticks were classified, and polymerase chain reaction (PCR) tests and cultures were performed.
Results
The first patient, a 46-year-old female, visited a forest in Gangwon province, which was 900 m above sea level, where the tick bite occurred. Two weeks after the tick bite, erythema migrans (12 × 6 cm2 in size) appeared on the site of tick bite, along with fever, chill, fatigue, myalgia, and arthralgia on shoulders, knees, and hips. The second patient, a 44-year-old male, visited a mountain in Gangwon province, which was 1200 m above sea level, where a tick bite occurred. One month after the tick bite, erythema migrans appeared at the site of the tick bite, along with fatigue, myalgia, and arthralgia on the right shoulder and temporomandibular joint. Indirect fluorescent antibody testing and Western blotting were carried out in these two cases for diagnosis, and positive findings were obtained. As a result, Lyme borreliosis could be confirmed. To estimate the pathogens and vectors, the ticks were collected. A total of 122 ticks were collected and only two species, Haemaphysalis japonica and Haemaphysalis flava, were identified. PCR and culture were performed on ticks. However, Borrelia burgdo rferi sensu lato was not isolated from any collected ticks.
Conclusions
This study is significant to confirm Lyme borreliosis officially at first by the national surveillance system, although identification of the mites and pathogens failed.

Citations

Citations to this article as recorded by  
  • Surveillance and Molecular Identification of Borrelia Species in Ticks Collected at U.S. Army Garrison Humphreys, Republic of Korea, 2018–2019
    Seung-Ho Lee, Sung-Tae Chong, Heung-Chul Kim, Terry A Klein, Kyungmin Park, Jingyeong Lee, Jeong-Ah Kim, Won-Keun Kim, Jin-Won Song, Sarah Hamer
    Journal of Medical Entomology.2022; 59(1): 363.     CrossRef
  • De novo transcriptome sequencing and comparative profiling of the ovary in partially engorged and fully engorged Haemaphysalis flava ticks
    Yu Zhao, Zhe-Hui Qu, Feng-Chao Jiao
    Parasitology International.2021; 83: 102344.     CrossRef
  • Characterization of AV422 from Haemaphysalis flava ticks in vitro
    Lei Liu, Hao Tang, De-yong Duan, Jin-bao Liu, Jie Wang, Li-li Feng, Tian-yin Cheng
    Experimental and Applied Acarology.2021; 84(4): 809.     CrossRef
  • iSeq 100 for metagenomic pathogen screening in ticks
    Ju Yeong Kim, Myung-hee Yi, Alghurabi Areej Sabri Mahdi, Tai-Soon Yong
    Parasites & Vectors.2021;[Epub]     CrossRef
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    Choong Won Seo
    The Korean Journal of Clinical Laboratory Science.2019; 51(4): 436.     CrossRef
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    Parasitology Research.2019; 118(5): 1581.     CrossRef
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    X.-M. He, T.-Y. Cheng
    Journal of Applied Entomology.2018; 142(1-2): 173.     CrossRef
  • Molecular detection of Rickettsia species in ticks collected from the southwestern provinces of the Republic of Korea
    Yoontae Noh, Yeong Seon Lee, Heung-Chul Kim, Sung-Tae Chong, Terry A. Klein, Ju Jiang, Allen L. Richards, Hae Kyeong Lee, Su Yeon Kim
    Parasites & Vectors.2017;[Epub]     CrossRef
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    Journal of Medical Entomology.2017; 54(5): 1397.     CrossRef
  • Serological Detection of Borrelia burgdorferi among Horses in Korea
    Seung-Hun Lee, Sun-Hee Yun, Eunsang Choi, Yong-Soo Park, Sang-Eun Lee, Gil-Jae Cho, Oh-Deog Kwon, Dongmi Kwak
    The Korean Journal of Parasitology.2016; 54(1): 97.     CrossRef
  • De novo assembly and analysis of midgut transcriptome of Haemaphysalis flava and identification of genes involved in blood digestion, feeding and defending from pathogens
    Xing-Li Xu, Tian-Yin Cheng, Hu Yang, Zhi-Hui Liao
    Infection, Genetics and Evolution.2016; 38: 62.     CrossRef
  • Enolase, a plasminogen receptor isolated from salivary gland transcriptome of the ixodid tick Haemaphysalis flava
    Xing-Li Xu, Tian-Yin Cheng, Hu Yang
    Parasitology Research.2016; 115(5): 1955.     CrossRef
  • Seasonal Patterns of Ticks in Pocheon and Cheolwon, Republic of Korea
    Yong Chil Shin, In Yong Lee, Jang Hoon Seo
    Korean Journal of Clinical Laboratory Science.2015; 47(3): 147.     CrossRef
  • Epidemiological Features and Clinical Manifestations of Lyme Borreliosis in Korea during the Period 2005^|^ndash;2012
    Shinje Moon, Yeongseon Hong, Kyu-Jam Hwang, Suyeon Kim, Jihye Eom, Donghyok Kwon, Ji-Hyuk Park, Seung-Ki Youn, Aeree Sohn
    Japanese Journal of Infectious Diseases.2015; 68(1): 1.     CrossRef
  • Insight into the Pathogenesis of Lyme Disease
    Ok Sarah Shin
    Journal of Bacteriology and Virology.2014; 44(1): 10.     CrossRef
  • Epidemic Intelligence Service Officers and Field Epidemiology Training Program in Korea
    Geun-Yong Kwon, Shinje Moon, Wooseok Kwak, Jin Gwack, Chaeshin Chu, Seung-Ki Youn
    Osong Public Health and Research Perspectives.2013; 4(4): 215.     CrossRef
Prion Diseases as Transmissible Zoonotic Diseases
Jeongmin Lee, Su Yeon Kim, Kyu Jam Hwang, Young Ran Ju, Hee-Jong Woo
Osong Public Health Res Perspect. 2013;4(1):57-66.   Published online February 28, 2013
DOI: https://doi.org/10.1016/j.phrp.2012.12.008
  • 1,985 View
  • 16 Download
  • 18 Citations
AbstractAbstract PDF
Prion diseases, also called transmissible spongiform encephalopathies (TSEs), lead to neurological dysfunction in animals and are fatal. Infectious prion proteins are causative agents of many mammalian TSEs, including scrapie (in sheep), chronic wasting disease (in deer and elk), bovine spongiform encephalopathy (BSE; in cattle), and Creutzfeldt–Jakob disease (CJD; in humans). BSE, better known as mad cow disease, is among the many recently discovered zoonotic diseases. BSE cases were first reported in the United Kingdom in 1986. Variant CJD (vCJD) is a disease that was first detected in 1996, which affects humans and is linked to the BSE epidemic in cattle. vCJD is presumed to be caused by consumption of contaminated meat and other food products derived from affected cattle. The BSE epidemic peaked in 1992 and decreased thereafter; this decline is continuing sharply owing to intensive surveillance and screening programs in the Western world. However, there are still new outbreaks and/or progression of prion diseases, including atypical BSE, and iatrogenic CJD and vCJD via organ transplantation and blood transfusion. This paper summarizes studies on prions, particularly on prion molecular mechanisms, BSE, vCJD, and diagnostic procedures. Risk perception and communication policies of the European Union for the prevention of prion diseases are also addressed to provide recommendations for appropriate government policies in Korea.

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    Yeoungsug Kim, Angel Emmanuel Rodriguez, Hessam Nowzari
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Epidemiological Characteristics of Serologically Confirmed Q Fever Cases in South Korea, 2006–2011
Wooseok Kwak, Hyuk Chu, Seondo Hwang, Ji-Hyuk Park, Kyu Jam Hwang, Jin Gwack, Young-Sil Choi, Seung-Ki Youn, Mi-Yeoun Park
Osong Public Health Res Perspect. 2013;4(1):34-38.   Published online February 28, 2013
DOI: https://doi.org/10.1016/j.phrp.2012.12.006
  • 2,283 View
  • 15 Download
  • 22 Citations
AbstractAbstract PDF
Objectives
Q fever has been reported worldwide; however, there was almost no official report of Q fever in Korea. In this study, we describe the current status of human Q fever occurrence in Korea.
Methods
Demographic data of Q fever patients were collected from the National Notifiable Diseases Surveillance System from 2006 to 2011. Case investigation reports from regional public health departments were used for additional information, like risk factors and clinical manifestation, of the patients since 2008.
Results
There were 65 serologically confirmed cases during the study period. The annual notification rate of Q fever was 0.22 cases per million persons. The majority of cases were men (87.7%), adults (98.5%), and urban inhabitants (67.7%). Relevant exposures to risk factors were identified in 45.7% of patients. The most common symptoms of acute Q fever were fever (89.3%), myalgia (67.9%) and asthenia (53.6%). Two cases with endocarditis were identified in chronic Q fever.
Conclusion
This study suggests that Q fever has a low endemicity in Korea. However, management and research at national level is required for prevention of a future epidemic.

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PHRP : Osong Public Health and Research Perspectives