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Ju Yeon Park 2 Articles
Associations Between Estimated Desaturase Activity and Insulin Resistance in Korean Boys
Young Sim Choi, Han Byul Jang, Ju Yeon Park, Hye-Ja Lee, Jae-Heon Kang, Kyung-Hee Park, Jong Ho Lee, Sang Ick Park, Jihyun Song
Osong Public Health Res Perspect. 2014;5(5):251-257.   Published online October 31, 2014
DOI: https://doi.org/10.1016/j.phrp.2014.08.008
  • 2,001 View
  • 15 Download
  • 8 Citations
AbstractAbstract PDF
Objectives
Obesity in childhood increases the risk of obesity in adulthood, and is predictive of the development of metabolic disorders. The fatty acid compositions of various tissues, including blood, are associated with obesity and obesity-associated disorders. Thus, tracking plasma phospholipid (PL) features and metabolic parameters in young individuals may strengthen the utility of fatty acid composition as an early biomarker of future metabolic disorders.
Methods
Anthropometric and blood biochemical data were obtained from 131 Korean males aged 10.5 ± 0.4 years, and followed up at 2 years. We analyzed the plasma PL fatty acids according to obesity. Obese children were defined as those with a body mass index (BMI) greater than the 85th percentile for age and gender, based on Korean child growth standards.
Results
Activities of lipid desaturases, stearyl-CoAD (SCD-16,16:1n-7/16:0), delta-6D (D6D, 20:3n-6/18:2n-6), and delta-5D (D5D, 20:4n-6/20:3n-6), were estimated. Obese individuals had significantly higher proportions of palmitoleic acid (16:1n-7) and dihomo-gamma linolenic acid (DGLA, 20:3n-6) at both baseline and follow-up than did lean individuals. The activities of SCD-16 and D6D were higher in obese than lean boys. The baseline SCD-16 activity level was positively associated with the baseline waist circumference (WC) and the metabolic risk score. The baseline D6D level was positively associated with WC and also with the homeostasis model of assessment of insulin resistance (HOMA-IR), a surrogate marker of insulin resistance (IR), and metabolic risk score at both baseline and follow-up.
Conclusion
In young Korean males, higher D6D activity predicts the future development of IR and associated metabolic disorders including dyslipidemia.

Citations

Citations to this article as recorded by  
  • Palmitoleic and Dihomo-γ-Linolenic Acids Are Positively Associated With Abdominal Obesity and Increased Metabolic Risk in Children
    Man-Chin Hua, Hui-Min Su, Ming-Wei Lai, Tsung-Chieh Yao, Ming-Han Tsai, Sui-Ling Liao, Shen-Hao Lai, Jing-Long Huang
    Frontiers in Pediatrics.2021;[Epub]     CrossRef
  • Is Palmitoleic Acid a Plausible Nonpharmacological Strategy to Prevent or Control Chronic Metabolic and Inflammatory Disorders?
    Camila O. de Souza, Gretchen K. Vannice, José C. Rosa Neto, Philip C. Calder
    Molecular Nutrition & Food Research.2018; 62(1): 1700504.     CrossRef
  • Associations Among Fatty Acids, Desaturase and Elongase, and Insulin Resistance in Children
    Lori M. Beccarelli, Rachel Erin Scherr, John W. Newman, Alison G. Borkowska, Ira J. Gray, Jessica D. Linnell, Carl L. Keen, Heather M. Young
    Journal of the American College of Nutrition.2018; 37(1): 44.     CrossRef
  • Continuous cardiometabolic risk score definitions in early childhood: a scoping review
    M. Kamel, B. T. Smith, G. Wahi, S. Carsley, C. S. Birken, L. N. Anderson
    Obesity Reviews.2018; 19(12): 1688.     CrossRef
  • FADS1-FADS2 gene cluster confers risk to polycystic ovary syndrome
    Ye Tian, Wei Zhang, Shigang Zhao, Yinhua Sun, Yuehong Bian, Tailai Chen, Yanzhi Du, Jiangtao Zhang, Zhao Wang, Tao Huang, Yingqian Peng, Ping Yang, Han Zhao, Zi-Jiang Chen
    Scientific Reports.2016;[Epub]     CrossRef
  • Association of plasma fatty acid composition with plasma irisin levels in normal weight and overweight/obese children
    A. Viitasalo, J. Ågren, T. Venäläinen, J. Pihlajamäki, J. Jääskeläinen, A. Korkmaz, M. Atalay, T. A. Lakka
    Pediatric Obesity.2016; 11(4): 299.     CrossRef
  • Linoleic acid and the pathogenesis of obesity
    Shaan S. Naughton, Michael L. Mathai, Deanne H. Hryciw, Andrew J. McAinch
    Prostaglandins & Other Lipid Mediators.2016; 125: 90.     CrossRef
  • Effect of Exercise and Calorie Restriction on Tissue Acylcarnitines, Tissue Desaturase Indices, and Fat Accumulation in Diet-Induced Obese Rats
    Venkatesh Gopalan, Navin Michael, Seigo Ishino, Swee Shean Lee, Adonsia Yating Yang, K. N. Bhanu Prakash, Jadegoud Yaligar, Suresh Anand Sadananthan, Manami Kaneko, Zhihong Zhou, Yoshinori Satomi, Megumi Hirayama, Hidenori Kamiguchi, Bin Zhu, Takashi Hori
    Scientific Reports.2016;[Epub]     CrossRef
Association Between Serum Vitamin D and Metabolic Risk Factors in Korean Schoolgirls
Han Byul Jang, Hye-Ja Lee, Ju Yeon Park, Jae-Heon Kang, Jihyun Song
Osong Public Health Res Perspect. 2013;4(4):179-186.   Published online August 31, 2013
DOI: https://doi.org/10.1016/j.phrp.2013.06.004
  • 1,805 View
  • 17 Download
  • 14 Citations
AbstractAbstract PDF
Objectives
Vitamin D, a key regulator of bone metabolism, has been recently been linked with energy homeostasis and metabolic disorders in western countries. However, few studies have focused on the association of vitamin D with metabolic risk factors among Asian children. We studied the prevalence of vitamin D insufficiency and the association of 25-hydroxyvitamin D [25(OH)D] with metabolic risk factors in Korean schoolgirls.
Methods
The sample consisted of 320 13-year-old girls recruited from two middle schools in the city of Gwacheon, Korea (latitude 37°N), in July 2011. Anthropometric and blood biochemistry data were obtained for this cross-sectional observational study. We also obtained lifestyle data from questionnaires and dietary data from 3-day food diaries.
Results
Vitamin D deficiency [25(OH)D < 20 ng/mL] was noted in 63.8% of participants. The mean 25(OH)D level was not significantly lower in the overweight group. Level of physical activity and vitamin D intake did not significantly affect 25(OH)D. However, 25(OH)D levels were positively correlated with milk intake and negatively correlated with soft drink intake. Serum 25(OH)D had a negative relationship with fasting glucose and insulin resistance index (homeostasis model assessment-insulin resistance; HOMA-IR) after adjustment for physical activity and body mass index z score (r = −0.144, p = 0.015), and with metabolic risk score similarly (r = −0.141, p = 0.012). Levels of insulin, HOMA-IR, and systolic blood pressure were higher in girls with deficient 25(OH)D levels than in those with sufficient levels.
Conclusion
We found that low 25(OH)D levels were associated with higher blood glucose and insulin resistance. Korean girls with low 25(OH)D levels could be at increased risk for metabolic disorders.

Citations

Citations to this article as recorded by  
  • Vitamin D status and blood pressure in children and adolescents: a systematic review of observational studies
    Myriam Abboud, Fatme Al Anouti, Dimitrios Papandreou, Rana Rizk, Nadine Mahboub, Suzan Haidar
    Systematic Reviews.2021;[Epub]     CrossRef
  • Relationship Between Vitamin D Status and the Relevant Parameters of Glucose in Patients with Type 2 Diabetes
    Thanh Tung Tran Huu, Huu Dang Tran, Thua Nguyen Tran, Bui Bao Hoang
    Diabetes, Metabolic Syndrome and Obesity: Targets .2021; Volume 14: 2489.     CrossRef
  • Different Cabergoline Effect on Metabolic and Anthropometric Parameters in Female Prolactinoma Patients Versus Idiopathic Hyperprolactinemia Patients
    Mohamed M. Aboelnaga, Eman H. Eladawy, Maha M. Elshafei, Nahed Abdullah, Moustafa El. Shaer
    Endocrine, Metabolic & Immune Disorders - Drug Tar.2019; 19(4): 511.     CrossRef
  • Seasonality of tuberculosis in the Republic of Korea, 2006-2016
    Eun Hee Kim, Jong-Myon Bae
    Epidemiology and Health.2018; 40: e2018051.     CrossRef
  • Current Evidence on Vitamin D Deficiency and Metabolic Syndrome in Obese Children: What Does the Evidence from Saudi Arabia Tell Us?
    Asma Alaklabi, Naser Alsharairi
    Children.2018; 5(1): 11.     CrossRef
  • The association between gender difference with metabolic syndrome, metabolic syndrome score and serum vitamin D levels in Korean adults
    Hyun Yoon, Dae Keun Jeong, Chang Eun Park, Hye Jong Oh, Sung Gil Kim
    International Journal of Food Sciences and Nutriti.2017; 68(1): 121.     CrossRef
  • Serum 25-Hydroxyvitamin D associated with indicators of body fat and insulin resistance in prepubertal chilean children
    G Cediel, C Corvalán, C Aguirre, D L de Romaña, R Uauy
    International Journal of Obesity.2016; 40(1): 147.     CrossRef
  • The relationship between metabolic syndrome and increase of metabolic syndrome score and serum vitamin D levels in Korean adults: 2012 Korean National Health and Nutrition Examination Survey
    Hyun Yoon, Gwang Seok Kim, Sung Gil Kim, Ae Eun Moon
    Journal of Clinical Biochemistry and Nutrition.2015; 57(1): 82.     CrossRef
  • Vitamin D Deficiency and Cardiometabolic Risks: A Juxtaposition of Arab Adolescents and Adults
    Nasser M. Al-Daghri, Yousef Al-Saleh, Naji Aljohani, Majed Alokail, Omar Al-Attas, Abdullah M. Alnaami, Shaun Sabico, Maha Alsulaimani, Mohammed Al-Harbi, Hanan Alfawaz, George P. Chrousos, Joseph Devaney
    PLOS ONE.2015; 10(7): e0131315.     CrossRef
  • Association of Serum 25-Hydroxyvitamin D with Life Style and Dietary Factors in Egyptian Prepubescent Children
    Mones M. Abu Shady, Mai M. Youssef, Manal A. Shehata, Ebtissam M. Salah El-Din, Heba A. ElMalt
    Open Access Macedonian Journal of Medical Sciences.2015; 3(1): 80.     CrossRef
  • The Study of Serum Vitamin D and Insulin Resistance in Chinese Populations with Normal Glucose Tolerance
    Lin Ding, Congcong Wang, Heliang Ma, Yuling Tian, Yong Lu, Shuguang Pang
    International Journal of Endocrinology.2014; 2014: 1.     CrossRef
  • Does Sufficient Evidence Exist to Support a Causal Association between Vitamin D Status and Cardiovascular Disease Risk? An Assessment Using Hill’s Criteria for Causality
    Patricia Weyland, William Grant, Jill Howie-Esquivel
    Nutrients.2014; 6(9): 3403.     CrossRef
  • Vitamin D insufficiency and insulin resistance in obese adolescents
    Catherine A. Peterson, Aneesh K. Tosh, Anthony M. Belenchia
    Therapeutic Advances in Endocrinology and Metaboli.2014; 5(6): 166.     CrossRef
  • Vitamin D Status among Thai School Children and the Association with 1,25-Dihydroxyvitamin D and Parathyroid Hormone Levels
    Lisa A. Houghton, Andrew R. Gray, Michelle J. Harper, Pattanee Winichagoon, Tippawan Pongcharoen, Sueppong Gowachirapant, Rosalind S. Gibson, Dominique Heymann
    PLoS ONE.2014; 9(8): e104825.     CrossRef

PHRP : Osong Public Health and Research Perspectives